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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FUBP1-USP33

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FUBP1-USP33
	FusionPDB ID: 31755
	FusionGDB2.0 ID: 31755
		Hgene	Tgene
	Gene symbol	FUBP1	USP33
	Gene ID	8880	23032
	Gene name	far upstream element binding protein 1	ubiquitin specific peptidase 33
	Synonyms	FBP\|FUBP\|hDH V	VDU1
	Cytomap	1p31.1	1p31.1
	Type of gene	protein-coding	protein-coding
	Description	far upstream element-binding protein 1DNA helicase VFUSE binding protein 1epididymis secretory sperm binding proteinfar upstream element (FUSE) binding protein 1	ubiquitin carboxyl-terminal hydrolase 33VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33
	Modification date	20200313	20200313
	UniProtAcc	Q96AE4	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000370767, ENST00000370768, ENST00000436586, ENST00000489495,	ENST00000357428, ENST00000370792, ENST00000370793, ENST00000370794, ENST00000528150,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 10 X 7=630	13 X 11 X 8=1144
	# samples	14	16
	** MAII score	log2(14/630*10)=-2.16992500144231 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(16/1144*10)=-2.83794324189103 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FUBP1 [Title/Abstract] AND USP33 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	USP33(78225328)-FUBP1(78435699), # samples:2 FUBP1(78428454)-USP33(78167156), # samples:1 FUBP1(78428455)-USP33(78207433), # samples:1 FUBP1(78444569)-USP33(78207433), # samples:1 FUBP1(78428455)-USP33(78167156), # samples:1
Anticipated loss of major functional domain due to fusion event.	FUBP1-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FUBP1-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FUBP1-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FUBP1-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FUBP1	GO:0010628	positive regulation of gene expression	19087307
Tgene	USP33	GO:0009267	cellular response to starvation	24056301
Tgene	USP33	GO:0016579	protein deubiquitination	11739384\|19363159\|19424180\|23486064
Tgene	USP33	GO:0070536	protein K63-linked deubiquitination	19363159
Tgene	USP33	GO:0071108	protein K48-linked deubiquitination	19363159

Fusion gene breakpoints across FUBP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across USP33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BLCA	TCGA-DK-A1AD-01A	FUBP1	chr1	78428455	-	USP33	chr1	78207433	-
ChimerDB4	HNSC	TCGA-CR-7379	FUBP1	chr1	78444569	-	USP33	chr1	78207433	-
ChimerDB4	STAD	TCGA-VQ-A94O-01A	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-
ChimerDB4	STAD	TCGA-VQ-A94O	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000370768	FUBP1	chr1	78428454	-	ENST00000370794	USP33	chr1	78167156	-	3086	1426	82	1755	557
ENST00000370768	FUBP1	chr1	78428454	-	ENST00000357428	USP33	chr1	78167156	-	3082	1426	82	1755	557
ENST00000370768	FUBP1	chr1	78428454	-	ENST00000370793	USP33	chr1	78167156	-	3082	1426	82	1755	557
ENST00000370767	FUBP1	chr1	78428454	-	ENST00000370794	USP33	chr1	78167156	-	3092	1432	88	1761	557
ENST00000370767	FUBP1	chr1	78428454	-	ENST00000357428	USP33	chr1	78167156	-	3088	1432	88	1761	557
ENST00000370767	FUBP1	chr1	78428454	-	ENST00000370793	USP33	chr1	78167156	-	3088	1432	88	1761	557
ENST00000436586	FUBP1	chr1	78428454	-	ENST00000370794	USP33	chr1	78167156	-	3124	1464	57	1793	578
ENST00000436586	FUBP1	chr1	78428454	-	ENST00000357428	USP33	chr1	78167156	-	3120	1464	57	1793	578
ENST00000436586	FUBP1	chr1	78428454	-	ENST00000370793	USP33	chr1	78167156	-	3120	1464	57	1793	578
ENST00000370768	FUBP1	chr1	78428455	-	ENST00000370794	USP33	chr1	78167156	-	3086	1426	82	1755	557
ENST00000370768	FUBP1	chr1	78428455	-	ENST00000357428	USP33	chr1	78167156	-	3082	1426	82	1755	557
ENST00000370768	FUBP1	chr1	78428455	-	ENST00000370793	USP33	chr1	78167156	-	3082	1426	82	1755	557
ENST00000370767	FUBP1	chr1	78428455	-	ENST00000370794	USP33	chr1	78167156	-	3092	1432	88	1761	557
ENST00000370767	FUBP1	chr1	78428455	-	ENST00000357428	USP33	chr1	78167156	-	3088	1432	88	1761	557
ENST00000370767	FUBP1	chr1	78428455	-	ENST00000370793	USP33	chr1	78167156	-	3088	1432	88	1761	557
ENST00000436586	FUBP1	chr1	78428455	-	ENST00000370794	USP33	chr1	78167156	-	3124	1464	57	1793	578
ENST00000436586	FUBP1	chr1	78428455	-	ENST00000357428	USP33	chr1	78167156	-	3120	1464	57	1793	578
ENST00000436586	FUBP1	chr1	78428455	-	ENST00000370793	USP33	chr1	78167156	-	3120	1464	57	1793	578

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370768	ENST00000370794	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000247153	0.9997528
ENST00000370768	ENST00000357428	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000251569	0.9997484
ENST00000370768	ENST00000370793	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000251569	0.9997484
ENST00000370767	ENST00000370794	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000244632	0.9997553
ENST00000370767	ENST00000357428	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.00024902	0.99975103
ENST00000370767	ENST00000370793	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.00024902	0.99975103
ENST00000436586	ENST00000370794	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.00015517	0.9998448
ENST00000436586	ENST00000357428	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000157707	0.9998423
ENST00000436586	ENST00000370793	FUBP1	chr1	78428454	-	USP33	chr1	78167156	-	0.000157707	0.9998423
ENST00000370768	ENST00000370794	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000247153	0.9997528
ENST00000370768	ENST00000357428	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000251569	0.9997484
ENST00000370768	ENST00000370793	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000251569	0.9997484
ENST00000370767	ENST00000370794	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000244632	0.9997553
ENST00000370767	ENST00000357428	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.00024902	0.99975103
ENST00000370767	ENST00000370793	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.00024902	0.99975103
ENST00000436586	ENST00000370794	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.00015517	0.9998448
ENST00000436586	ENST00000357428	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000157707	0.9998423
ENST00000436586	ENST00000370793	FUBP1	chr1	78428455	-	USP33	chr1	78167156	-	0.000157707	0.9998423

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31755_31755_1_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370767_USP33_chr1_78167156_ENST00000357428_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_2_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370767_USP33_chr1_78167156_ENST00000370793_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_3_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370767_USP33_chr1_78167156_ENST00000370794_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_4_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370768_USP33_chr1_78167156_ENST00000357428_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_5_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370768_USP33_chr1_78167156_ENST00000370793_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_6_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000370768_USP33_chr1_78167156_ENST00000370794_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_7_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000436586_USP33_chr1_78167156_ENST00000357428_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

>31755_31755_8_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000436586_USP33_chr1_78167156_ENST00000370793_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

>31755_31755_9_FUBP1-USP33_FUBP1_chr1_78428454_ENST00000436586_USP33_chr1_78167156_ENST00000370794_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

>31755_31755_10_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370767_USP33_chr1_78167156_ENST00000357428_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_11_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370767_USP33_chr1_78167156_ENST00000370793_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_12_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370767_USP33_chr1_78167156_ENST00000370794_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_13_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370768_USP33_chr1_78167156_ENST00000357428_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_14_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370768_USP33_chr1_78167156_ENST00000370793_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_15_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000370768_USP33_chr1_78167156_ENST00000370794_length(amino acids)=557AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDQPDAKKVAPQNDSFGTQLP
PMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQSAKRLLDQIVEKGRPAPGFHHG
DGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKEMVLELIRDQGGFREVRNEYGS
RIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEIITDLLRSVQAGNPGGPGPGGRG
RGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTIRGTPQQIDYARQLIEEKIGLN
RAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNFLQSIYGGGPEVILRPPVVHVD

--------------------------------------------------------------

>31755_31755_16_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000436586_USP33_chr1_78167156_ENST00000357428_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

>31755_31755_17_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000436586_USP33_chr1_78167156_ENST00000370793_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

>31755_31755_18_FUBP1-USP33_FUBP1_chr1_78428455_ENST00000436586_USP33_chr1_78167156_ENST00000370794_length(amino acids)=578AA_BP=0
MADYSTVPPPSSGSAGGGGGGGGGGGVNDAFKDALQRARQIAAKIGGDAGTSLNSNDYGYGGQKRPLEDGDGSWTSPSSTTHWEGMPSPF
KDQPDAKKVAPQNDSFGTQLPPMHQQQSRSVMTEEYKVPDGMVGFIIGRGGEQISRIQQESGCKIQIAPDSGGLPERSCMLTGTPESVQS
AKRLLDQIVEKGRPAPGFHHGDGPGNAVQEIMIPASKAGLVIGKGGETIKQLQERAGVKMVMIQDGPQNTGADKPLRITGDPYKVQQAKE
MVLELIRDQGGFREVRNEYGSRIGGNEGIDVPIPRFAVGIVIGRNGEMIKKIQNDAGVRIQFKPDDGTTPERIAQITGPPDRCQHAAEII
TDLLRSVQAGNPGGPGPGGRGRGRGQGNWNMGPPGGLQEFNFIVPTGKTGLIIGKGGETIKSISQQSGARIELQRNPPPNADPNMKLFTI
RGTPQQIDYARQLIEEKIGLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLRQGADSGQISEETWNF

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:78225328/chr1:78435699)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FUBP1 Q96AE4	.
FUNCTION: Regulates MYC expression by binding to a single-stranded far-upstream element (FUSE) upstream of the MYC promoter. May act both as activator and repressor of transcription. {ECO:0000269\|PubMed:8125259}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

13_26

448.0

645.0

Compositional bias

Note=Gly-rich

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

349_396

448.0

645.0

Compositional bias

Note=Gly-rich

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

13_26

448.0

645.0

Compositional bias

Note=Gly-rich

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

349_396

448.0

645.0

Compositional bias

Note=Gly-rich

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

100_164

448.0

645.0

Domain

KH 1

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

185_251

448.0

645.0

Domain

KH 2

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

275_339

448.0

645.0

Domain

KH 3

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

376_443

448.0

645.0

Domain

KH 4

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

100_164

448.0

645.0

Domain

KH 1

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

185_251

448.0

645.0

Domain

KH 2

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

275_339

448.0

645.0

Domain

KH 3

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

376_443

448.0

645.0

Domain

KH 4

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370792

185_715

829.0

Domain

Note=USP

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370792

717_810

829.0

Domain

DUSP 1

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370792

818_921

829.0

Domain

DUSP 2

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370794

818_921

802.0

912.0

Domain

DUSP 2

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370792

185_715

829.0

Domain

Note=USP

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370792

717_810

829.0

Domain

DUSP 1

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370792

818_921

829.0

Domain

DUSP 2

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370794

818_921

802.0

912.0

Domain

DUSP 2

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370792

59_123

829.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370792

59_123

829.0

Zinc finger

UBP-type

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FUBP1

chr1:78428454

chr1:78167156

ENST00000370768

450_560

448.0

645.0

Compositional bias

Note=Pro-rich

Hgene

FUBP1

chr1:78428455

chr1:78167156

ENST00000370768

450_560

448.0

645.0

Compositional bias

Note=Pro-rich

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000357428

185_715

833.0

943.0

Domain

Note=USP

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000357428

717_810

833.0

943.0

Domain

DUSP 1

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000357428

818_921

833.0

943.0

Domain

DUSP 2

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370793

185_715

833.0

943.0

Domain

Note=USP

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370793

717_810

833.0

943.0

Domain

DUSP 1

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370793

818_921

833.0

943.0

Domain

DUSP 2

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370794

185_715

802.0

912.0

Domain

Note=USP

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370794

717_810

802.0

912.0

Domain

DUSP 1

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000357428

185_715

833.0

943.0

Domain

Note=USP

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000357428

717_810

833.0

943.0

Domain

DUSP 1

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000357428

818_921

833.0

943.0

Domain

DUSP 2

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370793

185_715

833.0

943.0

Domain

Note=USP

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370793

717_810

833.0

943.0

Domain

DUSP 1

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370793

818_921

833.0

943.0

Domain

DUSP 2

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370794

185_715

802.0

912.0

Domain

Note=USP

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370794

717_810

802.0

912.0

Domain

DUSP 1

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000357428

59_123

833.0

943.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370793

59_123

833.0

943.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428454

chr1:78167156

ENST00000370794

59_123

802.0

912.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000357428

59_123

833.0

943.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370793

59_123

833.0

943.0

Zinc finger

UBP-type

Tgene

USP33

chr1:78428455

chr1:78167156

ENST00000370794

59_123

802.0

912.0

Zinc finger

UBP-type

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FUBP1
USP33

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FUBP1-USP33

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FUBP1-USP33

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source