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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FUS-ATF1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FUS-ATF1
FusionPDB ID: 31790
FusionGDB2.0 ID: 31790
HgeneTgene
Gene symbol

FUS

ATF1

Gene ID

2521

2668

Gene nameFUS RNA binding proteinglial cell derived neurotrophic factor
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSATF|ATF1|ATF2|HFB1-GDNF|HSCR3
Cytomap

16p11.2

5p13.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteinglial cell line-derived neurotrophic factorastrocyte-derived trophic factor
Modification date2020032920200314
UniProtAcc

P35637

P18846

Ensembl transtripts involved in fusion geneENST idsENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
ENST00000539132, ENST00000262053, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score37 X 37 X 16=2190410 X 16 X 7=1120
# samples 4416
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1120*10)=-2.8073549220576
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FUS [Title/Abstract] AND ATF1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FUS(31195717)-ATF1(51207791), # samples:2
Anticipated loss of major functional domain due to fusion event.FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ATF1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneATF1

GO:0001755

neural crest cell migration

15242795

TgeneATF1

GO:0008284

positive regulation of cell proliferation

22897442

TgeneATF1

GO:0031175

neuron projection development

15242795

TgeneATF1

GO:0032770

positive regulation of monooxygenase activity

12358785

TgeneATF1

GO:0043524

negative regulation of neuron apoptotic process

8493557

TgeneATF1

GO:0045944

positive regulation of transcription by RNA polymerase II

12358785

TgeneATF1

GO:0048255

mRNA stabilization

12358785

TgeneATF1

GO:0051584

regulation of dopamine uptake involved in synaptic transmission

8493557

TgeneATF1

GO:0072107

positive regulation of ureteric bud formation

8657307

TgeneATF1

GO:0090190

positive regulation of branching involved in ureteric bud morphogenesis

8657307|17229286

TgeneATF1

GO:2001240

negative regulation of extrinsic apoptotic signaling pathway in absence of ligand

10921886


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATF1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4refractory anemia;angiomatoid malignant fibrous histiocytomaAJ295163FUSchr16

31195717

ATF1chr12

51207791
ChimerKB3..FUSchr16

31195323

+ATF1chr12

51157788

+
ChimerKB3..FUSchr16

31195705

+ATF1chr12

51207792

+
ChimerKB3..FUSchr16

31195705

+ATF1chr5

37835929

-
ChimerKB3..FUSchr16

31195717

+ATF1chr12

51207791

+
ChiTaRS5.0N/AAJ295163FUSchr16

31195717

+ATF1chr12

51207791

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631195705+ENST00000262053ATF1chr1251207792+228345273939288
ENST00000380244FUSchr1631195705+ENST00000262053ATF1chr1251207792+225142044907287
ENST00000568685FUSchr1631195705+ENST00000262053ATF1chr1251207792+224241132898288
ENST00000254108FUSchr1631195717+ENST00000262053ATF1chr1251207791+2459628271115362
ENST00000380244FUSchr1631195717+ENST00000262053ATF1chr1251207791+2427596521083343
ENST00000568685FUSchr1631195717+ENST00000262053ATF1chr1251207791+2418587401074344
ENST00000254108FUSchr1631195717ENST00000262053ATF1chr12512077912459628271115362
ENST00000380244FUSchr1631195717ENST00000262053ATF1chr12512077912427596521083343
ENST00000568685FUSchr1631195717ENST00000262053ATF1chr12512077912418587401074344

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254108ENST00000262053FUSchr1631195717ATF1chr12512077910.0005676120.9994324
ENST00000380244ENST00000262053FUSchr1631195717ATF1chr12512077910.0001216270.9998784
ENST00000568685ENST00000262053FUSchr1631195717ATF1chr12512077910.000547540.9994524

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31790_31790_1_FUS-ATF1_FUS_chr16_31195705_ENST00000254108_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=288AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVP
SNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNK

--------------------------------------------------------------

>31790_31790_2_FUS-ATF1_FUS_chr16_31195705_ENST00000380244_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=287AA_BP=125
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAA
MAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPS
NQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKT

--------------------------------------------------------------

>31790_31790_3_FUS-ATF1_FUS_chr16_31195705_ENST00000568685_ATF1_chr12_51207792_ENST00000262053_length(amino acids)=288AA_BP=126
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTVVIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLA
AMAVARAPNRLTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVP
SNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNK

--------------------------------------------------------------

>31790_31790_4_FUS-ATF1_FUS_chr16_31195717_ENST00000254108_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=362AA_BP=200
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTY
QIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEELKTLKDLYSNK

--------------------------------------------------------------

>31790_31790_5_FUS-ATF1_FUS_chr16_31195717_ENST00000380244_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=343AA_BP=181
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTS

--------------------------------------------------------------

>31790_31790_6_FUS-ATF1_FUS_chr16_31195717_ENST00000568685_ATF1_chr12_51207791_ENST00000262053_length(amino acids)=344AA_BP=182
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGVAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:31195717/chr12:51207791)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

ATF1

P18846

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: This protein binds the cAMP response element (CRE) (consensus: 5'-GTGACGT[AC][AG]-3'), a sequence present in many viral and cellular promoters. Binds to the Tax-responsive element (TRE) of HTLV-I. Mediates PKA-induced stimulation of CRE-reporter genes. Represses the expression of FTH1 and other antioxidant detoxification genes. Triggers cell proliferation and transformation. {ECO:0000269|PubMed:18794154, ECO:0000269|PubMed:20980392}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+5151_165174.33333333333334527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+5151_165173.33333333333334526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337213_271109.33333333333333272.0DomainbZIP
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337215_239109.33333333333333272.0RegionBasic motif
TgeneATF1chr16:31195717chr12:51207791ENST0000026205337241_262109.33333333333333272.0RegionLeucine-zipper

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515166_267174.33333333333334527.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515371_526174.33333333333334527.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515166_267173.33333333333334526.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515371_526173.33333333333334526.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515285_371174.33333333333334527.0DomainRRM
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515285_371173.33333333333334526.0DomainRRM
HgeneFUSchr16:31195717chr12:51207791ENST00000254108+515422_453174.33333333333334527.0Zinc fingerRanBP2-type
HgeneFUSchr16:31195717chr12:51207791ENST00000380244+515422_453173.33333333333334526.0Zinc fingerRanBP2-type
TgeneATF1chr16:31195717chr12:51207791ENST000002620533731_90109.33333333333333272.0DomainKID


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (54) >>>54.pdbFusion protein BP residue: 125
CIF file (54) >>>54.cif		FUSchr1631195705+ATF1chr1251207792+
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTAMELSQLPRDMARLAAMAVARAPNRL
TGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQTL
TMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRTT
PSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRKK
287
3D view using mol* of 54 (AA BP:125)
PDB file (56) >>>56.pdbFusion protein BP residue: 126
CIF file (56) >>>56.cif		FUSchr1631195705+ATF1chr1251207792+
MLACLCARARTWPQTIIPNKQPKAMGPTPPSPGRAIPSRAVSPTDSRVTV
VIASPRTLQAMARAAILLMARARTQAMELSQLPRDMARLAAMAVARAPNR
LTGSSPPTLAMASSQLPAAPREGGGGVAIAPNGALQLASPGTDGVQGLQT
LTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQTYQIRT
TPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAARECRRK
288
3D view using mol* of 56 (AA BP:126)
PDB file (105) >>>105.pdbFusion protein BP residue: 181
CIF file (105) >>>105.cif		FUSchr1631195717+ATF1chr1251207791+
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGSSQSSQSSYGQ
QSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSY
GQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGVAIAPNGALQLASPGTDGV
QGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQT
YQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAAR
343
3D view using mol* of 105 (AA BP:181)
PDB file (108) >>>108.pdbFusion protein BP residue: 182
CIF file (108) >>>108.cif		FUSchr1631195717+ATF1chr1251207791+
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG
QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQS
YGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGVAIAPNGALQLASPGTDG
VQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQILVPSNQVVVQTASGDMQ
TYQIRTTPSATSLPQTVVMTSPVTLTSQTTKTDDPQLKREIRLMKNREAA
344
3D view using mol* of 108 (AA BP:182)
PDB file (114) >>>114.pdbFusion protein BP residue: 200
CIF file (114) >>>114.cif		FUSchr1631195717+ATF1chr1251207791+
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQG
YSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQG
YGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQ
PQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGG
VAIAPNGALQLASPGTDGVQGLQTLTMTNSGSTQQGTTILQYAQTSDGQQ
ILVPSNQVVVQTASGDMQTYQIRTTPSATSLPQTVVMTSPVTLTSQTTKT
DDPQLKREIRLMKNREAARECRRKKKEYVKCLENRVAVLENQNKTLIEEL
362
3D view using mol* of 114 (AA BP:200)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_pLDDT.png
all structure
all structure
ATF1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_ATF1_54_PAE.png (AA BP:125)
all structure
FUS_ATF1_54_pLDDT.png (AA BP:125)
all structure
FUS_ATF1_54_pLDDT_and_active_sites.png (AA BP:125)
all structure
FUS_ATF1_54_violinplot.png (AA BP:125)
all structure
FUS_ATF1_56_PAE.png (AA BP:126)
all structure
FUS_ATF1_56_pLDDT.png (AA BP:126)
all structure
FUS_ATF1_56_pLDDT_and_active_sites.png (AA BP:126)
all structure
FUS_ATF1_56_violinplot.png (AA BP:126)
all structure
FUS_ATF1_105_PAE.png (AA BP:181)
all structure
FUS_ATF1_105_pLDDT.png (AA BP:181)
all structure
FUS_ATF1_105_pLDDT_and_active_sites.png (AA BP:181)
all structure
FUS_ATF1_105_violinplot.png (AA BP:181)
all structure
FUS_ATF1_108_PAE.png (AA BP:182)
all structure
FUS_ATF1_108_pLDDT.png (AA BP:182)
all structure
FUS_ATF1_108_pLDDT_and_active_sites.png (AA BP:182)
all structure
FUS_ATF1_108_violinplot.png (AA BP:182)
all structure
FUS_ATF1_114_PAE.png (AA BP:200)
all structure
FUS_ATF1_114_pLDDT.png (AA BP:200)
all structure
FUS_ATF1_114_pLDDT_and_active_sites.png (AA BP:200)
all structure
FUS_ATF1_114_violinplot.png (AA BP:200)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
FUS_ATF1_54.png
all structure
FUS_ATF1_56.png
all structure
FUS_ATF1_105.png
all structure
FUS_ATF1_108.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
540.928750.977249.0180.6410.6250.8180.8680.651.3340.267Chain A: 2,3,4,5,6,7,9,10,68,69,71,72,73,76,239,24
2,243,245,246,247,250
560.911150.92195.8530.6310.5640.8410.4061.10.3691.176Chain A: 134,135,136,137,138,139,144,145,146,147,1
48,149,150,151,152,168,169,170,171,172,176,177
1051.0161041.104258.6220.6730.5910.7750.9730.5841.6671.501Chain A: 2,3,6,7,9,10,13,14,301,304,305,308,309,31
1,312,313,315,316,319,320
1080.9711221.01224.6650.440.6220.9230.5640.9310.6060.98Chain A: 238,240,251,252,253,254,255,256,257,265,2
66,267,268,269,270
1141.012901.095287.0910.6430.6220.7881.0080.5221.9290.82Chain A: 16,18,19,21,24,27,28,31,317,320,321,324,3
25,327,328

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FUSall structure
ATF1all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FUS-ATF1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FUS-ATF1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
FUSATF1Lung AdenocarcinomaMyCancerGenome
FUSATF1Breast Invasive Ductal CarcinomaMyCancerGenome
FUSATF1GlioblastomaMyCancerGenome
FUSATF1Pancreatic AdenocarcinomaMyCancerGenome
FUSATF1Anaplastic AstrocytomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
TgeneATF1C0032460Polycystic Ovary Syndrome1CTD_human
TgeneATF1C0206651Clear Cell Sarcoma of Soft Tissue1ORPHANET
TgeneATF1C1136382Sclerocystic Ovaries1CTD_human