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Center for Computational Systems Medicine level3
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Potential Active Site Information

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Potentially Interacting Small Molecules through Virtual Screening

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Biochemical Features of Small Molecules with ADME

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Drug Toxicity Information

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FUS-ERG

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FUS-ERG
FusionPDB ID: 31800
FusionGDB2.0 ID: 31800
HgeneTgene
Gene symbol

FUS

ERG

Gene ID

2521

2078

Gene nameFUS RNA binding proteinETS transcription factor ERG
SynonymsALS6|ETM4|FUS1|HNRNPP2|POMP75|TLSerg-3|p55
Cytomap

16p11.2

21q22.2

Type of geneprotein-codingprotein-coding
DescriptionRNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma proteintranscriptional regulator ERGERG, ETS transcription factorFUS/ERG fusion proteinTMPRSS2/ERG fusionerythroblast transformation-specific transcription factor ERG variant 10ets-relatedtranscriptional regulator ERG (transforming protein ERG)v-ets avian
Modification date2020032920200320
UniProtAcc

P35637

Q9Y282

Ensembl transtripts involved in fusion geneENST idsENST00000474990, ENST00000254108, 
ENST00000380244, ENST00000568685, 
ENST00000288319, ENST00000398897, 
ENST00000398905, ENST00000398907, 
ENST00000398910, ENST00000398911, 
ENST00000398919, ENST00000417133, 
ENST00000442448, ENST00000453032, 
ENST00000429727, ENST00000485493, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score37 X 37 X 16=2190421 X 74 X 12=18648
# samples 4496
** MAII scorelog2(44/21904*10)=-5.63754701773324
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(96/18648*10)=-4.27984269352035
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FUS [Title/Abstract] AND ERG [Title/Abstract] AND fusion [Title/Abstract]

Sinonasal FUS-ERG-Rearranged Ewing's Sarcoma Mimicking Glomangiopericytoma (pmid: 33442361)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FUS(31198157)-ERG(39764367), # samples:2
Anticipated loss of major functional domain due to fusion event.FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-ERG seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
FUS-ERG seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
FUS-ERG seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
FUS-ERG seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

HgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

HgeneFUS

GO:0008380

RNA splicing

26124092

HgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

HgeneFUS

GO:0048255

mRNA stabilization

27378374

HgeneFUS

GO:0051260

protein homooligomerization

25453086

HgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410

TgeneERG

GO:0045944

positive regulation of transcription by RNA polymerase II

18195090|23913826


check buttonFusion gene breakpoints across FUS (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ERG (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4acute myeloid leukemia;ewing tumorS77574FUSchr16

31198158

ERGchr21

39755726
ChimerKB3..FUSchr16

31196500

+ERGchr21

39762964

-
ChimerKB3..FUSchr16

31198157

+ERGchr21

39755845

-
ChimerKB3..FUSchr16

31198157

+ERGchr21

39763637

-
ChimerKB3..FUSchr16

31198158

+ERGchr21

39755726

-
ChimerKB3..FUSchr16

31198569

+ERGchr21

39758105

-
ChiTaRS5.0N/AKY081286FUSchr16

31199009

+ERGchr21

39765864

-
ChiTaRS5.0N/AKY081288FUSchr16

31199121

+ERGchr21

39756552

-
ChiTaRS5.0N/AKY081289FUSchr16

31198157

+ERGchr21

39764367

-
ChiTaRS5.0N/AKY081290FUSchr16

31198157

+ERGchr21

39764367

-
ChiTaRS5.0N/AS77574FUSchr16

31198158

+ERGchr21

39755846

-
ChiTaRS5.0N/AY10001FUSchr16

31198569

+ERGchr21

39758163

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000254108FUSchr1631198157+ENST00000398897ERGchr2139755845-4801904271424465
ENST00000254108FUSchr1631198157+ENST00000398911ERGchr2139755845-4801904271424465
ENST00000254108FUSchr1631198157+ENST00000398910ERGchr2139755845-4801904271424465
ENST00000254108FUSchr1631198157+ENST00000417133ERGchr2139755845-4801904271424465
ENST00000254108FUSchr1631198157+ENST00000453032ERGchr2139755845-1702904271424465
ENST00000380244FUSchr1631198157+ENST00000398897ERGchr2139755845-4769872521392446
ENST00000380244FUSchr1631198157+ENST00000398911ERGchr2139755845-4769872521392446
ENST00000380244FUSchr1631198157+ENST00000398910ERGchr2139755845-4769872521392446
ENST00000380244FUSchr1631198157+ENST00000417133ERGchr2139755845-4769872521392446
ENST00000380244FUSchr1631198157+ENST00000453032ERGchr2139755845-1670872521392446
ENST00000568685FUSchr1631198157+ENST00000398897ERGchr2139755845-4760863401383447
ENST00000568685FUSchr1631198157+ENST00000398911ERGchr2139755845-4760863401383447
ENST00000568685FUSchr1631198157+ENST00000398910ERGchr2139755845-4760863401383447
ENST00000568685FUSchr1631198157+ENST00000417133ERGchr2139755845-4760863401383447
ENST00000568685FUSchr1631198157+ENST00000453032ERGchr2139755845-1661863401383447
ENST00000254108FUSchr1631198157+ENST00000398907ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000398905ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000288319ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000398897ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000398911ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000398910ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000417133ERGchr2139763637-4906904271529500
ENST00000254108FUSchr1631198157+ENST00000442448ERGchr2139763637-4903904271529500
ENST00000254108FUSchr1631198157+ENST00000453032ERGchr2139763637-1807904271529500
ENST00000254108FUSchr1631198157+ENST00000398919ERGchr2139763637-1642904271529500
ENST00000380244FUSchr1631198157+ENST00000398907ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000398905ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000288319ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000398897ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000398911ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000398910ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000417133ERGchr2139763637-4874872521497481
ENST00000380244FUSchr1631198157+ENST00000442448ERGchr2139763637-4871872521497481
ENST00000380244FUSchr1631198157+ENST00000453032ERGchr2139763637-1775872521497481
ENST00000380244FUSchr1631198157+ENST00000398919ERGchr2139763637-1610872521497481
ENST00000568685FUSchr1631198157+ENST00000398907ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000398905ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000288319ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000398897ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000398911ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000398910ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000417133ERGchr2139763637-4865863401488482
ENST00000568685FUSchr1631198157+ENST00000442448ERGchr2139763637-4862863401488482
ENST00000568685FUSchr1631198157+ENST00000453032ERGchr2139763637-1766863401488482
ENST00000568685FUSchr1631198157+ENST00000398919ERGchr2139763637-1601863401488482
ENST00000254108FUSchr1631198158+ENST00000398897ERGchr2139755726-468290427956309
ENST00000254108FUSchr1631198158+ENST00000398911ERGchr2139755726-468290427956309
ENST00000254108FUSchr1631198158+ENST00000398910ERGchr2139755726-468290427956309
ENST00000254108FUSchr1631198158+ENST00000417133ERGchr2139755726-468290427956309
ENST00000254108FUSchr1631198158+ENST00000453032ERGchr2139755726-158390427956309
ENST00000380244FUSchr1631198158+ENST00000398897ERGchr2139755726-465087252924290
ENST00000380244FUSchr1631198158+ENST00000398911ERGchr2139755726-465087252924290
ENST00000380244FUSchr1631198158+ENST00000398910ERGchr2139755726-465087252924290
ENST00000380244FUSchr1631198158+ENST00000417133ERGchr2139755726-465087252924290
ENST00000380244FUSchr1631198158+ENST00000453032ERGchr2139755726-155187252924290
ENST00000568685FUSchr1631198158+ENST00000398897ERGchr2139755726-464186340915291
ENST00000568685FUSchr1631198158+ENST00000398911ERGchr2139755726-464186340915291
ENST00000568685FUSchr1631198158+ENST00000398910ERGchr2139755726-464186340915291
ENST00000568685FUSchr1631198158+ENST00000417133ERGchr2139755726-464186340915291
ENST00000568685FUSchr1631198158+ENST00000453032ERGchr2139755726-154286340915291
ENST00000254108FUSchr1631198158ENST00000398897ERGchr2139755726468290427956309
ENST00000254108FUSchr1631198158ENST00000398911ERGchr2139755726468290427956309
ENST00000254108FUSchr1631198158ENST00000398910ERGchr2139755726468290427956309
ENST00000254108FUSchr1631198158ENST00000417133ERGchr2139755726468290427956309
ENST00000254108FUSchr1631198158ENST00000453032ERGchr2139755726158390427956309
ENST00000380244FUSchr1631198158ENST00000398897ERGchr2139755726465087252924290
ENST00000380244FUSchr1631198158ENST00000398911ERGchr2139755726465087252924290
ENST00000380244FUSchr1631198158ENST00000398910ERGchr2139755726465087252924290
ENST00000380244FUSchr1631198158ENST00000417133ERGchr2139755726465087252924290
ENST00000380244FUSchr1631198158ENST00000453032ERGchr2139755726155187252924290
ENST00000568685FUSchr1631198158ENST00000398897ERGchr2139755726464186340915291
ENST00000568685FUSchr1631198158ENST00000398911ERGchr2139755726464186340915291
ENST00000568685FUSchr1631198158ENST00000398910ERGchr2139755726464186340915291
ENST00000568685FUSchr1631198158ENST00000417133ERGchr2139755726464186340915291
ENST00000568685FUSchr1631198158ENST00000453032ERGchr2139755726154286340915291
ENST00000254108FUSchr1631198158+ENST00000398897ERGchr2139755846-4801904271424465
ENST00000254108FUSchr1631198158+ENST00000398911ERGchr2139755846-4801904271424465
ENST00000254108FUSchr1631198158+ENST00000398910ERGchr2139755846-4801904271424465
ENST00000254108FUSchr1631198158+ENST00000417133ERGchr2139755846-4801904271424465
ENST00000254108FUSchr1631198158+ENST00000453032ERGchr2139755846-1702904271424465
ENST00000380244FUSchr1631198158+ENST00000398897ERGchr2139755846-4769872521392446
ENST00000380244FUSchr1631198158+ENST00000398911ERGchr2139755846-4769872521392446
ENST00000380244FUSchr1631198158+ENST00000398910ERGchr2139755846-4769872521392446
ENST00000380244FUSchr1631198158+ENST00000417133ERGchr2139755846-4769872521392446
ENST00000380244FUSchr1631198158+ENST00000453032ERGchr2139755846-1670872521392446
ENST00000568685FUSchr1631198158+ENST00000398897ERGchr2139755846-4760863401383447
ENST00000568685FUSchr1631198158+ENST00000398911ERGchr2139755846-4760863401383447
ENST00000568685FUSchr1631198158+ENST00000398910ERGchr2139755846-4760863401383447
ENST00000568685FUSchr1631198158+ENST00000417133ERGchr2139755846-4760863401383447
ENST00000568685FUSchr1631198158+ENST00000453032ERGchr2139755846-1661863401383447

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000254108ENST00000398897FUSchr1631198158ERGchr21397557260.0023990460.997601
ENST00000254108ENST00000398911FUSchr1631198158ERGchr21397557260.0023990460.997601
ENST00000254108ENST00000398910FUSchr1631198158ERGchr21397557260.0023990460.997601
ENST00000254108ENST00000417133FUSchr1631198158ERGchr21397557260.0023990460.997601
ENST00000254108ENST00000453032FUSchr1631198158ERGchr21397557260.0074500860.9925499
ENST00000380244ENST00000398897FUSchr1631198158ERGchr21397557260.0005830070.99941707
ENST00000380244ENST00000398911FUSchr1631198158ERGchr21397557260.0005830070.99941707
ENST00000380244ENST00000398910FUSchr1631198158ERGchr21397557260.0005830070.99941707
ENST00000380244ENST00000417133FUSchr1631198158ERGchr21397557260.0005830070.99941707
ENST00000380244ENST00000453032FUSchr1631198158ERGchr21397557260.0025443120.99745566
ENST00000568685ENST00000398897FUSchr1631198158ERGchr21397557260.0023269480.9976731
ENST00000568685ENST00000398911FUSchr1631198158ERGchr21397557260.0023269480.9976731
ENST00000568685ENST00000398910FUSchr1631198158ERGchr21397557260.0023269480.9976731
ENST00000568685ENST00000417133FUSchr1631198158ERGchr21397557260.0023269480.9976731
ENST00000568685ENST00000453032FUSchr1631198158ERGchr21397557260.0084517310.99154824
ENST00000254108ENST00000398897FUSchr1631198158+ERGchr2139755846-0.0016106120.99838936
ENST00000254108ENST00000398911FUSchr1631198158+ERGchr2139755846-0.0016106120.99838936
ENST00000254108ENST00000398910FUSchr1631198158+ERGchr2139755846-0.0016106120.99838936
ENST00000254108ENST00000417133FUSchr1631198158+ERGchr2139755846-0.0016106120.99838936
ENST00000254108ENST00000453032FUSchr1631198158+ERGchr2139755846-0.0101570560.98984295
ENST00000380244ENST00000398897FUSchr1631198158+ERGchr2139755846-0.0007956250.99920434
ENST00000380244ENST00000398911FUSchr1631198158+ERGchr2139755846-0.0007956250.99920434
ENST00000380244ENST00000398910FUSchr1631198158+ERGchr2139755846-0.0007956250.99920434
ENST00000380244ENST00000417133FUSchr1631198158+ERGchr2139755846-0.0007956250.99920434
ENST00000380244ENST00000453032FUSchr1631198158+ERGchr2139755846-0.0057142620.99428576
ENST00000568685ENST00000398897FUSchr1631198158+ERGchr2139755846-0.0015368840.99846315
ENST00000568685ENST00000398911FUSchr1631198158+ERGchr2139755846-0.0015368840.99846315
ENST00000568685ENST00000398910FUSchr1631198158+ERGchr2139755846-0.0015368840.99846315
ENST00000568685ENST00000417133FUSchr1631198158+ERGchr2139755846-0.0015368840.99846315
ENST00000568685ENST00000453032FUSchr1631198158+ERGchr2139755846-0.0102937880.98970616

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31800_31800_1_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39755845_ENST00000398897_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_2_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39755845_ENST00000398910_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_3_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39755845_ENST00000398911_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_4_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39755845_ENST00000417133_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_5_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39755845_ENST00000453032_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_6_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000288319_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_7_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398897_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_8_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398905_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_9_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398907_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_10_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398910_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_11_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398911_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_12_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000398919_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_13_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000417133_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_14_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000442448_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_15_FUS-ERG_FUS_chr16_31198157_ENST00000254108_ERG_chr21_39763637_ENST00000453032_length(amino acids)=500AA_BP=290
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEF
KMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN

--------------------------------------------------------------

>31800_31800_16_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39755845_ENST00000398897_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_17_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39755845_ENST00000398910_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_18_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39755845_ENST00000398911_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_19_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39755845_ENST00000417133_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_20_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39755845_ENST00000453032_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_21_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000288319_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_22_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398897_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_23_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398905_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_24_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398907_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_25_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398910_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_26_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398911_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_27_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000398919_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_28_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000417133_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_29_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000442448_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_30_FUS-ERG_FUS_chr16_31198157_ENST00000380244_ERG_chr21_39763637_ENST00000453032_length(amino acids)=481AA_BP=271
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKP
NMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA

--------------------------------------------------------------

>31800_31800_31_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39755845_ENST00000398897_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_32_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39755845_ENST00000398910_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_33_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39755845_ENST00000398911_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_34_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39755845_ENST00000417133_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_35_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39755845_ENST00000453032_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_36_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000288319_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_37_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398897_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_38_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398905_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_39_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398907_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_40_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398910_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_41_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398911_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_42_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000398919_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_43_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000417133_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_44_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000442448_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_45_FUS-ERG_FUS_chr16_31198157_ENST00000568685_ERG_chr21_39763637_ENST00000453032_length(amino acids)=482AA_BP=272
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGAAQPSPSTVPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSK
PNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA

--------------------------------------------------------------

>31800_31800_46_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755726_ENST00000398897_length(amino acids)=309AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------

>31800_31800_47_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755726_ENST00000398910_length(amino acids)=309AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------

>31800_31800_48_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755726_ENST00000398911_length(amino acids)=309AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------

>31800_31800_49_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755726_ENST00000417133_length(amino acids)=309AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------

>31800_31800_50_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755726_ENST00000453032_length(amino acids)=309AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR

--------------------------------------------------------------

>31800_31800_51_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755846_ENST00000398897_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_52_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755846_ENST00000398910_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_53_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755846_ENST00000398911_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_54_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755846_ENST00000417133_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_55_FUS-ERG_FUS_chr16_31198158_ENST00000254108_ERG_chr21_39755846_ENST00000453032_length(amino acids)=465AA_BP=292
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNT
GYGTQSTPQGYGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQG
YGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGR
GGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYD
KNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT

--------------------------------------------------------------

>31800_31800_56_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755726_ENST00000398897_length(amino acids)=290AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN

--------------------------------------------------------------

>31800_31800_57_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755726_ENST00000398910_length(amino acids)=290AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN

--------------------------------------------------------------

>31800_31800_58_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755726_ENST00000398911_length(amino acids)=290AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN

--------------------------------------------------------------

>31800_31800_59_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755726_ENST00000417133_length(amino acids)=290AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN

--------------------------------------------------------------

>31800_31800_60_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755726_ENST00000453032_length(amino acids)=290AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN

--------------------------------------------------------------

>31800_31800_61_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755846_ENST00000398897_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_62_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755846_ENST00000398910_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_63_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755846_ENST00000398911_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_64_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755846_ENST00000417133_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_65_FUS-ERG_FUS_chr16_31198158_ENST00000380244_ERG_chr21_39755846_ENST00000453032_length(amino acids)=446AA_BP=273
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGS
SQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGG
GGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFN
KFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFH

--------------------------------------------------------------

>31800_31800_66_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755726_ENST00000398897_length(amino acids)=291AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF

--------------------------------------------------------------

>31800_31800_67_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755726_ENST00000398910_length(amino acids)=291AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF

--------------------------------------------------------------

>31800_31800_68_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755726_ENST00000398911_length(amino acids)=291AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF

--------------------------------------------------------------

>31800_31800_69_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755726_ENST00000417133_length(amino acids)=291AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF

--------------------------------------------------------------

>31800_31800_70_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755726_ENST00000453032_length(amino acids)=291AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF

--------------------------------------------------------------

>31800_31800_71_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755846_ENST00000398897_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_72_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755846_ENST00000398910_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_73_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755846_ENST00000398911_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_74_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755846_ENST00000417133_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

>31800_31800_75_FUS-ERG_FUS_chr16_31198158_ENST00000568685_ERG_chr21_39755846_ENST00000453032_length(amino acids)=447AA_BP=274
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYG
SSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGG
GGGNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGF
NKFGGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDF

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr16:31198157/chr21:39764367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FUS

P35637

ERG

Q9Y282

FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.FUNCTION: Possible role in transport between endoplasmic reticulum and Golgi. {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31198158chr21:39755846ENST00000254108+715166_267266.3333333333333527.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31198158chr21:39755846ENST00000254108+7151_165266.3333333333333527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
HgeneFUSchr16:31198158chr21:39755846ENST00000380244+715166_267265.3333333333333526.0Compositional biasNote=Gly-rich
HgeneFUSchr16:31198158chr21:39755846ENST00000380244+7151_165265.3333333333333526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneERGchr16:31198158chr21:39755846ENST00000288319810311_391306.3333333333333480.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST0000039889779311_391190.33333333333334364.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST00000398911810311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST000003989191012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST000004171331012311_391313.3333333333333487.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST00000442448911311_391289.3333333333333463.0DNA bindingETS
TgeneERGchr16:31198158chr21:39755846ENST0000045303279311_391214.33333333333334388.0DNA bindingETS

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFUSchr16:31198158chr21:39755846ENST00000254108+715371_526266.3333333333333527.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31198158chr21:39755846ENST00000380244+715371_526265.3333333333333526.0Compositional biasNote=Arg/Gly-rich
HgeneFUSchr16:31198158chr21:39755846ENST00000254108+715285_371266.3333333333333527.0DomainRRM
HgeneFUSchr16:31198158chr21:39755846ENST00000380244+715285_371265.3333333333333526.0DomainRRM
HgeneFUSchr16:31198158chr21:39755846ENST00000254108+715422_453266.3333333333333527.0Zinc fingerRanBP2-type
HgeneFUSchr16:31198158chr21:39755846ENST00000380244+715422_453265.3333333333333526.0Zinc fingerRanBP2-type
TgeneERGchr16:31198158chr21:39755846ENST00000288319810113_199306.3333333333333480.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST0000039889779113_199190.33333333333334364.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST00000398911810113_199289.3333333333333463.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST000003989191012113_199313.3333333333333487.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST000004171331012113_199313.3333333333333487.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST00000442448911113_199289.3333333333333463.0DomainPNT
TgeneERGchr16:31198158chr21:39755846ENST0000045303279113_199214.33333333333334388.0DomainPNT


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file (57) >>>57.pdbFusion protein BP residue: 273
CIF file (57) >>>57.cif		FUSchr1631198158+ERGchr2139755726-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGSSQSSQSSYGQ
QSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSY
GQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGG
YGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRG
290
3D view using mol* of 57 (AA BP:273)
PDB file (59) >>>59.pdbFusion protein BP residue: 274
CIF file (59) >>>59.cif		FUSchr1631198158+ERGchr2139755726-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG
QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQS
YGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGG
GYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPR
291
3D view using mol* of 59 (AA BP:274)
PDB file (68) >>>68.pdbFusion protein BP residue: 292
CIF file (68) >>>68.cif		FUSchr1631198158+ERGchr2139755726-
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQG
YSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQG
YGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQ
PQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGG
GNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGG
GGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGGPALGRA
309
3D view using mol* of 68 (AA BP:292)
PDB file (213) >>>213.pdbFusion protein BP residue: 273
CIF file (213) >>>213.cif		FUSchr1631198157+ERGchr2139755845-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGSSQSSQSSYGQ
QSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSY
GQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGG
YGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRG
RGGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITWE
GTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHG
KRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAP
446
3D view using mol* of 213 (AA BP:273)
PDB file (215) >>>215.pdbFusion protein BP residue: 274
CIF file (215) >>>215.cif		FUSchr1631198157+ERGchr2139755845-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG
QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQS
YGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGG
GYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPR
GRGGGRGGRGGMGGSDRGGFNKFGGSGQIQLWQFLLELLSDSSNSSCITW
EGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVH
GKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVA
447
3D view using mol* of 215 (AA BP:274)
PDB file (240) >>>240.pdbFusion protein BP residue: 292
CIF file (240) >>>240.cif		FUSchr1631198157+ERGchr2139755845-
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQG
YSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQG
YGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQ
PQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGG
GNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGG
GGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGGSGQIQLW
QFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDK
LSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSD
LPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNT
465
3D view using mol* of 240 (AA BP:292)
PDB file (267) >>>267.pdbFusion protein BP residue: 271
CIF file (267) >>>267.cif		FUSchr1631198157+ERGchr2139763637-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNSYGTQSTPQGYGSTGGYGSSQSSQSSYGQ
QSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQSY
GQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGGG
YGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPRG
RGGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILGP
TSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEVA
RRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQA
LQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFAA
481
3D view using mol* of 267 (AA BP:271)
PDB file (270) >>>270.pdbFusion protein BP residue: 272
CIF file (270) >>>270.cif		FUSchr1631198157+ERGchr2139763637-
MPVRACADMASNDYTQQATQSYGAYPTQPGQGYSQQSSQPYGQQSYSGYS
QSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQGYGSTGGYGSSQSSQSSYG
QQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQPQSGSYSQQPSYGGQQQS
YGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGGGNYGQDQSSMSSGGGSGG
GYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGGGGGGGGGYNRSSGGYEPR
GRGGGRGGRGGMGGSDRGGFNKFGAAQPSPSTVPKTEDQRPQLDPYQILG
PTSSRLANPGSGQIQLWQFLLELLSDSSNSSCITWEGTNGEFKMTDPDEV
ARRWGERKSKPNMNYDKLSRALRYYYDKNIMTKVHGKRYAYKFDFHGIAQ
ALQPHPPESSLYKYPSDLPYMGSYHAHPQKMNFVAPHPPALPVTSSSFFA
482
3D view using mol* of 270 (AA BP:272)
PDB file (300) >>>300.pdbFusion protein BP residue: 290
CIF file (300) >>>300.cif		FUSchr1631198157+ERGchr2139763637-
MLSPPGVGTQRCWNFVACLPVRACADMASNDYTQQATQSYGAYPTQPGQG
YSQQSSQPYGQQSYSGYSQSTDTSGYGQSSYSSYGQSQNTGYGTQSTPQG
YGSTGGYGSSQSSQSSYGQQSSYPGYGQQPAPSSTSGSYGSSSQSSSYGQ
PQSGSYSQQPSYGGQQQSYGQQQSYNPPQGYGQQNQYNSSSGGGGGGGGG
GNYGQDQSSMSSGGGSGGGYGNQDQSGGGGSGGYGQQDRGGRGRGGSGGG
GGGGGGGYNRSSGGYEPRGRGGGRGGRGGMGGSDRGGFNKFGAAQPSPST
VPKTEDQRPQLDPYQILGPTSSRLANPGSGQIQLWQFLLELLSDSSNSSC
ITWEGTNGEFKMTDPDEVARRWGERKSKPNMNYDKLSRALRYYYDKNIMT
KVHGKRYAYKFDFHGIAQALQPHPPESSLYKYPSDLPYMGSYHAHPQKMN
FVAPHPPALPVTSSSFFAAPNPYWNSPTGGIYPNTRLPTSHMPSHLGTYY
500
3D view using mol* of 300 (AA BP:290)


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_pLDDT.png
all structure
all structure
ERG_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
FUS_ERG_57_PAE.png (AA BP:273)
all structure
FUS_ERG_57_pLDDT.png (AA BP:273)
all structure
FUS_ERG_59_PAE.png (AA BP:274)
all structure
FUS_ERG_59_pLDDT.png (AA BP:274)
all structure
FUS_ERG_68_PAE.png (AA BP:292)
all structure
FUS_ERG_68_pLDDT.png (AA BP:292)
all structure
FUS_ERG_68_pLDDT_and_active_sites.png (AA BP:292)
all structure
FUS_ERG_68_violinplot.png (AA BP:292)
all structure
FUS_ERG_213_PAE.png (AA BP:273)
all structure
FUS_ERG_213_pLDDT.png (AA BP:273)
all structure
FUS_ERG_213_pLDDT_and_active_sites.png (AA BP:273)
all structure
FUS_ERG_213_violinplot.png (AA BP:273)
all structure
FUS_ERG_215_PAE.png (AA BP:274)
all structure
FUS_ERG_215_pLDDT.png (AA BP:274)
all structure
FUS_ERG_215_pLDDT_and_active_sites.png (AA BP:274)
all structure
FUS_ERG_215_violinplot.png (AA BP:274)
all structure
FUS_ERG_240_PAE.png (AA BP:292)
all structure
FUS_ERG_240_pLDDT.png (AA BP:292)
all structure
FUS_ERG_240_pLDDT_and_active_sites.png (AA BP:292)
all structure
FUS_ERG_240_violinplot.png (AA BP:292)
all structure
FUS_ERG_267_PAE.png (AA BP:271)
all structure
FUS_ERG_267_pLDDT.png (AA BP:271)
all structure
FUS_ERG_267_pLDDT_and_active_sites.png (AA BP:271)
all structure
FUS_ERG_267_violinplot.png (AA BP:271)
all structure
FUS_ERG_270_pLDDT.png (AA BP:272)
all structure
FUS_ERG_270_pLDDT_and_active_sites.png (AA BP:272)
all structure
FUS_ERG_270_violinplot.png (AA BP:272)
all structure
FUS_ERG_300_pLDDT.png (AA BP:290)
all structure
FUS_ERG_300_pLDDT_and_active_sites.png (AA BP:290)
all structure
FUS_ERG_300_violinplot.png (AA BP:290)
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots
FUS_ERG_57.png
all structure
FUS_ERG_59.png
all structure
FUS_ERG_68.png
all structure
FUS_ERG_213.png
all structure
FUS_ERG_215.png
all structure
FUS_ERG_240.png
all structure
FUS_ERG_267.png
all structure
FUS_ERG_270.png
all structure
FUS_ERG_300.png
all structure

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Potential Active Site Information


check button The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.
Fusion AA seq ID in FusionPDBSite scoreSizeD scoreVolumeExposureEnclosureContactPhobicPhilicBalanceDon/AccResidues
680.1951-0.0521.3720.90.4810.95101.33404.989Chain A: 284,288
2131.116881.223210.6020.5710.7181.0412.8680.27410.4621.188Chain A: 2,3,6,7,9,10,11,13,14,281,282,285,286,289
,299,303,359,360,362,363,366
2151.0971241.213304.2410.6140.6450.8541.7390.3514.9561.096Chain A: 2,3,6,7,9,10,13,14,17,282,283,286,287,290
,304,347,357,358,359,360,361,363,364,367
2400.9691351.008326.1930.6490.620.8750.7090.9310.7621.139Chain A: 15,16,18,19,20,21,22,23,24,25,26,27,28,29
8,300,301,304,361,363,378,379,381,382,383,384,385,
386,387,388
2670.42290.32821.2660.7950.5540.8740.3830.8770.4361.012Chain A: 289,290,291,292,337
2700.709470.66391.2380.6050.6080.9470.2261.0620.2130.826Chain A: 290,291,292,293,295,298,299,335,336,337,3
38,339,340,341
3000.9631610.989612.2550.670.6370.8080.3211.0210.3150.317Chain A: 18,19,20,21,23,24,25,26,27,28,324,325,326
,329,331,332,333,334,335,336,372,376,378,379,380,3
81,385,386,388,389,392,393,396,397,398,415,418,419
,420,421,422,423

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Potentially Interacting Small Molecules through Virtual Screening


check button The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.
Fusion AA seq ID in FusionPDBZINC IDDrugBank IDDrug nameDocking scoreGlide gscore

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check button Drug information from DrugBank of the top 20 interacting small molecules.
ZINC IDDrugBank IDDrug nameDrug typeSMILESDrug group

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Biochemical Features of Small Molecules


check button ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)
ZINC IDmol_MWdipoleSASAFOSAFISAPISAWPSAvolumedonorHBaccptHBIPHuman Oral AbsorptionPercent Human Oral AbsorptionRule Of FiveRule Of Three


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Drug Toxicity Information


check button Toxicity information of individual drugs using eToxPred
ZINC IDSmileSurface AccessibilityToxicity


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
ERGJUN, ETS2, AR, HSPA4, HSPA8, NEDD4, PRKDC, XRCC5, XRCC6, PARP1, XRCC4, NME1, DDX3X, PCBP1, HNRNPA2B1, DDX5, TRIM21, TPM1, HNRNPM, EIF2S1, RPLP0, PRPF8, RPL7A, HNRNPDL, TUBB, CAD, ACTB, ATP5A1, RPS18, HNRNPU, SPTAN1, DNAJA1, DNAJA2, DNAJA4, APP, USP9X, ADAR, CDC5L, CLTC, DDX21, DDX23, DKC1, EEF1A2, ELAVL1, FBL, HNRNPA1, HNRNPAB, HNRNPC, HNRNPD, HNRNPF, HNRNPH1, HNRNPH3, HNRNPUL1, HNRNPUL2, HSPD1, ILF2, ILF3, LANCL1, MATR3, NCL, NOLC1, NONO, NPM1, NUMA1, POLR2A, PRPF40A, PUF60, RCC2, SF3B1, SF3B2, SF3B3, SFPQ, SNRNP200, SYN1, TOP1, TOP2B, XRN2, CUL3, SPOP, TRIM25, UBR5, TRIM33, RING1, UBR4, RNF2, TRIP12, HUWE1, STUB1, UHRF1, HERC2, BRD4, BRD2, BRD3, EP300, APEX1, PVT1, E7, TRIM8, MEF2D, SMARCE1, FOXP1, RERE, NFIB, FLI1, NFIA, BCL9, ARID1A, KMT2D, ZNF609, TRIM24, KDM6A, MITF, SS18L1, NCOR1, PIAS1, ATXN1L, HIVEP1, GATA4, SMARCA2, SMARCA4, ATXN1, MLLT10, LMO4, TLE1, TLE3, AES, SMARCB1, NCOA6, GSE1, SS18, NCOA2, QSER1, ARID4B, BCL7A, PRRC2B, NIPBL, TET2, ZNF746, ELMSAN1, SMARCD3, ATF7IP, BCOR, C15orf39, PAXIP1, ASXL2, C11orf30, LDB1, ZFHX4, FOXP4, RYBP, KMT2C, ARID1B, KDM2B, SMARCC2, MORC4, BCL7C, MAML1, DPF1, DPF3, DPF2, CREBBP, SMARCC1, SMARCD2, ISL2, SMARCD1, ZNF521, CIC, ARID3A, BCL7B, PYGO2, PCGF1, PAGR1, DNTTIP1, HIPK2, CPVL, ZNF703, FBRS, KIAA1551, FBRSL1, HMG20A, TCF7L2, GLTSCR1, CHD7, TCF20, TRPS1, ZNF608, PRR12, SATB2, ZNF148, ZNF281, RAD54L2, NCOR2, NCOA3, PSMB5, DBN1, NFIC,
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FUSall structure
ERGall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FUS-ERG


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID
FUSERGEribulin PubMed28681998

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Related Diseases to FUS-ERG


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID
FUSERGEwing's SarcomaPubMed28681998
FUSERGProstate AdenocarcinomaMyCancerGenome
FUSERGLung AdenocarcinomaMyCancerGenome
FUSERGBreast Invasive Ductal CarcinomaMyCancerGenome
FUSERGGlioblastomaMyCancerGenome
FUSERGPancreatic AdenocarcinomaMyCancerGenome

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
HgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
HgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
HgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
HgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
HgeneFUSC0497327Dementia1GENOMICS_ENGLAND
HgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
HgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
HgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET
TgeneERGC0033578Prostatic Neoplasms7CTD_human
TgeneERGC0376358Malignant neoplasm of prostate7CTD_human
TgeneERGC0023418leukemia1CTD_human
TgeneERGC0023452Childhood Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023453L2 Acute Lymphoblastic Leukemia1CTD_human
TgeneERGC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneERGC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneERGC0279980Extra-osseous Ewing's sarcoma1ORPHANET
TgeneERGC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneERGC1961102Precursor Cell Lymphoblastic Leukemia Lymphoma1CTD_human