UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FXR1-MCCC1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FXR1-MCCC1
	FusionPDB ID: 31873
	FusionGDB2.0 ID: 31873
		Hgene	Tgene
	Gene symbol	FXR1	MCCC1
	Gene ID	8087	56922
	Gene name	FMR1 autosomal homolog 1	methylcrotonoyl-CoA carboxylase 1
	Synonyms	FXR1P	MCC-B\|MCCA
	Cytomap	3q26.33	3q27.1
	Type of gene	protein-coding	protein-coding
	Description	fragile X mental retardation syndrome-related protein 1fragile X mental retardation, autosomal homolog 1	methylcrotonoyl-CoA carboxylase subunit alpha, mitochondrial3-methylcrotonyl-CoA carboxylase 13-methylcrotonyl-CoA carboxylase biotin-containing subunit3-methylcrotonyl-CoA:carbon dioxide ligase subunit alphaMCCase subunit alphamethylcrotonoyl-CoA ca
	Modification date	20200320	20200313
	UniProtAcc	P51114	Q96RQ3
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000357559, ENST00000445140, ENST00000491062, ENST00000491674, ENST00000305586, ENST00000468861, ENST00000480918,	ENST00000539926, ENST00000489909, ENST00000265594, ENST00000492597,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	17 X 9 X 7=1071	8 X 8 X 4=256
	# samples	20	8
	** MAII score	log2(20/1071*10)=-2.42088657497553 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FXR1 [Title/Abstract] AND MCCC1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FXR1(180630524)-MCCC1(182790275), # samples:4 MCCC1(182788787)-FXR1(180679256), # samples:3
Anticipated loss of major functional domain due to fusion event.	FXR1-MCCC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FXR1-MCCC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FXR1-MCCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FXR1-MCCC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. MCCC1-FXR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. MCCC1-FXR1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	FXR1	GO:2000637	positive regulation of gene silencing by miRNA	17057366

Fusion gene breakpoints across FXR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across MCCC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUSC	TCGA-85-8580-01A	FXR1	chr3	180630524	-	MCCC1	chr3	182790275	-
ChimerDB4	LUSC	TCGA-85-8580-01A	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-
ChimerDB4	LUSC	TCGA-85-8580	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000357559	FXR1	chr3	180630524	+	ENST00000265594	MCCC1	chr3	182790275	-	2464	435	0	2243	747
ENST00000357559	FXR1	chr3	180630524	+	ENST00000492597	MCCC1	chr3	182790275	-	2464	435	0	2243	747
ENST00000491674	FXR1	chr3	180630524	+	ENST00000265594	MCCC1	chr3	182790275	-	2228	199	97	2007	636
ENST00000491674	FXR1	chr3	180630524	+	ENST00000492597	MCCC1	chr3	182790275	-	2228	199	97	2007	636
ENST00000491062	FXR1	chr3	180630524	+	ENST00000265594	MCCC1	chr3	182790275	-	2095	66	15	1874	619
ENST00000491062	FXR1	chr3	180630524	+	ENST00000492597	MCCC1	chr3	182790275	-	2095	66	15	1874	619
ENST00000445140	FXR1	chr3	180630524	+	ENST00000265594	MCCC1	chr3	182790275	-	2094	65	14	1873	619
ENST00000445140	FXR1	chr3	180630524	+	ENST00000492597	MCCC1	chr3	182790275	-	2094	65	14	1873	619

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000357559	ENST00000265594	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.00383827	0.9961617
ENST00000357559	ENST00000492597	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.00383827	0.9961617
ENST00000491674	ENST00000265594	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001576857	0.9984231
ENST00000491674	ENST00000492597	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001576857	0.9984231
ENST00000491062	ENST00000265594	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001874799	0.99812526
ENST00000491062	ENST00000492597	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001874799	0.99812526
ENST00000445140	ENST00000265594	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001883588	0.9981165
ENST00000445140	ENST00000492597	FXR1	chr3	180630524	+	MCCC1	chr3	182790275	-	0.001883588	0.9981165

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31873_31873_1_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=747AA_BP=145
MPMRRAGCAWAVHSVAAGGTTRPPRCELRALWGGDLGAGQQRSGDCVWRQIRRRRRQAEPKAGDAGCAGIPPGESGRHVETPGVKGGGSQ
SQPCFPLPFPRLLLAPPPSSPLVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIR
DMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK
FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNT
RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV
HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILK
EKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASK
AKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVF

--------------------------------------------------------------

>31873_31873_2_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000357559_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=747AA_BP=145
MPMRRAGCAWAVHSVAAGGTTRPPRCELRALWGGDLGAGQQRSGDCVWRQIRRRRRQAEPKAGDAGCAGIPPGESGRHVETPGVKGGGSQ
SQPCFPLPFPRLLLAPPPSSPLVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIR
DMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK
FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNT
RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV
HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILK
EKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASK
AKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVF

--------------------------------------------------------------

>31873_31873_3_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------

>31873_31873_4_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000445140_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------

>31873_31873_5_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------

>31873_31873_6_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491062_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=619AA_BP=17
MAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHAR
RIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKII
EEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEIT
LQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTN
IDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLK
DGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQ

--------------------------------------------------------------

>31873_31873_7_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000265594_length(amino acids)=636AA_BP=34
MVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE
GYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAV
YLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQ
LRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALT
KLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSS
SSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEI
DIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEES

--------------------------------------------------------------

>31873_31873_8_FXR1-MCCC1_FXR1_chr3_180630524_ENST00000491674_MCCC1_chr3_182790275_ENST00000492597_length(amino acids)=636AA_BP=34
MVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIRDMGIKSTSKSIMAAAGVPVVE
GYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEKFVDTPRHVEVQVFGDHHGNAV
YLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNTRLQVEHPVTEMITGTDLVEWQ
LRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSVHYDPMIAKLVVWAADRQAALT
KLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILKEKAMTDTFTLQAHDQFSPFSS
SSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASKAKLIILENTIYLFSKEGSIEI
DIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVFYREGAQANRHTPLVEFEEEES

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:180630524/chr3:182790275)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FXR1 P51114	MCCC1 Q96RQ3
FUNCTION: RNA-binding protein required for embryonic and postnatal development of muscle tissue (PubMed:30770808). May regulate intracellular transport and local translation of certain mRNAs (By similarity). {ECO:0000250\|UniProtKB:Q61584, ECO:0000269\|PubMed:30770808}.	FUNCTION: Biotin-attachment subunit of the 3-methylcrotonyl-CoA carboxylase, an enzyme that catalyzes the conversion of 3-methylcrotonyl-CoA to 3-methylglutaconyl-CoA, a critical step for leucine and isovaleric acid catabolism. {ECO:0000269\|PubMed:17360195}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

MCCC1

chr3:180630524

chr3:182790275

ENST00000265594

167_364

123.0

726.0

Domain

ATP-grasp

Tgene

MCCC1

chr3:180630524

chr3:182790275

ENST00000265594

643_715

123.0

726.0

Domain

Biotinyl-binding

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

502_510

537.0

Compositional bias

Note=Poly-Arg

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

50_53

537.0

Compositional bias

Note=Poly-Pro

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

502_510

17.0

622.0

Compositional bias

Note=Poly-Arg

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

50_53

17.0

622.0

Compositional bias

Note=Poly-Pro

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

502_510

17.0

540.0

Compositional bias

Note=Poly-Arg

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

50_53

17.0

540.0

Compositional bias

Note=Poly-Pro

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

222_251

537.0

Domain

KH 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

285_314

537.0

Domain

KH 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

4_50

537.0

Domain

Agenet-like 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

63_115

537.0

Domain

Agenet-like 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

222_251

17.0

622.0

Domain

KH 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

285_314

17.0

622.0

Domain

KH 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

4_50

17.0

622.0

Domain

Agenet-like 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

63_115

17.0

622.0

Domain

Agenet-like 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

222_251

17.0

540.0

Domain

KH 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

285_314

17.0

540.0

Domain

KH 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

4_50

17.0

540.0

Domain

Agenet-like 1

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

63_115

17.0

540.0

Domain

Agenet-like 2

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000305586

442_457

537.0

Region

Note=RNA-binding RGG-box

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000357559

442_457

17.0

622.0

Region

Note=RNA-binding RGG-box

Hgene

FXR1

chr3:180630524

chr3:182790275

ENST00000445140

442_457

17.0

540.0

Region

Note=RNA-binding RGG-box

Tgene

MCCC1

chr3:180630524

chr3:182790275

ENST00000265594

48_494

123.0

726.0

Domain

Note=Biotin carboxylation

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1507_FXR1_180630524_MCCC1_182790275_ranked_0.pdb	FXR1	180630524	180630524	ENST00000492597	MCCC1	chr3	182790275	-	MPMRRAGCAWAVHSVAAGGTTRPPRCELRALWGGDLGAGQQRSGDCVWRQIRRRRRQAEPKAGDAGCAGIPPGESGRHVETPGVKGGGSQ SQPCFPLPFPRLLLAPPPSSPLVGKFLESLPSGLCGSNMAELTVEVRGSNGAFYKAIHPGCGFLSENMEFAELCKQEGIIFIGPPPSAIR DMGIKSTSKSIMAAAGVPVVEGYHGEDQSDQCLKEHARRIGYPVMIKAVRGGGGKGMRIVRSEQEFQEQLESARREAKKSFNDDAMLIEK FVDTPRHVEVQVFGDHHGNAVYLFERDCSVQRRHQKIIEEAPAPGIKSEVRKKLGEAAVRAAKAVNYVGAGTVEFIMDSKHNFCFMEMNT RLQVEHPVTEMITGTDLVEWQLRIAAGEKIPLSQEEITLQGHAFEARIYAEDPSNNFMPVAGPLVHLSTPRADPSTRIETGVRQGDEVSV HYDPMIAKLVVWAADRQAALTKLRYSLRQYNIVGLHTNIDFLLNLSGHPEFEAGNVHTDFIPQHHKQLLLSRKAAAKESLCQAALGLILK EKAMTDTFTLQAHDQFSPFSSSSGRRLNISYTRNMTLKDGKNNVAIAVTYNHDGSYSMQIEDKTFQVLGNLYSEGDCTYLKCSVNGVASK AKLIILENTIYLFSKEGSIEIDIPVPKYLSSVSSQETQGGPLAPMTGTIEKVFVKAGDKVKAGDSLMVMIAMKMEHTIKSPKDGTVKKVF	747

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FXR1_pLDDT.png

MCCC1_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FXR1
MCCC1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to FXR1-MCCC1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to FXR1-MCCC1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source