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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:FYTTD1-DDOST

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: FYTTD1-DDOST
	FusionPDB ID: 31939
	FusionGDB2.0 ID: 31939
		Hgene	Tgene
	Gene symbol	FYTTD1	DDOST
	Gene ID	84248	1650
	Gene name	forty-two-three domain containing 1	dolichyl-diphosphooligosaccharide--protein glycosyltransferase non-catalytic subunit
	Synonyms	UIF	AGER1\|CDG1R\|GATD6\|OKSWcl45\|OST\|OST48\|WBP1
	Cytomap	3q29	1p36.12
	Type of gene	protein-coding	protein-coding
	Description	UAP56-interacting factorforty-two-three domain-containing protein 1protein 40-2-3	dolichyl-diphosphooligosaccharide--protein glycosyltransferase 48 kDa subunitadvanced glycation end-product receptor 1advanced glycation endproduct receptor 1dolichyl-diphosphooligosaccharide--protein glycosyltransferase subunit (non-catalytic)dolichy
	Modification date	20200313	20200327
	UniProtAcc	Q96QD9	P39656
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000241502, ENST00000415708, ENST00000424384, ENST00000428395, ENST00000492360,	ENST00000477229, ENST00000375048, ENST00000415136, ENST00000602624,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	7 X 7 X 6=294	6 X 5 X 3=90
	# samples	7	7
	** MAII score	log2(7/294*10)=-2.0703893278914 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(7/90*10)=-0.362570079384708 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: FYTTD1 [Title/Abstract] AND DDOST [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	FYTTD1(197483428)-DDOST(20982680), # samples:3
Anticipated loss of major functional domain due to fusion event.	FYTTD1-DDOST seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FYTTD1-DDOST seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FYTTD1-DDOST seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. FYTTD1-DDOST seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	DDOST	GO:0006487	protein N-linked glycosylation	9642163
Tgene	DDOST	GO:0034097	response to cytokine	9642163
Tgene	DDOST	GO:0042110	T cell activation	9642163

Fusion gene breakpoints across FYTTD1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDOST (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-36-1577-01A	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-
ChimerDB4	OV	TCGA-36-1577-01A	FYTTD1	chr3	197490509	+	DDOST	chr1	20982680	-
ChimerDB4	OV	TCGA-36-1577	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415708	FYTTD1	chr3	197483428	+	ENST00000602624	DDOST	chr1	20982680	-	2052	395	238	1449	403
ENST00000415708	FYTTD1	chr3	197483428	+	ENST00000375048	DDOST	chr1	20982680	-	2052	395	238	1449	403
ENST00000415708	FYTTD1	chr3	197483428	+	ENST00000415136	DDOST	chr1	20982680	-	1775	395	238	1449	403
ENST00000241502	FYTTD1	chr3	197483428	+	ENST00000602624	DDOST	chr1	20982680	-	2114	457	144	1511	455
ENST00000241502	FYTTD1	chr3	197483428	+	ENST00000375048	DDOST	chr1	20982680	-	2114	457	144	1511	455
ENST00000241502	FYTTD1	chr3	197483428	+	ENST00000415136	DDOST	chr1	20982680	-	1837	457	144	1511	455
ENST00000424384	FYTTD1	chr3	197483428	+	ENST00000602624	DDOST	chr1	20982680	-	2222	565	408	1619	403
ENST00000424384	FYTTD1	chr3	197483428	+	ENST00000375048	DDOST	chr1	20982680	-	2222	565	408	1619	403
ENST00000424384	FYTTD1	chr3	197483428	+	ENST00000415136	DDOST	chr1	20982680	-	1945	565	408	1619	403

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415708	ENST00000602624	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003569198	0.99643075
ENST00000415708	ENST00000375048	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003569198	0.99643075
ENST00000415708	ENST00000415136	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003978842	0.9960212
ENST00000241502	ENST00000602624	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.005480501	0.99451953
ENST00000241502	ENST00000375048	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.005480501	0.99451953
ENST00000241502	ENST00000415136	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.006211283	0.99378866
ENST00000424384	ENST00000602624	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003222483	0.9967775
ENST00000424384	ENST00000375048	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003222483	0.9967775
ENST00000424384	ENST00000415136	FYTTD1	chr3	197483428	+	DDOST	chr1	20982680	-	0.003476975	0.996523

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31939_31939_1_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000241502_DDOST_chr1_20982680_ENST00000375048_length(amino acids)=455AA_BP=103
MRARVGGGRPATPALSAPALGATSPAMNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQ
QFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLL
KAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNS
AVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRID
PFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKE

--------------------------------------------------------------

>31939_31939_2_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000241502_DDOST_chr1_20982680_ENST00000415136_length(amino acids)=455AA_BP=103
MRARVGGGRPATPALSAPALGATSPAMNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQ
QFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLL
KAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNS
AVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRID
PFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKE

--------------------------------------------------------------

>31939_31939_3_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000241502_DDOST_chr1_20982680_ENST00000602624_length(amino acids)=455AA_BP=103
MRARVGGGRPATPALSAPALGATSPAMNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQ
QFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLL
KAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNS
AVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRID
PFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKE

--------------------------------------------------------------

>31939_31939_4_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000415708_DDOST_chr1_20982680_ENST00000375048_length(amino acids)=403AA_BP=51
MEPSVIMGNDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

>31939_31939_5_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000415708_DDOST_chr1_20982680_ENST00000415136_length(amino acids)=403AA_BP=51
MEPSVIMGNDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

>31939_31939_6_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000415708_DDOST_chr1_20982680_ENST00000602624_length(amino acids)=403AA_BP=51
MEPSVIMGNDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

>31939_31939_7_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000424384_DDOST_chr1_20982680_ENST00000375048_length(amino acids)=403AA_BP=51
MLWLAEKPDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

>31939_31939_8_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000424384_DDOST_chr1_20982680_ENST00000415136_length(amino acids)=403AA_BP=51
MLWLAEKPDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

>31939_31939_9_FYTTD1-DDOST_FYTTD1_chr3_197483428_ENST00000424384_DDOST_chr1_20982680_ENST00000602624_length(amino acids)=403AA_BP=51
MLWLAEKPDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQQFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGS
ECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLLKAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQY
PHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNSAVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPN
AYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRIDPFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:197483428/chr1:20982680)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
FYTTD1 Q96QD9	DDOST P39656
FUNCTION: Required for mRNA export from the nucleus to the cytoplasm. Acts as an adapter that uses the DDX39B/UAP56-NFX1 pathway to ensure efficient mRNA export and delivering to the nuclear pore. Associates with spliced and unspliced mRNAs simultaneously with ALYREF/THOC4. {ECO:0000269\|PubMed:19836239}.	FUNCTION: Essential subunit of the N-oligosaccharyl transferase (OST) complex which catalyzes the transfer of a high mannose oligosaccharide from a lipid-linked oligosaccharide donor to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains. Required for the assembly of both SST3A- and SS3B-containing OST complexes. Required for efficient N-glycosylation. {ECO:0000250\|UniProtKB:Q05052, ECO:0000269\|PubMed:22467853, ECO:0000305}.; FUNCTION: Subunit of the oligosaccharyl transferase (OST) complex that catalyzes the initial transfer of a defined glycan (Glc(3)Man(9)GlcNAc(2) in eukaryotes) from the lipid carrier dolichol-pyrophosphate to an asparagine residue within an Asn-X-Ser/Thr consensus motif in nascent polypeptide chains, the first step in protein N-glycosylation. N-glycosylation occurs cotranslationally and the complex associates with the Sec61 complex at the channel-forming translocon complex that mediates protein translocation across the endoplasmic reticulum (ER). All subunits are required for a maximal enzyme activity (By similarity). Required for the assembly of both SST3A- and SS3B-containing OST complexes (PubMed:22467853). {ECO:0000250\|UniProtKB:Q05052, ECO:0000269\|PubMed:22467853}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FYTTD1

chr3:197483428

chr1:20982680

ENST00000241502

26_44

78.33333333333333

319.0

Motif

Note=UAP56-binding motif

Hgene

FYTTD1

chr3:197483428

chr1:20982680

ENST00000415708

26_44

52.333333333333336

293.0

Motif

Note=UAP56-binding motif

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000375048

448_456

105.33333333333333

457.0

Topological domain

Cytoplasmic

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000602624

448_456

88.33333333333333

440.0

Topological domain

Cytoplasmic

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000375048

428_447

105.33333333333333

457.0

Transmembrane

Helical

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000602624

428_447

88.33333333333333

440.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

FYTTD1

chr3:197483428

chr1:20982680

ENST00000424384

26_44

11.333333333333334

252.0

Motif

Note=UAP56-binding motif

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000375048

43_427

105.33333333333333

457.0

Topological domain

Lumenal

Tgene

DDOST

chr3:197483428

chr1:20982680

ENST00000602624

43_427

88.33333333333333

440.0

Topological domain

Lumenal

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>950_FYTTD1_197483428_DDOST_20982680_950_FYTTD1_197483428_DDOST_20982680_ranked_0.pdb	FYTTD1	197483428	197483428	ENST00000415136	DDOST	chr1	20982680	-	MRARVGGGRPATPALSAPALGATSPAMNRFGTRLVGATATSSPPPKARSNENLDKIDMSLDDIIKLNRKEGKKQNFPRLNRRLLQQSGAQ QFRMRVRWGIQQNSDFGGNINVETISAFIDGGGSVLVAASSDIGDPLRELGSECGIEFDEEKTAVIDHHNYDISDLGQHTLIVADTENLL KAPTIVGKSSLNPILFRGVGMVADPDNPLVLDILTGSSTSYSFFPDKPITQYPHAVGKNTLLIAGLQARNNARVIFSGSLDFFSDSFFNS AVQKAAPGSQRYSQTGNYELAVALSRWVFKEEGVLRVGPVSHHRVGETAPPNAYTVTDLVEYSIVIQQLSNGKWVPFDGDDIQLEFVRID PFVRTFLKKKGGKYSVQFKLPDVYGVFQFKVDYNRLGYTHLYSSTQVSVRPLQHTQYERFIPSAYPYYASAFSMMLGLFIFSIVFLHMKE	455

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

FYTTD1_pLDDT.png

DDOST_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
FYTTD1
DDOST

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to FYTTD1-DDOST

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to FYTTD1-DDOST

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source