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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:FZR1-GNA11

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: FZR1-GNA11
FusionPDB ID: 31970
FusionGDB2.0 ID: 31970
HgeneTgene
Gene symbol

FZR1

GNA11

Gene ID

51343

2767

Gene namefizzy and cell division cycle 20 related 1G protein subunit alpha 11
SynonymsCDC20C|CDH1|FZR|FZR2|HCDH|HCDH1FBH|FBH2|FHH2|GNA-11|HHC2|HYPOC2
Cytomap

19p13.3

19p13.3

Type of geneprotein-codingprotein-coding
Descriptionfizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1guanine nucleotide-binding protein subunit alpha-11g alpha-11guanine nucleotide binding protein (G protein), alpha 11 (Gq class)guanine nucleotide-binding protein G(y) subunit alpha
Modification date2020031320200313
UniProtAcc

Q9UM11

P29992

Ensembl transtripts involved in fusion geneENST idsENST00000313639, ENST00000395095, 
ENST00000441788, 		ENST00000586180, 
ENST00000078429, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score11 X 9 X 10=9905 X 7 X 5=175
# samples 157
** MAII scorelog2(15/990*10)=-2.72246602447109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/175*10)=-1.32192809488736
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: FZR1 [Title/Abstract] AND GNA11 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)FZR1(3534511)-GNA11(3113327), # samples:1
FZR1(3534511)-GNA11(3113328), # samples:1
Anticipated loss of major functional domain due to fusion event.FZR1-GNA11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FZR1-GNA11 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
FZR1-GNA11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
FZR1-GNA11 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneFZR1

GO:0031145

anaphase-promoting complex-dependent catabolic process

18662541|21596315

HgeneFZR1

GO:0072425

signal transduction involved in G2 DNA damage checkpoint

18662541

HgeneFZR1

GO:1904668

positive regulation of ubiquitin protein ligase activity

11459826


check buttonFusion gene breakpoints across FZR1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across GNA11 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4UCECTCGA-FI-A2D2-01AFZR1chr19

3534511

+GNA11chr19

3113328

+
ChimerDB4UCECTCGA-FI-A2D2FZR1chr19

3534511

+GNA11chr19

3113327

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000441788FZR1chr193534511+ENST00000078429GNA11chr193113327+526016762092434741
ENST00000313639FZR1chr193534511+ENST00000078429GNA11chr193113327+4757117301931643
ENST00000395095FZR1chr193534511+ENST00000078429GNA11chr193113327+4940135602114704
ENST00000441788FZR1chr193534511+ENST00000078429GNA11chr193113328+526016762092434741
ENST00000313639FZR1chr193534511+ENST00000078429GNA11chr193113328+4757117301931643
ENST00000395095FZR1chr193534511+ENST00000078429GNA11chr193113328+4940135602114704

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000441788ENST00000078429FZR1chr193534511+GNA11chr193113327+0.0026609340.99733907
ENST00000313639ENST00000078429FZR1chr193534511+GNA11chr193113327+0.0023450190.9976549
ENST00000395095ENST00000078429FZR1chr193534511+GNA11chr193113327+0.0023654880.99763453
ENST00000441788ENST00000078429FZR1chr193534511+GNA11chr193113328+0.0026609340.99733907
ENST00000313639ENST00000078429FZR1chr193534511+GNA11chr193113328+0.0023450190.9976549
ENST00000395095ENST00000078429FZR1chr193534511+GNA11chr193113328+0.0023654880.99763453

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>31970_31970_1_FZR1-GNA11_FZR1_chr19_3534511_ENST00000313639_GNA11_chr19_3113327_ENST00000078429_length(amino acids)=643AA_BP=391
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA
YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG
HTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVK
AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYL
AMSPDGEAIVTGAGDETLRFWNVFSKTRSTKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDR
IATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFR
TIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKD

--------------------------------------------------------------

>31970_31970_2_FZR1-GNA11_FZR1_chr19_3534511_ENST00000313639_GNA11_chr19_3113328_ENST00000078429_length(amino acids)=643AA_BP=391
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA
YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEG
HTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVK
AIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYL
AMSPDGEAIVTGAGDETLRFWNVFSKTRSTKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDR
IATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFR
TIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIRFVFAAVKD

--------------------------------------------------------------

>31970_31970_3_FZR1-GNA11_FZR1_chr19_3534511_ENST00000395095_GNA11_chr19_3113327_ENST00000078429_length(amino acids)=704AA_BP=452
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA
YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD
APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH
TARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA
IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLV
KWANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFD
LENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILY

--------------------------------------------------------------

>31970_31970_4_FZR1-GNA11_FZR1_chr19_3534511_ENST00000395095_GNA11_chr19_3113328_ENST00000078429_length(amino acids)=704AA_BP=452
MDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDATSDNGKDGLA
YSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKISKIPFKVLD
APELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAGKKLSMLEGH
TARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQYTEHLAAVKA
IAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTGHSYRVLYLV
KWANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAKYYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFD
LENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRMEESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILY

--------------------------------------------------------------

>31970_31970_5_FZR1-GNA11_FZR1_chr19_3534511_ENST00000441788_GNA11_chr19_3113327_ENST00000078429_length(amino acids)=741AA_BP=489
MPRAEPCLAMDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDAT
SDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKI
SKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG
KKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY
TEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG
HSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAK
YYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRM
EESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIR

--------------------------------------------------------------

>31970_31970_6_FZR1-GNA11_FZR1_chr19_3534511_ENST00000441788_GNA11_chr19_3113328_ENST00000078429_length(amino acids)=741AA_BP=489
MPRAEPCLAMDQDYERRLLRQIVIQNENTMPRVTEMRRTLTPASSPVSSPSKHGDRFIPSRAGANWSVNFHRINENEKSPSQNRKAKDAT
SDNGKDGLAYSALLKNELLGAGIEKVQDPQTEDRRLQPSTPEKKGLFTYSLSTKRSSPDDGNDVSPYSLSPVSNKSQKLLRSPRKPTRKI
SKIPFKVLDAPELQDDFYLNLVDWSSLNVLSVGLGTCVYLWSACTSQVTRLCDLSVEGDSVTSVGWSERGNLVAVGTHKGFVQIWDAAAG
KKLSMLEGHTARVGALAWNAEQLSSGSRDRMILQRDIRTPPLQSERRLQGHRQEVCGLKWSTDHQLLASGGNDNKLLVWNHSSLSPVQQY
TEHLAAVKAIAWSPHQHGLLASGGGTADRCIRFWNTLTGQPLQCIDTGSQVCNLAWSKHANELVSTHGYSQNQILVWKYPSLTQVAKLTG
HSYRVLYLAMSPDGEAIVTGAGDETLRFWNVFSKTRSTKANALLIREVDVEKVTTFEHQYVSAIKTLWEDPGIQECYDRRREYQLSDSAK
YYLTDVDRIATLGYLPTQQDVLRVRVPTTGIIEYPFDLENIIFRMVDVGGQRSERRKWIHCFENVTSIMFLVALSEYDQVLVESDNENRM
EESKALFRTIITYPWFQNSSVILFLNKKDLLEDKILYSHLVDYFPEFDGPQRDAQAAREFILKMFVDLNPDSDKIIYSHFTCATDTENIR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3534511/chr19:3113327)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
FZR1

Q9UM11

GNA11

P29992

FUNCTION: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}.FUNCTION: Guanine nucleotide-binding proteins (G proteins) are involved as modulators or transducers in various transmembrane signaling systems. Acts as an activator of phospholipase C. Transduces FFAR4 signaling in response to long-chain fatty acids (LCFAs). {ECO:0000269|PubMed:27852822}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+101147_52391.0405.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+131447_52480.0494.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+101147_52391.0405.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+131447_52480.0494.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011182_222391.0405.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011227_266391.0405.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011269_306391.0405.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011311_350391.0405.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314182_222480.0494.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314227_266480.0494.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314269_306480.0494.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314311_350480.0494.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314353_395480.0494.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314397_438480.0494.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113327ENST00000441788+1314441_480480.0494.0RepeatNote=WD 7
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011182_222391.0405.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011227_266391.0405.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011269_306391.0405.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011311_350391.0405.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314182_222480.0494.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314227_266480.0494.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314269_306480.0494.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314311_350480.0494.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314353_395480.0494.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314397_438480.0494.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113328ENST00000441788+1314441_480480.0494.0RepeatNote=WD 7
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917180_186107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917205_209107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917274_277107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917180_186107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917205_209107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917274_277107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917178_186107.0360.0RegionG2 motif
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917201_210107.0360.0RegionG3 motif
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917270_277107.0360.0RegionG4 motif
TgeneGNA11chr19:3534511chr19:3113327ENST0000007842917329_334107.0360.0RegionG5 motif
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917178_186107.0360.0RegionG2 motif
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917201_210107.0360.0RegionG3 motif
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917270_277107.0360.0RegionG4 motif
TgeneGNA11chr19:3534511chr19:3113328ENST0000007842917329_334107.0360.0RegionG5 motif

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+11347_520.0497.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+11347_520.0497.0RegionInvolved in APC/FZR1 E3 ubiquitin-protein ligase complex activity
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011353_395391.0405.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011397_438391.0405.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113327ENST00000313639+1011441_480391.0405.0RepeatNote=WD 7
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113182_2220.0497.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113227_2660.0497.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113269_3060.0497.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113311_3500.0497.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113353_3950.0497.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113397_4380.0497.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113327ENST00000395095+113441_4800.0497.0RepeatNote=WD 7
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011353_395391.0405.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011397_438391.0405.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113328ENST00000313639+1011441_480391.0405.0RepeatNote=WD 7
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113182_2220.0497.0RepeatNote=WD 1
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113227_2660.0497.0RepeatNote=WD 2
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113269_3060.0497.0RepeatNote=WD 3
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113311_3500.0497.0RepeatNote=WD 4
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113353_3950.0497.0RepeatNote=WD 5
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113397_4380.0497.0RepeatNote=WD 6
HgeneFZR1chr19:3534511chr19:3113328ENST00000395095+113441_4800.0497.0RepeatNote=WD 7
TgeneGNA11chr19:3534511chr19:3113327ENST000000784291738_359107.0360.0DomainG-alpha
TgeneGNA11chr19:3534511chr19:3113328ENST000000784291738_359107.0360.0DomainG-alpha
TgeneGNA11chr19:3534511chr19:3113327ENST000000784291746_53107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113328ENST000000784291746_53107.0360.0Nucleotide bindingGTP
TgeneGNA11chr19:3534511chr19:3113327ENST000000784291741_54107.0360.0RegionG1 motif
TgeneGNA11chr19:3534511chr19:3113328ENST000000784291741_54107.0360.0RegionG1 motif


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
FZR1
GNA11


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to FZR1-GNA11


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to FZR1-GNA11


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource