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Fusion Protein:FZR1-NCLN |
Fusion Protein Summary |
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Fusion partner gene information | Fusion gene name: FZR1-NCLN | FusionPDB ID: 31974 | FusionGDB2.0 ID: 31974 | Hgene | Tgene | Gene symbol | FZR1 | NCLN | Gene ID | 51343 | 56926 |
Gene name | fizzy and cell division cycle 20 related 1 | nicalin | |
Synonyms | CDC20C|CDH1|FZR|FZR2|HCDH|HCDH1 | NET59 | |
Cytomap | 19p13.3 | 19p13.3 | |
Type of gene | protein-coding | protein-coding | |
Description | fizzy-related protein homologCDC20 homolog 1CDC20-like 1bCDC20-like protein 1cdh1/Hct1 homologfizzy/cell division cycle 20 related 1 | nicalinnicalin homolognicastrin-like protein | |
Modification date | 20200313 | 20200313 | |
UniProtAcc | Q9UM11 | Q969V3 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000313639, ENST00000395095, ENST00000441788, | ENST00000591062, ENST00000246117, ENST00000590671, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 11 X 9 X 10=990 | 3 X 3 X 3=27 |
# samples | 15 | 3 | |
** MAII score | log2(15/990*10)=-2.72246602447109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(3/27*10)=0.15200309344505 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: FZR1 [Title/Abstract] AND NCLN [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | FZR1(3523056)-NCLN(3201521), # samples:3 | ||
Anticipated loss of major functional domain due to fusion event. | FZR1-NCLN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. FZR1-NCLN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
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Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | FZR1 | GO:0031145 | anaphase-promoting complex-dependent catabolic process | 18662541|21596315 |
Hgene | FZR1 | GO:0072425 | signal transduction involved in G2 DNA damage checkpoint | 18662541 |
Hgene | FZR1 | GO:1904668 | positive regulation of ubiquitin protein ligase activity | 11459826 |
Tgene | NCLN | GO:0043254 | regulation of protein complex assembly | 20538592 |
Tgene | NCLN | GO:0061635 | regulation of protein complex stability | 20538592 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
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![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | LUAD | TCGA-55-7903-01A | FZR1 | chr19 | 3523056 | - | NCLN | chr19 | 3201521 | + |
ChimerDB4 | LUAD | TCGA-55-7903-01A | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + |
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Fusion ORF Analysis |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000441788 | FZR1 | chr19 | 3523056 | + | ENST00000590671 | NCLN | chr19 | 3201521 | + | 1469 | 305 | 1402 | 203 | 399 |
ENST00000441788 | FZR1 | chr19 | 3523056 | + | ENST00000246117 | NCLN | chr19 | 3201521 | + | 3183 | 305 | 1402 | 203 | 399 |
ENST00000313639 | FZR1 | chr19 | 3523056 | + | ENST00000590671 | NCLN | chr19 | 3201521 | + | 1233 | 69 | 1166 | 0 | 389 |
ENST00000313639 | FZR1 | chr19 | 3523056 | + | ENST00000246117 | NCLN | chr19 | 3201521 | + | 2947 | 69 | 1166 | 0 | 389 |
ENST00000395095 | FZR1 | chr19 | 3523056 | + | ENST00000590671 | NCLN | chr19 | 3201521 | + | 1233 | 69 | 1166 | 0 | 389 |
ENST00000395095 | FZR1 | chr19 | 3523056 | + | ENST00000246117 | NCLN | chr19 | 3201521 | + | 2947 | 69 | 1166 | 0 | 389 |
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Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000441788 | ENST00000590671 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.011884265 | 0.9881158 |
ENST00000441788 | ENST00000246117 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.008075486 | 0.99192446 |
ENST00000313639 | ENST00000590671 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.011530292 | 0.9884697 |
ENST00000313639 | ENST00000246117 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.007612206 | 0.9923878 |
ENST00000395095 | ENST00000590671 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.011530292 | 0.9884697 |
ENST00000395095 | ENST00000246117 | FZR1 | chr19 | 3523056 | + | NCLN | chr19 | 3201521 | + | 0.007612206 | 0.9923878 |
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Fusion Amino Acid Sequences |
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>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >31974_31974_1_FZR1-NCLN_FZR1_chr19_3523056_ENST00000313639_NCLN_chr19_3201521_ENST00000246117_length(amino acids)=389AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- >31974_31974_2_FZR1-NCLN_FZR1_chr19_3523056_ENST00000313639_NCLN_chr19_3201521_ENST00000590671_length(amino acids)=389AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- >31974_31974_3_FZR1-NCLN_FZR1_chr19_3523056_ENST00000395095_NCLN_chr19_3201521_ENST00000246117_length(amino acids)=389AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- >31974_31974_4_FZR1-NCLN_FZR1_chr19_3523056_ENST00000395095_NCLN_chr19_3201521_ENST00000590671_length(amino acids)=389AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- >31974_31974_5_FZR1-NCLN_FZR1_chr19_3523056_ENST00000441788_NCLN_chr19_3201521_ENST00000246117_length(amino acids)=399AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- >31974_31974_6_FZR1-NCLN_FZR1_chr19_3523056_ENST00000441788_NCLN_chr19_3201521_ENST00000590671_length(amino acids)=399AA_BP=1 MSLQGRPRRGSVHSLVLGPRDCGAAGAPAVGVAVSLCLGLHEQPLDGLVEEAEVLDSHVGHAEVGSNANSQEQVKDGRLDSVRIHHLLQL VVEDKLWVPLVSLDVVLLHVLQVAAQVVLQRAEEGAVLVHQLRGPRLVGEPVHHRVQLLLLDLHLLCEHRHVWGCPLLCQVVDDSSQGLC NDPRVTGQGLRIHPGPHVHDAAALAVTVALQVGQREGGQSADGEALVLPGQHVLRQVDPLVHHGEPYLRELVRGHRLQLPQEGVLQGALP RRLGHVQVQAAAPAHGVQAQHEGHIVLKQAGVCVVQVVFQPALGSLVVKLASSRRKEQEVVGGVRALVGVEPGEEACQLQQHRDAAPVGV -------------------------------------------------------------- |
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Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:3523056/chr19:3201521) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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Hgene | Tgene |
FZR1 | NCLN |
FUNCTION: Substrate-specific adapter for the anaphase promoting complex/cyclosome (APC/C) E3 ubiquitin-protein ligase complex. Associates with the APC/C in late mitosis, in replacement of CDC20, and activates the APC/C during anaphase and telophase. The APC/C remains active in degrading substrates to ensure that positive regulators of the cell cycle do not accumulate prematurely. At the G1/S transition FZR1 is phosphorylated, leading to its dissociation from the APC/C. Following DNA damage, it is required for the G2 DNA damage checkpoint: its dephosphorylation and reassociation with the APC/C leads to the ubiquitination of PLK1, preventing entry into mitosis. Acts as an adapter for APC/C to target the DNA-end resection factor RBBP8/CtIP for ubiquitination and subsequent proteasomal degradation. Through the regulation of RBBP8/CtIP protein turnover, may play a role in DNA damage response, favoring DNA double-strand repair through error-prone non-homologous end joining (NHEJ) over error-free, RBBP8-mediated homologous recombination (HR) (PubMed:25349192). {ECO:0000269|PubMed:18662541, ECO:0000269|PubMed:21596315, ECO:0000269|PubMed:25349192, ECO:0000269|PubMed:9734353}. | FUNCTION: Component of a ribosome-associated translocon complex involved in multi-pass membrane protein transport into the endoplasmic reticulum (ER) membrane and biogenesis (PubMed:32820719). May antagonize Nodal signaling and subsequent organization of axial structures during mesodermal patterning, via its interaction with NOMO (By similarity). {ECO:0000250|UniProtKB:Q6NZ07, ECO:0000269|PubMed:32820719}. |
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- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | NCLN | chr19:3523056 | chr19:3201521 | ENST00000246117 | 4 | 15 | 544_563 | 232.0 | 564.0 | Topological domain | Cytoplasmic | |
Tgene | NCLN | chr19:3523056 | chr19:3201521 | ENST00000246117 | 4 | 15 | 523_543 | 232.0 | 564.0 | Transmembrane | Helical |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 47_52 | 23.0 | 405.0 | Region | Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 47_52 | 23.0 | 497.0 | Region | Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 47_52 | 23.0 | 494.0 | Region | Involved in APC/FZR1 E3 ubiquitin-protein ligase complex activity |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 182_222 | 23.0 | 405.0 | Repeat | Note=WD 1 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 227_266 | 23.0 | 405.0 | Repeat | Note=WD 2 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 269_306 | 23.0 | 405.0 | Repeat | Note=WD 3 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 311_350 | 23.0 | 405.0 | Repeat | Note=WD 4 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 353_395 | 23.0 | 405.0 | Repeat | Note=WD 5 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 397_438 | 23.0 | 405.0 | Repeat | Note=WD 6 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000313639 | + | 1 | 11 | 441_480 | 23.0 | 405.0 | Repeat | Note=WD 7 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 182_222 | 23.0 | 497.0 | Repeat | Note=WD 1 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 227_266 | 23.0 | 497.0 | Repeat | Note=WD 2 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 269_306 | 23.0 | 497.0 | Repeat | Note=WD 3 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 311_350 | 23.0 | 497.0 | Repeat | Note=WD 4 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 353_395 | 23.0 | 497.0 | Repeat | Note=WD 5 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 397_438 | 23.0 | 497.0 | Repeat | Note=WD 6 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000395095 | + | 1 | 13 | 441_480 | 23.0 | 497.0 | Repeat | Note=WD 7 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 182_222 | 23.0 | 494.0 | Repeat | Note=WD 1 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 227_266 | 23.0 | 494.0 | Repeat | Note=WD 2 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 269_306 | 23.0 | 494.0 | Repeat | Note=WD 3 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 311_350 | 23.0 | 494.0 | Repeat | Note=WD 4 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 353_395 | 23.0 | 494.0 | Repeat | Note=WD 5 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 397_438 | 23.0 | 494.0 | Repeat | Note=WD 6 |
Hgene | FZR1 | chr19:3523056 | chr19:3201521 | ENST00000441788 | + | 2 | 14 | 441_480 | 23.0 | 494.0 | Repeat | Note=WD 7 |
Tgene | NCLN | chr19:3523056 | chr19:3201521 | ENST00000246117 | 4 | 15 | 43_522 | 232.0 | 564.0 | Topological domain | Lumenal |
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Fusion Protein-Protein Interaction |
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Gene | PPI interactors |
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Gene | STRING network |
FZR1 | |
NCLN |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
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Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to FZR1-NCLN |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to FZR1-NCLN |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |