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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GALNT11-PRKAG2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GALNT11-PRKAG2
	FusionPDB ID: 32230
	FusionGDB2.0 ID: 32230
		Hgene	Tgene
	Gene symbol	GALNT11	PRKAG2
	Gene ID	63917	51422
	Gene name	polypeptide N-acetylgalactosaminyltransferase 11	protein kinase AMP-activated non-catalytic subunit gamma 2
	Synonyms	GALNAC-T11\|GALNACT11	AAKG\|AAKG2\|CMH6\|H91620p\|WPWS
	Cytomap	7q36.1\|7q36.1	7q36.1
	Type of gene	protein-coding	protein-coding
	Description	polypeptide N-acetylgalactosaminyltransferase 11UDP-GalNAc:polypeptide N-acetylgalactosaminyltransferase 11UDP-N-acetyl-alpha-D-galactosamine:polypeptide N-acetylgalactosaminyltransferase 11 (GalNAc-T11)polypeptide GalNAc transferase 11pp-GaNTase 11p	5'-AMP-activated protein kinase subunit gamma-2AMPK subunit gamma-2epididymis secretory sperm binding proteinprotein kinase, AMP-activated, gamma 2 non-catalytic subunit
	Modification date	20200313	20200320
	UniProtAcc	Q8NCW6	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000320311, ENST00000430044, ENST00000434507, ENST00000452146, ENST00000415421, ENST00000422997, ENST00000482812,	ENST00000461529, ENST00000287878, ENST00000392801, ENST00000418337, ENST00000433631, ENST00000492843,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	14 X 8 X 9=1008	14 X 12 X 9=1512
	# samples	16	17
	** MAII score	log2(16/1008*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/1512*10)=-3.15285148808337 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GALNT11 [Title/Abstract] AND PRKAG2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GALNT11(151810483)-PRKAG2(151262971), # samples:4
Anticipated loss of major functional domain due to fusion event.	GALNT11-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GALNT11-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GALNT11-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GALNT11-PRKAG2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GALNT11	GO:0018243	protein O-linked glycosylation via threonine	24226769
Tgene	PRKAG2	GO:0006469	negative regulation of protein kinase activity	17255938

Fusion gene breakpoints across GALNT11 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRKAG2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	BRCA	TCGA-AO-A12E-01A	GALNT11	chr7	151810483	-	PRKAG2	chr7	151262971	-
ChimerDB4	BRCA	TCGA-AO-A12E-01A	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-
ChimerDB4	BRCA	TCGA-AO-A12E	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000430044	GALNT11	chr7	151810483	+	ENST00000287878	PRKAG2	chr7	151262971	-	3030	1463	230	1939	569
ENST00000430044	GALNT11	chr7	151810483	+	ENST00000418337	PRKAG2	chr7	151262971	-	3017	1463	230	1939	569
ENST00000430044	GALNT11	chr7	151810483	+	ENST00000433631	PRKAG2	chr7	151262971	-	2980	1463	230	1939	569
ENST00000430044	GALNT11	chr7	151810483	+	ENST00000492843	PRKAG2	chr7	151262971	-	2980	1463	230	1939	569
ENST00000430044	GALNT11	chr7	151810483	+	ENST00000392801	PRKAG2	chr7	151262971	-	2200	1463	230	1939	569
ENST00000452146	GALNT11	chr7	151810483	+	ENST00000287878	PRKAG2	chr7	151262971	-	2639	1072	7	1548	513
ENST00000452146	GALNT11	chr7	151810483	+	ENST00000418337	PRKAG2	chr7	151262971	-	2626	1072	7	1548	513
ENST00000452146	GALNT11	chr7	151810483	+	ENST00000433631	PRKAG2	chr7	151262971	-	2589	1072	7	1548	513
ENST00000452146	GALNT11	chr7	151810483	+	ENST00000492843	PRKAG2	chr7	151262971	-	2589	1072	7	1548	513
ENST00000452146	GALNT11	chr7	151810483	+	ENST00000392801	PRKAG2	chr7	151262971	-	1809	1072	7	1548	513
ENST00000434507	GALNT11	chr7	151810483	+	ENST00000287878	PRKAG2	chr7	151262971	-	3237	1670	437	2146	569
ENST00000434507	GALNT11	chr7	151810483	+	ENST00000418337	PRKAG2	chr7	151262971	-	3224	1670	437	2146	569
ENST00000434507	GALNT11	chr7	151810483	+	ENST00000433631	PRKAG2	chr7	151262971	-	3187	1670	437	2146	569
ENST00000434507	GALNT11	chr7	151810483	+	ENST00000492843	PRKAG2	chr7	151262971	-	3187	1670	437	2146	569
ENST00000434507	GALNT11	chr7	151810483	+	ENST00000392801	PRKAG2	chr7	151262971	-	2407	1670	437	2146	569
ENST00000320311	GALNT11	chr7	151810483	+	ENST00000287878	PRKAG2	chr7	151262971	-	2972	1405	172	1881	569
ENST00000320311	GALNT11	chr7	151810483	+	ENST00000418337	PRKAG2	chr7	151262971	-	2959	1405	172	1881	569
ENST00000320311	GALNT11	chr7	151810483	+	ENST00000433631	PRKAG2	chr7	151262971	-	2922	1405	172	1881	569
ENST00000320311	GALNT11	chr7	151810483	+	ENST00000492843	PRKAG2	chr7	151262971	-	2922	1405	172	1881	569
ENST00000320311	GALNT11	chr7	151810483	+	ENST00000392801	PRKAG2	chr7	151262971	-	2142	1405	172	1881	569

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000430044	ENST00000287878	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000113336	0.99988663
ENST00000430044	ENST00000418337	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000117521	0.99988246
ENST00000430044	ENST00000433631	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000123636	0.9998764
ENST00000430044	ENST00000492843	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000123636	0.9998764
ENST00000430044	ENST00000392801	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.00037409	0.9996259
ENST00000452146	ENST00000287878	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000174352	0.99982566
ENST00000452146	ENST00000418337	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000182117	0.9998179
ENST00000452146	ENST00000433631	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000189932	0.99981004
ENST00000452146	ENST00000492843	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000189932	0.99981004
ENST00000452146	ENST00000392801	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000648962	0.9993511
ENST00000434507	ENST00000287878	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000123906	0.999876
ENST00000434507	ENST00000418337	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000127158	0.9998728
ENST00000434507	ENST00000433631	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000128593	0.9998714
ENST00000434507	ENST00000492843	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000128593	0.9998714
ENST00000434507	ENST00000392801	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000299329	0.99970067
ENST00000320311	ENST00000287878	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000105785	0.99989426
ENST00000320311	ENST00000418337	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000109065	0.9998909
ENST00000320311	ENST00000433631	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.00010979	0.9998902
ENST00000320311	ENST00000492843	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.00010979	0.9998902
ENST00000320311	ENST00000392801	GALNT11	chr7	151810483	+	PRKAG2	chr7	151262971	-	0.000274588	0.9997254

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32230_32230_1_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000320311_PRKAG2_chr7_151262971_ENST00000287878_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_2_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000320311_PRKAG2_chr7_151262971_ENST00000392801_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_3_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000320311_PRKAG2_chr7_151262971_ENST00000418337_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_4_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000320311_PRKAG2_chr7_151262971_ENST00000433631_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_5_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000320311_PRKAG2_chr7_151262971_ENST00000492843_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_6_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000430044_PRKAG2_chr7_151262971_ENST00000287878_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_7_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000430044_PRKAG2_chr7_151262971_ENST00000392801_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_8_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000430044_PRKAG2_chr7_151262971_ENST00000418337_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_9_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000430044_PRKAG2_chr7_151262971_ENST00000433631_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_10_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000430044_PRKAG2_chr7_151262971_ENST00000492843_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_11_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000434507_PRKAG2_chr7_151262971_ENST00000287878_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_12_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000434507_PRKAG2_chr7_151262971_ENST00000392801_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_13_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000434507_PRKAG2_chr7_151262971_ENST00000418337_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_14_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000434507_PRKAG2_chr7_151262971_ENST00000433631_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_15_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000434507_PRKAG2_chr7_151262971_ENST00000492843_length(amino acids)=569AA_BP=411
MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG
HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA
HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV
CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR
IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN
IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS

--------------------------------------------------------------

>32230_32230_16_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000452146_PRKAG2_chr7_151262971_ENST00000287878_length(amino acids)=513AA_BP=355
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFY
PPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHA
TGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMA
GGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMP
KPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFE

--------------------------------------------------------------

>32230_32230_17_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000452146_PRKAG2_chr7_151262971_ENST00000392801_length(amino acids)=513AA_BP=355
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFY
PPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHA
TGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMA
GGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMP
KPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFE

--------------------------------------------------------------

>32230_32230_18_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000452146_PRKAG2_chr7_151262971_ENST00000418337_length(amino acids)=513AA_BP=355
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFY
PPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHA
TGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMA
GGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMP
KPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFE

--------------------------------------------------------------

>32230_32230_19_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000452146_PRKAG2_chr7_151262971_ENST00000433631_length(amino acids)=513AA_BP=355
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFY
PPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHA
TGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMA
GGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMP
KPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFE

--------------------------------------------------------------

>32230_32230_20_GALNT11-PRKAG2_GALNT11_chr7_151810483_ENST00000452146_PRKAG2_chr7_151262971_ENST00000492843_length(amino acids)=513AA_BP=355
MAAGPRGSSARAAPAGRTGAVAGEKMPQPESQKAAILGCGQGGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFY
PPDLPAASVVICFYNEAFSALLRTVHSVIDRTPAHLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHA
TGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVVCPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMA
GGLFAMNRQYFHELGQYDSGMDIWGGENLEISFRIWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMP
KPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALNIFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFE

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:151810483/chr7:151262971)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GALNT11 Q8NCW6	.
FUNCTION: Polypeptide N-acetylgalactosaminyltransferase that catalyzes the initiation of protein O-linked glycosylation and is involved in left/right asymmetry by mediating O-glycosylation of NOTCH1. O-glycosylation of NOTCH1 promotes activation of NOTCH1, modulating the balance between motile and immotile (sensory) cilia at the left-right organiser (LRO). Polypeptide N-acetylgalactosaminyltransferases catalyze the transfer of an N-acetyl-D-galactosamine residue to a serine or threonine residue on the protein receptor. Displays the same enzyme activity toward MUC1, MUC4, and EA2 than GALNT1. Not involved in glycosylation of erythropoietin (EPO). {ECO:0000269\|PubMed:11925450, ECO:0000269\|PubMed:24226769}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

150_261

411.0

609.0

Region

Note=Catalytic subdomain A

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

319_381

411.0

609.0

Region

Note=Catalytic subdomain B

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

150_261

411.0

609.0

Region

Note=Catalytic subdomain A

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

319_381

411.0

609.0

Region

Note=Catalytic subdomain B

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

150_261

411.0

609.0

Region

Note=Catalytic subdomain A

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

319_381

411.0

609.0

Region

Note=Catalytic subdomain B

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

1_6

411.0

609.0

Topological domain

Cytoplasmic

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

1_6

411.0

609.0

Topological domain

Cytoplasmic

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

1_6

411.0

609.0

Topological domain

Cytoplasmic

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

7_29

411.0

609.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

7_29

411.0

609.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

7_29

411.0

609.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

430_492

411.0

570.0

Domain

CBS 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

504_562

411.0

570.0

Domain

CBS 4

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

430_492

367.0

526.0

Domain

CBS 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

504_562

367.0

526.0

Domain

CBS 4

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

275_335

170.0

329.0

Domain

CBS 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

357_415

170.0

329.0

Domain

CBS 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

430_492

170.0

329.0

Domain

CBS 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

504_562

170.0

329.0

Domain

CBS 4

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

370_391

367.0

526.0

Motif

Note=AMPK pseudosubstrate

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

370_391

170.0

329.0

Motif

Note=AMPK pseudosubstrate

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

458_459

411.0

570.0

Nucleotide binding

AMP 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

474_477

411.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

530_531

411.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

546_549

411.0

570.0

Nucleotide binding

AMP 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

383_384

367.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

458_459

367.0

526.0

Nucleotide binding

AMP 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

474_477

367.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

530_531

367.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

546_549

367.0

526.0

Nucleotide binding

AMP 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

319_322

170.0

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

383_384

170.0

329.0

Nucleotide binding

AMP%2C ADP or ATP 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

458_459

170.0

329.0

Nucleotide binding

AMP 3

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

474_477

170.0

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

530_531

170.0

329.0

Nucleotide binding

AMP%2C ADP or ATP 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000418337

546_549

170.0

329.0

Nucleotide binding

AMP 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

476_607

411.0

609.0

Domain

Ricin B-type lectin

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

476_607

203.0

Domain

Ricin B-type lectin

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

476_607

411.0

609.0

Domain

Ricin B-type lectin

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

476_607

411.0

609.0

Domain

Ricin B-type lectin

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

150_261

203.0

Region

Note=Catalytic subdomain A

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

319_381

203.0

Region

Note=Catalytic subdomain B

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000320311

30_608

411.0

609.0

Topological domain

Lumenal

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

1_6

203.0

Topological domain

Cytoplasmic

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

30_608

203.0

Topological domain

Lumenal

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000430044

30_608

411.0

609.0

Topological domain

Lumenal

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000434507

30_608

411.0

609.0

Topological domain

Lumenal

Hgene

GALNT11

chr7:151810483

chr7:151262971

ENST00000415421

7_29

203.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

275_335

411.0

570.0

Domain

CBS 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

357_415

411.0

570.0

Domain

CBS 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

275_335

367.0

526.0

Domain

CBS 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

357_415

367.0

526.0

Domain

CBS 2

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

370_391

411.0

570.0

Motif

Note=AMPK pseudosubstrate

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

319_322

411.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000287878

383_384

411.0

570.0

Nucleotide binding

AMP%2C ADP or ATP 1

Tgene

PRKAG2

chr7:151810483

chr7:151262971

ENST00000392801

319_322

367.0

526.0

Nucleotide binding

AMP%2C ADP or ATP 1

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>1217_GALNT11_151810483_PRKAG2_151262971_1217_GALNT11_151810483_PRKAG2_151262971_ranked_0.pdb	GALNT11	151810483	151810483	ENST00000392801	PRKAG2	chr7	151262971	-	MGSVTVRYFCYGCLFTSATWTVLLFVYFNFSEVTQPLKNVPVKGSGPHGPSPKKFYPRFTRGPSRVLEPQFKANKIDDVIDSRVEDPEEG HLKFSSELGMIFNERDQELRDLGYQKHAFNMLISDRLGYHRDVPDTRNAACKEKFYPPDLPAASVVICFYNEAFSALLRTVHSVIDRTPA HLLHEIILVDDDSDFDDLKGELDEYVQKYLPGKIKVIRNTKREGLIRGRMIGAAHATGEVLVFLDSHCEVNVMWLQPLLAAIREDRHTVV CPVIDIISADTLAYSSSPVVRGGFNWGLHFKWDLVPLSELGRAEGATAPIKSPTMAGGLFAMNRQYFHELGQYDSGMDIWGGENLEISFR IWMCGGKLFIIPCSRVGHIFRKRRPYGSPEGQDTMTHNSLRLAHVWLDEYKMSDMPKPAFMKQNLDELGIGTYHNIAFIHPDTPIIKALN IFVERRISALPVVDESGKVVDIYSKFDVINLAAEKTYNNLDITVTQALQHRSQYFEGVVKCNKLEILETIVDRIVRAEVHRLVVVNEADS	569

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GALNT11_pLDDT.png

PRKAG2_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GALNT11
PRKAG2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to GALNT11-PRKAG2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to GALNT11-PRKAG2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source