UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:ABCD3-AK5

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: ABCD3-AK5
FusionPDB ID: 323
FusionGDB2.0 ID: 323
HgeneTgene
Gene symbol

ABCD3

AK5

Gene ID

5825

26289

Gene nameATP binding cassette subfamily D member 3adenylate kinase 5
SynonymsABC43|CBAS5|PMP70|PXMP1|ZWS2AK6
Cytomap

1p21.3

1p31.1

Type of geneprotein-codingprotein-coding
DescriptionATP-binding cassette sub-family D member 370 kDa peroxisomal membrane proteinATP-binding cassette, sub-family D (ALD), member 3Peroxisomal membrane protein-1 (70kD)dJ824O18.1 (ATP-binding cassette, sub-family D (ALD), member 3 (PMP70, PXMP1))peroxisoadenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6
Modification date2020031320200313
UniProtAcc

P28288

Q9Y6K8

Ensembl transtripts involved in fusion geneENST idsENST00000484213, ENST00000370214, 
ENST00000394233, ENST00000454898, 
ENST00000536817, ENST00000315713, 
ENST00000344720, ENST00000354567, 
ENST00000317704, ENST00000478255, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 5 X 4=1207 X 6 X 6=252
# samples 67
** MAII scorelog2(6/120*10)=-1
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/252*10)=-1.84799690655495
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: ABCD3 [Title/Abstract] AND AK5 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)ABCD3(94965170)-AK5(77876666), # samples:1
Anticipated loss of major functional domain due to fusion event.ABCD3-AK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCD3-AK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCD3-AK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
ABCD3-AK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneABCD3

GO:0007031

peroxisome organization

9425230

TgeneAK5

GO:0006165

nucleoside diphosphate phosphorylation

23416111

TgeneAK5

GO:0009142

nucleoside triphosphate biosynthetic process

23416111


check buttonFusion gene breakpoints across ABCD3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across AK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-66-2756-01AABCD3chr1

94965170

-AK5chr1

77876666

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394233ABCD3chr194965170-ENST00000354567AK5chr177876666+360615121022309735
ENST00000394233ABCD3chr194965170-ENST00000344720AK5chr177876666+360215121022309735
ENST00000454898ABCD3chr194965170-ENST00000354567AK5chr177876666+39721878662675869
ENST00000454898ABCD3chr194965170-ENST00000344720AK5chr177876666+39681878662675869
ENST00000536817ABCD3chr194965170-ENST00000354567AK5chr177876666+386117671322564810
ENST00000536817ABCD3chr194965170-ENST00000344720AK5chr177876666+385717671322564810
ENST00000370214ABCD3chr194965170-ENST00000354567AK5chr177876666+38581764242561845
ENST00000370214ABCD3chr194965170-ENST00000344720AK5chr177876666+38541764242561845

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394233ENST00000354567ABCD3chr194965170-AK5chr177876666+0.0002243710.9997756
ENST00000394233ENST00000344720ABCD3chr194965170-AK5chr177876666+0.0002241530.9997758
ENST00000454898ENST00000354567ABCD3chr194965170-AK5chr177876666+0.0003500450.99965
ENST00000454898ENST00000344720ABCD3chr194965170-AK5chr177876666+0.0003505770.9996494
ENST00000536817ENST00000354567ABCD3chr194965170-AK5chr177876666+0.0003690760.9996309
ENST00000536817ENST00000344720ABCD3chr194965170-AK5chr177876666+0.0003690220.9996309
ENST00000370214ENST00000354567ABCD3chr194965170-AK5chr177876666+0.0001391150.9998609
ENST00000370214ENST00000344720ABCD3chr194965170-AK5chr177876666+0.0001388650.9998611

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>323_323_1_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000370214_AK5_chr1_77876666_ENST00000344720_length(amino acids)=845AA_BP=580
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATP
NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTG
SDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPS
GIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIP

--------------------------------------------------------------

>323_323_2_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000370214_AK5_chr1_77876666_ENST00000354567_length(amino acids)=845AA_BP=580
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQS
GRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATP
NGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDL
VLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTG
SDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPS
GIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIP

--------------------------------------------------------------

>323_323_3_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000394233_AK5_chr1_77876666_ENST00000344720_length(amino acids)=735AA_BP=470
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVL
ICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGG
WDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMG
GFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRG
FLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTP

--------------------------------------------------------------

>323_323_4_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000394233_AK5_chr1_77876666_ENST00000354567_length(amino acids)=735AA_BP=470
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGKKSGKPPLQNNEKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIA
VMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDN
RIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNS
RLITNSFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVL
ICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGG
WDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMG
GFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRG
FLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTP

--------------------------------------------------------------

>323_323_5_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000454898_AK5_chr1_77876666_ENST00000344720_length(amino acids)=869AA_BP=604
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGYFMETWREKSDEVMGELTDHVTHCKKSGKPPLQNNEKEGKKERAVVDKVFFSR
LIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRV
RLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTR
LRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRP
FLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPL
IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTL
GTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNK
EAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLRE
ELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRS

--------------------------------------------------------------

>323_323_6_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000454898_AK5_chr1_77876666_ENST00000354567_length(amino acids)=869AA_BP=604
MAAFSKYLTARNSSLAGAAFLLLCLLHKRRRALGLHGYFMETWREKSDEVMGELTDHVTHCKKSGKPPLQNNEKEGKKERAVVDKVFFSR
LIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRYLLNFIAAMPLISLVNNFLKYGLNELKLCFRV
RLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIVLYIFKLTSAIGAQGPASMMAYLVVSGLFLTR
LRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHNFILFRFSMGFIDSIIAKYLATVVGYLVVSRP
FLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELMQVLKDLNHGKYERTMVSQQEKGIEGVQVIPL
IPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRVLGELWPLFGGRLTKPERGKLFYVPQRPYMTL
GTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGEKQRMAFDADRDEDEVFYDISMAVDNKLFPNK
EAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLRE
ELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRS

--------------------------------------------------------------

>323_323_7_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000536817_AK5_chr1_77876666_ENST00000344720_length(amino acids)=810AA_BP=545
MPAPQAAPRPRPARKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRY
LLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIV
LYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHN
FILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELM
QVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRV
LGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGE
KQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFII
GGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEE
FGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF

--------------------------------------------------------------

>323_323_8_ABCD3-AK5_ABCD3_chr1_94965170_ENST00000536817_AK5_chr1_77876666_ENST00000354567_length(amino acids)=810AA_BP=545
MPAPQAAPRPRPARKEGKKERAVVDKVFFSRLIQILKIMVPRTFCKETGYLVLIAVMLVSRTYCDVWMIQNGTLIESGIIGRSRKDFKRY
LLNFIAAMPLISLVNNFLKYGLNELKLCFRVRLTKYLYEEYLQAFTYYKMGNLDNRIANPDQLLTQDVEKFCNSVVDLYSNLSKPFLDIV
LYIFKLTSAIGAQGPASMMAYLVVSGLFLTRLRRPIGKMTITEQKYEGEYRYVNSRLITNSEEIAFYNGNKREKQTVHSVFRKLVEHLHN
FILFRFSMGFIDSIIAKYLATVVGYLVVSRPFLDLSHPRHLKSTHSELLEDYYQSGRMLLRMSQALGRIVLAGREMTRLAGFTARITELM
QVLKDLNHGKYERTMVSQQEKGIEGVQVIPLIPGAGEIIIADNIIKFDHVPLATPNGDVLIRDLNFEVRSGANVLICGPNGCGKSSLFRV
LGELWPLFGGRLTKPERGKLFYVPQRPYMTLGTLRDQVIYPDGREDQKRKGISDLVLKEYLDNVQLGHILEREGGWDSVQDWMDVLSGGE
KQRMAFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFII
GGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEE
FGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKINAEGTPEDVFLQLCTAIDSIF

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:94965170/chr1:77876666)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
ABCD3

P28288

AK5

Q9Y6K8

FUNCTION: Probable transporter involved in the transport of branched-chain fatty acids and C27 bile acids into the peroxisome; the latter function is a crucial step in bile acid biosynthesis (PubMed:25168382). The nucleotide-binding fold acts as an ATP-binding subunit with ATPase activity (PubMed:11248239). {ECO:0000269|PubMed:11248239, ECO:0000269|PubMed:25168382}.FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-202385_372580.0660.0DomainABC transmembrane type-1
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-161985_372470.0550.0DomainABC transmembrane type-1
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-2023473_480580.0660.0Nucleotide bindingATP
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-20231_124580.0660.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-16191_124470.0550.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-2023126_146580.0660.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-2023224_244580.0660.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-2023313_333580.0660.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-202384_104580.0660.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-1619126_146470.0550.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-1619224_244470.0550.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-1619313_333470.0550.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-161984_104470.0550.0TransmembraneHelical
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514386_391271.0537.0Nucleotide bindingATP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514433_435271.0537.0Nucleotide bindingAMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514462_465271.0537.0Nucleotide bindingAMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514386_391297.0563.0Nucleotide bindingATP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514433_435297.0563.0Nucleotide bindingAMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514462_465297.0563.0Nucleotide bindingAMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514377_559271.0537.0RegionAdenylate kinase 2
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514406_435271.0537.0RegionNMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514499_509271.0537.0RegionLID 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514377_559297.0563.0RegionAdenylate kinase 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514406_435297.0563.0RegionNMP 2
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514499_509297.0563.0RegionLID 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-19440_6590.0237.0DomainABC transporter
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-1985_3720.0237.0DomainABC transmembrane type-1
HgeneABCD3chr1:94965170chr1:77876666ENST00000370214-2023440_659580.0660.0DomainABC transporter
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-1619440_659470.0550.0DomainABC transporter
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-19473_4800.0237.0Nucleotide bindingATP
HgeneABCD3chr1:94965170chr1:77876666ENST00000394233-1619473_480470.0550.0Nucleotide bindingATP
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-191_1240.0237.0RegionNote=Targeting to peroxisomes
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-19126_1460.0237.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-19224_2440.0237.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-19313_3330.0237.0TransmembraneHelical
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-1984_1040.0237.0TransmembraneHelical
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514142_147271.0537.0Nucleotide bindingATP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514191_193271.0537.0Nucleotide bindingAMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514219_222271.0537.0Nucleotide bindingAMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514142_147297.0563.0Nucleotide bindingATP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514191_193297.0563.0Nucleotide bindingAMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514219_222297.0563.0Nucleotide bindingAMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514133_316271.0537.0RegionAdenylate kinase 1
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514162_193271.0537.0RegionNMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000344720514256_266271.0537.0RegionLID 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514133_316297.0563.0RegionAdenylate kinase 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514162_193297.0563.0RegionNMP 1
TgeneAK5chr1:94965170chr1:77876666ENST00000354567514256_266297.0563.0RegionLID 1


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
ABCD3
AK5


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneABCD3chr1:94965170chr1:77876666ENST00000315713-191_1990.0237.0PEX19


Top

Related Drugs to ABCD3-AK5


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to ABCD3-AK5


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource