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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AK5-USP33

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AK5-USP33
FusionPDB ID: 3250
FusionGDB2.0 ID: 3250
HgeneTgene
Gene symbol

AK5

USP33

Gene ID

26289

23032

Gene nameadenylate kinase 5ubiquitin specific peptidase 33
SynonymsAK6VDU1
Cytomap

1p31.1

1p31.1

Type of geneprotein-codingprotein-coding
Descriptionadenylate kinase isoenzyme 5AK 5ATP-AMP transphosphorylase 5adenylate kinase 6ubiquitin carboxyl-terminal hydrolase 33VHL-interacting deubiquitinating enzyme 1deubiquitinating enzyme 33pVHL-interacting deubiquitinating enzyme 1ubiquitin thioesterase 33ubiquitin thiolesterase 33ubiquitin-specific-processing protease 33
Modification date2020031320200313
UniProtAcc

Q9Y6K8

.
Ensembl transtripts involved in fusion geneENST idsENST00000344720, ENST00000354567, 
ENST00000478255, ENST00000317704, 
ENST00000370792, ENST00000528150, 
ENST00000357428, ENST00000370793, 
ENST00000370794, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score5 X 5 X 3=7513 X 11 X 8=1144
# samples 516
** MAII scorelog2(5/75*10)=-0.584962500721156
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(16/1144*10)=-2.83794324189103
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AK5 [Title/Abstract] AND USP33 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AK5(78001723)-USP33(78167156), # samples:1
Anticipated loss of major functional domain due to fusion event.AK5-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AK5-USP33 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AK5-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AK5-USP33 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAK5

GO:0006165

nucleoside diphosphate phosphorylation

23416111

HgeneAK5

GO:0009142

nucleoside triphosphate biosynthetic process

23416111

TgeneUSP33

GO:0009267

cellular response to starvation

24056301

TgeneUSP33

GO:0016579

protein deubiquitination

11739384|19363159|19424180|23486064

TgeneUSP33

GO:0070536

protein K63-linked deubiquitination

19363159

TgeneUSP33

GO:0071108

protein K48-linked deubiquitination

19363159


check buttonFusion gene breakpoints across AK5 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across USP33 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4CESCTCGA-WL-A834-01AAK5chr1

78001723

-USP33chr1

78167156

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354567AK5chr178001723-ENST00000370794USP33chr178167156-354318831612212683
ENST00000354567AK5chr178001723-ENST00000357428USP33chr178167156-353918831612212683
ENST00000354567AK5chr178001723-ENST00000370793USP33chr178167156-353918831612212683
ENST00000344720AK5chr178001723-ENST00000370794USP33chr178167156-4228256810142897627
ENST00000344720AK5chr178001723-ENST00000357428USP33chr178167156-4224256810142897627
ENST00000344720AK5chr178001723-ENST00000370793USP33chr178167156-4224256810142897627
ENST00000478255AK5chr178001723-ENST00000370794USP33chr178167156-2086426249755168
ENST00000478255AK5chr178001723-ENST00000357428USP33chr178167156-2082426249755168
ENST00000478255AK5chr178001723-ENST00000370793USP33chr178167156-2082426249755168

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354567ENST00000370794AK5chr178001723-USP33chr178167156-0.0009413340.99905866
ENST00000354567ENST00000357428AK5chr178001723-USP33chr178167156-0.0009610710.99903893
ENST00000354567ENST00000370793AK5chr178001723-USP33chr178167156-0.0009610710.99903893
ENST00000344720ENST00000370794AK5chr178001723-USP33chr178167156-0.0003221450.9996779
ENST00000344720ENST00000357428AK5chr178001723-USP33chr178167156-0.0003286530.99967134
ENST00000344720ENST00000370793AK5chr178001723-USP33chr178167156-0.0003286530.99967134
ENST00000478255ENST00000370794AK5chr178001723-USP33chr178167156-0.002205480.9977945
ENST00000478255ENST00000357428AK5chr178001723-USP33chr178167156-0.0023074840.9976926
ENST00000478255ENST00000370793AK5chr178001723-USP33chr178167156-0.0023074840.9976926

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3250_3250_1_AK5-USP33_AK5_chr1_78001723_ENST00000344720_USP33_chr1_78167156_ENST00000357428_length(amino acids)=627AA_BP=518
MNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDL
SETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEI
KQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEK
GLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFII
GGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEE
FGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWF

--------------------------------------------------------------

>3250_3250_2_AK5-USP33_AK5_chr1_78001723_ENST00000344720_USP33_chr1_78167156_ENST00000370793_length(amino acids)=627AA_BP=518
MNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDL
SETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEI
KQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEK
GLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFII
GGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEE
FGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWF

--------------------------------------------------------------

>3250_3250_3_AK5-USP33_AK5_chr1_78001723_ENST00000344720_USP33_chr1_78167156_ENST00000370794_length(amino acids)=627AA_BP=518
MNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKWDTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDL
SETAELIEEYEVFDPTRPRPKIILVIGGPGSGKGTQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEI
KQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICTPDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEK
GLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAAAGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFII
GGPGSGKGTQCEKLVEKYGFTHLSTGELLREELASESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEE
FGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWF

--------------------------------------------------------------

>3250_3250_4_AK5-USP33_AK5_chr1_78001723_ENST00000354567_USP33_chr1_78167156_ENST00000357428_length(amino acids)=683AA_BP=574
MLGADSASPSFSPGSGRRSPGASPLAPQGTRGTAMNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKW
DTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKG
TQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICT
PDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAA
AGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELA
SESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLP
VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLR

--------------------------------------------------------------

>3250_3250_5_AK5-USP33_AK5_chr1_78001723_ENST00000354567_USP33_chr1_78167156_ENST00000370793_length(amino acids)=683AA_BP=574
MLGADSASPSFSPGSGRRSPGASPLAPQGTRGTAMNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKW
DTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKG
TQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICT
PDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAA
AGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELA
SESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLP
VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLR

--------------------------------------------------------------

>3250_3250_6_AK5-USP33_AK5_chr1_78001723_ENST00000354567_USP33_chr1_78167156_ENST00000370794_length(amino acids)=683AA_BP=574
MLGADSASPSFSPGSGRRSPGASPLAPQGTRGTAMNTNDAKEYLARREIPQLFESLLNGLMCSKPEDPVEYLESCLQKVKELGGCDKVKW
DTFVSQEKKTLPPLNGGQSRRSFLRNVMPENSNFPYRRYDRLPPIHQFSIESDTDLSETAELIEEYEVFDPTRPRPKIILVIGGPGSGKG
TQSLKIAERYGFQYISVGELLRKKIHSTSSNRKWSLIAKIITTGELAPQETTITEIKQKLMQIPDEEGIVIDGFPRDVAQALSFEDQICT
PDLVVFLACANQRLKERLLKRAEQQGRPDDNVKATQRRLMNFKQNAAPLVKYFQEKGLIMTFDADRDEDEVFYDISMAVDNKLFPNKEAA
AGSSDLDPSMILDTGEIIDTGSDYEDQGDDQLNVFGEDTMGGFMEDLRKCKIIFIIGGPGSGKGTQCEKLVEKYGFTHLSTGELLREELA
SESERSKLIRDIMERGDLVPSGIVLELLKEAMVASLGDTRGFLIDGYPREVKQGEEFGRRIGDPQLVICMDCSADTMTNRLLQRSRSSLP
VDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKGKDGDPPGPIDNTKIAVTKCGNVMLR

--------------------------------------------------------------

>3250_3250_7_AK5-USP33_AK5_chr1_78001723_ENST00000478255_USP33_chr1_78167156_ENST00000357428_length(amino acids)=168AA_BP=59
MVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKG

--------------------------------------------------------------

>3250_3250_8_AK5-USP33_AK5_chr1_78001723_ENST00000478255_USP33_chr1_78167156_ENST00000370793_length(amino acids)=168AA_BP=59
MVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKG

--------------------------------------------------------------

>3250_3250_9_AK5-USP33_AK5_chr1_78001723_ENST00000478255_USP33_chr1_78167156_ENST00000370794_length(amino acids)=168AA_BP=59
MVICMDCSADTMTNRLLQRSRSSLPVDDTTKTIAKRLEAYYRASIPVIAYYETKTQLHKLNRAFQKEDSPATFYCISMQWFREWESFVKG

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:78001723/chr1:78167156)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AK5

Q9Y6K8

.
FUNCTION: Nucleoside monophosphate (NMP) kinase that catalyzes the reversible transfer of the terminal phosphate group between nucleoside triphosphates and monophosphates. Active on AMP and dAMP with ATP as a donor. When GTP is used as phosphate donor, the enzyme phosphorylates AMP, CMP, and to a small extent dCMP. Also displays broad nucleoside diphosphate kinase activity. {ECO:0000269|PubMed:19647735, ECO:0000269|PubMed:23416111}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314142_147514.0537.0Nucleotide bindingATP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314191_193514.0537.0Nucleotide bindingAMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314219_222514.0537.0Nucleotide bindingAMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314386_391514.0537.0Nucleotide bindingATP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314433_435514.0537.0Nucleotide bindingAMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314462_465514.0537.0Nucleotide bindingAMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314142_147540.0563.0Nucleotide bindingATP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314191_193540.0563.0Nucleotide bindingAMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314219_222540.0563.0Nucleotide bindingAMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314386_391540.0563.0Nucleotide bindingATP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314433_435540.0563.0Nucleotide bindingAMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314462_465540.0563.0Nucleotide bindingAMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314133_316514.0537.0RegionAdenylate kinase 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314162_193514.0537.0RegionNMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314256_266514.0537.0RegionLID 1
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314406_435514.0537.0RegionNMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314499_509514.0537.0RegionLID 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314133_316540.0563.0RegionAdenylate kinase 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314162_193540.0563.0RegionNMP 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314256_266540.0563.0RegionLID 1
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314406_435540.0563.0RegionNMP 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314499_509540.0563.0RegionLID 2
TgeneUSP33chr1:78001723chr1:78167156ENST00000370792022185_7150829.0DomainNote=USP
TgeneUSP33chr1:78001723chr1:78167156ENST00000370792022717_8100829.0DomainDUSP 1
TgeneUSP33chr1:78001723chr1:78167156ENST00000370792022818_9210829.0DomainDUSP 2
TgeneUSP33chr1:78001723chr1:78167156ENST000003707942024818_921802.0912.0DomainDUSP 2
TgeneUSP33chr1:78001723chr1:78167156ENST0000037079202259_1230829.0Zinc fingerUBP-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAK5chr1:78001723chr1:78167156ENST00000344720-1314377_559514.0537.0RegionAdenylate kinase 2
HgeneAK5chr1:78001723chr1:78167156ENST00000354567-1314377_559540.0563.0RegionAdenylate kinase 2
TgeneUSP33chr1:78001723chr1:78167156ENST000003574282024185_715833.0943.0DomainNote=USP
TgeneUSP33chr1:78001723chr1:78167156ENST000003574282024717_810833.0943.0DomainDUSP 1
TgeneUSP33chr1:78001723chr1:78167156ENST000003574282024818_921833.0943.0DomainDUSP 2
TgeneUSP33chr1:78001723chr1:78167156ENST000003707932125185_715833.0943.0DomainNote=USP
TgeneUSP33chr1:78001723chr1:78167156ENST000003707932125717_810833.0943.0DomainDUSP 1
TgeneUSP33chr1:78001723chr1:78167156ENST000003707932125818_921833.0943.0DomainDUSP 2
TgeneUSP33chr1:78001723chr1:78167156ENST000003707942024185_715802.0912.0DomainNote=USP
TgeneUSP33chr1:78001723chr1:78167156ENST000003707942024717_810802.0912.0DomainDUSP 1
TgeneUSP33chr1:78001723chr1:78167156ENST00000357428202459_123833.0943.0Zinc fingerUBP-type
TgeneUSP33chr1:78001723chr1:78167156ENST00000370793212559_123833.0943.0Zinc fingerUBP-type
TgeneUSP33chr1:78001723chr1:78167156ENST00000370794202459_123802.0912.0Zinc fingerUBP-type


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AK5
USP33


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AK5-USP33


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AK5-USP33


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource