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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GAS7-TTLL9

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GAS7-TTLL9
FusionPDB ID: 32567
FusionGDB2.0 ID: 32567
HgeneTgene
Gene symbol

GAS7

TTLL9

Gene ID

8522

164395

Gene namegrowth arrest specific 7tubulin tyrosine ligase like 9
Synonyms-C20orf125
Cytomap

17p13.1

20q11.21

Type of geneprotein-codingprotein-coding
Descriptiongrowth arrest-specific protein 7probable tubulin polyglutamylase TTLL9tubulin tyrosine ligase-like family, member 9tubulin--tyrosine ligase-like protein 9
Modification date2020031320200313
UniProtAcc

O60861

.
Ensembl transtripts involved in fusion geneENST idsENST00000578655, ENST00000323816, 
ENST00000396115, ENST00000432992, 
ENST00000437099, ENST00000540214, 
ENST00000542249, ENST00000585266, 
ENST00000579158, ENST00000580865, 
ENST00000583882, 		ENST00000310998, 
ENST00000375921, ENST00000375922, 
ENST00000375934, ENST00000375938, 
ENST00000535842, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 14 X 7=14705 X 8 X 6=240
# samples 177
** MAII scorelog2(17/1470*10)=-3.11220950358603
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(7/240*10)=-1.77760757866355
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GAS7 [Title/Abstract] AND TTLL9 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GAS7(9923094)-TTLL9(30497540), # samples:1
Anticipated loss of major functional domain due to fusion event.GAS7-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GAS7-TTLL9 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GAS7 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TTLL9 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-D8-A1JM-01AGAS7chr17

9923094

-TTLL9chr20

30497540

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000579158GAS7chr179923094-ENST00000310998TTLL9chr2030497540+1102226581101348
ENST00000579158GAS7chr179923094-ENST00000535842TTLL9chr2030497540+1262226581227389
ENST00000579158GAS7chr179923094-ENST00000375921TTLL9chr2030497540+205722658750230
ENST00000579158GAS7chr179923094-ENST00000375938TTLL9chr2030497540+2278226581227389
ENST00000579158GAS7chr179923094-ENST00000375934TTLL9chr2030497540+117122658801247
ENST00000579158GAS7chr179923094-ENST00000375922TTLL9chr2030497540+1466226581125355

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000579158ENST00000310998GAS7chr179923094-TTLL9chr2030497540+0.0038340970.9961659
ENST00000579158ENST00000535842GAS7chr179923094-TTLL9chr2030497540+0.0058126170.99418736
ENST00000579158ENST00000375921GAS7chr179923094-TTLL9chr2030497540+0.0058518660.99414814
ENST00000579158ENST00000375938GAS7chr179923094-TTLL9chr2030497540+0.0021331940.9978668
ENST00000579158ENST00000375934GAS7chr179923094-TTLL9chr2030497540+0.1090920340.890908
ENST00000579158ENST00000375922GAS7chr179923094-TTLL9chr2030497540+0.0071482830.9928517

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32567_32567_1_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000310998_length(amino acids)=348AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVY
VLVMSYIPLRAWLYRDGFARFSNTRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKS

--------------------------------------------------------------

>32567_32567_2_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000375921_length(amino acids)=230AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSN

--------------------------------------------------------------

>32567_32567_3_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000375922_length(amino acids)=355AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVYVLVMSYIPLRAWLYRDGFARFSN
TRFTLNSIDDQYVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCFELYGYDIL

--------------------------------------------------------------

>32567_32567_4_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000375934_length(amino acids)=247AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVY

--------------------------------------------------------------

>32567_32567_5_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000375938_length(amino acids)=389AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVY
VLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCF
ELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVT

--------------------------------------------------------------

>32567_32567_6_GAS7-TTLL9_GAS7_chr17_9923094_ENST00000579158_TTLL9_chr20_30497540_ENST00000535842_length(amino acids)=389AA_BP=56
MQKCQMGVTFSFFSNRSLEWSPLRREKKARRSSFHLAGRATCRLRAGGTMSTRPPMLTRKNYMVKNLKRFRKQLEREAGKLEAAKCDFFP
KTFEMPCEYHLFVEEFRKNPGITWIMKPVARSQGKGIFLFRRLKDIVDWRKDTRSSDDQKDDIPVENYVAQRYIENPYLIGGRKFDLRVY
VLVMSVFAECLLWSGHRRQDVHLTNVAVQKTSPDYHPKKGCKWTLQRFRQYLASKHGPEAVETLFRDIDNIFVKSLQSVQKVIISDKHCF
ELYGYDILIDQDLKPWLLEVNASPSLTASSQEDYELKTCLLEDTLHVVDMEARLTGREKRVGGFDLMWNDGPVSREEGAPDLSGMGNFVT

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr17:9923094/chr20:30497540)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GAS7

O60861

.
FUNCTION: May play a role in promoting maturation and morphological differentiation of cerebellar neurons.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS7chr17:9923094chr20:30497540ENST00000432992-21467_70101.33333333333333477.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000432992-2141_62101.33333333333333477.0DomainSH3
TgeneTTLL9chr17:9923094chr20:30497540ENST00000310998414211_21456.0348.0Nucleotide bindingATP binding
TgeneTTLL9chr17:9923094chr20:30497540ENST00000375921415211_21456.0495.3333333333333Nucleotide bindingATP binding
TgeneTTLL9chr17:9923094chr20:30497540ENST00000375938417211_214106.0671.3333333333334Nucleotide bindingATP binding
TgeneTTLL9chr17:9923094chr20:30497540ENST00000535842415211_214106.0440.0Nucleotide bindingATP binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGAS7chr17:9923094chr20:30497540ENST00000323816-315309_41941.333333333333336417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000396115-27309_41937.333333333333336182.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000432992-214309_419101.33333333333333477.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000437099-214309_41937.333333333333336413.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000580865-110309_4190337.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000585266-214309_41941.333333333333336417.0Coiled coilOntology_term=ECO:0000255
HgeneGAS7chr17:9923094chr20:30497540ENST00000323816-31567_7041.333333333333336417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000396115-2767_7037.333333333333336182.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000437099-21467_7037.333333333333336413.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000580865-11067_700337.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000585266-21467_7041.333333333333336417.0Compositional biasNote=Poly-Pro
HgeneGAS7chr17:9923094chr20:30497540ENST00000323816-315196_45641.333333333333336417.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000323816-3151_6241.333333333333336417.0DomainSH3
HgeneGAS7chr17:9923094chr20:30497540ENST00000323816-31577_11041.333333333333336417.0DomainWW
HgeneGAS7chr17:9923094chr20:30497540ENST00000396115-27196_45637.333333333333336182.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000396115-271_6237.333333333333336182.0DomainSH3
HgeneGAS7chr17:9923094chr20:30497540ENST00000396115-2777_11037.333333333333336182.0DomainWW
HgeneGAS7chr17:9923094chr20:30497540ENST00000432992-214196_456101.33333333333333477.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000432992-21477_110101.33333333333333477.0DomainWW
HgeneGAS7chr17:9923094chr20:30497540ENST00000437099-214196_45637.333333333333336413.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000437099-2141_6237.333333333333336413.0DomainSH3
HgeneGAS7chr17:9923094chr20:30497540ENST00000437099-21477_11037.333333333333336413.0DomainWW
HgeneGAS7chr17:9923094chr20:30497540ENST00000580865-110196_4560337.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000580865-1101_620337.0DomainSH3
HgeneGAS7chr17:9923094chr20:30497540ENST00000580865-11077_1100337.0DomainWW
HgeneGAS7chr17:9923094chr20:30497540ENST00000585266-214196_45641.333333333333336417.0DomainF-BAR
HgeneGAS7chr17:9923094chr20:30497540ENST00000585266-2141_6241.333333333333336417.0DomainSH3
HgeneGAS7chr17:9923094chr20:30497540ENST00000585266-21477_11041.333333333333336417.0DomainWW
TgeneTTLL9chr17:9923094chr20:30497540ENST0000031099841440_38056.0348.0DomainTTL
TgeneTTLL9chr17:9923094chr20:30497540ENST0000037592141540_38056.0495.3333333333333DomainTTL
TgeneTTLL9chr17:9923094chr20:30497540ENST0000037593841740_380106.0671.3333333333334DomainTTL
TgeneTTLL9chr17:9923094chr20:30497540ENST0000053584241540_380106.0440.0DomainTTL


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
GAS7PACSIN1, GAS7, ATXN1L, CREB3L2, HNRNPU, KHDRBS1, SF1, SF3A1, SFPQ, RPLP0, ABI1, CYFIP1, CYFIP2, DIAPH1, FMNL1, WAS, WASF2, APBB1IP, NCKAP1, NCKAP1L, GAPDH, WDYHV1, NCKIPSD, CDC37, LSM4, YIF1A, MCRS1, MYBPC2, BRD4, DDX58,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GAS7all structure
TTLL9


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GAS7-TTLL9


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GAS7-TTLL9


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneGAS7C0028754Obesity1CTD_human