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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GBGT1-GRK5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GBGT1-GRK5
	FusionPDB ID: 32732
	FusionGDB2.0 ID: 32732
		Hgene	Tgene
	Gene symbol	GBGT1	GRK5
	Gene ID	26301	2869
	Gene name	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1 (FORS blood group)	G protein-coupled receptor kinase 5
	Synonyms	A3GALNT\|FS\|UNQ2513	FP2025\|GPRK5
	Cytomap	9q34.2	10q26.11
	Type of gene	protein-coding	protein-coding
	Description	globoside alpha-1,3-N-acetylgalactosaminyltransferase 1Forssman blood groupForssman glycolipid synthetase (FS)forssman glycolipid synthase-like protein	G protein-coupled receptor kinase 5g protein-coupled receptor kinase GRK5
	Modification date	20200313	20200313
	UniProtAcc	Q8N5D6	P34947
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000372036, ENST00000372038, ENST00000372040, ENST00000372043, ENST00000540636, ENST00000472281,	ENST00000473264, ENST00000369108, ENST00000392870,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	1 X 1 X 1=1	19 X 19 X 6=2166
	# samples	1	19
	** MAII score	log2(1/1*10)=3.32192809488736	log2(19/2166*10)=-3.51096191927738 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GBGT1 [Title/Abstract] AND GRK5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GBGT1(136036854)-GRK5(121189887), # samples:1
Anticipated loss of major functional domain due to fusion event.	GBGT1-GRK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GBGT1-GRK5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GBGT1-GRK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GBGT1-GRK5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	GRK5	GO:0007217	tachykinin receptor signaling pathway	17986524
Tgene	GRK5	GO:0043066	negative regulation of apoptotic process	20124405
Tgene	GRK5	GO:0046777	protein autophosphorylation	14976207

Fusion gene breakpoints across GBGT1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across GRK5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-BR-8077-01A	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000372043	GBGT1	chr9	136036854	-	ENST00000392870	GRK5	chr10	121189887	+	2215	423	172	1662	496
ENST00000372043	GBGT1	chr9	136036854	-	ENST00000369108	GRK5	chr10	121189887	+	1714	423	172	1662	496
ENST00000372040	GBGT1	chr9	136036854	-	ENST00000392870	GRK5	chr10	121189887	+	2241	449	198	1688	496
ENST00000372040	GBGT1	chr9	136036854	-	ENST00000369108	GRK5	chr10	121189887	+	1740	449	198	1688	496
ENST00000540636	GBGT1	chr9	136036854	-	ENST00000392870	GRK5	chr10	121189887	+	2210	418	167	1657	496
ENST00000540636	GBGT1	chr9	136036854	-	ENST00000369108	GRK5	chr10	121189887	+	1709	418	167	1657	496
ENST00000372038	GBGT1	chr9	136036854	-	ENST00000392870	GRK5	chr10	121189887	+	2193	401	150	1640	496
ENST00000372038	GBGT1	chr9	136036854	-	ENST00000369108	GRK5	chr10	121189887	+	1692	401	150	1640	496
ENST00000372036	GBGT1	chr9	136036854	-	ENST00000392870	GRK5	chr10	121189887	+	2191	399	148	1638	496
ENST00000372036	GBGT1	chr9	136036854	-	ENST00000369108	GRK5	chr10	121189887	+	1690	399	148	1638	496

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000372043	ENST00000392870	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.002417316	0.9975827
ENST00000372043	ENST00000369108	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.005939394	0.9940606
ENST00000372040	ENST00000392870	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.002203477	0.99779654
ENST00000372040	ENST00000369108	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.005477617	0.99452233
ENST00000540636	ENST00000392870	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.002447714	0.99755234
ENST00000540636	ENST00000369108	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.00605086	0.9939492
ENST00000372038	ENST00000392870	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.002508342	0.9974917
ENST00000372038	ENST00000369108	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.006228175	0.99377185
ENST00000372036	ENST00000392870	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.002514128	0.9974859
ENST00000372036	ENST00000369108	GBGT1	chr9	136036854	-	GRK5	chr10	121189887	+	0.00622507	0.9937749

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32732_32732_1_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372036_GRK5_chr10_121189887_ENST00000369108_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_2_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372036_GRK5_chr10_121189887_ENST00000392870_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_3_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372038_GRK5_chr10_121189887_ENST00000369108_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_4_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372038_GRK5_chr10_121189887_ENST00000392870_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_5_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372040_GRK5_chr10_121189887_ENST00000369108_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_6_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372040_GRK5_chr10_121189887_ENST00000392870_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_7_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372043_GRK5_chr10_121189887_ENST00000369108_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_8_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000372043_GRK5_chr10_121189887_ENST00000392870_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_9_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000540636_GRK5_chr10_121189887_ENST00000369108_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

>32732_32732_10_GBGT1-GRK5_GBGT1_chr9_136036854_ENST00000540636_GRK5_chr10_121189887_ENST00000392870_length(amino acids)=496AA_BP=84
MGPQRPGSEPDIPARGQPHPPRPVGVSTSAQAQVQPPAMHRRRLALGLGFCLLAGTSLSVLWVYLENWLPVSYVPYYLPCPEILQPVTKN
TFRQYRVLGKGGFGEVCACQVRATGKMYACKRLEKKRIKKRKGESMALNEKQILEKVNSQFVVNLAYAYETKDALCLVLTIMNGGDLKFH
IYNMGNPGFEEERALFYAAEILCGLEDLHRENTVYRDLKPENILLDDYGHIRISDLGLAVKIPEGDLIRGRVGTVGYMAPEVLNNQRYGL
SPDYWGLGCLIYEMIEGQSPFRGRKEKVKREEVDRRVLETEEVYSHKFSEEAKSICKMLLTKDAKQRLGCQEEGAAEVKRHPFFRNMNFK
RLEAGMLDPPFVPDPRAVYCKDVLDIEQFSTVKGVNLDHTDDDFYSKFSTGSVSIPWQNEMIETECFKELNVFGPNGTLPPDLNRNHPPE

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:136036854/chr10:121189887)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GBGT1 Q8N5D6	GRK5 P34947
FUNCTION: Does not catalyze the formation of Forssman glycolipid but may catalyze the formation of some glycolipid via the addition of N-acetylgalactosamine (GalNAc) in alpha-1,3-linkage to some substrate (PubMed:10506200). Glycolipids probably serve for adherence of some pathogens (PubMed:10506200). {ECO:0000269\|PubMed:10506200}.	FUNCTION: Serine/threonine kinase that phosphorylates preferentially the activated forms of a variety of G-protein-coupled receptors (GPCRs). Such receptor phosphorylation initiates beta-arrestin-mediated receptor desensitization, internalization, and signaling events leading to their down-regulation. Phosphorylates a variety of GPCRs, including adrenergic receptors, muscarinic acetylcholine receptors (more specifically Gi-coupled M2/M4 subtypes), dopamine receptors and opioid receptors. In addition to GPCRs, also phosphorylates various substrates: Hsc70-interacting protein/ST13, TP53/p53, HDAC5, and arrestin-1/ARRB1. Phosphorylation of ARRB1 by GRK5 inhibits G-protein independent MAPK1/MAPK3 signaling downstream of 5HT4-receptors. Phosphorylation of HDAC5, a repressor of myocyte enhancer factor 2 (MEF2) leading to nuclear export of HDAC5 and allowing MEF2-mediated transcription. Phosphorylation of TP53/p53, a crucial tumor suppressor, inhibits TP53/p53-mediated apoptosis. Phosphorylation of ST13 regulates internalization of the chemokine receptor. Phosphorylates rhodopsin (RHO) (in vitro) and a non G-protein-coupled receptor, LRP6 during Wnt signaling (in vitro). {ECO:0000269\|PubMed:19661922, ECO:0000269\|PubMed:19801552, ECO:0000269\|PubMed:20038610, ECO:0000269\|PubMed:20124405, ECO:0000269\|PubMed:21728385}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

1_5

45.666666666666664

348.0

Topological domain

Cytoplasmic

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

1_5

45.666666666666664

295.0

Topological domain

Cytoplasmic

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

6_26

45.666666666666664

348.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

6_26

45.666666666666664

295.0

Transmembrane

Helical%3B Signal-anchor for type II membrane protein

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

186_448

177.66666666666666

591.0

Domain

Protein kinase

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

449_514

177.66666666666666

591.0

Domain

AGC-kinase C-terminal

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

388_395

177.66666666666666

591.0

Motif

Nuclear localization signal

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

192_200

177.66666666666666

591.0

Nucleotide binding

ATP

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

546_565

177.66666666666666

591.0

Region

Note=Sufficient for membrane localization

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

116_121

45.666666666666664

348.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

206_208

45.666666666666664

348.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

228_231

45.666666666666664

348.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

116_121

45.666666666666664

295.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

206_208

45.666666666666664

295.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

228_231

45.666666666666664

295.0

Region

Substrate binding

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372040

27_347

45.666666666666664

348.0

Topological domain

Lumenal

Hgene

GBGT1

chr9:136036854

chr10:121189887

ENST00000372043

27_347

45.666666666666664

295.0

Topological domain

Lumenal

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

53_171

177.66666666666666

591.0

Domain

RGS

Tgene

GRK5

chr9:136036854

chr10:121189887

ENST00000392870

1_185

177.66666666666666

591.0

Region

Note=N-terminal

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GBGT1
GRK5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	GRK5	chr9:136036854	chr10:121189887	ENST00000392870		5	16	20_39	177.66666666666666	591.0	calmodulin

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Related Drugs to GBGT1-GRK5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to GBGT1-GRK5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source