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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GCN1L1-CCND2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GCN1L1-CCND2
FusionPDB ID: 32771
FusionGDB2.0 ID: 32771
HgeneTgene
Gene symbol

GCN1L1

CCND2

Gene ID

10985

894

Gene nameGCN1 activator of EIF2AK4cyclin D2
SynonymsGCN1L|GCN1L1|PRIC295KIAK0002|MPPH3
Cytomap

12q24.23

12p13.32

Type of geneprotein-codingprotein-coding
DescriptioneIF-2-alpha kinase activator GCN1GCN1 (general control of amino-acid synthesis 1, yeast)-like 1GCN1 eIF-2-alpha kinase activator homologGCN1 general control of amino-acid synthesis 1-like 1GCN1, eIF2 alpha kinase activator homologGCN1-like protein 1G1/S-specific cyclin-D2
Modification date2020031320200313
UniProtAcc.

P30279

Ensembl transtripts involved in fusion geneENST idsENST00000300648, ENST00000541542, 
ENST00000261254, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 15 X 8=9604 X 6 X 3=72
# samples 126
** MAII scorelog2(12/960*10)=-3
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/72*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GCN1L1 [Title/Abstract] AND CCND2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GCN1L1(120600873)-CCND2(4398007), # samples:1
GCN1L1(120600874)-CCND2(4398008), # samples:1
GCN1L1(120600651)-CCND2(4398008), # samples:1
Anticipated loss of major functional domain due to fusion event.GCN1L1-CCND2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GCN1L1-CCND2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GCN1L1-CCND2 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCCND2

GO:0001934

positive regulation of protein phosphorylation

8114739

TgeneCCND2

GO:0045737

positive regulation of cyclin-dependent protein serine/threonine kinase activity

8114739


check buttonFusion gene breakpoints across GCN1L1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CCND2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUSCTCGA-22-1017-01AGCN1L1chr12

120600651

-CCND2chr12

4398008

+
ChimerDB4LUSCTCGA-22-1017GCN1L1chr12

120600873

-CCND2chr12

4398007

+
ChimerDB4LUSCTCGA-22-1017GCN1L1chr12

120600874

-CCND2chr12

4398008

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000300648GCN1L1chr12120600873-ENST00000261254CCND2chr124398007+76912051132349778
ENST00000300648GCN1L1chr12120600874-ENST00000261254CCND2chr124398008+76912051132349778

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000300648ENST00000261254GCN1L1chr12120600873-CCND2chr124398007+0.0007150110.99928504
ENST00000300648ENST00000261254GCN1L1chr12120600874-CCND2chr124398008+0.0007150110.99928504

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>32771_32771_1_GCN1L1-CCND2_GCN1L1_chr12_120600873_ENST00000300648_CCND2_chr12_4398007_ENST00000261254_length(amino acids)=778AA_BP=679
MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLL
HSLQSSGIGSKAGVPSKSSGSAALLALTWTCLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV
EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPKYLLDSCAPLLRYLSHSEFKDLILPTIQKSL
LRSPENVIETISSLLASVTLDLSQYAMDIVKGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM
SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTMEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCM
LASYRGDTLLQALDLLPLLIQTVEKAASQSTQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC
TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKLAHGLLEELKTVLSSHKVLPLEALVTDAGEV
TEAGKAYVPPRVLQEALCVISGVPGLKGDVTDTEQLAQEMLIISHHPSLDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTEL

--------------------------------------------------------------

>32771_32771_2_GCN1L1-CCND2_GCN1L1_chr12_120600874_ENST00000300648_CCND2_chr12_4398008_ENST00000261254_length(amino acids)=778AA_BP=679
MAADTQVSETLKRFAGKVTTASVKERREILSELGKCVAGKDLPEGAVKGLCKLFCLTLHRYRDAASRRALQAAIQQLAEAQPEATAKNLL
HSLQSSGIGSKAGVPSKSSGSAALLALTWTCLLVRIVFPSRAKRQGDIWNKLVEVQCLLLLEVLGGSHKHAVDGAVKKLTKLWKENPGLV
EQYLSAILSLEPNQNYAGMLGLLVQFCTSHKEMDVVSQHKSALLDFYMKNILMSKVKPPKYLLDSCAPLLRYLSHSEFKDLILPTIQKSL
LRSPENVIETISSLLASVTLDLSQYAMDIVKGLAGHLKSNSPRLMDEAVLALRNLARQCSDSSAMESLTKHLFAILGGSEGKLTVVAQKM
SVLSGIGSVSHHVVSGPSSQVLNGIVAELFIPFLQQEVHEGTLVHAVSVLALWCNRFTMEVPKKLTEWFKKAFSLKTSTSAVRHAYLQCM
LASYRGDTLLQALDLLPLLIQTVEKAASQSTQVPTITEGVAAALLLLKLSVADSQAEAKLSSFWQLIVDEKKQVFTSEKFLVMASEDALC
TVLHLTERLFLDHPHRLTGNKVQQYHRALVAVLLSRTWHVRRQAQQTVRKLLSSLGGFKLAHGLLEELKTVLSSHKVLPLEALVTDAGEV
TEAGKAYVPPRVLQEALCVISGVPGLKGDVTDTEQLAQEMLIISHHPSLDFKFAMYPPSMIATGSVGAAICGLQQDEEVSSLTCDALTEL

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:120600873/chr12:4398007)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
.CCND2

P30279

FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.FUNCTION: Regulatory component of the cyclin D2-CDK4 (DC) complex that phosphorylates and inhibits members of the retinoblastoma (RB) protein family including RB1 and regulates the cell-cycle during G(1)/S transition. Phosphorylation of RB1 allows dissociation of the transcription factor E2F from the RB/E2F complex and the subsequent transcription of E2F target genes which are responsible for the progression through the G(1) phase. Hypophosphorylates RB1 in early G(1) phase. Cyclin D-CDK4 complexes are major integrators of various mitogenenic and antimitogenic signals. Also substrate for SMAD3, phosphorylating SMAD3 in a cell-cycle-dependent manner and repressing its transcriptional activity. Component of the ternary complex, cyclin D2/CDK4/CDKN1B, required for nuclear translocation and activity of the cyclin D-CDK4 complex (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958140_178679.33333333333342672.0RepeatHEAT 1
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958257_293679.33333333333342672.0RepeatHEAT 2
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958294_331679.33333333333342672.0RepeatHEAT 3
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958385_423679.33333333333342672.0RepeatHEAT 4
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958425_459679.33333333333342672.0RepeatHEAT 5
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958460_503679.33333333333342672.0RepeatHEAT 6
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958560_597679.33333333333342672.0RepeatHEAT 7
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958599_636679.33333333333342672.0RepeatHEAT 8
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958140_178679.33333333333342672.0RepeatHEAT 1
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958257_293679.33333333333342672.0RepeatHEAT 2
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958294_331679.33333333333342672.0RepeatHEAT 3
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958385_423679.33333333333342672.0RepeatHEAT 4
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958425_459679.33333333333342672.0RepeatHEAT 5
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958460_503679.33333333333342672.0RepeatHEAT 6
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958560_597679.33333333333342672.0RepeatHEAT 7
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958599_636679.33333333333342672.0RepeatHEAT 8

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958804_863679.33333333333342672.0Coiled coilOntology_term=ECO:0000255
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958804_863679.33333333333342672.0Coiled coilOntology_term=ECO:0000255
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581035_1072679.33333333333342672.0RepeatHEAT 13
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581078_1115679.33333333333342672.0RepeatHEAT 14
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581155_1192679.33333333333342672.0RepeatHEAT 15
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581210_1250679.33333333333342672.0RepeatHEAT 16
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581251_1289679.33333333333342672.0RepeatHEAT 17
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581290_1332679.33333333333342672.0RepeatHEAT 18
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581335_1372679.33333333333342672.0RepeatHEAT 19
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581374_1410679.33333333333342672.0RepeatHEAT 20
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581413_1451679.33333333333342672.0RepeatHEAT 21
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581455_1492679.33333333333342672.0RepeatHEAT 22
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581493_1530679.33333333333342672.0RepeatHEAT 23
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581534_1571679.33333333333342672.0RepeatHEAT 24
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581573_1609679.33333333333342672.0RepeatHEAT 25
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581611_1648679.33333333333342672.0RepeatHEAT 26
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581653_1690679.33333333333342672.0RepeatHEAT 27
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581692_1729679.33333333333342672.0RepeatHEAT 28
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581731_1769679.33333333333342672.0RepeatHEAT 29
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581773_1810679.33333333333342672.0RepeatHEAT 30
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581812_1848679.33333333333342672.0RepeatHEAT 31
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581921_1958679.33333333333342672.0RepeatHEAT 32
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19581959_1996679.33333333333342672.0RepeatHEAT 33
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582001_2038679.33333333333342672.0RepeatHEAT 34
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582039_2076679.33333333333342672.0RepeatHEAT 35
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582078_2106679.33333333333342672.0RepeatHEAT 36
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582107_2146679.33333333333342672.0RepeatHEAT 37
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582147_2184679.33333333333342672.0RepeatHEAT 38
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582188_2225679.33333333333342672.0RepeatHEAT 39
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582259_2296679.33333333333342672.0RepeatHEAT 40
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582301_2338679.33333333333342672.0RepeatHEAT 41
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582339_2380679.33333333333342672.0RepeatHEAT 42
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582382_2417679.33333333333342672.0RepeatHEAT 43
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582422_2459679.33333333333342672.0RepeatHEAT 44
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582546_2583679.33333333333342672.0RepeatHEAT 45
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582588_2625679.33333333333342672.0RepeatHEAT 46
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-19582627_2661679.33333333333342672.0RepeatHEAT 47%3B degenerate
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958697_732679.33333333333342672.0RepeatHEAT 9
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958733_770679.33333333333342672.0RepeatHEAT 10
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958879_925679.33333333333342672.0RepeatHEAT 11
HgeneGCN1L1chr12:120600873chr12:4398007ENST00000300648-1958979_1016679.33333333333342672.0RepeatHEAT 12
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581035_1072679.33333333333342672.0RepeatHEAT 13
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581078_1115679.33333333333342672.0RepeatHEAT 14
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581155_1192679.33333333333342672.0RepeatHEAT 15
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581210_1250679.33333333333342672.0RepeatHEAT 16
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581251_1289679.33333333333342672.0RepeatHEAT 17
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581290_1332679.33333333333342672.0RepeatHEAT 18
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581335_1372679.33333333333342672.0RepeatHEAT 19
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581374_1410679.33333333333342672.0RepeatHEAT 20
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581413_1451679.33333333333342672.0RepeatHEAT 21
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581455_1492679.33333333333342672.0RepeatHEAT 22
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581493_1530679.33333333333342672.0RepeatHEAT 23
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581534_1571679.33333333333342672.0RepeatHEAT 24
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581573_1609679.33333333333342672.0RepeatHEAT 25
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581611_1648679.33333333333342672.0RepeatHEAT 26
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581653_1690679.33333333333342672.0RepeatHEAT 27
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581692_1729679.33333333333342672.0RepeatHEAT 28
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581731_1769679.33333333333342672.0RepeatHEAT 29
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581773_1810679.33333333333342672.0RepeatHEAT 30
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581812_1848679.33333333333342672.0RepeatHEAT 31
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581921_1958679.33333333333342672.0RepeatHEAT 32
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19581959_1996679.33333333333342672.0RepeatHEAT 33
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582001_2038679.33333333333342672.0RepeatHEAT 34
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582039_2076679.33333333333342672.0RepeatHEAT 35
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582078_2106679.33333333333342672.0RepeatHEAT 36
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582107_2146679.33333333333342672.0RepeatHEAT 37
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582147_2184679.33333333333342672.0RepeatHEAT 38
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582188_2225679.33333333333342672.0RepeatHEAT 39
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582259_2296679.33333333333342672.0RepeatHEAT 40
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582301_2338679.33333333333342672.0RepeatHEAT 41
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582339_2380679.33333333333342672.0RepeatHEAT 42
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582382_2417679.33333333333342672.0RepeatHEAT 43
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582422_2459679.33333333333342672.0RepeatHEAT 44
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582546_2583679.33333333333342672.0RepeatHEAT 45
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582588_2625679.33333333333342672.0RepeatHEAT 46
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-19582627_2661679.33333333333342672.0RepeatHEAT 47%3B degenerate
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958697_732679.33333333333342672.0RepeatHEAT 9
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958733_770679.33333333333342672.0RepeatHEAT 10
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958879_925679.33333333333342672.0RepeatHEAT 11
HgeneGCN1L1chr12:120600874chr12:4398008ENST00000300648-1958979_1016679.33333333333342672.0RepeatHEAT 12
TgeneCCND2chr12:120600873chr12:4398007ENST000002612542526_151190.33333333333334290.0DomainNote=Cyclin N-terminal
TgeneCCND2chr12:120600874chr12:4398008ENST000002612542526_151190.33333333333334290.0DomainNote=Cyclin N-terminal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GCN1L1
CCND2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GCN1L1-CCND2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GCN1L1-CCND2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource