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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GLRB-KLHL2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GLRB-KLHL2
FusionPDB ID: 33341
FusionGDB2.0 ID: 33341
HgeneTgene
Gene symbol

GLRB

KLHL2

Gene ID

2743

11275

Gene nameglycine receptor betakelch like family member 2
SynonymsHKPX2ABP-KELCH|MAV|MAYVEN
Cytomap

4q32.1

4q32.3

Type of geneprotein-codingprotein-coding
Descriptionglycine receptor subunit betaglycine receptor 58 kDa subunitglycine receptor, beta subunitkelch-like protein 2actin-binding protein Mayvenkelch-like 2, Mayven
Modification date2020031320200327
UniProtAcc

P48167

Q96CT2

Ensembl transtripts involved in fusion geneENST idsENST00000264428, ENST00000509282, 
ENST00000512619, ENST00000541722, 
ENST00000421009, ENST00000506761, 
ENST00000509028, ENST00000538127, 
ENST00000226725, ENST00000514860, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=483 X 3 X 3=27
# samples 43
** MAII scorelog2(4/48*10)=-0.263034405833794
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/27*10)=0.15200309344505
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GLRB [Title/Abstract] AND KLHL2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GLRB(157999298)-KLHL2(166149959), # samples:1
Anticipated loss of major functional domain due to fusion event.GLRB-KLHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GLRB-KLHL2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GLRB-KLHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GLRB-KLHL2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGLRB

GO:0006811

ion transport

8717357

HgeneGLRB

GO:0007218

neuropeptide signaling pathway

8717357


check buttonFusion gene breakpoints across GLRB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KLHL2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-E9-A228-01AGLRBchr4

157999298

+KLHL2chr4

166149959

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000264428GLRBchr4157999298+ENST00000226725KLHL2chr4166149959+31153921292021630
ENST00000264428GLRBchr4157999298+ENST00000514860KLHL2chr4166149959+24203921292021630
ENST00000541722GLRBchr4157999298+ENST00000226725KLHL2chr4166149959+3047324611953630
ENST00000541722GLRBchr4157999298+ENST00000514860KLHL2chr4166149959+2352324611953630
ENST00000512619GLRBchr4157999298+ENST00000226725KLHL2chr4166149959+2977254811883600
ENST00000512619GLRBchr4157999298+ENST00000514860KLHL2chr4166149959+2282254811883600
ENST00000509282GLRBchr4157999298+ENST00000226725KLHL2chr4166149959+3030307231936637
ENST00000509282GLRBchr4157999298+ENST00000514860KLHL2chr4166149959+2335307231936637

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264428ENST00000226725GLRBchr4157999298+KLHL2chr4166149959+0.000303720.99969625
ENST00000264428ENST00000514860GLRBchr4157999298+KLHL2chr4166149959+0.0015384850.9984615
ENST00000541722ENST00000226725GLRBchr4157999298+KLHL2chr4166149959+0.0003244260.99967563
ENST00000541722ENST00000514860GLRBchr4157999298+KLHL2chr4166149959+0.0016601490.9983398
ENST00000512619ENST00000226725GLRBchr4157999298+KLHL2chr4166149959+0.0002748480.99972516
ENST00000512619ENST00000514860GLRBchr4157999298+KLHL2chr4166149959+0.0012775570.9987224
ENST00000509282ENST00000226725GLRBchr4157999298+KLHL2chr4166149959+0.0002627160.9997373
ENST00000509282ENST00000514860GLRBchr4157999298+KLHL2chr4166149959+0.0013566450.99864334

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33341_33341_1_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000264428_KLHL2_chr4_166149959_ENST00000226725_length(amino acids)=630AA_BP=87
MGRSCPRSAPAAPLAATATWARSLHDLARRLWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQN
LLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK
TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV
RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV
ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG
LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG
HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

--------------------------------------------------------------

>33341_33341_2_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000264428_KLHL2_chr4_166149959_ENST00000514860_length(amino acids)=630AA_BP=87
MGRSCPRSAPAAPLAATATWARSLHDLARRLWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQN
LLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK
TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV
RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV
ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG
LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG
HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

--------------------------------------------------------------

>33341_33341_3_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000509282_KLHL2_chr4_166149959_ENST00000226725_length(amino acids)=637AA_BP=94
MRRAREDARCPARERGAGRLAAAAGSPLRWRPRRRSGWRDAEGRDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQ
YLCPSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLL
QLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW
VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA
PKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVG
GFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN
LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGV

--------------------------------------------------------------

>33341_33341_4_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000509282_KLHL2_chr4_166149959_ENST00000514860_length(amino acids)=637AA_BP=94
MRRAREDARCPARERGAGRLAAAAGSPLRWRPRRRSGWRDAEGRDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQ
YLCPSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLL
QLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAW
VNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQA
PKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVG
GFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNN
LLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGV

--------------------------------------------------------------

>33341_33341_5_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000512619_KLHL2_chr4_166149959_ENST00000226725_length(amino acids)=600AA_BP=57
MWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHA
MFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDL
LNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA
LVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG
LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG
VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCR

--------------------------------------------------------------

>33341_33341_6_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000512619_KLHL2_chr4_166149959_ENST00000514860_length(amino acids)=600AA_BP=57
MWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQNLLCDVTIVAEDMEISAHRVVLAACSPYFHA
MFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKKTCCEFLESQLHPVNCLGIRAFADMHACTDL
LNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDVRQEFMARLMEHVRLPLLPREYLVQRVEEEA
LVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSVECYDFKEERWHQVAELPSRRCRAGMVYMAG
LVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTGLSSVEAYNIKSNEWFHVAPMNTRRSSVGVG
VVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGGHDGPLVRKSVEVYDPTTNAWRQVADMNMCR

--------------------------------------------------------------

>33341_33341_7_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000541722_KLHL2_chr4_166149959_ENST00000226725_length(amino acids)=630AA_BP=87
MGRSCPRSAPAAPLAATATWARSLHDLARRLWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQN
LLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK
TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV
RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV
ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG
LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG
HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

--------------------------------------------------------------

>33341_33341_8_GLRB-KLHL2_GLRB_chr4_157999298_ENST00000541722_KLHL2_chr4_166149959_ENST00000514860_length(amino acids)=630AA_BP=87
MGRSCPRSAPAAPLAATATWARSLHDLARRLWAGAPPDRSSEIQVFKMKFLLTTAFLILISLWVEEAYSKEKSSKKGKGKKKQYLCPSQN
LLCDVTIVAEDMEISAHRVVLAACSPYFHAMFTGEMSESRAKRVRIKEVDGWTLRMLIDYVYTAEIQVTEENVQVLLPAAGLLQLQDVKK
TCCEFLESQLHPVNCLGIRAFADMHACTDLLNKANTYAEQHFADVVLSEEFLNLGIEQVCSLISSDKLTISSEEKVFEAVIAWVNHDKDV
RQEFMARLMEHVRLPLLPREYLVQRVEEEALVKNSSACKDYLIEAMKYHLLPTEQRILMKSVRTRLRTPMNLPKLMVVVGGQAPKAIRSV
ECYDFKEERWHQVAELPSRRCRAGMVYMAGLVFAVGGFNGSLRVRTVDSYDPVKDQWTSVANMRDRRSTLGAAVLNGLLYAVGGFDGSTG
LSSVEAYNIKSNEWFHVAPMNTRRSSVGVGVVGGLLYAVGGYDGASRQCLSTVECYNATTNEWTYIAEMSTRRSGAGVGVLNNLLYAVGG
HDGPLVRKSVEVYDPTTNAWRQVADMNMCRRNAGVCAVNGLLYVVGGDDGSCNLASVEYYNPTTDKWTVVSSCMSTGRSYAGVTVIDKPL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr4:157999298/chr4:166149959)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GLRB

P48167

KLHL2

Q96CT2

FUNCTION: Glycine receptors are ligand-gated chloride channels. GLRB does not form ligand-gated ion channels by itself, but is part of heteromeric ligand-gated chloride channels. Channel opening is triggered by extracellular glycine (PubMed:8717357, PubMed:15302677, PubMed:16144831, PubMed:22715885, PubMed:25445488, PubMed:11929858, PubMed:23238346). Heteropentameric channels composed of GLRB and GLRA1 are activated by lower glycine levels than homopentameric GLRA1 (PubMed:8717357). Plays an important role in the down-regulation of neuronal excitability (PubMed:11929858, PubMed:23238346). Contributes to the generation of inhibitory postsynaptic currents (PubMed:25445488). {ECO:0000269|PubMed:11929858, ECO:0000269|PubMed:15302677, ECO:0000269|PubMed:16144831, ECO:0000269|PubMed:22715885, ECO:0000269|PubMed:23238346, ECO:0000269|PubMed:25445488, ECO:0000269|PubMed:8717357}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKLHL2chr4:157999298chr4:166149959ENST0000022672511556_12350.666666666666664594.0DomainBTB
TgeneKLHL2chr4:157999298chr4:166149959ENST0000051486011556_12354.666666666666664598.0DomainBTB
TgeneKLHL2chr4:157999298chr4:166149959ENST0000053812701456_1230506.0DomainBTB
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115308_35350.666666666666664594.0RepeatNote=Kelch 1
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115354_40050.666666666666664594.0RepeatNote=Kelch 2
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115402_44750.666666666666664594.0RepeatNote=Kelch 3
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115449_49650.666666666666664594.0RepeatNote=Kelch 4
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115497_54350.666666666666664594.0RepeatNote=Kelch 5
TgeneKLHL2chr4:157999298chr4:166149959ENST00000226725115545_59150.666666666666664594.0RepeatNote=Kelch 6
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115308_35354.666666666666664598.0RepeatNote=Kelch 1
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115354_40054.666666666666664598.0RepeatNote=Kelch 2
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115402_44754.666666666666664598.0RepeatNote=Kelch 3
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115449_49654.666666666666664598.0RepeatNote=Kelch 4
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115497_54354.666666666666664598.0RepeatNote=Kelch 5
TgeneKLHL2chr4:157999298chr4:166149959ENST00000514860115545_59154.666666666666664598.0RepeatNote=Kelch 6
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014308_3530506.0RepeatNote=Kelch 1
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014354_4000506.0RepeatNote=Kelch 2
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014402_4470506.0RepeatNote=Kelch 3
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014449_4960506.0RepeatNote=Kelch 4
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014497_5430506.0RepeatNote=Kelch 5
TgeneKLHL2chr4:157999298chr4:166149959ENST00000538127014545_5910506.0RepeatNote=Kelch 6

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210247_25340.666666666666664498.0RegionStrychnine-binding
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210247_25340.666666666666664498.0RegionStrychnine-binding
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29247_25340.666666666666664304.0RegionStrychnine-binding
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+21023_26840.666666666666664498.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210291_29540.666666666666664498.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210317_32740.666666666666664498.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210349_47540.666666666666664498.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+21023_26840.666666666666664498.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210291_29540.666666666666664498.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210317_32740.666666666666664498.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210349_47540.666666666666664498.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+2923_26840.666666666666664304.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29291_29540.666666666666664304.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29317_32740.666666666666664304.0Topological domainExtracellular
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29349_47540.666666666666664304.0Topological domainCytoplasmic
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210269_29040.666666666666664498.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210296_31640.666666666666664498.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210328_34840.666666666666664498.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:157999298chr4:166149959ENST00000264428+210476_49640.666666666666664498.0TransmembraneHelical%3B Name%3D4
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210269_29040.666666666666664498.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210296_31640.666666666666664498.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210328_34840.666666666666664498.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:157999298chr4:166149959ENST00000509282+210476_49640.666666666666664498.0TransmembraneHelical%3B Name%3D4
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29269_29040.666666666666664304.0TransmembraneHelical%3B Name%3D1
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29296_31640.666666666666664304.0TransmembraneHelical%3B Name%3D2
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29328_34840.666666666666664304.0TransmembraneHelical%3B Name%3D3
HgeneGLRBchr4:157999298chr4:166149959ENST00000541722+29476_49640.666666666666664304.0TransmembraneHelical%3B Name%3D4


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GLRB
KLHL2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GLRB-KLHL2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GLRB-KLHL2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource