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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AKAP8-BRD4

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AKAP8-BRD4
FusionPDB ID: 3365
FusionGDB2.0 ID: 3365
HgeneTgene
Gene symbol

AKAP8

BRD4

Gene ID

10270

23476

Gene nameA-kinase anchoring protein 8bromodomain containing 4
SynonymsAKAP 95|AKAP-8|AKAP-95|AKAP95CAP|HUNK1|HUNKI|MCAP
Cytomap

19p13.12

19p13.12

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 8A kinase (PRKA) anchor protein 8A-kinase anchor protein, 95kDabromodomain-containing protein 4chromosome-associated proteinmitotic chromosome-associated protein
Modification date2020031320200329
UniProtAcc

Q9ULX6

O60885

Ensembl transtripts involved in fusion geneENST idsENST00000269701, ENST00000602230, 
ENST00000263377, ENST00000360016, 
ENST00000371835, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score13 X 14 X 9=163815 X 19 X 13=3705
# samples 1728
** MAII scorelog2(17/1638*10)=-3.26832870550331
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/3705*10)=-3.72597481024823
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AKAP8 [Title/Abstract] AND BRD4 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AKAP8(15465385)-BRD4(15359824), # samples:1
AKAP8(15487787)-BRD4(15367984), # samples:1
AKAP8(15490524)-BRD4(15367984), # samples:1
AKAP8(15487787)-BRD4(15366403), # samples:1
Anticipated loss of major functional domain due to fusion event.AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a epigenetic factor due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKAP8-BRD4 seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneBRD4

GO:0032968

positive regulation of transcription elongation from RNA polymerase II promoter

19103749|23086925

TgeneBRD4

GO:0043123

positive regulation of I-kappaB kinase/NF-kappaB signaling

19103749

TgeneBRD4

GO:0045944

positive regulation of transcription by RNA polymerase II

23086925|23317504|24360279

TgeneBRD4

GO:0050727

regulation of inflammatory response

19103749

TgeneBRD4

GO:1901407

regulation of phosphorylation of RNA polymerase II C-terminal domain

23086925


check buttonFusion gene breakpoints across AKAP8 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across BRD4 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BLCATCGA-GV-A3QI-01AAKAP8chr19

15465385

-BRD4chr19

15359824

-
ChimerDB4BLCATCGA-ZF-AA4V-01AAKAP8chr19

15487787

-BRD4chr19

15367984

-
ChimerDB4BLCATCGA-ZF-AA4V-01AAKAP8chr19

15490524

-BRD4chr19

15367984

-
ChimerDB4OVTCGA-04-1338-01AAKAP8chr19

15487787

-BRD4chr19

15366403

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000269701AKAP8chr1915490524-ENST00000263377BRD4chr1915367984-436980142827937
ENST00000269701AKAP8chr1915490524-ENST00000371835BRD4chr1915367984-31318014907297
ENST00000269701AKAP8chr1915490524-ENST00000360016BRD4chr1915367984-168980141123369

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000269701ENST00000263377AKAP8chr1915490524-BRD4chr1915367984-0.0109304120.98906964
ENST00000269701ENST00000371835AKAP8chr1915490524-BRD4chr1915367984-0.003725810.99627423
ENST00000269701ENST00000360016AKAP8chr1915490524-BRD4chr1915367984-0.0079030140.992097

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3365_3365_1_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000263377_length(amino acids)=937AA_BP=547
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM
KGFSSSESESSSESSSSDSEDSETEMAPKSKKKGHPGREQKKHHHHHHQQMQQAPAPVPQQPPPPPQQPPPPPPPQQQQQPPPPPPPPSM
PQQAAPAMKSSPPPFIATQVPVLEPQLPGSVFDPIGHFTQPILHLPQPELPPHLPQPPEHSTPPHLNQHAVVSPPALHNALPQQPSRPSN
RAAALPPKPARPPAVSPALTQTPLLPQPPMAQPPQVLLEDEEPPAPPLTSMQMQLYLQQLQKVQPPTPLLPSVKVQSQPPPPLPPPPHPS
VQQQLQQQPPPPPPPQPQPPPQQQHQPPPRPVHLQPMQFSTHIQQPPPPQGQQPPHPPPGQQPPPPQPAKPQQVIQHHHSPRHHKSDPYS
TGHLREAPSPLMIHSPQMSQFQSLTHQSPPQQNVQPKKQELRAASVVQPQPLVVVKEEKIHSPIIRSEPFSPSLRPEPPKHPESIKAPVH
LPQRPEMKPVDVGRPVIRPPEQNAPPPGAPDKDKQKQEPKTPVAPKKDLKIKNMGSWASLVQKHPTTPSSTAKSSSDSFEQFRRAAREKE
EREKALKAQAEHAEKEKERLRQERMRSREDEDALEQARRAHEEARRRQEQQQQQRQEQQQQQQQQAAAVAAAATPQAQSSQPQSMLDQQR

--------------------------------------------------------------

>3365_3365_2_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000360016_length(amino acids)=369AA_BP=1
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM
KGFSSSESESSSESSSSDSEDSETAFCTSGDFVSPGPSPYHSHVQCGRFREMLRWFLVDVEQTAAGQPHRQSAAGPAITWAPAIAYPSPE

--------------------------------------------------------------

>3365_3365_3_AKAP8-BRD4_AKAP8_chr19_15490524_ENST00000269701_BRD4_chr19_15367984_ENST00000371835_length(amino acids)=297AA_BP=1
MWSPSKRGCWWAASKTWTRATEDVFEMRFAKMPDEPEEPVVAVSSPAVPPPTKVVAPPSSSDSSSDSSSDSDSSTDDSEEERAQRLAELQ
EQLKAVHEQLAALSQPQQNKPKKKEKDKKEKKKEKHKRKEEVEENKKSKAKEPPPKKTKKNNSSNSNVSKKEPAPMKSKPPPTYESEEED
KCKPMSYEEKRQLSLDINKLPGEKLGRVVHIIQSREPSLKNSNPDEIEIDFETLKPSTLRELERYVTSCLRKKRKPQAEKVDVIAGSSKM

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:15465385/chr19:15359824)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP8

Q9ULX6

BRD4

O60885

FUNCTION: Could play a role in constitutive transport element (CTE)-mediated gene expression by association with DHX9. Increases CTE-dependent nuclear unspliced mRNA export (PubMed:10748171, PubMed:11402034). Proposed to target PRKACA to the nucleus but does not seem to be implicated in the binding of regulatory subunit II of PKA (PubMed:10761695, PubMed:11884601). May be involved in nuclear envelope breakdown and chromatin condensation. May be involved in anchoring nuclear membranes to chromatin in interphase and in releasing membranes from chromating at mitosis (PubMed:11034899). May regulate the initiation phase of DNA replication when associated with TMPO isoform Beta (PubMed:12538639). Required for cell cycle G2/M transition and histone deacetylation during mitosis. In mitotic cells recruits HDAC3 to the vicinity of chromatin leading to deacetylation and subsequent phosphorylation at 'Ser-10' of histone H3; in this function seems to act redundantly with AKAP8 (PubMed:16980585). May be involved in regulation of pre-mRNA splicing (PubMed:17594903). {ECO:0000269|PubMed:10748171, ECO:0000269|PubMed:11034899, ECO:0000269|PubMed:11402034, ECO:0000269|PubMed:11884601, ECO:0000269|PubMed:12538639, ECO:0000269|PubMed:16980585, ECO:0000305|PubMed:10761695}.; FUNCTION: (Microbial infection) In case of EBV infection, may target PRKACA to EBNA-LP-containing nuclear sites to modulate transcription from specific promoters. {ECO:0000269|PubMed:11884601}.; FUNCTION: (Microbial infection) Can synergize with DHX9 to activate the CTE-mediated gene expression of type D retroviruses. {ECO:0000269|PubMed:11402034}.; FUNCTION: (Microbial infection) In case of HIV-1 infection, involved in the DHX9-promoted annealing of host tRNA(Lys3) to viral genomic RNA as a primer in reverse transcription; in vitro negatively regulates DHX9 annealing activity. {ECO:0000269|PubMed:25034436}.FUNCTION: Chromatin reader protein that recognizes and binds acetylated histones and plays a key role in transmission of epigenetic memory across cell divisions and transcription regulation. Remains associated with acetylated chromatin throughout the entire cell cycle and provides epigenetic memory for postmitotic G1 gene transcription by preserving acetylated chromatin status and maintaining high-order chromatin structure (PubMed:23589332, PubMed:23317504, PubMed:22334664). During interphase, plays a key role in regulating the transcription of signal-inducible genes by associating with the P-TEFb complex and recruiting it to promoters. Also recruits P-TEFb complex to distal enhancers, so called anti-pause enhancers in collaboration with JMJD6. BRD4 and JMJD6 are required to form the transcriptionally active P-TEFb complex by displacing negative regulators such as HEXIM1 and 7SKsnRNA complex from P-TEFb, thereby transforming it into an active form that can then phosphorylate the C-terminal domain (CTD) of RNA polymerase II (PubMed:23589332, PubMed:19596240, PubMed:16109377, PubMed:16109376, PubMed:24360279). Promotes phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II (PubMed:23086925). According to a report, directly acts as an atypical protein kinase and mediates phosphorylation of 'Ser-2' of the C-terminal domain (CTD) of RNA polymerase II; these data however need additional evidences in vivo (PubMed:22509028). In addition to acetylated histones, also recognizes and binds acetylated RELA, leading to further recruitment of the P-TEFb complex and subsequent activation of NF-kappa-B (PubMed:19103749). Also acts as a regulator of p53/TP53-mediated transcription: following phosphorylation by CK2, recruited to p53/TP53 specific target promoters (PubMed:23317504). {ECO:0000269|PubMed:16109376, ECO:0000269|PubMed:16109377, ECO:0000269|PubMed:19103749, ECO:0000269|PubMed:19596240, ECO:0000269|PubMed:22334664, ECO:0000269|PubMed:22509028, ECO:0000269|PubMed:23086925, ECO:0000269|PubMed:23317504, ECO:0000269|PubMed:23589332, ECO:0000269|PubMed:24360279}.; FUNCTION: [Isoform B]: Acts as a chromatin insulator in the DNA damage response pathway. Inhibits DNA damage response signaling by recruiting the condensin-2 complex to acetylated histones, leading to chromatin structure remodeling, insulating the region from DNA damage response by limiting spreading of histone H2AX/H2A.x phosphorylation. {ECO:0000269|PubMed:23728299}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201011_1014447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201028_1033447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201283_1300447.01363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201301_1308447.01363.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201335_1338447.01363.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620535_594447.01363.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620692_717447.01363.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620703_714447.01363.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620738_743447.01363.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620757_761447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620764_770447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620771_775447.01363.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620776_783447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620954_964447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620974_986447.01363.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121011_1014447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121028_1033447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121283_1300447.0795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121301_1308447.0795.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121335_1338447.0795.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612535_594447.0795.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612692_717447.0795.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612703_714447.0795.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612738_743447.0795.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612757_761447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612764_770447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612771_775447.0795.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612776_783447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612954_964447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612974_986447.0795.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121011_1014447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121028_1033447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121283_1300447.0723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121301_1308447.0723.0Compositional biasNote=Poly-Ala
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121335_1338447.0723.0Compositional biasNote=Poly-Arg
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612535_594447.0723.0Compositional biasNote=Lys-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612692_717447.0723.0Compositional biasNote=Ser-rich
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612703_714447.0723.0Compositional biasNote=Poly-Ser
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612738_743447.0723.0Compositional biasNote=Poly-His
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612757_761447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612764_770447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612771_775447.0723.0Compositional biasNote=Poly-Gln
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612776_783447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612954_964447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612974_986447.0723.0Compositional biasNote=Poly-Pro
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620600_682447.01363.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612600_682447.0795.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612600_682447.0723.0DomainNET
TgeneBRD4chr19:15490524chr19:15367984ENST000002633776201047_1362447.01363.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620484_503447.01363.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620524_579447.01363.0RegionNote=BID region
TgeneBRD4chr19:15490524chr19:15367984ENST000003600166121047_1362447.0795.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612484_503447.0795.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612524_579447.0795.0RegionNote=BID region
TgeneBRD4chr19:15490524chr19:15367984ENST000003718356121047_1362447.0723.0RegionNote=C-terminal (CTD) region
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612484_503447.0723.0RegionNote=NPS region
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612524_579447.0723.0RegionNote=BID region

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114107_1186.333333333333333693.0Compositional biasNote=Poly-Gly
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114289_3066.333333333333333693.0MotifBipartite nuclear localization signal
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114387_4506.333333333333333693.0RegionInvolved in chromatin-binding
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114525_5696.333333333333333693.0RegionInvolved in condensin complex recruitment
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114572_5896.333333333333333693.0RegionRII-binding
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114392_4146.333333333333333693.0Zinc fingerC2H2 AKAP95-type 1
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114481_5046.333333333333333693.0Zinc fingerC2H2 AKAP95-type 2
TgeneBRD4chr19:15490524chr19:15367984ENST00000263377620368_440447.01363.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000026337762075_147447.01363.0DomainBromo 1
TgeneBRD4chr19:15490524chr19:15367984ENST00000360016612368_440447.0795.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000036001661275_147447.0795.0DomainBromo 1
TgeneBRD4chr19:15490524chr19:15367984ENST00000371835612368_440447.0723.0DomainBromo 2
TgeneBRD4chr19:15490524chr19:15367984ENST0000037183561275_147447.0723.0DomainBromo 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AKAP8
BRD4all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-114109_2016.333333333333333693.0DDX5
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-1141_2106.333333333333333693.0DPY30
HgeneAKAP8chr19:15490524chr19:15367984ENST00000269701-1141_1956.333333333333333693.0MCM2


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Related Drugs to AKAP8-BRD4


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AKAP8-BRD4


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneBRD4C0017636Glioblastoma2CTD_human
TgeneBRD4C0334588Giant Cell Glioblastoma2CTD_human
TgeneBRD4C1621958Glioblastoma Multiforme2CTD_human
TgeneBRD4C0002170Alopecia1CTD_human
TgeneBRD4C0007102Malignant tumor of colon1CTD_human
TgeneBRD4C0009375Colonic Neoplasms1CTD_human
TgeneBRD4C0018798Congenital Heart Defects1GENOMICS_ENGLAND
TgeneBRD4C0019193Hepatitis, Toxic1CTD_human
TgeneBRD4C0020507Hyperplasia1CTD_human
TgeneBRD4C0020542Pulmonary Hypertension1CTD_human
TgeneBRD4C0025149Medulloblastoma1CTD_human
TgeneBRD4C0025958Microcephaly1GENOMICS_ENGLAND
TgeneBRD4C0029463Osteosarcoma1CTD_human
TgeneBRD4C0033578Prostatic Neoplasms1CTD_human
TgeneBRD4C0040136Thyroid Neoplasm1CTD_human
TgeneBRD4C0085413Polycystic Kidney, Autosomal Dominant1CTD_human
TgeneBRD4C0086873Pseudopelade1CTD_human
TgeneBRD4C0151468Thyroid Gland Follicular Adenoma1CTD_human
TgeneBRD4C0162311Androgenetic Alopecia1CTD_human
TgeneBRD4C0205833Medullomyoblastoma1CTD_human
TgeneBRD4C0263477Female pattern alopecia (disorder)1CTD_human
TgeneBRD4C0270972Cornelia De Lange Syndrome1CTD_human
TgeneBRD4C0278510Childhood Medulloblastoma1CTD_human
TgeneBRD4C0278876Adult Medulloblastoma1CTD_human
TgeneBRD4C0376358Malignant neoplasm of prostate1CTD_human
TgeneBRD4C0549473Thyroid carcinoma1CTD_human
TgeneBRD4C0751291Desmoplastic Medulloblastoma1CTD_human
TgeneBRD4C0860207Drug-Induced Liver Disease1CTD_human
TgeneBRD4C0887850Polycystic Kidney, Type 1 Autosomal Dominant Disease1CTD_human
TgeneBRD4C1262760Hepatitis, Drug-Induced1CTD_human
TgeneBRD4C1275668Melanotic medulloblastoma1CTD_human
TgeneBRD4C1707291NUT midline carcinoma1ORPHANET
TgeneBRD4C1802395Congenital muscular hypertrophy-cerebral syndrome1CTD_human
TgeneBRD4C1853099Cornelia de Lange Syndrome 31CTD_human
TgeneBRD4C2751306Polycystic kidney disease, type 21CTD_human
TgeneBRD4C3658290Drug-Induced Acute Liver Injury1CTD_human
TgeneBRD4C3714756Intellectual Disability1GENOMICS_ENGLAND
TgeneBRD4C4025871Abnormality of the face1GENOMICS_ENGLAND
TgeneBRD4C4083212Alopecia, Male Pattern1CTD_human
TgeneBRD4C4277682Chemical and Drug Induced Liver Injury1CTD_human
TgeneBRD4C4279912Chemically-Induced Liver Toxicity1CTD_human
TgeneBRD4C4551851Cornelia de Lange Syndrome 11CTD_human