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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GOLIM4-MECOM

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GOLIM4-MECOM
FusionPDB ID: 33948
FusionGDB2.0 ID: 33948
HgeneTgene
Gene symbol

GOLIM4

MECOM

Gene ID

27333

2122

Gene namegolgi integral membrane protein 4MDS1 and EVI1 complex locus
SynonymsGIMPC|GOLPH4|GPP130|P138AML1-EVI-1|EVI1|KMT8E|MDS1|MDS1-EVI1|PRDM3|RUSAT2
Cytomap

3q26.2

3q26.2

Type of geneprotein-codingprotein-coding
DescriptionGolgi integral membrane protein 4130 kDa golgi-localized phosphoproteincis Golgi-localized calcium-binding proteingolgi integral membrane protein, cisgolgi phosphoprotein 4golgi phosphoprotein of 130 kDagolgi-localized phosphoprotein of 130 kDatypehistone-lysine N-methyltransferase MECOMAML1-EVI-1 fusion proteinMDS1 and EVI1 complex locus protein EVI1MDS1 and EVI1 complex locus protein MDS1PR domain 3ecotropic virus integration site 1 protein homologmyelodysplasia syndrome-associated protein
Modification date2020031320200313
UniProtAcc

O00461

Q03112

Ensembl transtripts involved in fusion geneENST idsENST00000309027, ENST00000470487, 
ENST00000392736, ENST00000433243, 
ENST00000464456, ENST00000468789, 
ENST00000472280, ENST00000494292, 
ENST00000460814, ENST00000485957, 
ENST00000264674, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 11 X 10=154018 X 18 X 11=3564
# samples 1823
** MAII scorelog2(18/1540*10)=-3.09686153925259
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(23/3564*10)=-3.95379157057755
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GOLIM4 [Title/Abstract] AND MECOM [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GOLIM4(167742314)-MECOM(168861620), # samples:3
MECOM(169098975)-GOLIM4(167728611), # samples:1
Anticipated loss of major functional domain due to fusion event.MECOM-GOLIM4 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
MECOM-GOLIM4 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLIM4-MECOM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLIM4-MECOM seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLIM4-MECOM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GOLIM4-MECOM seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMECOM

GO:0045892

negative regulation of transcription, DNA-templated

10856240|11568182

TgeneMECOM

GO:0045893

positive regulation of transcription, DNA-templated

11568182|19767769

TgeneMECOM

GO:0051726

regulation of cell cycle

11568182


check buttonFusion gene breakpoints across GOLIM4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MECOM (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-W3-A828-06AGOLIM4chr3

167742314

-MECOMchr3

168861620

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000470487GOLIM4chr3167742314-ENST00000264674MECOMchr3168861620-7308255067258971741
ENST00000309027GOLIM4chr3167742314-ENST00000264674MECOMchr3168861620-659318354151821713

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000470487ENST00000264674GOLIM4chr3167742314-MECOMchr3168861620-0.0014632350.9985368
ENST00000309027ENST00000264674GOLIM4chr3167742314-MECOMchr3168861620-0.0006864880.9993135

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>33948_33948_1_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000309027_MECOM_chr3_168861620_ENST00000264674_length(amino acids)=1713AA_BP=598
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHSPQGYNTAREKPTREVQEVSRNNDVWQNH
EAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQAEHLEEEHDPSPEEQDREWKEQHEQREAA
NLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLLRQQEQQQQQVAREMALQRQAELEEGRPQ
HQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREADPESEADRAAVEDINPADDPNNQGEDEF
EEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEILDEFYNVKFCIDASQPDVGSWLKYIRFAGCY
DQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFESKAELADHQKFPCSTPHSAFSMVEEDFQ
QKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRHQMSHDSGKHYECENCAKQVFTDPSNLQR
HIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMHADCRTQIKCKDCGQMFSTTSSLNKHRRF
CEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFSFSFPGLFPSGLYHRPPLIPASSPVKGLS
STEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSESSDLDDVSTPSGSDLETTSGSDLESDIE
SDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASIAEKYFGSTGLVGLQDKKVGALPYPSMFP
LPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVPSKPPVTPATSQDQPLDLSMGSRSRASGT
KLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYLRPSPGFLFHPQFQLPDQRTWMSAIENMA
EKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTRHLRTHTGEQPYRCKYCDRSFSISSNLQR
HVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKEDAYFTEIRNFIGNSNHGSQSPRNVEERM
NGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDYEETSALEMSCKTSPVRYKEEEYKSGLSA
LDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKESLHSTSHSSSNVWHSMARAAAESSAIQSI

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>33948_33948_2_GOLIM4-MECOM_GOLIM4_chr3_167742314_ENST00000470487_MECOM_chr3_168861620_ENST00000264674_length(amino acids)=1741AA_BP=626
MGPGGTMGNGMCSRKQKRIFQTLLLLTVVFGFLYGAMLYYELQTQLRKAEAVALKYQQHQESLSAQLQVVYEHRSRLEKSLQKERLEHKK
AKEDFLVYKLEAQETLNKGRQDSNSRYSALNVQHQMLKSQHEELKKQHSDLEEEHRKQGEDFSRTFNDHKQKYLQLQQEKEQELSKLKET
VYNLREENRQLRKAHQDIHTQLQDVKQQHKNLLSEHEQLVVTLEDHKSALAAAQTQVAEYKQLKDTLNRIPSLRKPDPAEQQNVTQVAHS
PQGYNTAREKPTREVQEVSRNNDVWQNHEAVPGRAEDTKLYAPTHKEAEFQAPPEPIQQEVERREPEEHQVEEEHRKALEEEEMEQVGQA
EHLEEEHDPSPEEQDREWKEQHEQREAANLLEGHARAEVYPSAKPMIKFQSPYEEQLEQQRLAVQQVEEAQQLREHQEALHQQRLQGHLL
RQQEQQQQQVAREMALQRQAELEEGRPQHQEQLRQQAHYDAMDNDIVQGAEDQGIQGEEGAYERDNQHQDEAEGDPGNRHEPREQGPREA
DPESEADRAAVEDINPADDPNNQGEDEFEEAEQVREENLPDENEEQKQSNQKQENTEVEEHLVMAGNPDQQEDNVDEQYQEEAEEEILDE
FYNVKFCIDASQPDVGSWLKYIRFAGCYDQHNLVACQINDQIFYRVVADIAPGEELLLFMKSEDYPHETMAPDIHEERQYRCEDCDQLFE
SKAELADHQKFPCSTPHSAFSMVEEDFQQKLESENDLQEIHTIQECKECDQVFPDLQSLEKHMLSHTEEREYKCDQCPKAFNWKSNLIRH
QMSHDSGKHYECENCAKQVFTDPSNLQRHIRSQHVGARAHACPECGKTFATSSGLKQHKHIHSSVKPFICEVCHKSYTQFSNLCRHKRMH
ADCRTQIKCKDCGQMFSTTSSLNKHRRFCEGKNHFAAGGFFGQGISLPGTPAMDKTSMVNMSHANPGLADYFGANRHPAGLTFPTAPGFS
FSFPGLFPSGLYHRPPLIPASSPVKGLSSTEQTNKSQSPLMTHPQILPATQDILKALSKHPSVGDNKPVELQPERSSEERPFEKISDQSE
SSDLDDVSTPSGSDLETTSGSDLESDIESDKEKFKENGKMFKDKVSPLQNLASINNKKEYSNHSIFSPSLEEQTAVSGAVNDSIKAIASI
AEKYFGSTGLVGLQDKKVGALPYPSMFPLPFFPAFSQSMYPFPDRDLRSLPLKMEPQSPGEVKKLQKGSSESPFDLTTKRKDEKPLTPVP
SKPPVTPATSQDQPLDLSMGSRSRASGTKLTEPRKNHVFGGKKGSNVESRPASDGSLQHARPTPFFMDPIYRVEKRKLTDPLEALKEKYL
RPSPGFLFHPQFQLPDQRTWMSAIENMAEKLESFSALKPEASELLQSVPSMFNFRAPPNALPENLLRKGKERYTCRYCGKIFPRSANLTR
HLRTHTGEQPYRCKYCDRSFSISSNLQRHVRNIHNKEKPFKCHLCDRCFGQQTNLDRHLKKHENGNMSGTATSSPHSELESTGAILDDKE
DAYFTEIRNFIGNSNHGSQSPRNVEERMNGSHFKDEKALVTSQNSDLLDDEEVEDEVLLDEEDEDNDITGKTGKEPVTSNLHEGNPEDDY
EETSALEMSCKTSPVRYKEEEYKSGLSALDHIRHFTDSLKMRKMEDNQYSEAELSSFSTSHVPEELKQPLHRKSKSQAYAMMLSLSDKES

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:167742314/chr3:168861620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GOLIM4

O00461

MECOM

Q03112

FUNCTION: Plays a role in endosome to Golgi protein trafficking; mediates protein transport along the late endosome-bypass pathway from the early endosome to the Golgi. {ECO:0000269|PubMed:15331763}.FUNCTION: [Isoform 1]: Functions as a transcriptional regulator binding to DNA sequences in the promoter region of target genes and regulating positively or negatively their expression. Oncogene which plays a role in development, cell proliferation and differentiation. May also play a role in apoptosis through regulation of the JNK and TGF-beta signaling. Involved in hematopoiesis. {ECO:0000269|PubMed:10856240, ECO:0000269|PubMed:11568182, ECO:0000269|PubMed:15897867, ECO:0000269|PubMed:16462766, ECO:0000269|PubMed:19767769, ECO:0000269|PubMed:9665135}.; FUNCTION: [Isoform 7]: Displays histone methyltransferase activity and monomethylates 'Lys-9' of histone H3 (H3K9me1) in vitro. Probably catalyzes the monomethylation of free histone H3 in the cytoplasm which is then transported to the nucleus and incorporated into nucleosomes where SUV39H methyltransferases use it as a substrate to catalyze histone H3 'Lys-9' trimethylation. Likely to be one of the primary histone methyltransferases along with PRDM16 that direct cytoplasmic H3K9me1 methylation. {ECO:0000250|UniProtKB:P14404}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141635_244620.0697.0Coiled coilOntology_term=ECO:0000255
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416404_513620.0697.0Compositional biasNote=Gln-rich
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416176_248620.0697.0RegionNote=Golgi targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141638_107620.0697.0RegionNote=Golgi targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141680_175620.0697.0RegionNote=Endosome targeting
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-14162_12620.0697.0Topological domainCytoplasmic
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141613_33620.0697.0TransmembraneHelical%3B Signal-anchor for type II membrane protein
TgeneMECOMchr3:167742314chr3:168861620ENST000002646741171065_11161.01117.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000003927360161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004332431171065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004644560151065_111601043.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004687890161065_111601052.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST000004722800161065_111601053.0Compositional biasNote=Asp/Glu-rich (acidic)
TgeneMECOMchr3:167742314chr3:168861620ENST0000026467411778_1901.01117.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000039273601678_19001052.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000043324311778_19001053.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000046445601578_19001043.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000046878901678_19001052.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST0000047228001678_19001053.0DomainSET
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117609_6221.01117.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117741_7451.01117.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117772_7761.01117.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016609_62201052.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016741_74501052.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016772_77601052.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117609_62201053.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117741_74501053.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117772_77601053.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015609_62201043.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015741_74501043.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015772_77601043.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016609_62201052.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016741_74501052.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016772_77601052.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016609_62201053.0MotifNuclear localization signal
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016741_74501053.0MotifCTBP-binding motif 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016772_77601053.0MotifCTBP-binding motif 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117209_2361.01117.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117263_2851.01117.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117291_3131.01117.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117319_3421.01117.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117348_3701.01117.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117376_3981.01117.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117405_4271.01117.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117912_9341.01117.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117940_9631.01117.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000264674117969_9911.01117.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016209_23601052.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016263_28501052.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016291_31301052.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016319_34201052.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016348_37001052.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016376_39801052.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016405_42701052.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016912_93401052.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016940_96301052.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000392736016969_99101052.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117209_23601053.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117263_28501053.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117291_31301053.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117319_34201053.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117348_37001053.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117376_39801053.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117405_42701053.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117912_93401053.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117940_96301053.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000433243117969_99101053.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015209_23601043.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015263_28501043.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015291_31301043.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015319_34201043.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015348_37001043.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015376_39801043.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015405_42701043.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015912_93401043.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015940_96301043.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000464456015969_99101043.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016209_23601052.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016263_28501052.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016291_31301052.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016319_34201052.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016348_37001052.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016376_39801052.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016405_42701052.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016912_93401052.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016940_96301052.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000468789016969_99101052.0Zinc fingerC2H2-type 10
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016209_23601053.0Zinc fingerC2H2-type 1
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016263_28501053.0Zinc fingerC2H2-type 2
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016291_31301053.0Zinc fingerC2H2-type 3
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016319_34201053.0Zinc fingerC2H2-type 4
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016348_37001053.0Zinc fingerC2H2-type 5
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016376_39801053.0Zinc fingerC2H2-type 6
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016405_42701053.0Zinc fingerC2H2-type 7%3B atypical
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016912_93401053.0Zinc fingerC2H2-type 8
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016940_96301053.0Zinc fingerC2H2-type 9
TgeneMECOMchr3:167742314chr3:168861620ENST00000472280016969_99101053.0Zinc fingerC2H2-type 10

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-1416311_681620.0697.0Compositional biasNote=Glu-rich
HgeneGOLIM4chr3:167742314chr3:168861620ENST00000470487-141634_696620.0697.0Topological domainLumenal


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GOLIM4
MECOMall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GOLIM4-MECOM


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GOLIM4-MECOM


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneMECOMC4225221RADIOULNAR SYNOSTOSIS WITH AMEGAKARYOCYTIC THROMBOCYTOPENIA 23GENOMICS_ENGLAND;UNIPROT
TgeneMECOMC0006142Malignant neoplasm of breast1CTD_human
TgeneMECOMC0007102Malignant tumor of colon1CTD_human
TgeneMECOMC0009375Colonic Neoplasms1CTD_human
TgeneMECOMC0023448Lymphoid leukemia1CTD_human
TgeneMECOMC0023466Leukemia, Monocytic, Chronic1CTD_human
TgeneMECOMC0023467Leukemia, Myelocytic, Acute1CTD_human
TgeneMECOMC0023470Myeloid Leukemia1CTD_human
TgeneMECOMC0026998Acute Myeloid Leukemia, M11CTD_human
TgeneMECOMC0027022Myeloproliferative disease1CTD_human
TgeneMECOMC0027439Nasopharyngeal Neoplasms1CTD_human
TgeneMECOMC0030312Pancytopenia1CTD_human
TgeneMECOMC0038002Splenomegaly1CTD_human
TgeneMECOMC0238301Cancer of Nasopharynx1CTD_human
TgeneMECOMC0678222Breast Carcinoma1CTD_human
TgeneMECOMC0919267ovarian neoplasm1CTD_human
TgeneMECOMC1140680Malignant neoplasm of ovary1CTD_human
TgeneMECOMC1257931Mammary Neoplasms, Human1CTD_human
TgeneMECOMC1458155Mammary Neoplasms1CTD_human
TgeneMECOMC1854273Radioulnar Synostosis with Amegakaryocytic Thrombocytopenia1GENOMICS_ENGLAND;ORPHANET
TgeneMECOMC1879321Acute Myeloid Leukemia (AML-M2)1CTD_human
TgeneMECOMC2931456Prostate cancer, familial1CTD_human
TgeneMECOMC4704874Mammary Carcinoma, Human1CTD_human
TgeneMECOMC4722327PROSTATE CANCER, HEREDITARY, 11CTD_human