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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GORAB-DST

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GORAB-DST
FusionPDB ID: 34015
FusionGDB2.0 ID: 34015
HgeneTgene
Gene symbol

GORAB

DST

Gene ID

92344

667

Gene namegolgin, RAB6 interactingdystonin
SynonymsGO|NTKLBP1|SCYL1BP1BP240|BPA|BPAG1|CATX-15|CATX15|D6S1101|DMH|DT|EBSB2|HSAN6|MACF2
Cytomap

1q24.2

6p12.1

Type of geneprotein-codingprotein-coding
DescriptionRAB6-interacting golginN-terminal kinase-like-binding protein 1NTKL-binding protein 1SCY1-like 1-binding protein 1SCYL1-binding protein 1dystoninbullous pemphigoid antigen 1dystonia musculorum proteinhemidesmosomal plaque proteintrabeculin-beta
Modification date2020031320200313
UniProtAcc

Q5T7V8

Q6XUX3

Ensembl transtripts involved in fusion geneENST idsENST00000367763, ENST00000367762, 
ENST00000465717, 		ENST00000244364, 
ENST00000312431, ENST00000361203, 
ENST00000370754, ENST00000370788, 
ENST00000446842, ENST00000340834, 
ENST00000370765, ENST00000518935, 
ENST00000370769, ENST00000421834, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score1 X 1 X 1=117 X 18 X 8=2448
# samples 119
** MAII scorelog2(1/1*10)=3.32192809488736log2(19/2448*10)=-3.6875322343617
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GORAB [Title/Abstract] AND DST [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GORAB(170521415)-DST(56382351), # samples:1
Anticipated loss of major functional domain due to fusion event.GORAB-DST seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GORAB-DST seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GORAB-DST seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GORAB-DST seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneDST

GO:0009611

response to wounding

19403692


check buttonFusion gene breakpoints across GORAB (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across DST (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/ABG952262GORABchr1

170521415

-DSTchr6

56382351

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000367763GORABchr1170521415-ENST00000421834DSTchr656382351+8014192953007060586
ENST00000367763GORABchr1170521415-ENST00000370769DSTchr656382351+8095192953817141586

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000367763ENST00000421834GORABchr1170521415-DSTchr656382351+0.00172120.99827886
ENST00000367763ENST00000370769GORABchr1170521415-DSTchr656382351+0.0017650320.998235

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34015_34015_1_GORAB-DST_GORAB_chr1_170521415_ENST00000367763_DST_chr6_56382351_ENST00000370769_length(amino acids)=586AA_BP=
MGYHMWKICGKFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLL
ISVQSRWEKVVQRLVERGRSLDDARKRAKQTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKEVCAAFEA
KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV
HMVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQHKLEGALLALGQFQHALDELLA
WLTHTEGLLSEQKPVGGDPKAIEIELAKHHQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQAV
FDWVDIAGGKLASMSPIGTDLETVKQQIEELKLNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQTIREEIDGLQEELDIVINLGSELI

--------------------------------------------------------------

>34015_34015_2_GORAB-DST_GORAB_chr1_170521415_ENST00000367763_DST_chr6_56382351_ENST00000421834_length(amino acids)=586AA_BP=
MGYHMWKICGKFHEAWSKLMEWLEESEKSLDSELEIANDPDKIKTQLAQHKVFANEVNSHREQIIELDKTGTHLKYFSQKQDVVLIKNLL
ISVQSRWEKVVQRLVERGRSLDDARKRAKQTKLEEALNLAMEFHNSLQDFINWLTQAEQTLNVASRPSLILDTVLFQIDEHKEVCAAFEA
KEETYKSLMQKGQQMLARCPKSAETNIDQDINNLKEKWESVETKLNERKAKGFHGEIEDLQQWLTDTERHLLASKPLGGLPETAKEQLNV
HMVLQNDVLAHQSTVEAVNKAGNDLIESSAGEEASNLQNKLEVLNQRWQNVLEKTEQRKQQLDGALRQHKLEGALLALGQFQHALDELLA
WLTHTEGLLSEQKPVGGDPKAIEIELAKHHQFKSEAYQQQIEMERLNHQAELLLKKVTEESDKHTVQDPLMELKLIWDSLEERIINRQAV
FDWVDIAGGKLASMSPIGTDLETVKQQIEELKLNSAWDSLNKAWKDRIDKLEEAMQAAVQYQDGLQTIREEIDGLQEELDIVINLGSELI

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:170521415/chr6:56382351)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GORAB

Q5T7V8

DST

Q6XUX3

FUNCTION: Acts as a positive regulator of ERK phosphorylation downstream of fibroblast growth factor-receptor activation (PubMed:23862974, PubMed:28157540). Involved in the regulation of both caspase-dependent apoptosis and caspase-independent cell death (PubMed:15178406). In the skin, it plays a predominant role in suppressing caspase-dependent apoptosis in response to UV stress in a range of dermal cell types (PubMed:28157540). {ECO:0000269|PubMed:15178406, ECO:0000269|PubMed:23862974, ECO:0000269|PubMed:28157540}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847210_722105172.0Calcium binding1
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847246_725705172.0Calcium binding2
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247210_722102650.0Calcium binding1
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247246_725702650.0Calcium binding2
TgeneDSTchr1:170521415chr6:56382351ENST000002443640842394_243105172.0Compositional biasNote=Asp-rich
TgeneDSTchr1:170521415chr6:56382351ENST000002443640842592_259905172.0Compositional biasNote=Poly-Asp
TgeneDSTchr1:170521415chr6:56382351ENST000003707650242394_243102650.0Compositional biasNote=Asp-rich
TgeneDSTchr1:170521415chr6:56382351ENST000003707650242592_259902650.0Compositional biasNote=Poly-Asp
TgeneDSTchr1:170521415chr6:56382351ENST00000244364084151_25505172.0DomainCalponin-homology (CH) 2
TgeneDSTchr1:170521415chr6:56382351ENST0000024436408435_13805172.0DomainCalponin-homology (CH) 1
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847197_723205172.0DomainEF-hand 1
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847233_726805172.0DomainEF-hand 2
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847273_735105172.0DomainGAR
TgeneDSTchr1:170521415chr6:56382351ENST00000244364084887_94405172.0DomainSH3
TgeneDSTchr1:170521415chr6:56382351ENST00000370765024151_25502650.0DomainCalponin-homology (CH) 2
TgeneDSTchr1:170521415chr6:56382351ENST0000037076502435_13802650.0DomainCalponin-homology (CH) 1
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247197_723202650.0DomainEF-hand 1
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247233_726802650.0DomainEF-hand 2
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247273_735102650.0DomainGAR
TgeneDSTchr1:170521415chr6:56382351ENST00000370765024887_94402650.0DomainSH3
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841383_138905172.0MotifNuclear localization signal%3B in isoform 6
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847550_755305172.0MotifNote=Microtubule tip localization signal
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241383_138902650.0MotifNuclear localization signal%3B in isoform 6
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247550_755302650.0MotifNote=Microtubule tip localization signal
TgeneDSTchr1:170521415chr6:56382351ENST0000024436408435_25205172.0RegionNote=Actin-binding
TgeneDSTchr1:170521415chr6:56382351ENST0000037076502435_25202650.0RegionNote=Actin-binding
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841293_142205172.0RepeatNote=Spectrin 3
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841440_154005172.0RepeatNote=Spectrin 4
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841584_162605172.0RepeatNote=Plectin 1
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841660_170305172.0RepeatNote=Plectin 2
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841774_181705172.0RepeatNote=Plectin 3
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841818_185505172.0RepeatNote=Plectin 4
TgeneDSTchr1:170521415chr6:56382351ENST000002443640841856_189105172.0RepeatNote=Plectin 5
TgeneDSTchr1:170521415chr6:56382351ENST000002443640843395_350105172.0RepeatNote=Spectrin 5
TgeneDSTchr1:170521415chr6:56382351ENST000002443640843643_375205172.0RepeatNote=Spectrin 6
TgeneDSTchr1:170521415chr6:56382351ENST000002443640843926_404005172.0RepeatNote=Spectrin 7
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844047_415305172.0RepeatNote=Spectrin 8
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844160_425905172.0RepeatNote=Spectrin 9
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844269_436805172.0RepeatNote=Spectrin 10
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844516_462105172.0RepeatNote=Spectrin 11
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844628_473205172.0RepeatNote=Spectrin 12
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844742_484205172.0RepeatNote=Spectrin 13
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844849_495105172.0RepeatNote=Spectrin 14
TgeneDSTchr1:170521415chr6:56382351ENST000002443640844958_505805172.0RepeatNote=Spectrin 15
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845068_516705172.0RepeatNote=Spectrin 16
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845174_527705172.0RepeatNote=Spectrin 17
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845284_538805172.0RepeatNote=Spectrin 18
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845395_549705172.0RepeatNote=Spectrin 19
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845504_571505172.0RepeatNote=Spectrin 20
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845831_593305172.0RepeatNote=Spectrin 21
TgeneDSTchr1:170521415chr6:56382351ENST000002443640845941_604105172.0RepeatNote=Spectrin 22
TgeneDSTchr1:170521415chr6:56382351ENST00000244364084602_69905172.0RepeatNote=Spectrin 1
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846048_615405172.0RepeatNote=Spectrin 23
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846161_626305172.0RepeatNote=Spectrin 24
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846270_637305172.0RepeatNote=Spectrin 25
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846380_648205172.0RepeatNote=Spectrin 26
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846489_659105172.0RepeatNote=Spectrin 27
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846598_670005172.0RepeatNote=Spectrin 28
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846707_681005172.0RepeatNote=Spectrin 29
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846817_691805172.0RepeatNote=Spectrin 30
TgeneDSTchr1:170521415chr6:56382351ENST000002443640846925_702705172.0RepeatNote=Spectrin 31
TgeneDSTchr1:170521415chr6:56382351ENST00000244364084701_80205172.0RepeatNote=Spectrin 2
TgeneDSTchr1:170521415chr6:56382351ENST000002443640847037_716705172.0RepeatNote=Spectrin 32
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241293_142202650.0RepeatNote=Spectrin 3
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241440_154002650.0RepeatNote=Spectrin 4
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241584_162602650.0RepeatNote=Plectin 1
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241660_170302650.0RepeatNote=Plectin 2
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241774_181702650.0RepeatNote=Plectin 3
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241818_185502650.0RepeatNote=Plectin 4
TgeneDSTchr1:170521415chr6:56382351ENST000003707650241856_189102650.0RepeatNote=Plectin 5
TgeneDSTchr1:170521415chr6:56382351ENST000003707650243395_350102650.0RepeatNote=Spectrin 5
TgeneDSTchr1:170521415chr6:56382351ENST000003707650243643_375202650.0RepeatNote=Spectrin 6
TgeneDSTchr1:170521415chr6:56382351ENST000003707650243926_404002650.0RepeatNote=Spectrin 7
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244047_415302650.0RepeatNote=Spectrin 8
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244160_425902650.0RepeatNote=Spectrin 9
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244269_436802650.0RepeatNote=Spectrin 10
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244516_462102650.0RepeatNote=Spectrin 11
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244628_473202650.0RepeatNote=Spectrin 12
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244742_484202650.0RepeatNote=Spectrin 13
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244849_495102650.0RepeatNote=Spectrin 14
TgeneDSTchr1:170521415chr6:56382351ENST000003707650244958_505802650.0RepeatNote=Spectrin 15
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245068_516702650.0RepeatNote=Spectrin 16
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245174_527702650.0RepeatNote=Spectrin 17
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245284_538802650.0RepeatNote=Spectrin 18
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245395_549702650.0RepeatNote=Spectrin 19
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245504_571502650.0RepeatNote=Spectrin 20
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245831_593302650.0RepeatNote=Spectrin 21
TgeneDSTchr1:170521415chr6:56382351ENST000003707650245941_604102650.0RepeatNote=Spectrin 22
TgeneDSTchr1:170521415chr6:56382351ENST00000370765024602_69902650.0RepeatNote=Spectrin 1
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246048_615402650.0RepeatNote=Spectrin 23
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246161_626302650.0RepeatNote=Spectrin 24
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246270_637302650.0RepeatNote=Spectrin 25
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246380_648202650.0RepeatNote=Spectrin 26
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246489_659102650.0RepeatNote=Spectrin 27
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246598_670002650.0RepeatNote=Spectrin 28
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246707_681002650.0RepeatNote=Spectrin 29
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246817_691802650.0RepeatNote=Spectrin 30
TgeneDSTchr1:170521415chr6:56382351ENST000003707650246925_702702650.0RepeatNote=Spectrin 31
TgeneDSTchr1:170521415chr6:56382351ENST00000370765024701_80202650.0RepeatNote=Spectrin 2
TgeneDSTchr1:170521415chr6:56382351ENST000003707650247037_716702650.0RepeatNote=Spectrin 32

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGORABchr1:170521415chr6:56382351ENST00000367762-14145_2970247.0Coiled coilOntology_term=ECO:0000255
HgeneGORABchr1:170521415chr6:56382351ENST00000367763-15145_2970395.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GORAB
DST


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GORAB-DST


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GORAB-DST


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource