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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AKAP9-TRPS1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AKAP9-TRPS1
FusionPDB ID: 3403
FusionGDB2.0 ID: 3403
HgeneTgene
Gene symbol

AKAP9

TRPS1

Gene ID

10142

7227

Gene nameA-kinase anchoring protein 9transcriptional repressor GATA binding 1
SynonymsAKAP-9|AKAP350|AKAP450|CG-NAP|HYPERION|LQT11|MU-RMS-40.16A|PPP1R45|PRKA9|YOTIAOGC79|LGCR
Cytomap

7q21.2

8q23.3

Type of geneprotein-codingprotein-coding
DescriptionA-kinase anchor protein 9A kinase (PRKA) anchor protein (yotiao) 9A kinase (PRKA) anchor protein 9A-kinase anchor protein 350 kDaA-kinase anchor protein 450 kDaAKAP 120-like proteinAKAP9-BRAF fusion proteincentrosome- and Golgi-localized PKN-associzinc finger transcription factor Trps1tricho-rhino-phalangeal syndrome type I proteintrichorhinophalangeal syndrome Izinc finger protein GC79
Modification date2020032820200313
UniProtAcc

Q99996

.
Ensembl transtripts involved in fusion geneENST idsENST00000356239, ENST00000358100, 
ENST00000359028, ENST00000394564, 
ENST00000491695, 		ENST00000519076, 
ENST00000519674, ENST00000520276, 
ENST00000220888, ENST00000395715, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score17 X 21 X 11=392714 X 16 X 3=672
# samples 2814
** MAII scorelog2(28/3927*10)=-3.80992886572143
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(14/672*10)=-2.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AKAP9 [Title/Abstract] AND TRPS1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AKAP9(91670151)-TRPS1(116616688), # samples:2
Anticipated loss of major functional domain due to fusion event.AKAP9-TRPS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-TRPS1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-TRPS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKAP9-TRPS1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKAP9

GO:0098962

regulation of postsynaptic neurotransmitter receptor activity

10390370

HgeneAKAP9

GO:1903358

regulation of Golgi organization

27666745

TgeneTRPS1

GO:0000122

negative regulation of transcription by RNA polymerase II

12885770|21673316


check buttonFusion gene breakpoints across AKAP9 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TRPS1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAK000948AKAP9chr7

91670151

+TRPS1chr8

116616688

-
ChiTaRS5.0N/AAU117784AKAP9chr7

91670151

+TRPS1chr8

116616688

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000356239AKAP9chr791670151+ENST00000395715TRPS1chr8116616688-12891498620349601585
ENST00000356239AKAP9chr791670151+ENST00000220888TRPS1chr8116616688-8838498620349601585
ENST00000358100AKAP9chr791670151+ENST00000395715TRPS1chr8116616688-12919501419549881597
ENST00000358100AKAP9chr791670151+ENST00000220888TRPS1chr8116616688-8866501419549881597
ENST00000359028AKAP9chr791670151+ENST00000395715TRPS1chr8116616688-12919501419549881597
ENST00000359028AKAP9chr791670151+ENST00000220888TRPS1chr8116616688-8866501419549881597

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000356239ENST00000395715AKAP9chr791670151+TRPS1chr8116616688-0.0003253860.9996747
ENST00000356239ENST00000220888AKAP9chr791670151+TRPS1chr8116616688-0.0009171550.9990828
ENST00000358100ENST00000395715AKAP9chr791670151+TRPS1chr8116616688-0.0003254930.99967456
ENST00000358100ENST00000220888AKAP9chr791670151+TRPS1chr8116616688-0.0009096670.9990903
ENST00000359028ENST00000395715AKAP9chr791670151+TRPS1chr8116616688-0.0003254930.99967456
ENST00000359028ENST00000220888AKAP9chr791670151+TRPS1chr8116616688-0.0009096670.9990903

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3403_3403_1_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000356239_TRPS1_chr8_116616688_ENST00000220888_length(amino acids)=1585AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPE
STIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE
IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA
ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD
KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM
YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL
EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA
ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV
NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE
ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK
SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV
KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL
ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE
LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ
DFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQV
QELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVK
LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE

--------------------------------------------------------------

>3403_3403_2_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000356239_TRPS1_chr8_116616688_ENST00000395715_length(amino acids)=1585AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYINSSQRVESTVIPE
STIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLEMMESELAGKQHE
IEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQASETLRNSTHSSTA
ADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKIIEEEKKTLELKD
KLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQRKLEQLRAELDEM
YGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGLILEEKCALQRQL
EDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKNAVLDRMAESQEA
ELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILEISKLKDLQQSLV
NSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLEDMLKIHTPVSQE
ERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDLEDSKNKQELEYK
SKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQKHGEISFLNEEV
KSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFENMTVGEESKQEQL
ILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKEELIFAQEEKIKE
LQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENEDPELQDYRYEVQ
DFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSLQDLEKTKLEEQV
QELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSGEFGVKEETNIVK
LLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDVKFKEEFKPLSKE

--------------------------------------------------------------

>3403_3403_3_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000358100_TRPS1_chr8_116616688_ENST00000220888_length(amino acids)=1597AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN
SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE
MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS
ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI
IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR
KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL
ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN
AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE
ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE
DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL
EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ
KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN
MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE
ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE
DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL
QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG
EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV

--------------------------------------------------------------

>3403_3403_4_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000358100_TRPS1_chr8_116616688_ENST00000395715_length(amino acids)=1597AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN
SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE
MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS
ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI
IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR
KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL
ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN
AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE
ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE
DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL
EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ
KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN
MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE
ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE
DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL
QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG
EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV

--------------------------------------------------------------

>3403_3403_5_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000359028_TRPS1_chr8_116616688_ENST00000220888_length(amino acids)=1597AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN
SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE
MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS
ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI
IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR
KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL
ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN
AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE
ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE
DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL
EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ
KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN
MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE
ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE
DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL
QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG
EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV

--------------------------------------------------------------

>3403_3403_6_AKAP9-TRPS1_AKAP9_chr7_91670151_ENST00000359028_TRPS1_chr8_116616688_ENST00000395715_length(amino acids)=1597AA_BP=
MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN
SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE
MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS
ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI
IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR
KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL
ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN
AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE
ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE
DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL
EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ
KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN
MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE
ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE
DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL
QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG
EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:91670151/chr8:116616688)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKAP9

Q99996

.
FUNCTION: Scaffolding protein that assembles several protein kinases and phosphatases on the centrosome and Golgi apparatus. Required to maintain the integrity of the Golgi apparatus (PubMed:10202149, PubMed:15047863). Required for microtubule nucleation at the cis-side of the Golgi apparatus (PubMed:15047863, PubMed:19242490). Required for association of the centrosomes with the poles of the bipolar mitotic spindle during metaphase (PubMed:25657325). In complex with PDE4DIP isoform 13/MMG8/SMYLE, recruits CAMSAP2 to the Golgi apparatus and tethers non-centrosomal minus-end microtubules to the Golgi, an important step for polarized cell movement (PubMed:27666745, PubMed:28814570). In complex with PDE4DIP isoform 13/MMG8/SMYLE, EB1/MAPRE1 and CDK5RAP2, contributes to microtubules nucleation and extension also from the centrosome to the cell periphery (PubMed:29162697). {ECO:0000269|PubMed:10202149, ECO:0000269|PubMed:15047863, ECO:0000269|PubMed:19242490, ECO:0000269|PubMed:25657325, ECO:0000269|PubMed:27666745, ECO:0000269|PubMed:28814570, ECO:0000269|PubMed:29162697}.; FUNCTION: [Isoform 4]: Associated with the N-methyl-D-aspartate receptor and is specifically found in the neuromuscular junction (NMJ) as well as in neuronal synapses, suggesting a role in the organization of postsynaptic specializations. {ECO:0000269|PubMed:9482789}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTRPS1chr7:91670151chr8:116616688ENST00000220888061163_128101282.0RegionTranscriptional repressor domain
TgeneTRPS1chr7:91670151chr8:116616688ENST00000395715071163_128101295.0RegionTranscriptional repressor domain
TgeneTRPS1chr7:91670151chr8:116616688ENST00000520276061163_128101286.0RegionTranscriptional repressor domain
TgeneTRPS1chr7:91670151chr8:116616688ENST00000220888061215_123701282.0Zinc fingerC2H2-type 6
TgeneTRPS1chr7:91670151chr8:116616688ENST00000220888061243_126701282.0Zinc fingerC2H2-type 7
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806222_24701282.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806333_35801282.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806614_63701282.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806666_68901282.0Zinc fingerC2H2-type 4
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806692_71501282.0Zinc fingerC2H2-type 5
TgeneTRPS1chr7:91670151chr8:116616688ENST0000022088806896_92001282.0Zinc fingerGATA-type
TgeneTRPS1chr7:91670151chr8:116616688ENST00000395715071215_123701295.0Zinc fingerC2H2-type 6
TgeneTRPS1chr7:91670151chr8:116616688ENST00000395715071243_126701295.0Zinc fingerC2H2-type 7
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507222_24701295.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507333_35801295.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507614_63701295.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507666_68901295.0Zinc fingerC2H2-type 4
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507692_71501295.0Zinc fingerC2H2-type 5
TgeneTRPS1chr7:91670151chr8:116616688ENST0000039571507896_92001295.0Zinc fingerGATA-type
TgeneTRPS1chr7:91670151chr8:116616688ENST00000520276061215_123701286.0Zinc fingerC2H2-type 6
TgeneTRPS1chr7:91670151chr8:116616688ENST00000520276061243_126701286.0Zinc fingerC2H2-type 7
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606222_24701286.0Zinc fingerC2H2-type 1%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606333_35801286.0Zinc fingerC2H2-type 2%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606614_63701286.0Zinc fingerC2H2-type 3%3B atypical
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606666_68901286.0Zinc fingerC2H2-type 4
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606692_71501286.0Zinc fingerC2H2-type 5
TgeneTRPS1chr7:91670151chr8:116616688ENST0000052027606896_92001286.0Zinc fingerGATA-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501088_117303908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501241_126803908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501324_138003908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501422_144703908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+150152_90203908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501573_164703908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501845_244303908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1502532_254903908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1502591_276403908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1503061_308803908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1503120_346603908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1503583_368503908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+150932_101003908.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491088_117303858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491241_126803858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491324_138003858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491422_144703858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+149152_90203858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491573_164703858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491845_244303858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1492532_254903858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1492591_276403858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1493061_308803858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1493120_346603858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1493583_368503858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+149932_101003858.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501088_117303912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501241_126803912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501324_138003912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501422_144703912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+150152_90203912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501573_164703912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501845_244303912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1502532_254903912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1502591_276403912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1503061_308803912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1503120_346603912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1503583_368503912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+150932_101003912.0Coiled coilOntology_term=ECO:0000255
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1501834_276003908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+150191_28003908.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+150309_99803908.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1503722_372603908.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1491834_276003858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+149191_28003858.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+149309_99803858.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1493722_372603858.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1501834_276003912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+150191_28003912.0Compositional biasNote=Gln-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+150309_99803912.0Compositional biasNote=Glu-rich
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1503722_372603912.0Compositional biasNote=Poly-Leu
HgeneAKAP9chr7:91670151chr8:116616688ENST00000356239+1502542_255503908.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91670151chr8:116616688ENST00000358100+1492542_255503858.0RegionNote=PKA-RII subunit binding domain
HgeneAKAP9chr7:91670151chr8:116616688ENST00000359028+1502542_255503912.0RegionNote=PKA-RII subunit binding domain


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>2098_AKAP9_91670151_TRPS1_116616688_ranked_0.pdbAKAP99167015191670151ENST00000220888TRPS1chr8116616688-
MFSPAFLAEAMEDEERQKKLEAGKAKIEELSLAFLVRQLAQFRQRKAQSDGQSPSKKQKKKRKTSSSKHDVSAHHDLNIDQSQCNEMYIN
SSQRVESTVIPESTIMRTLHSGEITSHEQGFSVELESEISTTADDCSSEVNGCSFVMRTGKPTNLLREEEFGVDDSYSEQGAQDSPTHLE
MMESELAGKQHEIEELNRELEEMRVTYGTEGLQQLQEFEAAIKQRDGIITQLTANLQQARREKDETMREFLELTEQSQKLQIQFQQLQAS
ETLRNSTHSSTAADLLQAKQQILTHQQQLEEQDHLLEDYQKKKEDFTMQISFLQEKIKVYEMEQDKKVENSNKEEIQEKETIIEELNTKI
IEEEKKTLELKDKLTTADKLLGELQEQIVQKNQEIKNMKLELTNSKQKERQSSEEIKQLMGTVEELQKRNHKDSQFETDIVQRMEQETQR
KLEQLRAELDEMYGQQIVQMKQELIRQHMAQMEEMKTRHKGEMENALRSYSNITVNEDQIKLMNVAINELNIKLQDTNSQKEKLKEELGL
ILEEKCALQRQLEDLVEELSFSREQIQRARQTIAEQESKLNEAHKSLSTVEDLKAEIVSASESRKELELKHEAEVTNYKIKLEMLEKEKN
AVLDRMAESQEAELERLRTQLLFSHEEELSKLKEDLEIEHRINIEKLKDNLGIHYKQQIDGLQNEMSQKIETMQFEKDNLITKQNQLILE
ISKLKDLQQSLVNSKSEEMTLQINELQKEIEILRQEEKEKGTLEQEVQELQLKTELLEKQMKEKENDLQEKFAQLEAENSILKDEKKTLE
DMLKIHTPVSQEERLIFLDSIKSKSKDSVWEKEIEILIEENEDLKQQCIQLNEEIEKQRNTFSFAEKNFEVNYQELQEEYACLLKVKDDL
EDSKNKQELEYKSKLKALNEELHLQRINPTTVKMKSSVFDEDKTFVAETLEMGEVVEKDTTELMEKLEVTKREKLELSQRLSDLSEQLKQ
KHGEISFLNEEVKSLKQEKEQVSLRCRELEIIINHNRAENVQSCDTQVSSLLDGVVTMTSRGAEGSVSKVNKSFGEESKIMVEDKVSFEN
MTVGEESKQEQLILDHLPSVTKESSLRATQPSENDKLQKELNVLKSEQNDLRLQMEAQRICLSLVYSTHVDQVREYMENEKDKALCSLKE
ELIFAQEEKIKELQKIHQLELQTMKTQETGDEGKPLHLLIGKLQKAVSEECSYFLQTLCSVLGEYYTPALKCEVNAEDKENSGDYISENE
DPELQDYRYEVQDFQENMHTLLNKVTEEYNKLLVLQTRLSKIWGQQTDGMKLEFGEENLPKEETEFLSIHSQMTNLEDIDVNHKSKLSSL
QDLEKTKLEEQVQELESLISSLQQQLKETEQNYEAEIHCLQKRLQAVSESTVPPSLPVDSVVITESDAQRTMYPGSCVKKNIDGTIEFSG
EFGVKEETNIVKLLEKQYQEQLEEEVAKVIVSMSIAFAQQTELSRISGGKENTASSKQAHAVCQQEQHYFNEMKLSQDQIGFQTFETVDV
1597


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
AKAP9_pLDDT.png
all structure
all structure
TRPS1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
AKAP9TACC3, FNBP1, TRIP10, PRKAR2A, KCNQ1, CLIC1, CALM2, CALM1, TUBGCP3, PKN1, Csnk1d, Csnk1e, CSNK1E, CSNK1D, PMS1, CDC5L, DISC1, TNIK, CEBPA, CCNE1, TSG101, gag-pol, CDK5RAP2, KDM1A, TDP2, PCNT, GSK3A, RASSF2, SUV39H2, PRKACA, PRKACB, MAGEA6, HNRNPM, SSX2, BLZF1, USO1, MAGED1, IKZF3, WAC, THAP1, PRDM14, USHBP1, C1orf94, SAMD3, SUZ12, RNF2, BMI1, ROPN1L, MAPRE1, CEP170, CCDC68, PRKAR2B, HERC2, GPC4, DYNLL1, HUWE1, FGFR1OP, THOC2, CEP170P1, Mapre1, Prkacb, Prkar2a, Prkar2b, Uso1, Fgfr1op, Cdk5rap2, PCGF1, NANOG, ATOH1, TPTE2, PDE4DIP, PRKACG, C1orf87, DNAJC10, BIRC6, TPM2, HEY1, PPIE, RBM14, PCM1, RPA2, KIF19, GTSE1, PARD6G, KLC4, CASK, PRC1, FMR1, CTBP1, RBM10, NDEL1, SF3B2, MED1, SLAIN1, FXR2, YWHAE, AKAP9, PKP2, MYO5A, DVL2, AGR2, KIAA1429, nsp13, VPS9D1, THOC1, RSRC2, SNRPB, GLIS2, BEX2, CCDC146, ABI2, FAM46B, SNF8, CCDC116, SCNM1, TLX3, SSX5, SSX3, LMO1, FAM90A1, TCEANC, CTNNA3, HDDC3, PTPN6, HNRNPC, HMGA1, RFC5, HSPD1, DHX9, HNRNPCL2, VDAC2, NONO, SMC3, nsp16, ORF6, TULP3, CIT, KIF14, MTX2, nsp13ab, HDAC1, ACBD5, AP2B1, CAMSAP2, CEP135, DCTN2, GOLGA2, IMPDH2, KRT19, KRT8, LATS1, MAPRE3, NDC80, PFN1, PXN, SEPT10, STIL, LOC338797, CTCFL, EFCAB1, SOGA1, OR10H1, STK11, PIGF, SYCE1, WHAMMP3, COQ3, RAMP1, ABCF3, RNF145, DDX55, DYNLL2, SLU7, BRK1, ZBTB44, FTSJ3, CCDC71, VDR, BNIP1, LINC00346, CEP57, ZNF252P-AS1, CARD9, NDUFAF1, ROPN1, NOLC1,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AKAP9all structure
TRPS1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AKAP9-TRPS1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AKAP9-TRPS1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
HgeneAKAP9C2678483Long Qt Syndrome 114CLINGEN;CTD_human;GENOMICS_ENGLAND;UNIPROT
HgeneAKAP9C0035828Romano-Ward Syndrome1ORPHANET
HgeneAKAP9C0037274Dermatologic disorders1CTD_human
HgeneAKAP9C0274861Arsenic Poisoning, Inorganic1CTD_human
HgeneAKAP9C0274862Nervous System, Organic Arsenic Poisoning1CTD_human
HgeneAKAP9C0311375Arsenic Poisoning1CTD_human
HgeneAKAP9C0751851Arsenic Encephalopathy1CTD_human
HgeneAKAP9C0751852Arsenic Induced Polyneuropathy1CTD_human
HgeneAKAP9C1142166Brugada Syndrome (disorder)1ORPHANET