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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GPC3-C2CD5

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GPC3-C2CD5
	FusionPDB ID: 34166
	FusionGDB2.0 ID: 34166
		Hgene	Tgene
	Gene symbol	GPC3	C2CD5
	Gene ID	2719	9847
	Gene name	glypican 3	C2 calcium dependent domain containing 5
	Synonyms	DGSX\|GTR2-2\|MXR7\|OCI-5\|SDYS\|SGB\|SGBS\|SGBS1	CDP138\|KIAA0528
	Cytomap	Xq26.2	12p12.1
	Type of gene	protein-coding	protein-coding
	Description	glypican-3glypican proteoglycan 3heparan sulphate proteoglycanintestinal protein OCI-5secreted glypican-3	C2 domain-containing protein 5138 kDa C2 domain-containing phosphoprotein
	Modification date	20200315	20200313
	UniProtAcc	P51654	Q86YS7
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000370818, ENST00000394299, ENST00000543339,	ENST00000540703, ENST00000333957, ENST00000396028, ENST00000446597, ENST00000536386, ENST00000542676, ENST00000544930, ENST00000545552,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 8 X 4=288	8 X 8 X 4=256
	# samples	10	8
	** MAII score	log2(10/288*10)=-1.52606881166759 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GPC3 [Title/Abstract] AND C2CD5 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GPC3(133087077)-C2CD5(22666313), # samples:1
Anticipated loss of major functional domain due to fusion event.	GPC3-C2CD5 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPC3-C2CD5 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPC3	GO:0060828	regulation of canonical Wnt signaling pathway	14610063
Hgene	GPC3	GO:0090263	positive regulation of canonical Wnt signaling pathway	24496449
Hgene	GPC3	GO:2000050	regulation of non-canonical Wnt signaling pathway	14610063
Tgene	C2CD5	GO:0032869	cellular response to insulin stimulus	21907143

Fusion gene breakpoints across GPC3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across C2CD5 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315374	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000370818	GPC3	chrX	133087077	-	ENST00000333957	C2CD5	chr12	22666313	-	4011	783	365	2833	822
ENST00000370818	GPC3	chrX	133087077	-	ENST00000446597	C2CD5	chr12	22666313	-	3202	783	365	2986	873
ENST00000370818	GPC3	chrX	133087077	-	ENST00000536386	C2CD5	chr12	22666313	-	3235	783	365	3019	884
ENST00000370818	GPC3	chrX	133087077	-	ENST00000396028	C2CD5	chr12	22666313	-	3202	783	365	2986	873
ENST00000370818	GPC3	chrX	133087077	-	ENST00000542676	C2CD5	chr12	22666313	-	3166	783	365	2986	873
ENST00000370818	GPC3	chrX	133087077	-	ENST00000544930	C2CD5	chr12	22666313	-	3127	783	365	3022	885
ENST00000370818	GPC3	chrX	133087077	-	ENST00000545552	C2CD5	chr12	22666313	-	3127	783	365	3022	885
ENST00000394299	GPC3	chrX	133087077	-	ENST00000333957	C2CD5	chr12	22666313	-	3762	534	116	2584	822
ENST00000394299	GPC3	chrX	133087077	-	ENST00000446597	C2CD5	chr12	22666313	-	2953	534	116	2737	873
ENST00000394299	GPC3	chrX	133087077	-	ENST00000536386	C2CD5	chr12	22666313	-	2986	534	116	2770	884
ENST00000394299	GPC3	chrX	133087077	-	ENST00000396028	C2CD5	chr12	22666313	-	2953	534	116	2737	873
ENST00000394299	GPC3	chrX	133087077	-	ENST00000542676	C2CD5	chr12	22666313	-	2917	534	116	2737	873
ENST00000394299	GPC3	chrX	133087077	-	ENST00000544930	C2CD5	chr12	22666313	-	2878	534	116	2773	885
ENST00000394299	GPC3	chrX	133087077	-	ENST00000545552	C2CD5	chr12	22666313	-	2878	534	116	2773	885

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000370818	ENST00000333957	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.000308623	0.99969137
ENST00000370818	ENST00000446597	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001312983	0.99868697
ENST00000370818	ENST00000536386	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001272987	0.998727
ENST00000370818	ENST00000396028	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001312983	0.99868697
ENST00000370818	ENST00000542676	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001390551	0.9986094
ENST00000370818	ENST00000544930	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001106923	0.9988931
ENST00000370818	ENST00000545552	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001106923	0.9988931
ENST00000394299	ENST00000333957	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.000274166	0.99972576
ENST00000394299	ENST00000446597	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001147115	0.99885285
ENST00000394299	ENST00000536386	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001129003	0.998871
ENST00000394299	ENST00000396028	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001147115	0.99885285
ENST00000394299	ENST00000542676	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.001225674	0.99877435
ENST00000394299	ENST00000544930	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.000964881	0.9990351
ENST00000394299	ENST00000545552	GPC3	chrX	133087077	-	C2CD5	chr12	22666313	-	0.000964881	0.9990351

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34166_34166_1_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000333957_length(amino acids)=822AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMF
FIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESDLEVVSSQQPTTN

--------------------------------------------------------------

>34166_34166_2_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000396028_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_3_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000446597_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_4_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000536386_length(amino acids)=884AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQRGGSPHRFCRRRE
FPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLN
PRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQA
EANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKK
INDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSC
NTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFD
KNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQT
IRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAM

--------------------------------------------------------------

>34166_34166_5_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000542676_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_6_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000544930_length(amino acids)=885AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCI
LSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQA
RLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGS
YEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLT
DVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQ
VTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRDRCSSWIELIKLKAQ
TIRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFA

--------------------------------------------------------------

>34166_34166_7_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000370818_C2CD5_chr12_22666313_ENST00000545552_length(amino acids)=885AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCI
LSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQA
RLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGS
YEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLT
DVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQ
VTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRDRCSSWIELIKLKAQ
TIRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFA

--------------------------------------------------------------

>34166_34166_8_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000333957_length(amino acids)=822AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKAMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMF
FIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGNAVVSYIMKQCVFMENPNKNQAQCLINVSGDAVVFVRESDLEVVSSQQPTTN

--------------------------------------------------------------

>34166_34166_9_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000396028_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_10_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000446597_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_11_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000536386_length(amino acids)=884AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQRGGSPHRFCRRRE
FPFFTLTAFPPGFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLN
PRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQA
EANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKK
INDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSC
NTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFD
KNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQT
IRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAM

--------------------------------------------------------------

>34166_34166_12_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000542676_length(amino acids)=873AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCILSASGTAAVLNPRFLQDGTVEG
CLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQARLCRLKKKAQAEANATAISNLL
PFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGSYEQHISHMQKKINDTIAKNKEL
YEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLTDVPPPSGFYSCNTEIMPGINNW
TSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQVTVTAVAITFDKNQALQTTKTP
VEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRATSVDYSSFADRCSSWIELIKLKAQTIRRGSIKTTMT
VEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFAMVRAHVAALGGN

--------------------------------------------------------------

>34166_34166_13_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000544930_length(amino acids)=885AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCI
LSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQA
RLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGS
YEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLT
DVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQ
VTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRDRCSSWIELIKLKAQ
TIRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFA

--------------------------------------------------------------

>34166_34166_14_GPC3-C2CD5_GPC3_chrX_133087077_ENST00000394299_C2CD5_chr12_22666313_ENST00000545552_length(amino acids)=885AA_BP=139
MPGLPSPGTALAPAATLPRSPSSLRSRMAGTVRTACLVVAMLLSLDFPGQAQPPPPPPDATCHQVRSFFQRLQPGLKWVPETPVPGSDLQ
VCLPKGPTCCSRKMEEKYQLTARLNMEQLLQSASMELKFLIIQNAAVFQGMGSGSAGKEGGPFKALLRQQTQSALEQREFPFFTLTAFPP
GFLVHVGGVVSARSVKLLDRIHNPAFVGIMGNTRSYKLLDWNSFNSDEPETRDAWWAEIRQEIKSHAKALGCHAVVGYSESTSICEEVCI
LSASGTAAVLNPRFLQDGTVEGCLEQRLEENLPTRCGFCHIPYDELNMPFPAHLTYCYNCRKQKVPDVLFTTIDLPTDATVIGKGCLIQA
RLCRLKKKAQAEANATAISNLLPFMEYEVHTQLMNKLKLKGMNALFGLRIQITVGENMLMGLASATGVYLAALPTPGGIQIAGKTPNDGS
YEQHISHMQKKINDTIAKNKELYEINPPEISEEIIGSPIPEPRQRSRLLRSQSESSDEVTELDLSHGKKDAFVLEIDDTDAMEDVHSLLT
DVPPPSGFYSCNTEIMPGINNWTSEIQMFTSVRVIRLSSLNLTNQALNKNFNDLCENLLKSLYFKLRSMIPCCLCHVNFTVSLPEDELIQ
VTVTAVAITFDKNQALQTTKTPVEKSLQRASTDNEELLQFPLELCSDSLPSHPFPPAKEHLESASSNSGIPAAQRDRCSSWIELIKLKAQ
TIRRGSIKTTMTVEKASPVGDGNFRNRSAPPCANSTVGVVKMTPLSFIPGAKITKYLGIINMFFIRETTSLREEGGVSGFLHAFIAEVFA

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chrX:133087077/chr12:22666313)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPC3 P51654	C2CD5 Q86YS7
FUNCTION: Cell surface proteoglycan that bears heparan sulfate (PubMed:14610063). Negatively regulates the hedgehog signaling pathway when attached via the GPI-anchor to the cell surface by competing with the hedgehog receptor PTC1 for binding to hedgehog proteins (By similarity). Binding to the hedgehog protein SHH triggers internalization of the complex by endocytosis and its subsequent lysosomal degradation (By similarity). Positively regulates the canonical Wnt signaling pathway by binding to the Wnt receptor Frizzled and stimulating the binding of the Frizzled receptor to Wnt ligands (PubMed:16227623, PubMed:24496449). Positively regulates the non-canonical Wnt signaling pathway (By similarity). Binds to CD81 which decreases the availability of free CD81 for binding to the transcriptional repressor HHEX, resulting in nuclear translocation of HHEX and transcriptional repression (By similarity). Inhibits the dipeptidyl peptidase activity of DPP4 (PubMed:17549790). Plays a role in limb patterning and skeletal development by controlling the cellular response to BMP4 (By similarity). Modulates the effects of growth factors BMP2, BMP7 and FGF7 on renal branching morphogenesis (By similarity). Required for coronary vascular development (By similarity). Plays a role in regulating cell movements during gastrulation (By similarity). {ECO:0000250\|UniProtKB:Q6V9Y8, ECO:0000250\|UniProtKB:Q8CFZ4, ECO:0000269\|PubMed:14610063, ECO:0000269\|PubMed:16227623, ECO:0000269\|PubMed:17549790, ECO:0000269\|PubMed:24496449}.	FUNCTION: Required for insulin-stimulated glucose transport and glucose transporter SLC2A4/GLUT4 translocation from intracellular glucose storage vesicle (GSV) to the plasma membrane (PM) in adipocytes. Binds phospholipid membranes in a calcium-dependent manner and is necessary for the optimal membrane fusion between SLC2A4/GLUT4 GSV and the PM. {ECO:0000269\|PubMed:21907143}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000333957

13_27

317.3333333333333

1001.0

Calcium binding

Note=1%3B low affinity

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000333957

75_86

317.3333333333333

1001.0

Calcium binding

Note=2%3B high affinity

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000396028

13_27

308.3333333333333

1043.0

Calcium binding

Note=1%3B low affinity

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000396028

75_86

308.3333333333333

1043.0

Calcium binding

Note=2%3B high affinity

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000333957

1_109

317.3333333333333

1001.0

Domain

Tgene

C2CD5

chrX:133087077

chr12:22666313

ENST00000396028

1_109

308.3333333333333

1043.0

Domain

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GPC3
C2CD5

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to GPC3-C2CD5

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to GPC3-C2CD5

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source