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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GPD2-NR4A2

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GPD2-NR4A2
FusionPDB ID: 34229
FusionGDB2.0 ID: 34229
HgeneTgene
Gene symbol

GPD2

NR4A2

Gene ID

2820

4929

Gene nameglycerol-3-phosphate dehydrogenase 2nuclear receptor subfamily 4 group A member 2
SynonymsGDH2|GPDM|mGPDHHZF-3|NOT|NURR1|RNR1|TINUR
Cytomap

2q24.1

2q24.1

Type of geneprotein-codingprotein-coding
Descriptionglycerol-3-phosphate dehydrogenase, mitochondrialGPD-MGPDH-Mglycerol-3-phosphate dehydrogenase 2 (mitochondrial)mitochondrial glycerophosphate dehydrogenasemtGPDtesticular tissue protein Li 76nuclear receptor subfamily 4 group A member 2NGFI-B/nur77 beta-type transcription factor homologT-cell nuclear receptor NOTimmediate-early response protein NOTintermediate-early receptor proteinnuclear receptor related 1nur related protein-1, human
Modification date2020031320200313
UniProtAcc

P43304

P43354

Ensembl transtripts involved in fusion geneENST idsENST00000409125, ENST00000310454, 
ENST00000409674, ENST00000438166, 
ENST00000540309, ENST00000496190, 
ENST00000339562, ENST00000409108, 
ENST00000409572, ENST00000426264, 
ENST00000429376, ENST00000539077, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score6 X 6 X 4=1444 X 6 X 3=72
# samples 75
** MAII scorelog2(7/144*10)=-1.04064198449735
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(5/72*10)=-0.526068811667588
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GPD2 [Title/Abstract] AND NR4A2 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GPD2(157332719)-NR4A2(157182840), # samples:3
NR4A2(157187180)-GPD2(157332610), # samples:3
Anticipated loss of major functional domain due to fusion event.GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GPD2-NR4A2 seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneNR4A2

GO:0006351

transcription, DNA-templated

17184956

TgeneNR4A2

GO:0031668

cellular response to extracellular stimulus

7877627


check buttonFusion gene breakpoints across GPD2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NR4A2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-HD-A634-01AGPD2chr2

157332719

+NR4A2chr2

157182512

-
ChimerDB4HNSCTCGA-HD-A634GPD2chr2

157332719

+NR4A2chr2

157182512

-
ChimerDB4HNSCTCGA-HD-A634GPD2chr2

157332719

+NR4A2chr2

157182840

-
ChimerDB4HNSCTCGA-HD-A634GPD2chr2

157332719

+NR4A2chr2

157183432

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000310454GPD2chr2157332719+ENST00000409572NR4A2chr2157182512-1377474299730143
ENST00000310454GPD2chr2157332719+ENST00000539077NR4A2chr2157182512-1164474299730143
ENST00000310454GPD2chr2157332719+ENST00000429376NR4A2chr2157182512-731474299730144
ENST00000438166GPD2chr2157332719+ENST00000409572NR4A2chr2157182512-113823536491151
ENST00000438166GPD2chr2157332719+ENST00000539077NR4A2chr2157182512-92523536491151
ENST00000438166GPD2chr2157332719+ENST00000429376NR4A2chr2157182512-49223536491151
ENST00000540309GPD2chr2157332719+ENST00000409572NR4A2chr2157182512-1042139569880103
ENST00000540309GPD2chr2157332719+ENST00000539077NR4A2chr2157182512-82913956982686
ENST00000540309GPD2chr2157332719+ENST00000429376NR4A2chr2157182512-39613911636482
ENST00000409674GPD2chr2157332719+ENST00000409572NR4A2chr2157182512-1078175605916103
ENST00000409674GPD2chr2157332719+ENST00000539077NR4A2chr2157182512-86517560586286
ENST00000409674GPD2chr2157332719+ENST00000429376NR4A2chr2157182512-4321752831190
ENST00000310454GPD2chr2157332719+ENST00000339562NR4A2chr2157183432-24254743721112246
ENST00000310454GPD2chr2157332719+ENST00000426264NR4A2chr2157183432-17754743721112246
ENST00000310454GPD2chr2157332719+ENST00000409572NR4A2chr2157183432-17594743721112246
ENST00000310454GPD2chr2157332719+ENST00000539077NR4A2chr2157183432-15464743721112246
ENST00000310454GPD2chr2157332719+ENST00000409108NR4A2chr2157183432-1009474372977201
ENST00000310454GPD2chr2157332719+ENST00000429376NR4A2chr2157183432-1009474372977201
ENST00000438166GPD2chr2157332719+ENST00000339562NR4A2chr2157183432-2186235133873246
ENST00000438166GPD2chr2157332719+ENST00000426264NR4A2chr2157183432-1536235133873246
ENST00000438166GPD2chr2157332719+ENST00000409572NR4A2chr2157183432-1520235133873246
ENST00000438166GPD2chr2157332719+ENST00000539077NR4A2chr2157183432-1307235133873246
ENST00000438166GPD2chr2157332719+ENST00000409108NR4A2chr2157183432-770235133738201
ENST00000438166GPD2chr2157332719+ENST00000429376NR4A2chr2157183432-770235133738201
ENST00000540309GPD2chr2157332719+ENST00000339562NR4A2chr2157183432-209013937777246
ENST00000540309GPD2chr2157332719+ENST00000426264NR4A2chr2157183432-144013937777246
ENST00000540309GPD2chr2157332719+ENST00000409572NR4A2chr2157183432-142413937777246
ENST00000540309GPD2chr2157332719+ENST00000539077NR4A2chr2157183432-121113937777246
ENST00000540309GPD2chr2157332719+ENST00000409108NR4A2chr2157183432-67413937642201
ENST00000540309GPD2chr2157332719+ENST00000429376NR4A2chr2157183432-67413937642201
ENST00000409674GPD2chr2157332719+ENST00000339562NR4A2chr2157183432-212617573813246
ENST00000409674GPD2chr2157332719+ENST00000426264NR4A2chr2157183432-147617573813246
ENST00000409674GPD2chr2157332719+ENST00000409572NR4A2chr2157183432-146017573813246
ENST00000409674GPD2chr2157332719+ENST00000539077NR4A2chr2157183432-124717573813246
ENST00000409674GPD2chr2157332719+ENST00000409108NR4A2chr2157183432-71017573678201
ENST00000409674GPD2chr2157332719+ENST00000429376NR4A2chr2157183432-71017573678201

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000310454ENST00000409572GPD2chr2157332719+NR4A2chr2157182512-0.775053140.22494683
ENST00000310454ENST00000539077GPD2chr2157332719+NR4A2chr2157182512-0.62596950.37403047
ENST00000310454ENST00000429376GPD2chr2157332719+NR4A2chr2157182512-0.54649230.45350772
ENST00000438166ENST00000409572GPD2chr2157332719+NR4A2chr2157182512-0.80180440.19819555
ENST00000438166ENST00000539077GPD2chr2157332719+NR4A2chr2157182512-0.670367060.32963294
ENST00000438166ENST00000429376GPD2chr2157332719+NR4A2chr2157182512-0.58304420.41695583
ENST00000540309ENST00000409572GPD2chr2157332719+NR4A2chr2157182512-0.89184990.10815013
ENST00000540309ENST00000539077GPD2chr2157332719+NR4A2chr2157182512-0.82030180.17969821
ENST00000540309ENST00000429376GPD2chr2157332719+NR4A2chr2157182512-0.734393660.2656063
ENST00000409674ENST00000409572GPD2chr2157332719+NR4A2chr2157182512-0.87260060.1273994
ENST00000409674ENST00000539077GPD2chr2157332719+NR4A2chr2157182512-0.66290260.33709738
ENST00000409674ENST00000429376GPD2chr2157332719+NR4A2chr2157182512-0.63681570.36318427
ENST00000310454ENST00000339562GPD2chr2157332719+NR4A2chr2157183432-0.0015244340.9984756
ENST00000310454ENST00000426264GPD2chr2157332719+NR4A2chr2157183432-0.0038381240.9961618
ENST00000310454ENST00000409572GPD2chr2157332719+NR4A2chr2157183432-0.0040389610.995961
ENST00000310454ENST00000539077GPD2chr2157332719+NR4A2chr2157183432-0.003915720.9960842
ENST00000310454ENST00000409108GPD2chr2157332719+NR4A2chr2157183432-0.024037450.9759626
ENST00000310454ENST00000429376GPD2chr2157332719+NR4A2chr2157183432-0.024037450.9759626
ENST00000438166ENST00000339562GPD2chr2157332719+NR4A2chr2157183432-0.0015088290.99849117
ENST00000438166ENST00000426264GPD2chr2157332719+NR4A2chr2157183432-0.0034928220.9965071
ENST00000438166ENST00000409572GPD2chr2157332719+NR4A2chr2157183432-0.0037532420.99624676
ENST00000438166ENST00000539077GPD2chr2157332719+NR4A2chr2157183432-0.0036632510.9963367
ENST00000438166ENST00000409108GPD2chr2157332719+NR4A2chr2157183432-0.0232037640.97679627
ENST00000438166ENST00000429376GPD2chr2157332719+NR4A2chr2157183432-0.0232037640.97679627
ENST00000540309ENST00000339562GPD2chr2157332719+NR4A2chr2157183432-0.0014617310.99853826
ENST00000540309ENST00000426264GPD2chr2157332719+NR4A2chr2157183432-0.0030692730.9969308
ENST00000540309ENST00000409572GPD2chr2157332719+NR4A2chr2157183432-0.0032858080.99671423
ENST00000540309ENST00000539077GPD2chr2157332719+NR4A2chr2157183432-0.0026683030.99733174
ENST00000540309ENST00000409108GPD2chr2157332719+NR4A2chr2157183432-0.0182663460.9817337
ENST00000540309ENST00000429376GPD2chr2157332719+NR4A2chr2157183432-0.0182663460.9817337
ENST00000409674ENST00000339562GPD2chr2157332719+NR4A2chr2157183432-0.0012409190.99875903
ENST00000409674ENST00000426264GPD2chr2157332719+NR4A2chr2157183432-0.0025346780.9974654
ENST00000409674ENST00000409572GPD2chr2157332719+NR4A2chr2157183432-0.0026665140.9973335
ENST00000409674ENST00000539077GPD2chr2157332719+NR4A2chr2157183432-0.001967970.99803203
ENST00000409674ENST00000409108GPD2chr2157332719+NR4A2chr2157183432-0.010732530.9892674
ENST00000409674ENST00000429376GPD2chr2157332719+NR4A2chr2157183432-0.010732530.9892674

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34229_34229_1_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157182512_ENST00000409572_length(amino acids)=143AA_BP=59
MPAGRYRVGEARSQGGQREVVRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKDHVTFNNGG

--------------------------------------------------------------

>34229_34229_2_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157182512_ENST00000429376_length(amino acids)=144AA_BP=59
MPAGRYRVGEARSQGGQREVVRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKDHVTFNNGG

--------------------------------------------------------------

>34229_34229_3_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157182512_ENST00000539077_length(amino acids)=143AA_BP=59
MPAGRYRVGEARSQGGQREVVRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKDHVTFNNGG

--------------------------------------------------------------

>34229_34229_4_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000339562_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_5_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000409108_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_6_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000409572_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_7_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000426264_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_8_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000429376_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_9_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000310454_NR4A2_chr2_157183432_ENST00000539077_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_10_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157182512_ENST00000409572_length(amino acids)=103AA_BP=
MLLFPNLQAEPERAFWLRGILDLEHGLHTIQWYKLFILSLKISLLFRRKIAIMYNGKCLAMLGCCSSDKCNTHTHTHTHTHTETHLKGTH

--------------------------------------------------------------

>34229_34229_11_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157182512_ENST00000429376_length(amino acids)=90AA_BP=1
MGRFNPPLLKVTWSLRQFTILFCSSSTLLGSLSPCLFVSFCNEQTEKVLKQLQEHLLQQESSLSLPFEMPFLSLKQRTCLTHSSVVVPRI

--------------------------------------------------------------

>34229_34229_12_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157182512_ENST00000539077_length(amino acids)=86AA_BP=

--------------------------------------------------------------

>34229_34229_13_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000339562_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_14_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000409108_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_15_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000409572_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_16_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000426264_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_17_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000429376_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_18_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000409674_NR4A2_chr2_157183432_ENST00000539077_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_19_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157182512_ENST00000409572_length(amino acids)=151AA_BP=67
MILGGGRLHPGWRNWVLLPAGPSRVRIYLRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKD

--------------------------------------------------------------

>34229_34229_20_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157182512_ENST00000429376_length(amino acids)=151AA_BP=67
MILGGGRLHPGWRNWVLLPAGPSRVRIYLRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKD

--------------------------------------------------------------

>34229_34229_21_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157182512_ENST00000539077_length(amino acids)=151AA_BP=67
MILGGGRLHPGWRNWVLLPAGPSRVRIYLRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKD

--------------------------------------------------------------

>34229_34229_22_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000339562_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_23_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000409108_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_24_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000409572_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_25_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000426264_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_26_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000429376_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_27_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000438166_NR4A2_chr2_157183432_ENST00000539077_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_28_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157182512_ENST00000409572_length(amino acids)=103AA_BP=
MLLFPNLQAEPERAFWLRGILDLEHGLHTIQWYKLFILSLKISLLFRRKIAIMYNGKCLAMLGCCSSDKCNTHTHTHTHTHTETHLKGTH

--------------------------------------------------------------

>34229_34229_29_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157182512_ENST00000429376_length(amino acids)=82AA_BP=8

--------------------------------------------------------------

>34229_34229_30_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157182512_ENST00000539077_length(amino acids)=86AA_BP=

--------------------------------------------------------------

>34229_34229_31_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000339562_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_32_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000409108_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_33_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000409572_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_34_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000426264_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

>34229_34229_35_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000429376_length(amino acids)=201AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEEYEHRHFCLLLHCCPGYGHRETRAQGTQESGRTAKQDCKLSQRPRDFQQWGVEPPQLFVQTVGEAPRTSYPLH

--------------------------------------------------------------

>34229_34229_36_GPD2-NR4A2_GPD2_chr2_157332719_ENST00000540309_NR4A2_chr2_157183432_ENST00000539077_length(amino acids)=246AA_BP=33
MAFQKAVKGTILVGGGALATVLGLSQFAHYRRKQFQANPDYQMSGDDTQHIQQFYDLLTGSMEIIRGWAEKIPGFADLPKADQDLLFESA
FLELFVLRLAYRSNPVEGKLIFCNGVVLHRLQCVRGFGEWIDSIVEFSSNLQNMNIDISAFSCIAALAMVTERHGLKEPKRVEELQNKIV

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:157332719/chr2:157182840)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPD2

P43304

NR4A2

P43354

FUNCTION: Calcium-responsive mitochondrial glycerol-3-phosphate dehydrogenase which seems to be a key component of the pancreatic beta-cell glucose-sensing device. {ECO:0000269|PubMed:9070847}.FUNCTION: Transcriptional regulator which is important for the differentiation and maintenance of meso-diencephalic dopaminergic (mdDA) neurons during development. It is crucial for expression of a set of genes such as SLC6A3, SLC18A2, TH and DRD2 which are essential for development of mdDA neurons (By similarity). {ECO:0000250, ECO:0000269|PubMed:17184956}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268568_577513.3333333333334599.0MotifNote=nuclear export sequence (NES2)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268568_577513.3333333333334599.0MotifNote=nuclear export sequence (NES2)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248443_452386.0599.0MotifNote=nuclear export sequence (NES1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248568_577386.0599.0MotifNote=nuclear export sequence (NES2)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248443_452386.0599.0MotifNote=nuclear export sequence (NES1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248568_577386.0599.0MotifNote=nuclear export sequence (NES2)

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPD2chr2:157332719chr2:157182512ENST00000310454+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157182512ENST00000409674+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157182512ENST00000438166+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157183432ENST00000310454+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157183432ENST00000409674+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157183432ENST00000438166+217672_68334.0728.0Calcium bindingOntology_term=ECO:0000255
HgeneGPD2chr2:157332719chr2:157182512ENST00000310454+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157182512ENST00000310454+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157182512ENST00000409674+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157182512ENST00000409674+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157182512ENST00000438166+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157182512ENST00000438166+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157183432ENST00000310454+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157183432ENST00000310454+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157183432ENST00000409674+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157183432ENST00000409674+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157183432ENST00000438166+217623_65834.0728.0DomainEF-hand 1
HgeneGPD2chr2:157332719chr2:157183432ENST00000438166+217659_69434.0728.0DomainEF-hand 2
HgeneGPD2chr2:157332719chr2:157182512ENST00000310454+21771_9934.0728.0Nucleotide bindingFAD
HgeneGPD2chr2:157332719chr2:157182512ENST00000409674+21771_9934.0728.0Nucleotide bindingFAD
HgeneGPD2chr2:157332719chr2:157182512ENST00000438166+21771_9934.0728.0Nucleotide bindingFAD
HgeneGPD2chr2:157332719chr2:157183432ENST00000310454+21771_9934.0728.0Nucleotide bindingFAD
HgeneGPD2chr2:157332719chr2:157183432ENST00000409674+21771_9934.0728.0Nucleotide bindingFAD
HgeneGPD2chr2:157332719chr2:157183432ENST00000438166+21771_9934.0728.0Nucleotide bindingFAD
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268127_233513.3333333333334599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268346_391513.3333333333334599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST000003395626880_138513.3333333333334599.0Compositional biasNote=Gln-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268127_233513.3333333333334599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268346_391513.3333333333334599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST000004095726880_138513.3333333333334599.0Compositional biasNote=Gln-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248127_233386.0599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248346_391386.0599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST000003395624880_138386.0599.0Compositional biasNote=Gln-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248127_233386.0599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248346_391386.0599.0Compositional biasNote=Pro-rich
TgeneNR4A2chr2:157332719chr2:157183432ENST000004095724880_138386.0599.0Compositional biasNote=Gln-rich
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268260_335513.3333333333334599.0DNA bindingNuclear receptor
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268260_335513.3333333333334599.0DNA bindingNuclear receptor
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248260_335386.0599.0DNA bindingNuclear receptor
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248260_335386.0599.0DNA bindingNuclear receptor
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268360_595513.3333333333334599.0DomainNR LBD
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268360_595513.3333333333334599.0DomainNR LBD
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248360_595386.0599.0DomainNR LBD
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248360_595386.0599.0DomainNR LBD
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268287_314513.3333333333334599.0MotifNote=Bipartite nuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268338_350513.3333333333334599.0MotifNuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268443_452513.3333333333334599.0MotifNote=nuclear export sequence (NES1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268287_314513.3333333333334599.0MotifNote=Bipartite nuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268338_350513.3333333333334599.0MotifNuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268443_452513.3333333333334599.0MotifNote=nuclear export sequence (NES1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248287_314386.0599.0MotifNote=Bipartite nuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248338_350386.0599.0MotifNuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248287_314386.0599.0MotifNote=Bipartite nuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248338_350386.0599.0MotifNuclear localization signal (NLS1)
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268263_283513.3333333333334599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157182512ENST0000033956268299_323513.3333333333334599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268263_283513.3333333333334599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157182512ENST0000040957268299_323513.3333333333334599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248263_283386.0599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157183432ENST0000033956248299_323386.0599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248263_283386.0599.0Zinc fingerNR C4-type
TgeneNR4A2chr2:157332719chr2:157183432ENST0000040957248299_323386.0599.0Zinc fingerNR C4-type


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>123_GPD2_157332719_NR4A2_157182512_ranked_0.pdbGPD2157332719157332719ENST00000429376NR4A2chr2157182512-
MILGGGRLHPGWRNWVLLPAGPSRVRIYLRLRNGISKGSERDDSCWRRCSCNCFRTFSVCSLQKETKRHGLKEPKRVEELQNKIVNCLKD
151


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
GPD2_pLDDT.png
all structure
all structure
NR4A2_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GPD2
NR4A2


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GPD2-NR4A2


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GPD2-NR4A2


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource