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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GPHN-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GPHN-RAD51B
	FusionPDB ID: 34267
	FusionGDB2.0 ID: 34267
		Hgene	Tgene
	Gene symbol	GPHN	RAD51B
	Gene ID	10243	5890
	Gene name	gephyrin	RAD51 paralog B
	Synonyms	GEPH\|GPH\|GPHRYN\|HKPX1\|MOCODC	R51H2\|RAD51L1\|REC2
	Cytomap	14q23.3-q24.1	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	gephyrin	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200313	20200313
	UniProtAcc	Q9NQX3	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000305960, ENST00000315266, ENST00000459628, ENST00000478722, ENST00000543237, ENST00000544752,	ENST00000469165, ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	38 X 33 X 10=12540	41 X 23 X 12=11316
	# samples	40	56
	** MAII score	log2(40/12540*10)=-4.97039353791468 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GPHN [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GPHN(67243239)-RAD51B(68301797), # samples:2 RAD51B(68353921)-GPHN(67626132), # samples:6
Anticipated loss of major functional domain due to fusion event.	GPHN-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPHN-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-GPHN seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. RAD51B-GPHN seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GPHN	GO:0032324	molybdopterin cofactor biosynthetic process	26613940
Hgene	GPHN	GO:0097112	gamma-aminobutyric acid receptor clustering	26613940

Fusion gene breakpoints across GPHN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	PRAD	TCGA-KK-A6E4-01A	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+
ChimerDB4	PRAD	TCGA-KK-A6E4	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000315266	GPHN	chr14	67243239	+	ENST00000487861	RAD51B	chr14	68301797	+	2720	1322	1025	2401	458
ENST00000315266	GPHN	chr14	67243239	+	ENST00000471583	RAD51B	chr14	68301797	+	2612	1322	1025	2176	383
ENST00000315266	GPHN	chr14	67243239	+	ENST00000487270	RAD51B	chr14	68301797	+	3672	1322	1025	2278	417
ENST00000315266	GPHN	chr14	67243239	+	ENST00000488612	RAD51B	chr14	68301797	+	2647	1322	1025	2224	399
ENST00000315266	GPHN	chr14	67243239	+	ENST00000390683	RAD51B	chr14	68301797	+	2225	1322	1025	2224	400
ENST00000478722	GPHN	chr14	67243239	+	ENST00000487861	RAD51B	chr14	68301797	+	2720	1322	1025	2401	458
ENST00000478722	GPHN	chr14	67243239	+	ENST00000471583	RAD51B	chr14	68301797	+	2612	1322	1025	2176	383
ENST00000478722	GPHN	chr14	67243239	+	ENST00000487270	RAD51B	chr14	68301797	+	3672	1322	1025	2278	417
ENST00000478722	GPHN	chr14	67243239	+	ENST00000488612	RAD51B	chr14	68301797	+	2647	1322	1025	2224	399
ENST00000478722	GPHN	chr14	67243239	+	ENST00000390683	RAD51B	chr14	68301797	+	2225	1322	1025	2224	400
ENST00000459628	GPHN	chr14	67243239	+	ENST00000487861	RAD51B	chr14	68301797	+	1989	591	294	1670	458
ENST00000459628	GPHN	chr14	67243239	+	ENST00000471583	RAD51B	chr14	68301797	+	1881	591	294	1445	383
ENST00000459628	GPHN	chr14	67243239	+	ENST00000487270	RAD51B	chr14	68301797	+	2941	591	294	1547	417
ENST00000459628	GPHN	chr14	67243239	+	ENST00000488612	RAD51B	chr14	68301797	+	1916	591	294	1493	399
ENST00000459628	GPHN	chr14	67243239	+	ENST00000390683	RAD51B	chr14	68301797	+	1494	591	294	1493	399
ENST00000543237	GPHN	chr14	67243239	+	ENST00000487861	RAD51B	chr14	68301797	+	1623	225	15	1304	429
ENST00000543237	GPHN	chr14	67243239	+	ENST00000471583	RAD51B	chr14	68301797	+	1515	225	15	1079	354
ENST00000543237	GPHN	chr14	67243239	+	ENST00000487270	RAD51B	chr14	68301797	+	2575	225	15	1181	388
ENST00000543237	GPHN	chr14	67243239	+	ENST00000488612	RAD51B	chr14	68301797	+	1550	225	15	1127	370
ENST00000543237	GPHN	chr14	67243239	+	ENST00000390683	RAD51B	chr14	68301797	+	1128	225	15	1127	370
ENST00000305960	GPHN	chr14	67243239	+	ENST00000487861	RAD51B	chr14	68301797	+	1614	216	6	1295	429
ENST00000305960	GPHN	chr14	67243239	+	ENST00000471583	RAD51B	chr14	68301797	+	1506	216	6	1070	354
ENST00000305960	GPHN	chr14	67243239	+	ENST00000487270	RAD51B	chr14	68301797	+	2566	216	6	1172	388
ENST00000305960	GPHN	chr14	67243239	+	ENST00000488612	RAD51B	chr14	68301797	+	1541	216	6	1118	370
ENST00000305960	GPHN	chr14	67243239	+	ENST00000390683	RAD51B	chr14	68301797	+	1119	216	6	1118	370

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000315266	ENST00000487861	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.002105269	0.9978947
ENST00000315266	ENST00000471583	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000686967	0.999313
ENST00000315266	ENST00000487270	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000813127	0.9991868
ENST00000315266	ENST00000488612	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.001087555	0.99891245
ENST00000315266	ENST00000390683	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.001452486	0.9985475
ENST00000478722	ENST00000487861	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.002105269	0.9978947
ENST00000478722	ENST00000471583	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000686967	0.999313
ENST00000478722	ENST00000487270	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000813127	0.9991868
ENST00000478722	ENST00000488612	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.001087555	0.99891245
ENST00000478722	ENST00000390683	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.001452486	0.9985475
ENST00000459628	ENST00000487861	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.001183964	0.998816
ENST00000459628	ENST00000471583	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000291827	0.9997081
ENST00000459628	ENST00000487270	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.00040495	0.9995951
ENST00000459628	ENST00000488612	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000685272	0.9993148
ENST00000459628	ENST00000390683	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000779731	0.99922025
ENST00000543237	ENST00000487861	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000650211	0.9993498
ENST00000543237	ENST00000471583	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000192402	0.99980766
ENST00000543237	ENST00000487270	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000229124	0.99977094
ENST00000543237	ENST00000488612	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000369969	0.99963
ENST00000543237	ENST00000390683	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000314538	0.9996855
ENST00000305960	ENST00000487861	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.00067172	0.99932826
ENST00000305960	ENST00000471583	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000203078	0.9997969
ENST00000305960	ENST00000487270	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000234636	0.99976534
ENST00000305960	ENST00000488612	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000384092	0.9996159
ENST00000305960	ENST00000390683	GPHN	chr14	67243239	+	RAD51B	chr14	68301797	+	0.000332966	0.99966705

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34267_34267_1_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000305960_RAD51B_chr14_68301797_ENST00000390683_length(amino acids)=370AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFS

--------------------------------------------------------------

>34267_34267_2_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000305960_RAD51B_chr14_68301797_ENST00000471583_length(amino acids)=354AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA

--------------------------------------------------------------

>34267_34267_3_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000305960_RAD51B_chr14_68301797_ENST00000487270_length(amino acids)=388AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAE

--------------------------------------------------------------

>34267_34267_4_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000305960_RAD51B_chr14_68301797_ENST00000487861_length(amino acids)=429AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPR

--------------------------------------------------------------

>34267_34267_5_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000305960_RAD51B_chr14_68301797_ENST00000488612_length(amino acids)=370AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFS

--------------------------------------------------------------

>34267_34267_6_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000315266_RAD51B_chr14_68301797_ENST00000390683_length(amino acids)=400AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_7_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000315266_RAD51B_chr14_68301797_ENST00000471583_length(amino acids)=383AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_8_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000315266_RAD51B_chr14_68301797_ENST00000487270_length(amino acids)=417AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_9_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000315266_RAD51B_chr14_68301797_ENST00000487861_length(amino acids)=458AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL
APFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALPPTNWATGIRT

--------------------------------------------------------------

>34267_34267_10_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000315266_RAD51B_chr14_68301797_ENST00000488612_length(amino acids)=399AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_11_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000459628_RAD51B_chr14_68301797_ENST00000390683_length(amino acids)=399AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_12_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000459628_RAD51B_chr14_68301797_ENST00000471583_length(amino acids)=383AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_13_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000459628_RAD51B_chr14_68301797_ENST00000487270_length(amino acids)=417AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_14_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000459628_RAD51B_chr14_68301797_ENST00000487861_length(amino acids)=458AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL
APFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALPPTNWATGIRT

--------------------------------------------------------------

>34267_34267_15_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000459628_RAD51B_chr14_68301797_ENST00000488612_length(amino acids)=399AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_16_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000478722_RAD51B_chr14_68301797_ENST00000390683_length(amino acids)=400AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_17_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000478722_RAD51B_chr14_68301797_ENST00000471583_length(amino acids)=383AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_18_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000478722_RAD51B_chr14_68301797_ENST00000487270_length(amino acids)=417AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_19_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000478722_RAD51B_chr14_68301797_ENST00000487861_length(amino acids)=458AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL
APFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALPPTNWATGIRT

--------------------------------------------------------------

>34267_34267_20_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000478722_RAD51B_chr14_68301797_ENST00000488612_length(amino acids)=399AA_BP=99
MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI
VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF
SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR
EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL

--------------------------------------------------------------

>34267_34267_21_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000543237_RAD51B_chr14_68301797_ENST00000390683_length(amino acids)=370AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFS

--------------------------------------------------------------

>34267_34267_22_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000543237_RAD51B_chr14_68301797_ENST00000471583_length(amino acids)=354AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA

--------------------------------------------------------------

>34267_34267_23_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000543237_RAD51B_chr14_68301797_ENST00000487270_length(amino acids)=388AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAE

--------------------------------------------------------------

>34267_34267_24_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000543237_RAD51B_chr14_68301797_ENST00000487861_length(amino acids)=429AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPR

--------------------------------------------------------------

>34267_34267_25_GPHN-RAD51B_GPHN_chr14_67243239_ENST00000543237_RAD51B_chr14_68301797_ENST00000488612_length(amino acids)=370AA_BP=70
MGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKIVPDEIEEIKAYGIKAQRSADFSPAFLSTT
LSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAFSAERLVEIAESRFPRYFNTEEKLLLTSSK
VHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAREASSLKYLAEEFSIPVILTNQITTHLSGA
LASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWHICISGFS

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:67243239/chr14:68301797)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPHN Q9NQX3	RAD51B O15315
FUNCTION: Microtubule-associated protein involved in membrane protein-cytoskeleton interactions. It is thought to anchor the inhibitory glycine receptor (GLYR) to subsynaptic microtubules (By similarity). Acts as a major instructive molecule at inhibitory synapses, where it also clusters GABA type A receptors (PubMed:25025157, PubMed:26613940). {ECO:0000250\|UniProtKB:Q03555, ECO:0000269\|PubMed:25025157, ECO:0000269\|PubMed:26613940}.; FUNCTION: Has also a catalytic activity and catalyzes two steps in the biosynthesis of the molybdenum cofactor. In the first step, molybdopterin is adenylated. Subsequently, molybdate is inserted into adenylated molybdopterin and AMP is released. {ECO:0000269\|PubMed:26613940}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAD51B

chr14:67243239

chr14:68301797

ENST00000390683

108_115

66.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67243239

chr14:68301797

ENST00000471583

108_115

66.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67243239

chr14:68301797

ENST00000487270

108_115

66.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr14:67243239

chr14:68301797

ENST00000488612

108_115

66.0

495.6666666666667

Nucleotide binding

ATP

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPHN

chr14:67243239

chr14:68301797

ENST00000315266

14_166

67.0

737.0

Region

Note=MPT Mo-transferase

Hgene

GPHN

chr14:67243239

chr14:68301797

ENST00000315266

326_736

67.0

737.0

Region

Note=MPT adenylyltransferase

Hgene

GPHN

chr14:67243239

chr14:68301797

ENST00000478722

14_166

67.0

770.0

Region

Note=MPT Mo-transferase

Hgene

GPHN

chr14:67243239

chr14:68301797

ENST00000478722

326_736

67.0

770.0

Region

Note=MPT adenylyltransferase

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)
PDB file >>>958_GPHN_67243239_RAD51B_68301797_958_GPHN_67243239_RAD51B_68301797_ranked_0.pdb	GPHN	67243239	67243239	ENST00000390683	RAD51B	chr14	68301797	+	MSRSPRRARSRPARSGLRFLPAPVSAVTALGNMATEGMILTNHDHQIRVGVLTVSDSCFRNLAEDRSGINLKDLVQDPSLLGGTISAYKI VPDEIEEIKAYGIKAQRSADFSPAFLSTTLSALDEALHGGVACGSLTEITGPPGCGKTQFCIMMSILATLPTNMGGLEGAVVYIDTESAF SAERLVEIAESRFPRYFNTEEKLLLTSSKVHLYRELTCDEVLQRIESLEEEIISKGIKLVILDSVASVVRKEFDAQLQGNLKERNKFLAR EASSLKYLAEEFSIPVILTNQITTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPL APFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSPTFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALPPTNWATGIRT	458

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GPHN_pLDDT.png

RAD51B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GPHN
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	GPHN	chr14:67243239	chr14:68301797	ENST00000315266	+	3	22	140_316	67.0	737.0	GABARAP
Hgene	GPHN	chr14:67243239	chr14:68301797	ENST00000478722	+	3	23	140_316	67.0	770.0	GABARAP
Tgene	RAD51B	chr14:67243239	chr14:68301797	ENST00000390683		1	10	1_75	66.0	367.0	RAD51C
Tgene	RAD51B	chr14:67243239	chr14:68301797	ENST00000471583		2	11	1_75	66.0	351.0	RAD51C
Tgene	RAD51B	chr14:67243239	chr14:68301797	ENST00000487270		2	11	1_75	66.0	385.0	RAD51C
Tgene	RAD51B	chr14:67243239	chr14:68301797	ENST00000488612		2	12	1_75	66.0	495.6666666666667	RAD51C

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Related Drugs to GPHN-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to GPHN-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	GPHN	C1854990	Molybdenum Cofactor Deficiency, Complementation Group C	5	CTD_human;GENOMICS_ENGLAND;ORPHANET;UNIPROT
Hgene	GPHN	C0001956	Alcohol Use Disorder	1	CTD_human
Hgene	GPHN	C0001973	Alcoholic Intoxication, Chronic	1	CTD_human
Hgene	GPHN	C0009171	Cocaine Abuse	1	CTD_human
Hgene	GPHN	C0085762	Alcohol abuse	1	CTD_human
Hgene	GPHN	C0236736	Cocaine-Related Disorders	1	CTD_human
Hgene	GPHN	C0543888	Epileptic encephalopathy	1	GENOMICS_ENGLAND
Hgene	GPHN	C0600427	Cocaine Dependence	1	CTD_human
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human