UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY

Home

Download

Statistics

Examples

Help

Contact

level2

	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GPI-EYS

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GPI-EYS
	FusionPDB ID: 34285
	FusionGDB2.0 ID: 34285
		Hgene	Tgene
	Gene symbol	GPI	EYS
	Gene ID	10007	346007
	Gene name	glucosamine-6-phosphate deaminase 1	eyes shut homolog
	Synonyms	GNP1\|GNPDA\|GNPI\|GPI\|HLN	C6orf178\|C6orf179\|C6orf180\|EGFL10\|EGFL11\|RP25\|SPAM\|bA166P24.2\|bA307F22.3\|bA74E24.1\|dJ1018A4.2\|dJ22I17.2\|dJ303F19.1
	Cytomap	5q31.3	6q12
	Type of gene	protein-coding	protein-coding
	Description	glucosamine-6-phosphate isomerase 1GNPDA 1glcN6P deaminase 1oscillin	protein eyes shut homologEGF-like-domain, multiple 10EGF-like-domain, multiple 11epidermal growth factor-like protein 10epidermal growth factor-like protein 11protein spacemaker homolog
	Modification date	20200313	20200313
	UniProtAcc	Q8IV16	Q5T1H1
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000356487, ENST00000415930, ENST00000586425,	ENST00000342421, ENST00000370618, ENST00000393380, ENST00000486069, ENST00000370616, ENST00000370621, ENST00000503581,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	27 X 23 X 11=6831	36 X 24 X 15=12960
	# samples	28	38
	** MAII score	log2(28/6831*10)=-4.60859805991281 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(38/12960*10)=-5.09192248944104 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GPI [Title/Abstract] AND EYS [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GPI(34887335)-EYS(65767620), # samples:4
Anticipated loss of major functional domain due to fusion event.	GPI-EYS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPI-EYS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GPI-EYS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GPI-EYS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GPI (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across EYS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Top

Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	HNSC	TCGA-CR-6478-01A	GPI	chr19	34887335	+	EYS	chr6	65767620	-
ChimerDB4	HNSC	TCGA-CR-6478	GPI	chr19	34887335	+	EYS	chr6	65767620	-

Top

Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000415930	GPI	chr19	34887335	+	ENST00000503581	EYS	chr6	65767620	-	9423	1395	170	8806	2878
ENST00000415930	GPI	chr19	34887335	+	ENST00000370621	EYS	chr6	65767620	-	9330	1395	170	8869	2899
ENST00000415930	GPI	chr19	34887335	+	ENST00000370616	EYS	chr6	65767620	-	8870	1395	170	8869	2900
ENST00000356487	GPI	chr19	34887335	+	ENST00000503581	EYS	chr6	65767620	-	9461	1433	172	8844	2890
ENST00000356487	GPI	chr19	34887335	+	ENST00000370621	EYS	chr6	65767620	-	9368	1433	172	8907	2911
ENST00000356487	GPI	chr19	34887335	+	ENST00000370616	EYS	chr6	65767620	-	8908	1433	172	8907	2912
ENST00000586425	GPI	chr19	34887335	+	ENST00000503581	EYS	chr6	65767620	-	9245	1217	25	8628	2867
ENST00000586425	GPI	chr19	34887335	+	ENST00000370621	EYS	chr6	65767620	-	9152	1217	25	8691	2888
ENST00000586425	GPI	chr19	34887335	+	ENST00000370616	EYS	chr6	65767620	-	8692	1217	25	8691	2889

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000415930	ENST00000503581	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000221926	0.9997781
ENST00000415930	ENST00000370621	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000417703	0.99958235
ENST00000415930	ENST00000370616	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000527403	0.99947256
ENST00000356487	ENST00000503581	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000227677	0.99977237
ENST00000356487	ENST00000370621	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000426411	0.9995735
ENST00000356487	ENST00000370616	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000534674	0.9994653
ENST00000586425	ENST00000503581	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000175618	0.99982446
ENST00000586425	ENST00000370621	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.000327778	0.9996722
ENST00000586425	ENST00000370616	GPI	chr19	34887335	+	EYS	chr6	65767620	-	0.0004233	0.99957675

Top

Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34285_34285_1_GPI-EYS_GPI_chr19_34887335_ENST00000356487_EYS_chr6_65767620_ENST00000370616_length(amino acids)=2912AA_BP=420
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGI
GGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALS
TNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHA
MLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYF
CQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYR
CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG
KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP
CLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYP
CSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS
GQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRIT
CLTPIFQRTDPISTQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELS
AKHSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPT
TSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALH
RFSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQT
ITSGHSFSSATEITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSV
SENILKLLKIRQYGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDF
SEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILA
PQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVR
VDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKA
VKNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG
LFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTN
AFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDE
ARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINIT
QPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEP
LNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLG
NPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTT
GIYCEQALILIVILEKPKPAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLV
NSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVG
FQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSF
SYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVN
LGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIK

--------------------------------------------------------------

>34285_34285_2_GPI-EYS_GPI_chr19_34887335_ENST00000356487_EYS_chr6_65767620_ENST00000370621_length(amino acids)=2911AA_BP=420
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGI
GGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALS
TNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHA
MLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYF
CQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYR
CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG
KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP
CLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYP
CSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS
GQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRIT
CLTPIFQRTDPISTQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELS
AKHSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPT
TSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALH
RFSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQT
ITSGHSFSSATEITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSV
SENILKLLKIRQYGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDF
SEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILA
PQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVR
VDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKA
VKNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG
LFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTN
AFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDE
ARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINIT
QPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEP
LNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLG
NPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTT
GIYCEQALILIVILEKPKPAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLV
NSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVG
FQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSF
SYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVN
LGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIK

--------------------------------------------------------------

>34285_34285_3_GPI-EYS_GPI_chr19_34887335_ENST00000356487_EYS_chr6_65767620_ENST00000503581_length(amino acids)=2890AA_BP=420
MLRAAGAPSSSARVSLSVPSSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRM
LVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGI
GGSDLGPLMVTEALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALS
TNTTKVKEFGIDPQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHA
MLPYDQYLHRFAAYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYF
CQCVPPFKVVDGFSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYR
CECTSGWTGQNCSEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEG
KNCEIDVKDCLFLSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISP
CLDEENCVYRTDGYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYP
CSCDADGTSTQCKIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFS
GQFCEININECSSSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRIT
CLTPIFQRTDPISTQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELS
AKHSLLSSADVSSSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPT
TSVIRSIPGADIELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALH
RFSTKAFNPSEYQAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQT
ITSGHSFSSATEITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSV
SENILKLLKIRQYGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDF
SEVTTNVAFYTVSATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILA
PQRLMISDFSCVRYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVR
VDNGQKYTLLIRQELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKA
VKNYHINNCRSQGFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAG
LFFPSFNGNSYLELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTN
AFTPITIRYTTPVGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDE
ARHGKNIENCHVPWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINIT
QPRFSGTDAFGYTSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEP
LNLSLGVHTVHLGKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLG
NPEGHPNAGRSVGQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTT
GIYCEQALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQ
KVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFG
AKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSF
STAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKW
HHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKLEGYNV

--------------------------------------------------------------

>34285_34285_4_GPI-EYS_GPI_chr19_34887335_ENST00000415930_EYS_chr6_65767620_ENST00000370616_length(amino acids)=2900AA_BP=408
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQGPLMVTE
ALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGID
PQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFA
AYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDG
FSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC
SEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLF
LSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD
GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQC
KIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECS
SSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPI
STQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVS
SSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADI
ELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEY
QAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATE
ITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQ
YGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTV
SATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCV
RYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIR
QELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQ
GFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYL
ELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTP
VGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHV
PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGY
TSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHL
GKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSV
GQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALILIV
ILEKPKPAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGD
RTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINN
QELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVG
RYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYN
NGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIE

--------------------------------------------------------------

>34285_34285_5_GPI-EYS_GPI_chr19_34887335_ENST00000415930_EYS_chr6_65767620_ENST00000370621_length(amino acids)=2899AA_BP=408
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQGPLMVTE
ALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGID
PQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFA
AYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDG
FSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC
SEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLF
LSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD
GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQC
KIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECS
SSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPI
STQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVS
SSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADI
ELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEY
QAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATE
ITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQ
YGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTV
SATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCV
RYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIR
QELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQ
GFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYL
ELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTP
VGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHV
PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGY
TSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHL
GKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSV
GQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALILIV
ILEKPKPAERKVKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGD
RTIILETLQKVTINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINN
QELQLTEFGAKGGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVG
RYCENKTSFSTAKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYN
NGTFCCNKWHHVVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIE

--------------------------------------------------------------

>34285_34285_6_GPI-EYS_GPI_chr19_34887335_ENST00000415930_EYS_chr6_65767620_ENST00000503581_length(amino acids)=2878AA_BP=408
MVALCSLQHLGSSDPRALPTLPTATSGQRPAKRRRKSPAMAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHI
LVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKINYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQGPLMVTE
ALKPYSSGGPRVWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGID
PQNMFEFWDWVGGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFA
AYFQQGDMESNGKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDG
FSCLCNPGYVGIRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNC
SEEINECDSDPCMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLF
LSCQDYGDCEDMVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTD
GYNCLCAPGYTGINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQC
KIKINDCTSIPCMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECS
SSPCLHGADCEDHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPI
STQTYTIPPSETLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVS
SSRFLNFGIRDPAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADI
ELNRQSLLSRGFLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEY
QAITEASSNQRLTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATE
ITPSVAFTEVPSLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQ
YGITMGPTEVLNQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTV
SATPALSIQTSSSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCV
RYYGDSYLEFQNVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIR
QELDPCNAELTILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQ
GFMLSPTASFVDASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYL
ELPFLKFVLEKEHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTP
VGSPGVVCMIEMTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHV
PWCAHHLCRNNGTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGY
TSFLAYSRISDISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHL
GKFFQEGWLKVDDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSV
GQCHASPCSLMKCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISD
PSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHII
KAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDG
TACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIK
YIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHHVVVIQNQTLI

--------------------------------------------------------------

>34285_34285_7_GPI-EYS_GPI_chr19_34887335_ENST00000586425_EYS_chr6_65767620_ENST00000370616_length(amino acids)=2889AA_BP=397
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWV
GGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVG
IRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP
CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCED
MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYT
GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP
CMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCE
DHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPSE
TLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRD
PAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRG
FLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQR
LTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATEITPSVAFTEVP
SLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVL
NQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQTS
SSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQ
NVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELT
ILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTASFV
DASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEK
EHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIE
MTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNN
GTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISD
ISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKV
DDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLM
KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALILIVILEKPKPAERK
VKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKV
TINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAK
GGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFST
AKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHH
VVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKLEGYNVYD

--------------------------------------------------------------

>34285_34285_8_GPI-EYS_GPI_chr19_34887335_ENST00000586425_EYS_chr6_65767620_ENST00000370621_length(amino acids)=2888AA_BP=397
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWV
GGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVG
IRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP
CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCED
MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYT
GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP
CMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCE
DHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPSE
TLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRD
PAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRG
FLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQR
LTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATEITPSVAFTEVP
SLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVL
NQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQTS
SSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQ
NVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELT
ILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTASFV
DASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEK
EHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIE
MTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNN
GTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISD
ISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKV
DDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLM
KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALILIVILEKPKPAERK
VKKEALSISDPSFRSNELSWMSFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKV
TINGSTWHIIKAGRVGAEGYLDLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAK
GGSNVGDCDGTACGYNTCRNGGECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFST
AKFMGNSYIKYIDPNYRMRNLQFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHH
VVVIQNQTLIKAYINNSLILSEDIDPHKNFVALNYDGICYLGGFEYGRKVNIVTQEIFKTNFVGKIKDVVFFQEPKNIELIKLEGYNVYD

--------------------------------------------------------------

>34285_34285_9_GPI-EYS_GPI_chr19_34887335_ENST00000586425_EYS_chr6_65767620_ENST00000503581_length(amino acids)=2867AA_BP=397
MAALTRDPQFQKLQQWYREHRSELNLRRLFDANKDRFNHFSLTLNTNHGHILVDYSKNLVTEDVMRMLVDLAKSRGVEAARERMFNGEKI
NYTEGRAVLHVALRNRSNTPILVDGKDVMPEVNKVLDKMKSFCQRVRSGDWKGYTGKTITDVINIGIGGSDLGPLMVTEALKPYSSGGPR
VWYVSNIDGTHIAKTLAQLNPESSLFIIASKTFTTQETITNAETAKEWFLQAAKDPSAVAKHFVALSTNTTKVKEFGIDPQNMFEFWDWV
GGRYSLWSAIGLSIALHVGFDNFEQLLSGAHWMDQHFRTTPLEKNAPVLLALLGIWYINCFGCETHAMLPYDQYLHRFAAYFQQGDMESN
GKYITKSGTRVDHQTGPIVWGEPGTNGQHAFYQLIHQGTQCEIDIDECASHPCKNGATCIDQPGNYFCQCVPPFKVVDGFSCLCNPGYVG
IRCEQDIDDCILNACEHNSTCKDLHLSYQCVCLSDWEGNFCEQESNECKMNPCKNNSTCTDLYKSYRCECTSGWTGQNCSEEINECDSDP
CMNGGLCHESTIPGQFVCLCPPLYTGQFCHQRYNLCDLLHNPCRNNSTCLALVDANQHCICREEFEGKNCEIDVKDCLFLSCQDYGDCED
MVNNFRCICRPGFSGSLCEIEINECSSEPCKNNGTCVDLTNRFFCNCEPEYHGPFCELDVNKCKISPCLDEENCVYRTDGYNCLCAPGYT
GINCEINLDECLSEPCLHDGVCIDGINHYTCDCKSGFFGTHCETNANDCLSNPCLHGRCTELINEYPCSCDADGTSTQCKIKINDCTSIP
CMNEGFCQKSAHGFTCICPRGYTGAYCEKSIDNCAEPELNSVICLNGGICVDGPGHTFDCRCLPGFSGQFCEININECSSSPCLHGADCE
DHINGYVCKCQPGWSGHHCENELECIPNSCVHELCMENEPGSTCLCTPGFMTCSIGLLCGDEIRRITCLTPIFQRTDPISTQTYTIPPSE
TLVSSFPSIKATRIPAIMDTYPVDQGPKQTGIVKHDILPTTGLATLRISTPLESYLLQELIVTRELSAKHSLLSSADVSSSRFLNFGIRD
PAQIVQDKTSVSHMPIRTSAATLGFFFPDRRARTPFIMSSLMSDFIFPTQSLLFENCQTVALSATPTTSVIRSIPGADIELNRQSLLSRG
FLLIAASISATPVVSRGAQEDIEEYSADSLISRREHWRLLSPSMSPIFPAKVIISKQVTILNSSALHRFSTKAFNPSEYQAITEASSNQR
LTNIKSQAADSLRELSQTCATCSMTEIKSSREFSDQVLHSKQSHFYETFWMNSAILASWYALMGAQTITSGHSFSSATEITPSVAFTEVP
SLFPSKKSAKRTILSSSLEESITLSSNLDVNLCLDKTCLSIVPSQTISSDLMNSDLTSKMTTDELSVSENILKLLKIRQYGITMGPTEVL
NQESLLDMEKSKGSHTLFKLHPSDSSLDFELNLQIYPDVTLKTYSEITHANDFKNNLPPLTGSVPDFSEVTTNVAFYTVSATPALSIQTS
SSMSVIRPDWPYFTDYMTSLKKEVKTSSEWSKWELQPSVQYQEFPTASRHLPFTRSLTLSSLESILAPQRLMISDFSCVRYYGDSYLEFQ
NVALNPQNNISLEFQTFSSYGLLLYVKQDSNLVDGFFIQLFIENGTLKYHFYCPGEAKFKSINTTVRVDNGQKYTLLIRQELDPCNAELT
ILGRNTQICESINHVLGKPLPKSGSVFIGGFPDLHGKIQMPVPVKNFTGCIEVIEINNWRSFIPSKAVKNYHINNCRSQGFMLSPTASFV
DASDVTQGVDTMWTSVSPSVAAPSVCQQDVCHNGGTCHAIFLSSGIVSFQCDCPLHFTGRFCEKDAGLFFPSFNGNSYLELPFLKFVLEK
EHNRTVTIYLTIKTNSLNGTILYSNGNNCGKQFLHLFLVEGRPSVKYGCGNSQNILTVSANYSINTNAFTPITIRYTTPVGSPGVVCMIE
MTADGKPPVQKKDTEISHASQAYFESMFLGHIPANVQIHKKAGPVYGFRGCILDLQVNNKEFFIIDEARHGKNIENCHVPWCAHHLCRNN
GTCISDNENLFCECPRLYSGKLCQFASCENNPCGNGATCVPKSGTDIVCLCPYGRSGPLCTDAINITQPRFSGTDAFGYTSFLAYSRISD
ISFHYEFHLKFQLANNHSALQNNLIFFTGQKGHGLNGDDFLAVGLLNGSVVYSYNLGSGIASIRSEPLNLSLGVHTVHLGKFFQEGWLKV
DDHKNKSIIAPGRLVGLNVFSQFYVGGYSEYTPDLLPNGADFKNGFQGCIFTLQVRTEKDGHFRGLGNPEGHPNAGRSVGQCHASPCSLM
KCGNGGTCIESGTSVYCNCTTGWKGSFCTETVSTCDPEHDPPHHCSRGATCISLPHGYTCFCPLGTTGIYCEQALSISDPSFRSNELSWM
SFASFHVRKKTHIQLQFQPLAADGILFYAAQHLKAQSGDFLCISLVNSSVQLRYNLGDRTIILETLQKVTINGSTWHIIKAGRVGAEGYL
DLDGINVTEKASTKMSSLDTNTDFYIGGVSSLNLVNPMAIENEPVGFQGCIRQVIINNQELQLTEFGAKGGSNVGDCDGTACGYNTCRNG
GECTVNGTTFSCRCLPDWAGNTCNQSVSCLNNLCLHQSLCIPDQSFSYSCLCTLGWVGRYCENKTSFSTAKFMGNSYIKYIDPNYRMRNL
QFTTISLNFSTTKTEGLIVWMGIAQNEENDFLAIGLHNQTLKIAVNLGERISVPMSYNNGTFCCNKWHHVVVIQNQTLIKAYINNSLILS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr19:34887335/chr6:65767620)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GPI Q8IV16	EYS Q5T1H1
FUNCTION: Mediates the transport of lipoprotein lipase LPL from the basolateral to the apical surface of endothelial cells in capillaries (By similarity). Anchors LPL on the surface of endothelial cells in the lumen of blood capillaries (By similarity). Protects LPL against loss of activity, and against ANGPTL4-mediated unfolding (PubMed:27929370, PubMed:29899144). Thereby, plays an important role in lipolytic processing of chylomicrons by LPL, triglyceride metabolism and lipid homeostasis (PubMed:19304573, PubMed:21314738). Binds chylomicrons and phospholipid particles that contain APOA5 (PubMed:17997385, PubMed:19304573). Binds high-density lipoprotein (HDL) and plays a role in the uptake of lipids from HDL (By similarity). {ECO:0000250\|UniProtKB:Q9D1N2, ECO:0000269\|PubMed:17997385, ECO:0000269\|PubMed:19304573, ECO:0000269\|PubMed:21314738, ECO:0000269\|PubMed:27929370, ECO:0000269\|PubMed:29899144}.	FUNCTION: Required to maintain the integrity of photoreceptor cells (PubMed:18836446). Specifically required for normal morphology of the photoreceptor ciliary pocket, and might thus facilitate protein trafficking between the photoreceptor inner and outer segments via the transition zone (By similarity). {ECO:0000250\|UniProtKB:B8JI71, ECO:0000269\|PubMed:18836446}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GPI

chr19:34887335

chr6:65767620

ENST00000356487

159_160

397.3333333333333

559.0

Region

Glucose-6-phosphate binding

Hgene

GPI

chr19:34887335

chr6:65767620

ENST00000356487

210_215

397.3333333333333

559.0

Region

Glucose-6-phosphate binding

Hgene

GPI

chr19:34887335

chr6:65767620

ENST00000415930

159_160

408.3333333333333

570.0

Region

Glucose-6-phosphate binding

Hgene

GPI

chr19:34887335

chr6:65767620

ENST00000415930

210_215

408.3333333333333

570.0

Region

Glucose-6-phosphate binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1004_1040

595.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1042_1077

595.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1079_1115

595.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1117_1159

595.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1161_1197

595.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

170_212

595.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

1883_2063

595.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2099_2140

595.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

213_254

595.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2145_2339

595.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2335_2368

595.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2371_2408

595.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2419_2609

595.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

256_292

595.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2610_2646

595.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2648_2689

595.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2717_2895

595.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2896_2932

595.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2933_2970

595.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

2975_3165

595.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

332_368

595.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

370_406

595.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

567_602

595.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

643_679

595.0

Domain

EGF-like 7

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

681_720

595.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

733_769

595.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

771_807

595.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

809_847

595.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

849_888

595.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

890_926

595.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

928_964

595.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000342421

966_1002

595.0

Domain

EGF-like 15

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1004_1040

674.3333333333334

3166.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1042_1077

674.3333333333334

3166.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1079_1115

674.3333333333334

3166.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1117_1159

674.3333333333334

3166.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1161_1197

674.3333333333334

3166.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

1883_2063

674.3333333333334

3166.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2099_2140

674.3333333333334

3166.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2145_2339

674.3333333333334

3166.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2335_2368

674.3333333333334

3166.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2371_2408

674.3333333333334

3166.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2419_2609

674.3333333333334

3166.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2610_2646

674.3333333333334

3166.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2648_2689

674.3333333333334

3166.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2717_2895

674.3333333333334

3166.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2896_2932

674.3333333333334

3166.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2933_2970

674.3333333333334

3166.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

2975_3165

674.3333333333334

3166.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

681_720

674.3333333333334

3166.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

733_769

674.3333333333334

3166.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

771_807

674.3333333333334

3166.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

809_847

674.3333333333334

3166.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

849_888

674.3333333333334

3166.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

890_926

674.3333333333334

3166.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

928_964

674.3333333333334

3166.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

966_1002

674.3333333333334

3166.0

Domain

EGF-like 15

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1004_1040

595.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1042_1077

595.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1079_1115

595.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1117_1159

595.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1161_1197

595.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

170_212

595.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

1883_2063

595.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2099_2140

595.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

213_254

595.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2145_2339

595.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2335_2368

595.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2371_2408

595.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2419_2609

595.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

256_292

595.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2610_2646

595.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2648_2689

595.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2717_2895

595.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2896_2932

595.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2933_2970

595.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

2975_3165

595.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

332_368

595.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

370_406

595.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

567_602

595.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

643_679

595.0

Domain

EGF-like 7

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

681_720

595.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

733_769

595.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

771_807

595.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

809_847

595.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

849_888

595.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

890_926

595.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

928_964

595.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370618

966_1002

595.0

Domain

EGF-like 15

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1004_1040

674.3333333333334

3166.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1042_1077

674.3333333333334

3166.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1079_1115

674.3333333333334

3166.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1117_1159

674.3333333333334

3166.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1161_1197

674.3333333333334

3166.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

1883_2063

674.3333333333334

3166.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2099_2140

674.3333333333334

3166.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2145_2339

674.3333333333334

3166.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2335_2368

674.3333333333334

3166.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2371_2408

674.3333333333334

3166.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2419_2609

674.3333333333334

3166.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2610_2646

674.3333333333334

3166.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2648_2689

674.3333333333334

3166.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2717_2895

674.3333333333334

3166.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2896_2932

674.3333333333334

3166.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2933_2970

674.3333333333334

3166.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

2975_3165

674.3333333333334

3166.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

681_720

674.3333333333334

3166.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

733_769

674.3333333333334

3166.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

771_807

674.3333333333334

3166.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

809_847

674.3333333333334

3166.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

849_888

674.3333333333334

3166.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

890_926

674.3333333333334

3166.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

928_964

674.3333333333334

3166.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

966_1002

674.3333333333334

3166.0

Domain

EGF-like 15

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1004_1040

620.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1042_1077

620.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1079_1115

620.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1117_1159

620.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1161_1197

620.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

170_212

620.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

1883_2063

620.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2099_2140

620.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

213_254

620.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2145_2339

620.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2335_2368

620.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2371_2408

620.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2419_2609

620.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

256_292

620.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2610_2646

620.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2648_2689

620.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2717_2895

620.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2896_2932

620.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2933_2970

620.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

2975_3165

620.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

332_368

620.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

370_406

620.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

567_602

620.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

643_679

620.0

Domain

EGF-like 7

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

681_720

620.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

733_769

620.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

771_807

620.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

809_847

620.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

849_888

620.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

890_926

620.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

928_964

620.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000393380

966_1002

620.0

Domain

EGF-like 15

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1004_1040

674.3333333333334

3145.0

Domain

EGF-like 16%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1042_1077

674.3333333333334

3145.0

Domain

EGF-like 17

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1079_1115

674.3333333333334

3145.0

Domain

EGF-like 18

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1117_1159

674.3333333333334

3145.0

Domain

EGF-like 19

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1161_1197

674.3333333333334

3145.0

Domain

EGF-like 20%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

1883_2063

674.3333333333334

3145.0

Domain

Laminin G-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2099_2140

674.3333333333334

3145.0

Domain

EGF-like 21

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2145_2339

674.3333333333334

3145.0

Domain

Laminin G-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2335_2368

674.3333333333334

3145.0

Domain

EGF-like 22

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2371_2408

674.3333333333334

3145.0

Domain

EGF-like 23

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2419_2609

674.3333333333334

3145.0

Domain

Laminin G-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2610_2646

674.3333333333334

3145.0

Domain

EGF-like 24

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2648_2689

674.3333333333334

3145.0

Domain

EGF-like 25

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2717_2895

674.3333333333334

3145.0

Domain

Laminin G-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2896_2932

674.3333333333334

3145.0

Domain

EGF-like 26

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2933_2970

674.3333333333334

3145.0

Domain

EGF-like 27

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

2975_3165

674.3333333333334

3145.0

Domain

Laminin G-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

681_720

674.3333333333334

3145.0

Domain

EGF-like 8%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

733_769

674.3333333333334

3145.0

Domain

EGF-like 9%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

771_807

674.3333333333334

3145.0

Domain

EGF-like 10%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

809_847

674.3333333333334

3145.0

Domain

EGF-like 11

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

849_888

674.3333333333334

3145.0

Domain

EGF-like 12

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

890_926

674.3333333333334

3145.0

Domain

EGF-like 13

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

928_964

674.3333333333334

3145.0

Domain

EGF-like 14%3B calcium-binding

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

966_1002

674.3333333333334

3145.0

Domain

EGF-like 15

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

170_212

674.3333333333334

3166.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

213_254

674.3333333333334

3166.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

256_292

674.3333333333334

3166.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

332_368

674.3333333333334

3166.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

370_406

674.3333333333334

3166.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

567_602

674.3333333333334

3166.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370616

643_679

674.3333333333334

3166.0

Domain

EGF-like 7

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

170_212

674.3333333333334

3166.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

213_254

674.3333333333334

3166.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

256_292

674.3333333333334

3166.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

332_368

674.3333333333334

3166.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

370_406

674.3333333333334

3166.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

567_602

674.3333333333334

3166.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000370621

643_679

674.3333333333334

3166.0

Domain

EGF-like 7

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

170_212

674.3333333333334

3145.0

Domain

EGF-like 1

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

213_254

674.3333333333334

3145.0

Domain

EGF-like 2

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

256_292

674.3333333333334

3145.0

Domain

EGF-like 3

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

332_368

674.3333333333334

3145.0

Domain

EGF-like 4

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

370_406

674.3333333333334

3145.0

Domain

EGF-like 5

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

567_602

674.3333333333334

3145.0

Domain

EGF-like 6

Tgene

EYS

chr19:34887335

chr6:65767620

ENST00000503581

643_679

674.3333333333334

3145.0

Domain

EGF-like 7

Top

Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

AA seq

Len(AA seq)

Top

pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

GPI_pLDDT.png

EYS_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

Top

Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GPI
EYS

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to GPI-EYS

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to GPI-EYS

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source