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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GPR158-MYO16

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GPR158-MYO16
FusionPDB ID: 34410
FusionGDB2.0 ID: 34410
HgeneTgene
Gene symbol

GPR158

MYO16

Gene ID

57512

23026

Gene nameG protein-coupled receptor 158myosin XVI
Synonyms-MYAP3|MYR8|Myo16b|NYAP3|PPP1R107
Cytomap

10p12.1

13q33.3

Type of geneprotein-codingprotein-coding
Descriptionprobable G-protein coupled receptor 158unconventional myosin-XVIMYO16 variant proteinmyosin heavy chain Myr 8neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adapter 3neuronal tyrosine-phosphorylated phosphoinositide-3-kinase adaptor 3protein phosphatase 1, regulatory subunit 10
Modification date2020031320200313
UniProtAcc

Q5T848

Q9Y6X6

Ensembl transtripts involved in fusion geneENST idsENST00000376351, ENST00000490549, 
ENST00000467639, ENST00000251041, 
ENST00000356711, ENST00000357550, 
ENST00000457511, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 4 X 3=4818 X 19 X 10=3420
# samples 521
** MAII scorelog2(5/48*10)=0.0588936890535686
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(21/3420*10)=-4.02553509210714
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GPR158 [Title/Abstract] AND MYO16 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GPR158(25465251)-MYO16(109644724), # samples:3
Anticipated loss of major functional domain due to fusion event.GPR158-MYO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPR158-MYO16 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPR158-MYO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPR158-MYO16 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across GPR158 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MYO16 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4BRCATCGA-C8-A1HO-01AGPR158chr10

25465251

-MYO16chr13

109644724

+
ChimerDB4BRCATCGA-C8-A1HO-01AGPR158chr10

25465251

+MYO16chr13

109644724

+
ChimerDB4BRCATCGA-C8-A1HOGPR158chr10

25465251

+MYO16chr13

109644723

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000376351GPR158chr1025465251+ENST00000356711MYO16chr13109644724+5706126135945341391
ENST00000376351GPR158chr1025465251+ENST00000251041MYO16chr13109644724+240912613591780473
ENST00000376351GPR158chr1025465251+ENST00000357550MYO16chr13109644724+5692126135945341391
ENST00000376351GPR158chr1025465251+ENST00000457511MYO16chr13109644724+308412613592995878
ENST00000376351GPR158chr1025465251+ENST00000356711MYO16chr13109644723+5706126135945341391
ENST00000376351GPR158chr1025465251+ENST00000251041MYO16chr13109644723+240912613591780473
ENST00000376351GPR158chr1025465251+ENST00000357550MYO16chr13109644723+5692126135945341391
ENST00000376351GPR158chr1025465251+ENST00000457511MYO16chr13109644723+308412613592995878

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000376351ENST00000356711GPR158chr1025465251+MYO16chr13109644724+0.0010090470.99899095
ENST00000376351ENST00000251041GPR158chr1025465251+MYO16chr13109644724+0.0020361880.9979638
ENST00000376351ENST00000357550GPR158chr1025465251+MYO16chr13109644724+0.0010342260.99896574
ENST00000376351ENST00000457511GPR158chr1025465251+MYO16chr13109644724+0.002118220.9978817
ENST00000376351ENST00000356711GPR158chr1025465251+MYO16chr13109644723+0.0010090470.99899095
ENST00000376351ENST00000251041GPR158chr1025465251+MYO16chr13109644723+0.0020361880.9979638
ENST00000376351ENST00000357550GPR158chr1025465251+MYO16chr13109644723+0.0010342260.99896574
ENST00000376351ENST00000457511GPR158chr1025465251+MYO16chr13109644723+0.002118220.9978817

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34410_34410_1_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644723_ENST00000251041_length(amino acids)=473AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG

--------------------------------------------------------------

>34410_34410_2_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644723_ENST00000356711_length(amino acids)=1391AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL
HSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEIS
GSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP
PLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQK
GDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPY
SPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNA
NNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQ

--------------------------------------------------------------

>34410_34410_3_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644723_ENST00000357550_length(amino acids)=1391AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL
HSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEIS
GSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP
PLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQK
GDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPY
SPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNA
NNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQ

--------------------------------------------------------------

>34410_34410_4_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644723_ENST00000457511_length(amino acids)=878AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL

--------------------------------------------------------------

>34410_34410_5_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644724_ENST00000251041_length(amino acids)=473AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG

--------------------------------------------------------------

>34410_34410_6_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644724_ENST00000356711_length(amino acids)=1391AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL
HSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEIS
GSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP
PLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQK
GDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPY
SPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNA
NNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQ

--------------------------------------------------------------

>34410_34410_7_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644724_ENST00000357550_length(amino acids)=1391AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL
HSVFSMDDSSSLPSPRKQPPPKPKRDPNTRLSASYEAVSACLSAAREAANEALARPRPHSDDYSTMKKIPPRKPKRSPNTKLSGSYEEIS
GSRPGDARPAGAPGAAARVLTPGTPQCALPPAAPPGDEDDSEPVYIEMLGHAARPDSPDPGESVYEEMKCCLPDDGGPGAGSFLLHGASP
PLLHRAPEDEAAGPPGDACDIPPPFPNLLPHRPPLLVFPPTPVTCSPASDESPLTPLEVKKLPVLETNLKYPVQPEGSSPLSPQYSKSQK
GDGDRPASPGLALFNGSGRASPPSTPPPPPPPPGPPPAPYRPCAHLAFPPEPAPVNAGKAGPSAEAPKVHPKPNSAPVAGPCSSFPKIPY
SPVKATRADARKAGSSASPPAPYSPPSSRPLSSPLDELASLFNSGRSVLRKSAAGRKIREAEGFETNMNISSRDDPSTSEITSETQDRNA
NNHGIQLSNSLSSAITAENGNSISNGLPEEDGYSRLSISGTGTSTFQRHRDSHTTQVIHQLRLSENESVALQELLDWRRKLCEEGQDWQQ

--------------------------------------------------------------

>34410_34410_8_GPR158-MYO16_GPR158_chr10_25465251_ENST00000376351_MYO16_chr13_109644724_ENST00000457511_length(amino acids)=878AA_BP=299
MGAMAYPLLLCLLLAQLGLGAVGASRDPQGRPDSPRERTPKGKPHAQQPGRASASDSSAPWSRSTDGTILAQKLAEEVPMDVASYLYTGD
SHQLKRANCSGRYELAGLPGKWPALASAHPSLHRALDTLTHATNFLNVMLQSNKSREQNLQDDLDWYQALVWSLLEGEPSISRAAITFST
DSLSAPAPQVFLQATREESRILLQDLSSSAPHLANATLETEWFHGLRRKWRPHLHRRGPNQGPRGLGHSWRRKDGLGGDKSHFKWSPPYL
ECENGSYKPGWLVTLSSAIYGLQPNLVPEFSMQTLDIGILDIFGFEEFQKNEFEQLCVNMTNEKMHHYINEVLFLHEQVECVQEGVTMET
AYSPGNQNGVLDFFFQKPSGFLTLLDEESQMIWSVESNFPKKLQSLLESSNTNAVYSPMKDGNGNVALKDHGTAFTIMHYAGRVMYDVVG
AIEKNKDSLSQNLLFVMKTSENVVINHLFQSKLSQTGSLVSAYPSFKFRGHKSALLSKKMTASSIIGENKNYLELSKLLKKKGTSTFLQR
LERGDPVTIASQLRKSLMDIIGKLQKCTPHFIHCIRPNNSKLPDTFDNFYVSAQLQYIGVLEMVKIFRYGYPVRLSFSDFLSRYKPLADT
FLREKKEQSAAERCRLVLQQCKLQGWQMGVRKVFLKYWHADQLNDLCLQLQRKIITCQKVIRGFLARQHLLQRISIRQQEVTSINSFLQN
TEDMGLKTYDALVIQNASDIARENDRLRSEMNAPYHKEKLEVRNMQEEGSKRTDDKSGPRHFHPSSMSVCAAVDGLGQCLVGPSIWSPSL

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:25465251/chr13:109644724)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPR158

Q5T848

MYO16

Q9Y6X6

FUNCTION: Orphan receptor.FUNCTION: Myosins are actin-based motor molecules with ATPase activity. Unconventional myosins serve in intracellular movements. Their highly divergent tails are presumed to bind to membranous compartments, which would be moved relative to actin filaments. May be involved in targeting of the catalytic subunit of protein phosphatase 1 during brain development. Activates PI3K and concomitantly recruits the WAVE1 complex to the close vicinity of PI3K and regulates neuronal morphogenesis (By similarity). {ECO:0000250}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMYO16chr10:25465251chr13:109644723ENST0000025104118241389_1671767.6666666666666941.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644723ENST0000035671119351389_1671767.66666666666661859.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644723ENST0000035755018341389_1671767.66666666666661859.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644724ENST0000025104118241389_1671767.6666666666666941.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644724ENST0000035671119351389_1671767.66666666666661859.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644724ENST0000035755018341389_1671767.66666666666661859.0Compositional biasPro-rich
TgeneMYO16chr10:25465251chr13:109644723ENST0000025104118241147_1176767.6666666666666941.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644723ENST0000035671119351147_1176767.66666666666661859.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644723ENST0000035755018341147_1176767.66666666666661859.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644724ENST0000025104118241147_1176767.6666666666666941.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644724ENST0000035671119351147_1176767.66666666666661859.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644724ENST0000035755018341147_1176767.66666666666661859.0DomainIQ
TgeneMYO16chr10:25465251chr13:109644723ENST0000025104118241111_1377767.6666666666666941.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr10:25465251chr13:109644723ENST0000035671119351111_1377767.66666666666661859.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr10:25465251chr13:109644723ENST0000035755018341111_1377767.66666666666661859.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr10:25465251chr13:109644724ENST0000025104118241111_1377767.6666666666666941.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr10:25465251chr13:109644724ENST0000035671119351111_1377767.66666666666661859.0RegionInvolved in CYFIP1- and NCKAP1-binding
TgeneMYO16chr10:25465251chr13:109644724ENST0000035755018341111_1377767.66666666666661859.0RegionInvolved in CYFIP1- and NCKAP1-binding

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+11124_417300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111439_451300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111473_483300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111507_528300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111550_579300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111601_613300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111635_643300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111665_1215300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+11124_417300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111439_451300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111473_483300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111507_528300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111550_579300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111601_613300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111635_643300.66666666666671216.0Topological domainExtracellular
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111665_1215300.66666666666671216.0Topological domainCytoplasmic
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111418_438300.66666666666671216.0TransmembraneHelical%3B Name%3D1
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111452_472300.66666666666671216.0TransmembraneHelical%3B Name%3D2
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111484_506300.66666666666671216.0TransmembraneHelical%3B Name%3D3
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111529_549300.66666666666671216.0TransmembraneHelical%3B Name%3D4
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111580_600300.66666666666671216.0TransmembraneHelical%3B Name%3D5
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111614_634300.66666666666671216.0TransmembraneHelical%3B Name%3D6
HgeneGPR158chr10:25465251chr13:109644723ENST00000376351+111644_664300.66666666666671216.0TransmembraneHelical%3B Name%3D7
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111418_438300.66666666666671216.0TransmembraneHelical%3B Name%3D1
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111452_472300.66666666666671216.0TransmembraneHelical%3B Name%3D2
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111484_506300.66666666666671216.0TransmembraneHelical%3B Name%3D3
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111529_549300.66666666666671216.0TransmembraneHelical%3B Name%3D4
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111580_600300.66666666666671216.0TransmembraneHelical%3B Name%3D5
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111614_634300.66666666666671216.0TransmembraneHelical%3B Name%3D6
HgeneGPR158chr10:25465251chr13:109644724ENST00000376351+111644_664300.66666666666671216.0TransmembraneHelical%3B Name%3D7
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824401_1145767.6666666666666941.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935401_1145767.66666666666661859.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834401_1145767.66666666666661859.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824401_1145767.6666666666666941.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935401_1145767.66666666666661859.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834401_1145767.66666666666661859.0DomainMyosin motor
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824497_504767.6666666666666941.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935497_504767.66666666666661859.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834497_504767.66666666666661859.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824497_504767.6666666666666941.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935497_504767.66666666666661859.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834497_504767.66666666666661859.0Nucleotide bindingATP
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824125_154767.6666666666666941.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824158_189767.6666666666666941.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824191_217767.6666666666666941.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824221_250767.6666666666666941.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644723ENST000002510411824254_283767.6666666666666941.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644723ENST00000251041182459_88767.6666666666666941.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644723ENST00000251041182492_121767.6666666666666941.0RepeatANK 2
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935125_154767.66666666666661859.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935158_189767.66666666666661859.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935191_217767.66666666666661859.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935221_250767.66666666666661859.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644723ENST000003567111935254_283767.66666666666661859.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644723ENST00000356711193559_88767.66666666666661859.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644723ENST00000356711193592_121767.66666666666661859.0RepeatANK 2
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834125_154767.66666666666661859.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834158_189767.66666666666661859.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834191_217767.66666666666661859.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834221_250767.66666666666661859.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644723ENST000003575501834254_283767.66666666666661859.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644723ENST00000357550183459_88767.66666666666661859.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644723ENST00000357550183492_121767.66666666666661859.0RepeatANK 2
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824125_154767.6666666666666941.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824158_189767.6666666666666941.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824191_217767.6666666666666941.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824221_250767.6666666666666941.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644724ENST000002510411824254_283767.6666666666666941.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644724ENST00000251041182459_88767.6666666666666941.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644724ENST00000251041182492_121767.6666666666666941.0RepeatANK 2
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935125_154767.66666666666661859.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935158_189767.66666666666661859.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935191_217767.66666666666661859.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935221_250767.66666666666661859.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644724ENST000003567111935254_283767.66666666666661859.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644724ENST00000356711193559_88767.66666666666661859.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644724ENST00000356711193592_121767.66666666666661859.0RepeatANK 2
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834125_154767.66666666666661859.0RepeatANK 3
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834158_189767.66666666666661859.0RepeatANK 4
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834191_217767.66666666666661859.0RepeatANK 5
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834221_250767.66666666666661859.0RepeatANK 6
TgeneMYO16chr10:25465251chr13:109644724ENST000003575501834254_283767.66666666666661859.0RepeatANK 7
TgeneMYO16chr10:25465251chr13:109644724ENST00000357550183459_88767.66666666666661859.0RepeatANK 1
TgeneMYO16chr10:25465251chr13:109644724ENST00000357550183492_121767.66666666666661859.0RepeatANK 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GPR158
MYO16


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


Top

Related Drugs to GPR158-MYO16


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GPR158-MYO16


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource