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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GPSM1-NUP214

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GPSM1-NUP214
FusionPDB ID: 34517
FusionGDB2.0 ID: 34517
HgeneTgene
Gene symbol

GPSM1

NUP214

Gene ID

26086

8021

Gene nameG protein signaling modulator 1nucleoporin 214
SynonymsAGS3CAIN|CAN|IIAE9
Cytomap

9q34.3

9q34.13

Type of geneprotein-codingprotein-coding
DescriptionG-protein-signaling modulator 1G-protein signalling modulator 1 (AGS3-like, C. elegans)activator of G-protein signaling 3nuclear pore complex protein Nup214CAN protein, putative oncogenenucleoporin 214kDa
Modification date2020031320200322
UniProtAcc

Q86YR5

P35658

Ensembl transtripts involved in fusion geneENST idsENST00000392944, ENST00000429455, 
ENST00000440944, ENST00000392945, 
ENST00000465486, ENST00000483497, 
ENST00000359428, ENST00000411637, 
ENST00000451030, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score2 X 3 X 2=1219 X 26 X 11=5434
# samples 329
** MAII scorelog2(3/12*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(29/5434*10)=-4.22788976020704
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GPSM1 [Title/Abstract] AND NUP214 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GPSM1(139252661)-NUP214(134002911), # samples:2
GPSM1(139251002)-NUP214(134002911), # samples:2
Anticipated loss of major functional domain due to fusion event.GPSM1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPSM1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GPSM1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPSM1-NUP214 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GPSM1-NUP214 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
GPSM1-NUP214 seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGPSM1

GO:0016239

positive regulation of macroautophagy

12642577

HgeneGPSM1

GO:0034260

negative regulation of GTPase activity

11024022

HgeneGPSM1

GO:1905098

negative regulation of guanyl-nucleotide exchange factor activity

11024022


check buttonFusion gene breakpoints across GPSM1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across NUP214 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LGGTCGA-HT-7873-01BGPSM1chr9

139251002

-NUP214chr9

134002911

+
ChimerDB4LGGTCGA-HT-7873-01BGPSM1chr9

139252661

+NUP214chr9

134002911

+
ChimerDB4LGGTCGA-HT-7873GPSM1chr9

139251002

+NUP214chr9

134002911

+
ChimerDB4LGGTCGA-HT-7873GPSM1chr9

139252661

+NUP214chr9

134002911

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000440944GPSM1chr9139251002+ENST00000359428NUP214chr9134002911+9452204122082682682
ENST00000440944GPSM1chr9139251002+ENST00000411637NUP214chr9134002911+9415204122082382672
ENST00000440944GPSM1chr9139251002+ENST00000451030NUP214chr9134002911+8486204122082712683
ENST00000429455GPSM1chr9139251002+ENST00000359428NUP214chr9134002911+78764653366922219
ENST00000429455GPSM1chr9139251002+ENST00000411637NUP214chr9134002911+78394653366622209
ENST00000429455GPSM1chr9139251002+ENST00000451030NUP214chr9134002911+69104653366952220
ENST00000392944GPSM1chr9139251002+ENST00000359428NUP214chr9134002911+799258115568082217
ENST00000392944GPSM1chr9139251002+ENST00000411637NUP214chr9134002911+795558115567782207
ENST00000392944GPSM1chr9139251002+ENST00000451030NUP214chr9134002911+702658115568112218

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000440944ENST00000359428GPSM1chr9139251002+NUP214chr9134002911+0.0033789640.996621
ENST00000440944ENST00000411637GPSM1chr9139251002+NUP214chr9134002911+0.0033715620.99662846
ENST00000440944ENST00000451030GPSM1chr9139251002+NUP214chr9134002911+0.003693460.99630654
ENST00000429455ENST00000359428GPSM1chr9139251002+NUP214chr9134002911+0.0030528460.9969471
ENST00000429455ENST00000411637GPSM1chr9139251002+NUP214chr9134002911+0.0030355540.9969644
ENST00000429455ENST00000451030GPSM1chr9139251002+NUP214chr9134002911+0.0033843070.9966157
ENST00000392944ENST00000359428GPSM1chr9139251002+NUP214chr9134002911+0.003355210.99664485
ENST00000392944ENST00000411637GPSM1chr9139251002+NUP214chr9134002911+0.0033344020.99666554
ENST00000392944ENST00000451030GPSM1chr9139251002+NUP214chr9134002911+0.0036908610.9963091

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34517_34517_1_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000392944_NUP214_chr9_134002911_ENST00000359428_length(amino acids)=2217AA_BP=141
MDWGSTHERGEVRGSRRVPRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLI
ASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKS
LQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLL
EGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLAN
NREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAK
RKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHG
SSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPA
TPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGF
NFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETP
PSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAAT
STSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRST
EEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVP
PASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPV
FGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASST
PTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQ
AASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKP
TGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTT

--------------------------------------------------------------

>34517_34517_2_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000392944_NUP214_chr9_134002911_ENST00000411637_length(amino acids)=2207AA_BP=141
MDWGSTHERGEVRGSRRVPRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLI
ASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENSSQ
SAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEKQG
HQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEEAR
EQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQRK
RLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRSTA
PASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGTSV
ATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGSSV
PYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPTPS
SNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELLFP
SSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVFGS
LPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSALPE
KPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVPGQ
TAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAASTAP
SLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSVFG
AASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIVFG
QQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGGGS
VASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQNA

--------------------------------------------------------------

>34517_34517_3_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000392944_NUP214_chr9_134002911_ENST00000451030_length(amino acids)=2218AA_BP=141
MDWGSTHERGEVRGSRRVPRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFDLI
ASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLVFA
GGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAYHK
LLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPCPP
FYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASAAS
TEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVKSL
IKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPSYS
SGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKFTA
AATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAK
SLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTL
LEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLA
NNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLA
KRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVH
GSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNP
ATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTG
FNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLET
PPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAA
TSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRS
TEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAV
PPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATP
VFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASS
TPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFG
QAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQK
PTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNT

--------------------------------------------------------------

>34517_34517_4_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000429455_NUP214_chr9_134002911_ENST00000359428_length(amino acids)=2219AA_BP=143
MRSVWPSTQRGSLLLWRQPVIRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFD
LIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLV
FAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAY
HKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPC
PPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASA
ASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVK
SLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPS
YSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKF
TAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQA
KSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTT
LLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTL
ANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFL
AKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLV
HGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNN
PATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGT
GFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLE
TPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPA
ATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGR
STEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEA
VPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSAT
PVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPAS
STPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVF
GQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQ
KPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSN

--------------------------------------------------------------

>34517_34517_5_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000429455_NUP214_chr9_134002911_ENST00000411637_length(amino acids)=2209AA_BP=143
MRSVWPSTQRGSLLLWRQPVIRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFD
LIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLV
FAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAY
HKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPC
PPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASA
ASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVK
SLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPS
YSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSENS
SQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQAKSLQPAVAEK
QGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKTTLLEGFAGVEE
AREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNTLANNREIINQQ
RKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNFLAKRKTPPVRS
TAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHLVHGSSPGVMGT
SVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKNNPATPSTAMGS
SVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSGTGFNFGIITPT
PSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKLETPPSKLGELL
FPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPPAATSTSSTAVF
GSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAGRSTEEATSSAL
PEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTEAVPPASSFSVP
GQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSATPVFGQVAAST
APSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPASSTPTSTSGSV
FGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSVFGQAASTGGIV
FGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGEQKPTGTFSSGG
GSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSSNTTSFGTLASQ

--------------------------------------------------------------

>34517_34517_6_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000429455_NUP214_chr9_134002911_ENST00000451030_length(amino acids)=2220AA_BP=143
MRSVWPSTQRGSLLLWRQPVIRSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQPSMTASPQTEEFFD
LIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKERSSLLAVSNKYGLV
FAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTFSNEAKQQKRPFAY
HKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQYLPTLQEKKVIPC
PPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLSYIEEWDLVLAASA
ASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVLCPFYMINQNPGVK
SLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSSLKSSATVTGEPPS
YSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPPSTSAVKVNLSEKF
TAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGSPQ
AKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSLKT
TLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLFNT
LANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLRNF
LAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKSHL
VHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQELKN
NPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSPSG
TGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSSKL
ETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVAPP
AATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMSAG
RSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDARTE
AVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAPSA
TPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQPA
SSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTGSV
FGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSFGE
QKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGSSS

--------------------------------------------------------------

>34517_34517_7_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000440944_NUP214_chr9_134002911_ENST00000359428_length(amino acids)=2682AA_BP=606
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK
HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAE
YYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPV
RSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKER
SSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTF
SNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQ
YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLS
YIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVL
CPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSS
LKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPP
STSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSGRSAQGSSSPVPSMVQKSPR
ITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETT
ESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRH
LLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAK
LSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSL
LPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKN
VPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASG
QFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAP
SGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPV
TSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLS
SATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEAT
PATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFN
QLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQP
GFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQ
ASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAK
TFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAA

--------------------------------------------------------------

>34517_34517_8_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000440944_NUP214_chr9_134002911_ENST00000411637_length(amino acids)=2672AA_BP=606
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK
HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAE
YYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPV
RSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKER
SSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTF
SNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQ
YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLS
YIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVL
CPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSS
LKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPP
STSAVKVNLSENSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSPRITPPAAKPGS
PQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKETTESLHGDISSL
KTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQRHLLVPERETLF
NTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPAKLSPMKQAQLR
NFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPSLLPHAAPFAKS
HLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLKNVPQVVNVQEL
KNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSASGQFSKPFSFSP
SGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVAPSGTALSTTSS
KLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPPVTSSATTTSVA
PPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLLSSATTPSLPMS
AGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEATPATTGVPDAR
TEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAFNQLTNNTATAP
SATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQPGFSSVPAFGQ
PASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFCQASGFGSSNTG
SVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGAKTFGGFASSSF
GEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTAAASAGGFGFGS

--------------------------------------------------------------

>34517_34517_9_GPSM1-NUP214_GPSM1_chr9_139251002_ENST00000440944_NUP214_chr9_134002911_ENST00000451030_length(amino acids)=2683AA_BP=606
MAGPAPPVADELPGPAARRLYSRMEASCLELALEGERLCKAGDFKTGVAFFEAAVQVGTEDLKTLSAIYSQLGNAYFYLKEHGRALEYHK
HDLLLARTIGDRMGEAKASGNLGNTLKVLGRFDEAAVCCQRHLSIAQEQGDKVGEARALYNIGNVYHAKGKQLSWNAANATQDPGHLPPD
VRETLCKASEFYERNLSLVKELGDRAAQGRAYGNLGNTHYLLGNFTEATTFHKERLAIAKEFGDKAAERRAYSNLGNAHVFLGRFDVAAE
YYKKTLQLSRQLRDQAVEAQACYSLGNTYTLLQDYERAAEYHLRHLLIAQELADRVGEGRACWSLGNAYVSMGRPAQALTFAKKHLQISQ
EIGDRHGELTARMNVAQLQLVLGRLTSPAASEKPDLAGYEAQGARPKRTQRLSAETWDLLRLPLEREQNGDSHHSGDWRGPSRDSLPLPV
RSRKYQEGPDAERRPREGSHSPLDSADVRVHVPRTSIPRAPSSDEECFFDLLTKFQSSRMDDQRCPLDDGQAGAAEATAAPTLEDRIAQP
SMTASPQTEEFFDLIASSQSRRLDDQRASVGSLPGLRITHSNAGHLRGHGEPQEPGDDFFNMLIKYQDFQFRALKKVRIFDSPEELPKER
SSLLAVSNKYGLVFAGGASGLQIFPTKNLLIQNKPGDDPNKIVDKVQGLLVPMKFPIHHLALSCDNLTLSACMMSSEYGSIIAFFDVRTF
SNEAKQQKRPFAYHKLLKDAGGMVIDMKWNPTVPSMVAVCLADGSIAVLQVTETVKVCATLPSTVAVTSVCWSPKGKQLAVGKQNGTVVQ
YLPTLQEKKVIPCPPFYESDHPVRVLDVLWIGTYVFAIVYAAADGTLETSPDVVMALLPKKEEKHPEIFVNFMEPCYGSCTERQHHYYLS
YIEEWDLVLAASAASTEVSILARQSDQINWESWLLEDSSRAELPVTDKSDDSLPMGVVVDYTNQVEITISDEKTLPPAPVLMLLSTDGVL
CPFYMINQNPGVKSLIKTPERLSLEGERQPKSPGSTPTTPTSSQAPQKLDASAAAAPASLPPSSPAAPIATFSLLPAGGAPTVFSFGSSS
LKSSATVTGEPPSYSSGSDSSKAAPGPGPSTFSFVPPSKASLAPTPAASPVAPSAASFSFGSSGFKPTLESTPVPSVSAPNIAMKPSFPP
STSAVKVNLSEKFTAAATSTPVSSSQSAPPMSPFSSASKPAASGPLSHPTPLSAPPSSVPLKSSVLPSPSAGRSAQGSSSPVPSMVQKSP
RITPPAAKPGSPQAKSLQPAVAEKQGHQWKDSDPVMAGIGEEIAHFQKELEELKARTSKACFQVGTSEEMKMLRTESDDLHTFLLEIKET
TESLHGDISSLKTTLLEGFAGVEEAREQNERNRDSGYLHLLYKRPLDPKSEAQLQEIRRLHQYVKFAVQDVNDVLDLEWDQHLEQKKKQR
HLLVPERETLFNTLANNREIINQQRKRLNHLVDSLQQLRLYKQTSLWSLSSAVPSQSSIHSFDSDLESLCNALLKTTIESHTKSLPKVPA
KLSPMKQAQLRNFLAKRKTPPVRSTAPASLSRSAFLSQRYYEDLDEVSSTSSVSQSLESEDARTSCKDDEAVVQAPRHAPVVRTPSIQPS
LLPHAAPFAKSHLVHGSSPGVMGTSVATSASKIIPQGADSTMLATKTVKHGAPSPSHPISAPQAAAAAALRRQMASQAPAVNTLTESTLK
NVPQVVNVQELKNNPATPSTAMGSSVPYSTAKTPHPVLTPVAANQAKQGSLINSLKPSGPTPASGQLSSGDKASGTAKIETAVTSTPSAS
GQFSKPFSFSPSGTGFNFGIITPTPSSNFTAAQGATPSTKESSQPDAFSSGGGSKPSYEAIPESSPPSGITSASNTTPGEPAASSSRPVA
PSGTALSTTSSKLETPPSKLGELLFPSSLAGETLGSFSGLRVGQADDSTKPTNKASSTSLTSTQPTKTSGVPSGFNFTAPPVLGKHTEPP
VTSSATTTSVAPPAATSTSSTAVFGSLPVTSAGSSGVISFGGTSLSAGKTSFSFGSQQTNSTVPPSAPPPTTAATPLPTSFPTLSFGSLL
SSATTPSLPMSAGRSTEEATSSALPEKPGDSEVSASAASLLEEQQSAQLPQAPPQTSDSVKKEPVLAQPAVSNSGTAASSTSLVALSAEA
TPATTGVPDARTEAVPPASSFSVPGQTAVTAAAISSAGPVAVETSSTPIASSTTSIVAPGPSAEAAAFGTVTSGSSVFAQPPAASSSSAF
NQLTNNTATAPSATPVFGQVAASTAPSLFGQQTGSTASTAAATPQVSSSGFSSPAFGTTAPGVFGQTTFGQASVFGQSASSAASVFSFSQ
PGFSSVPAFGQPASSTPTSTSGSVFGAASSTSSSSSFSFGQSSPNTGGGLFGQSNAPAFGQSPGFGQGGSVFGGTSAATTTAATSGFSFC
QASGFGSSNTGSVFGQAASTGGIVFGQQSSSSSGSVFGSGNTGRGGGFFSGLGGKPSQDAANKNPFSSASGGFGSTATSNTSNLFGNSGA
KTFGGFASSSFGEQKPTGTFSSGGGSVASQGFGFSSPNKTGGFGAAPVFGSPPTFGGSPGFGGVPAFGSAPAFTSPLGSTGGKVFGEGTA

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:139252661/chr9:134002911)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GPSM1

Q86YR5

NUP214

P35658

FUNCTION: Guanine nucleotide dissociation inhibitor (GDI) which functions as a receptor-independent activator of heterotrimeric G-protein signaling. Keeps G(i/o) alpha subunit in its GDP-bound form thus uncoupling heterotrimeric G-proteins signaling from G protein-coupled receptors. Controls spindle orientation and asymmetric cell fate of cerebral cortical progenitors. May also be involved in macroautophagy in intestinal cells. May play a role in drug addiction. {ECO:0000269|PubMed:11024022, ECO:0000269|PubMed:12642577}.FUNCTION: Part of the nuclear pore complex (PubMed:9049309). Has a critical role in nucleocytoplasmic transport (PubMed:31178128). May serve as a docking site in the receptor-mediated import of substrates across the nuclear pore complex (PubMed:31178128, PubMed:8108440). {ECO:0000269|PubMed:31178128, ECO:0000269|PubMed:9049309, ECO:0000303|PubMed:8108440}.; FUNCTION: (Microbial infection) Required for capsid disassembly of the human adenovirus 5 (HadV-5) leading to release of the viral genome to the nucleus (in vitro). {ECO:0000269|PubMed:25410864}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314495_517607.0676.0DomainGoLoco 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314548_570607.0676.0DomainGoLoco 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+3428_6198.0167.0RepeatNote=TPR 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+3466_9998.0167.0RepeatNote=TPR 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+3428_6198.0167.0RepeatNote=TPR 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+3466_9998.0167.0RepeatNote=TPR 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314106_139607.0676.0RepeatNote=TPR 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314146_181607.0676.0RepeatNote=TPR 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314183_202607.0676.0RepeatNote=TPR 5
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314209_242607.0676.0RepeatNote=TPR 6
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314249_282607.0676.0RepeatNote=TPR 7
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314289_322607.0676.0RepeatNote=TPR 8
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+131428_61607.0676.0RepeatNote=TPR 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314329_362607.0676.0RepeatNote=TPR 9
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+131466_99607.0676.0RepeatNote=TPR 2
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036680_120915.02091.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036680_120915.02081.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036680_120915.02092.0Coiled coilOntology_term=ECO:0000269
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361213_209015.02091.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361213_209015.02081.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361213_209015.02092.0Compositional biasNote=Pro/Ser/Thr-rich
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361409_208415.02091.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361427_208515.02091.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036236_141815.02091.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139251002chr9:134002911ENST0000035942803641_40415.02091.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036450_58615.02091.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036481_207615.02091.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036740_76815.02091.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036861_88215.02091.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361409_208415.02081.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361427_208515.02081.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036236_141815.02081.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139251002chr9:134002911ENST0000041163703641_40415.02081.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036450_58615.02081.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036481_207615.02081.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036740_76815.02081.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036861_88215.02081.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361409_208415.02092.0RegionNote=18 X 4 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361427_208515.02092.0RegionNote=11 X 3 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036236_141815.02092.0Region44 X 2 AA repeats of F-G
TgeneNUP214chr9:139251002chr9:134002911ENST0000045103003641_40415.02092.0RegionNote=Seven-bladed beta propeller
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036450_58615.02092.0Region(Microbial infection) Binds human adenovirus 5 (HAdV-5) protein L3 (hexon)
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036481_207615.02092.0RegionNote=11 X 5 AA approximate repeats
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036740_76815.02092.0RegionNote=Leucine-zipper 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036861_88215.02092.0RegionNote=Leucine-zipper 2
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361225_122615.02091.0Repeat3
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361411_141215.02091.0Repeat4
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361427_142815.02091.0Repeat5
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361441_144215.02091.0Repeat6
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361473_147415.02091.0Repeat7
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036151_19315.02091.0RepeatNote=Blade 3
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361635_163615.02091.0Repeat8
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361674_167515.02091.0Repeat9
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361686_168715.02091.0Repeat10
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361713_171415.02091.0Repeat11
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361721_172215.02091.0Repeat12
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361726_172715.02091.0Repeat13
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361732_173315.02091.0Repeat14
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361756_175715.02091.0Repeat15
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361772_177315.02091.0Repeat16
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361786_178715.02091.0Repeat17
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361798_179915.02091.0Repeat18
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361806_180715.02091.0Repeat19
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361812_181315.02091.0Repeat20
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361819_182015.02091.0Repeat21
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361842_184315.02091.0Repeat22
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361851_185215.02091.0Repeat23
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361862_186315.02091.0Repeat24
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361874_187515.02091.0Repeat25
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361910_191115.02091.0Repeat26
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361922_192315.02091.0Repeat27
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361930_193115.02091.0Repeat28
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361938_193915.02091.0Repeat29
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036194_23915.02091.0RepeatNote=Blade 4
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361959_196015.02091.0Repeat30
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361970_197115.02091.0Repeat31
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361976_197715.02091.0Repeat32
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361982_198315.02091.0Repeat33
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361988_198915.02091.0Repeat34
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280361994_199515.02091.0Repeat35
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362012_201315.02091.0Repeat36
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362024_202515.02091.0Repeat37
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362026_202715.02091.0Repeat38
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362035_203615.02091.0Repeat39
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362046_204715.02091.0Repeat40
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362056_205715.02091.0Repeat41
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362066_206715.02091.0Repeat42
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362075_207615.02091.0Repeat43
TgeneNUP214chr9:139251002chr9:134002911ENST000003594280362085_208615.02091.0Repeat44
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036240_30315.02091.0RepeatNote=Blade 5
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036304_35915.02091.0RepeatNote=Blade 6
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036360_40415.02091.0RepeatNote=Blade 7
TgeneNUP214chr9:139251002chr9:134002911ENST0000035942803641_9315.02091.0RepeatNote=Blade 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036484_48515.02091.0Repeat1
TgeneNUP214chr9:139251002chr9:134002911ENST00000359428036548_54915.02091.0Repeat2
TgeneNUP214chr9:139251002chr9:134002911ENST0000035942803694_15015.02091.0RepeatNote=Blade 2
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361225_122615.02081.0Repeat3
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361411_141215.02081.0Repeat4
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361427_142815.02081.0Repeat5
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361441_144215.02081.0Repeat6
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361473_147415.02081.0Repeat7
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036151_19315.02081.0RepeatNote=Blade 3
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361635_163615.02081.0Repeat8
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361674_167515.02081.0Repeat9
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361686_168715.02081.0Repeat10
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361713_171415.02081.0Repeat11
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361721_172215.02081.0Repeat12
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361726_172715.02081.0Repeat13
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361732_173315.02081.0Repeat14
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361756_175715.02081.0Repeat15
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361772_177315.02081.0Repeat16
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361786_178715.02081.0Repeat17
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361798_179915.02081.0Repeat18
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361806_180715.02081.0Repeat19
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361812_181315.02081.0Repeat20
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361819_182015.02081.0Repeat21
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361842_184315.02081.0Repeat22
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361851_185215.02081.0Repeat23
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361862_186315.02081.0Repeat24
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361874_187515.02081.0Repeat25
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361910_191115.02081.0Repeat26
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361922_192315.02081.0Repeat27
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361930_193115.02081.0Repeat28
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361938_193915.02081.0Repeat29
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036194_23915.02081.0RepeatNote=Blade 4
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361959_196015.02081.0Repeat30
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361970_197115.02081.0Repeat31
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361976_197715.02081.0Repeat32
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361982_198315.02081.0Repeat33
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361988_198915.02081.0Repeat34
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370361994_199515.02081.0Repeat35
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362012_201315.02081.0Repeat36
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362024_202515.02081.0Repeat37
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362026_202715.02081.0Repeat38
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362035_203615.02081.0Repeat39
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362046_204715.02081.0Repeat40
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362056_205715.02081.0Repeat41
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362066_206715.02081.0Repeat42
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362075_207615.02081.0Repeat43
TgeneNUP214chr9:139251002chr9:134002911ENST000004116370362085_208615.02081.0Repeat44
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036240_30315.02081.0RepeatNote=Blade 5
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036304_35915.02081.0RepeatNote=Blade 6
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036360_40415.02081.0RepeatNote=Blade 7
TgeneNUP214chr9:139251002chr9:134002911ENST0000041163703641_9315.02081.0RepeatNote=Blade 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036484_48515.02081.0Repeat1
TgeneNUP214chr9:139251002chr9:134002911ENST00000411637036548_54915.02081.0Repeat2
TgeneNUP214chr9:139251002chr9:134002911ENST0000041163703694_15015.02081.0RepeatNote=Blade 2
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361225_122615.02092.0Repeat3
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361411_141215.02092.0Repeat4
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361427_142815.02092.0Repeat5
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361441_144215.02092.0Repeat6
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361473_147415.02092.0Repeat7
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036151_19315.02092.0RepeatNote=Blade 3
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361635_163615.02092.0Repeat8
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361674_167515.02092.0Repeat9
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361686_168715.02092.0Repeat10
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361713_171415.02092.0Repeat11
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361721_172215.02092.0Repeat12
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361726_172715.02092.0Repeat13
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361732_173315.02092.0Repeat14
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361756_175715.02092.0Repeat15
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361772_177315.02092.0Repeat16
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361786_178715.02092.0Repeat17
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361798_179915.02092.0Repeat18
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361806_180715.02092.0Repeat19
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361812_181315.02092.0Repeat20
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361819_182015.02092.0Repeat21
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361842_184315.02092.0Repeat22
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361851_185215.02092.0Repeat23
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361862_186315.02092.0Repeat24
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361874_187515.02092.0Repeat25
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361910_191115.02092.0Repeat26
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361922_192315.02092.0Repeat27
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361930_193115.02092.0Repeat28
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361938_193915.02092.0Repeat29
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036194_23915.02092.0RepeatNote=Blade 4
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361959_196015.02092.0Repeat30
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361970_197115.02092.0Repeat31
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361976_197715.02092.0Repeat32
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361982_198315.02092.0Repeat33
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361988_198915.02092.0Repeat34
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300361994_199515.02092.0Repeat35
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362012_201315.02092.0Repeat36
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362024_202515.02092.0Repeat37
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362026_202715.02092.0Repeat38
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362035_203615.02092.0Repeat39
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362046_204715.02092.0Repeat40
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362056_205715.02092.0Repeat41
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362066_206715.02092.0Repeat42
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362075_207615.02092.0Repeat43
TgeneNUP214chr9:139251002chr9:134002911ENST000004510300362085_208615.02092.0Repeat44
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036240_30315.02092.0RepeatNote=Blade 5
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036304_35915.02092.0RepeatNote=Blade 6
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036360_40415.02092.0RepeatNote=Blade 7
TgeneNUP214chr9:139251002chr9:134002911ENST0000045103003641_9315.02092.0RepeatNote=Blade 1
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036484_48515.02092.0Repeat1
TgeneNUP214chr9:139251002chr9:134002911ENST00000451030036548_54915.02092.0Repeat2
TgeneNUP214chr9:139251002chr9:134002911ENST0000045103003694_15015.02092.0RepeatNote=Blade 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34495_51798.0167.0DomainGoLoco 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34548_57098.0167.0DomainGoLoco 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34596_61898.0167.0DomainGoLoco 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34630_65298.0167.0DomainGoLoco 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19495_5170458.0DomainGoLoco 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19548_5700458.0DomainGoLoco 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19596_6180458.0DomainGoLoco 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19630_6520458.0DomainGoLoco 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34495_51798.0167.0DomainGoLoco 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34548_57098.0167.0DomainGoLoco 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34596_61898.0167.0DomainGoLoco 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34630_65298.0167.0DomainGoLoco 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314596_618607.0676.0DomainGoLoco 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000440944+1314630_652607.0676.0DomainGoLoco 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34106_13998.0167.0RepeatNote=TPR 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34146_18198.0167.0RepeatNote=TPR 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34183_20298.0167.0RepeatNote=TPR 5
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34209_24298.0167.0RepeatNote=TPR 6
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34249_28298.0167.0RepeatNote=TPR 7
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34289_32298.0167.0RepeatNote=TPR 8
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34329_36298.0167.0RepeatNote=TPR 9
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19106_1390458.0RepeatNote=TPR 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19146_1810458.0RepeatNote=TPR 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19183_2020458.0RepeatNote=TPR 5
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19209_2420458.0RepeatNote=TPR 6
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19249_2820458.0RepeatNote=TPR 7
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19289_3220458.0RepeatNote=TPR 8
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+1928_610458.0RepeatNote=TPR 1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19329_3620458.0RepeatNote=TPR 9
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+1966_990458.0RepeatNote=TPR 2
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34106_13998.0167.0RepeatNote=TPR 3
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34146_18198.0167.0RepeatNote=TPR 4
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34183_20298.0167.0RepeatNote=TPR 5
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34209_24298.0167.0RepeatNote=TPR 6
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34249_28298.0167.0RepeatNote=TPR 7
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34289_32298.0167.0RepeatNote=TPR 8
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34329_36298.0167.0RepeatNote=TPR 9


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
NUP214ZFP36, XPO1, NUP107, NXF2, NXF1, XPO5, CRM1, KAP104, IPO5, G3BP1, G3BP2, RAE1, APC, HDAC4, HDAC5, HDAC9, NUP88, SMAD1, Plk1, Nup88, Nup188, Nup214, CLEC4G, SMAD2, SMAD3, SMAD4, SIRT7, RANBP2, CUL3, CUL2, rev, NUPL2, NUP214, MEX67, ACOT13, PNPT1, HSPA1L, VPS4B, S100A6, EEF1A1, STRIP1, RPL19, NDUFA7, ITGA4, SOX2, LMNA, FBXO6, CUL7, OBSL1, NUP62, CLEC11A, DDX19A, KCMF1, CFL1, CSRP1, DYNC1LI1, TRIM28, TXNDC9, NTRK1, IFI16, NUP85, NUP35, KPNB1, UBE2I, NUPL1, NUP153, SEH1L, Ranbp2, Ube2i, Rcc1, Nup107, Kifc1, Nup155, Nup98, C11orf30, CDH1, RAN, FXR2, EMILIN1, SERPINB2, BRCA1, ORF10, CTNNB1, CUL4B, RNF31, ESR2, EZH2, SUZ12, MYC, CDK9, VCP, KIAA1429, NR2C2, HIST1H4A, PTPDC1, RHBDD1, RHBDF2, nsp9, BIRC3, LMBR1L, PLEKHA4, CYLD, ORF6, IMMP1L, IMMP2L, CTIF, DDX19B, GLE1, FARP1, Myo9b, ITSN1, PLEKHG6, ACACA, SUMO2, NFX1, NUPR1, DYRK1A, NUP155, SYNE3, NAA40, NXT2, SLFN11, CCNF, TAX1BP1, SIRT6, DVL2, ETV6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GPSM1
NUP214all structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392944+34364_48798.0167.0STK11/LKB1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000392945+19364_4870458.0STK11/LKB1
HgeneGPSM1chr9:139251002chr9:134002911ENST00000429455+34364_48798.0167.0STK11/LKB1


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Related Drugs to GPSM1-NUP214


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GPSM1-NUP214


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneNUP214C0025958Microcephaly1GENOMICS_ENGLAND
TgeneNUP214C0543888Epileptic encephalopathy1GENOMICS_ENGLAND
TgeneNUP214C1836830Developmental regression1GENOMICS_ENGLAND
TgeneNUP214C1961099Precursor T-Cell Lymphoblastic Leukemia-Lymphoma1ORPHANET