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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GRB10-DDC

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GRB10-DDC
	FusionPDB ID: 34619
	FusionGDB2.0 ID: 34619
		Hgene	Tgene
	Gene symbol	GRB10	DDC
	Gene ID	2887	1644
	Gene name	growth factor receptor bound protein 10	dopa decarboxylase
	Synonyms	GRB-IR\|Grb-10\|IRBP\|MEG1\|RSS	AADC
	Cytomap	7p12.1	7p12.2-p12.1
	Type of gene	protein-coding	protein-coding
	Description	growth factor receptor-bound protein 10GRB10 adapter proteinGRB10 adaptor proteininsulin receptor-binding protein Grb-IRmaternally expressed gene 1	aromatic-L-amino-acid decarboxylasedopa decarboxylase (aromatic L-amino acid decarboxylase)
	Modification date	20200327	20200313
	UniProtAcc	Q13322	P20711
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000335866, ENST00000357271, ENST00000398810, ENST00000398812, ENST00000401949, ENST00000402497, ENST00000402578, ENST00000403097, ENST00000406641, ENST00000407526, ENST00000439599, ENST00000483819,	ENST00000380984, ENST00000489162, ENST00000357936, ENST00000426377, ENST00000431062, ENST00000444124,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 10 X 8=1040	2 X 3 X 2=12
	# samples	16	3
	** MAII score	log2(16/1040*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(3/12*10)=1.32192809488736 effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs). DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)	PubMed: GRB10 [Title/Abstract] AND DDC [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GRB10(50737418)-DDC(50537869), # samples:1 GRB10(50737419)-DDC(50537869), # samples:1 GRB10(50737418)-DDC(50537868), # samples:1
Anticipated loss of major functional domain due to fusion event.	GRB10-DDC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GRB10-DDC seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GRB10-DDC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GRB10-DDC seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GRB10-DDC seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. GRB10-DDC seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. GRB10-DDC seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	GRB10	GO:0030178	negative regulation of Wnt signaling pathway	17376403
Hgene	GRB10	GO:0030949	positive regulation of vascular endothelial growth factor receptor signaling pathway	15060076

Fusion gene breakpoints across GRB10 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across DDC (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-55-8094-01A	GRB10	chr7	50737418	-	DDC	chr7	50537868	-
ChimerDB4	LUAD	TCGA-55-8094-01A	GRB10	chr7	50737419	-	DDC	chr7	50537869	-
ChimerDB4	LUAD	TCGA-55-8094	GRB10	chr7	50737418	-	DDC	chr7	50537869	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000398810	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537869	-	1443	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537869	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537869	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537869	-	1414	615	132	1016	294
ENST00000439599	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537869	-	1314	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537869	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537869	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537869	-	1285	486	0	887	295
ENST00000398812	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537869	-	1363	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537869	-	1334	535	31	936	301
ENST00000402578	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537869	-	1423	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537869	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537869	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537869	-	1394	595	244	996	250
ENST00000357271	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537869	-	1363	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537869	-	1334	535	31	936	301
ENST00000398810	GRB10	chr7	50737419	-	ENST00000357936	DDC	chr7	50537869	-	1443	615	132	1016	294
ENST00000398810	GRB10	chr7	50737419	-	ENST00000431062	DDC	chr7	50537869	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737419	-	ENST00000426377	DDC	chr7	50537869	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737419	-	ENST00000444124	DDC	chr7	50537869	-	1414	615	132	1016	294
ENST00000439599	GRB10	chr7	50737419	-	ENST00000357936	DDC	chr7	50537869	-	1314	486	0	887	295
ENST00000439599	GRB10	chr7	50737419	-	ENST00000431062	DDC	chr7	50537869	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737419	-	ENST00000426377	DDC	chr7	50537869	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737419	-	ENST00000444124	DDC	chr7	50537869	-	1285	486	0	887	295
ENST00000398812	GRB10	chr7	50737419	-	ENST00000357936	DDC	chr7	50537869	-	1363	535	31	936	301
ENST00000398812	GRB10	chr7	50737419	-	ENST00000431062	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737419	-	ENST00000426377	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737419	-	ENST00000444124	DDC	chr7	50537869	-	1334	535	31	936	301
ENST00000402578	GRB10	chr7	50737419	-	ENST00000357936	DDC	chr7	50537869	-	1423	595	244	996	250
ENST00000402578	GRB10	chr7	50737419	-	ENST00000431062	DDC	chr7	50537869	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737419	-	ENST00000426377	DDC	chr7	50537869	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737419	-	ENST00000444124	DDC	chr7	50537869	-	1394	595	244	996	250
ENST00000357271	GRB10	chr7	50737419	-	ENST00000357936	DDC	chr7	50537869	-	1363	535	31	936	301
ENST00000357271	GRB10	chr7	50737419	-	ENST00000431062	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737419	-	ENST00000426377	DDC	chr7	50537869	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737419	-	ENST00000444124	DDC	chr7	50537869	-	1334	535	31	936	301
ENST00000398810	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537868	-	1443	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537868	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537868	-	1439	615	132	1016	294
ENST00000398810	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537868	-	1414	615	132	1016	294
ENST00000439599	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537868	-	1314	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537868	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537868	-	1310	486	0	887	295
ENST00000439599	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537868	-	1285	486	0	887	295
ENST00000398812	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537868	-	1363	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537868	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537868	-	1359	535	31	936	301
ENST00000398812	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537868	-	1334	535	31	936	301
ENST00000402578	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537868	-	1423	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537868	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537868	-	1419	595	244	996	250
ENST00000402578	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537868	-	1394	595	244	996	250
ENST00000357271	GRB10	chr7	50737418	-	ENST00000357936	DDC	chr7	50537868	-	1363	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000431062	DDC	chr7	50537868	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000426377	DDC	chr7	50537868	-	1359	535	31	936	301
ENST00000357271	GRB10	chr7	50737418	-	ENST00000444124	DDC	chr7	50537868	-	1334	535	31	936	301

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000398810	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.15853214	0.84146786
ENST00000398810	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.1595366	0.8404634
ENST00000398810	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.1595366	0.8404634
ENST00000398810	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.16017956	0.83982044
ENST00000439599	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.052474745	0.94752526
ENST00000439599	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.053756043	0.946244
ENST00000439599	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.053756043	0.946244
ENST00000439599	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.05219882	0.9478012
ENST00000398812	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021067934	0.9789321
ENST00000398812	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000398812	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000398812	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.020696737	0.97930324
ENST00000402578	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.10556496	0.8944351
ENST00000402578	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.10621226	0.89378774
ENST00000402578	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.10621226	0.89378774
ENST00000402578	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.10428043	0.8957195
ENST00000357271	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021067934	0.9789321
ENST00000357271	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000357271	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000357271	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537869	-	0.020696737	0.97930324
ENST00000398810	ENST00000357936	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.15853214	0.84146786
ENST00000398810	ENST00000431062	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.1595366	0.8404634
ENST00000398810	ENST00000426377	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.1595366	0.8404634
ENST00000398810	ENST00000444124	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.16017956	0.83982044
ENST00000439599	ENST00000357936	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.052474745	0.94752526
ENST00000439599	ENST00000431062	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.053756043	0.946244
ENST00000439599	ENST00000426377	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.053756043	0.946244
ENST00000439599	ENST00000444124	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.05219882	0.9478012
ENST00000398812	ENST00000357936	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021067934	0.9789321
ENST00000398812	ENST00000431062	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000398812	ENST00000426377	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000398812	ENST00000444124	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.020696737	0.97930324
ENST00000402578	ENST00000357936	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.10556496	0.8944351
ENST00000402578	ENST00000431062	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.10621226	0.89378774
ENST00000402578	ENST00000426377	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.10621226	0.89378774
ENST00000402578	ENST00000444124	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.10428043	0.8957195
ENST00000357271	ENST00000357936	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021067934	0.9789321
ENST00000357271	ENST00000431062	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000357271	ENST00000426377	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.021642294	0.9783577
ENST00000357271	ENST00000444124	GRB10	chr7	50737419	-	DDC	chr7	50537869	-	0.020696737	0.97930324
ENST00000398810	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.15853214	0.84146786
ENST00000398810	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.1595366	0.8404634
ENST00000398810	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.1595366	0.8404634
ENST00000398810	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.16017956	0.83982044
ENST00000439599	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.052474745	0.94752526
ENST00000439599	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.053756043	0.946244
ENST00000439599	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.053756043	0.946244
ENST00000439599	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.05219882	0.9478012
ENST00000398812	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021067934	0.9789321
ENST00000398812	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021642294	0.9783577
ENST00000398812	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021642294	0.9783577
ENST00000398812	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.020696737	0.97930324
ENST00000402578	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.10556496	0.8944351
ENST00000402578	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.10621226	0.89378774
ENST00000402578	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.10621226	0.89378774
ENST00000402578	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.10428043	0.8957195
ENST00000357271	ENST00000357936	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021067934	0.9789321
ENST00000357271	ENST00000431062	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021642294	0.9783577
ENST00000357271	ENST00000426377	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.021642294	0.9783577
ENST00000357271	ENST00000444124	GRB10	chr7	50737418	-	DDC	chr7	50537868	-	0.020696737	0.97930324

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34619_34619_1_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537868_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_2_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537868_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_3_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537868_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_4_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537868_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_5_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537869_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_6_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537869_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_7_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537869_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_8_GRB10-DDC_GRB10_chr7_50737418_ENST00000357271_DDC_chr7_50537869_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_9_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537868_ENST00000357936_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_10_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537868_ENST00000426377_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_11_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537868_ENST00000431062_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_12_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537868_ENST00000444124_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_13_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537869_ENST00000357936_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_14_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537869_ENST00000426377_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_15_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537869_ENST00000431062_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_16_GRB10-DDC_GRB10_chr7_50737418_ENST00000398810_DDC_chr7_50537869_ENST00000444124_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_17_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537868_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_18_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537868_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_19_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537868_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_20_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537868_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_21_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537869_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_22_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537869_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_23_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537869_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_24_GRB10-DDC_GRB10_chr7_50737418_ENST00000398812_DDC_chr7_50537869_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_25_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537868_ENST00000357936_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_26_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537868_ENST00000426377_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_27_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537868_ENST00000431062_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_28_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537868_ENST00000444124_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_29_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537869_ENST00000357936_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_30_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537869_ENST00000426377_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_31_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537869_ENST00000431062_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_32_GRB10-DDC_GRB10_chr7_50737418_ENST00000402578_DDC_chr7_50537869_ENST00000444124_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_33_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537868_ENST00000357936_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_34_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537868_ENST00000426377_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_35_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537868_ENST00000431062_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_36_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537868_ENST00000444124_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_37_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537869_ENST00000357936_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_38_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537869_ENST00000426377_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_39_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537869_ENST00000431062_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_40_GRB10-DDC_GRB10_chr7_50737418_ENST00000439599_DDC_chr7_50537869_ENST00000444124_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_41_GRB10-DDC_GRB10_chr7_50737419_ENST00000357271_DDC_chr7_50537869_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_42_GRB10-DDC_GRB10_chr7_50737419_ENST00000357271_DDC_chr7_50537869_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_43_GRB10-DDC_GRB10_chr7_50737419_ENST00000357271_DDC_chr7_50537869_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_44_GRB10-DDC_GRB10_chr7_50737419_ENST00000357271_DDC_chr7_50537869_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_45_GRB10-DDC_GRB10_chr7_50737419_ENST00000398810_DDC_chr7_50537869_ENST00000357936_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_46_GRB10-DDC_GRB10_chr7_50737419_ENST00000398810_DDC_chr7_50537869_ENST00000426377_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_47_GRB10-DDC_GRB10_chr7_50737419_ENST00000398810_DDC_chr7_50537869_ENST00000431062_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_48_GRB10-DDC_GRB10_chr7_50737419_ENST00000398810_DDC_chr7_50537869_ENST00000444124_length(amino acids)=294AA_BP=1
MTRPKPVCSQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPR
SIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVF
RMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTVE

--------------------------------------------------------------

>34619_34619_49_GRB10-DDC_GRB10_chr7_50737419_ENST00000398812_DDC_chr7_50537869_ENST00000357936_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_50_GRB10-DDC_GRB10_chr7_50737419_ENST00000398812_DDC_chr7_50537869_ENST00000426377_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_51_GRB10-DDC_GRB10_chr7_50737419_ENST00000398812_DDC_chr7_50537869_ENST00000431062_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_52_GRB10-DDC_GRB10_chr7_50737419_ENST00000398812_DDC_chr7_50537869_ENST00000444124_length(amino acids)=301AA_BP=0
MALAGCPDSFLHHPYYQDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQP
RASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRS
LKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFA

--------------------------------------------------------------

>34619_34619_53_GRB10-DDC_GRB10_chr7_50737419_ENST00000402578_DDC_chr7_50537869_ENST00000357936_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_54_GRB10-DDC_GRB10_chr7_50737419_ENST00000402578_DDC_chr7_50537869_ENST00000426377_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_55_GRB10-DDC_GRB10_chr7_50737419_ENST00000402578_DDC_chr7_50537869_ENST00000431062_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_56_GRB10-DDC_GRB10_chr7_50737419_ENST00000402578_DDC_chr7_50537869_ENST00000444124_length(amino acids)=250AA_BP=1
MEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPPRSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNP
FPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFVFRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVC

--------------------------------------------------------------

>34619_34619_57_GRB10-DDC_GRB10_chr7_50737419_ENST00000439599_DDC_chr7_50537869_ENST00000357936_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_58_GRB10-DDC_GRB10_chr7_50737419_ENST00000439599_DDC_chr7_50537869_ENST00000426377_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_59_GRB10-DDC_GRB10_chr7_50737419_ENST00000439599_DDC_chr7_50537869_ENST00000431062_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

>34619_34619_60_GRB10-DDC_GRB10_chr7_50737419_ENST00000439599_DDC_chr7_50537869_ENST00000444124_length(amino acids)=295AA_BP=0
MQAAGPLFRSKDKVEQTPRSQQDPAGPGLPAQSDRLANHQEDDVDLEALVNDMNASLESLYSACSMQSDTVPLLQNGQHARSQPRASGPP
RSIQPQVSPRQRVQRSQPVHILAVRRLQEEDQQFRTSSLPAIPNPFPELCGPGSPPVLTPGSLPPSQAAAKQHWQIPLGRRFRSLKMWFV
FRMYGVKGLQAYIRKHVQLSHEFESLVRQDPRFEICVEVILGLVCFRLKGSNKVNEALLQRINSAKKIHLVPCHLRDKFVLRFAICSRTV

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:50737418/chr7:50537869)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRB10 Q13322	DDC P20711
FUNCTION: Adapter protein which modulates coupling of a number of cell surface receptor kinases with specific signaling pathways. Binds to, and suppress signals from, activated receptors tyrosine kinases, including the insulin (INSR) and insulin-like growth factor (IGF1R) receptors. The inhibitory effect can be achieved by 2 mechanisms: interference with the signaling pathway and increased receptor degradation. Delays and reduces AKT1 phosphorylation in response to insulin stimulation. Blocks association between INSR and IRS1 and IRS2 and prevents insulin-stimulated IRS1 and IRS2 tyrosine phosphorylation. Recruits NEDD4 to IGF1R, leading to IGF1R ubiquitination, increased internalization and degradation by both the proteasomal and lysosomal pathways. May play a role in mediating insulin-stimulated ubiquitination of INSR, leading to proteasomal degradation. Negatively regulates Wnt signaling by interacting with LRP6 intracellular portion and interfering with the binding of AXIN1 to LRP6. Positive regulator of the KDR/VEGFR-2 signaling pathway. May inhibit NEDD4-mediated degradation of KDR/VEGFR-2. {ECO:0000269\|PubMed:12493740, ECO:0000269\|PubMed:15060076, ECO:0000269\|PubMed:16434550, ECO:0000269\|PubMed:17376403}.	FUNCTION: Catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000380984

58_178

339.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000380984

58_178

339.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000380984

58_178

339.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000380984

118_178

339.0

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000380984

58_115

339.0

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000380984

118_178

339.0

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000380984

58_115

339.0

Repeat

Note=1

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000380984

118_178

339.0

Repeat

Note=2

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000380984

58_115

339.0

Repeat

Note=1

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000335866

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000335866

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000335866

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000357271

166_250

168.0

549.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000357271

290_399

168.0

549.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000357271

493_574

168.0

549.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398810

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398810

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398810

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398812

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398812

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000398812

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000401949

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000401949

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000401949

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402497

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402497

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402497

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402578

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402578

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000402578

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000403097

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000403097

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000403097

493_574

162.0

589.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000406641

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000406641

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000406641

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000407526

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000407526

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000407526

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000439599

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000439599

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537868

ENST00000439599

493_574

162.0

589.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000335866

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000335866

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000335866

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000357271

166_250

168.0

549.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000357271

290_399

168.0

549.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000357271

493_574

168.0

549.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398810

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398810

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398810

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398812

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398812

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000398812

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000401949

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000401949

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000401949

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402497

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402497

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402497

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402578

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402578

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000402578

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000403097

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000403097

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000403097

493_574

162.0

589.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000406641

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000406641

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000406641

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000407526

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000407526

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000407526

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000439599

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000439599

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737418

chr7:50537869

ENST00000439599

493_574

162.0

589.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000335866

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000335866

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000335866

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000357271

166_250

168.0

549.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000357271

290_399

168.0

549.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000357271

493_574

168.0

549.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398810

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398810

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398810

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398812

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398812

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000398812

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000401949

166_250

168.0

595.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000401949

290_399

168.0

595.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000401949

493_574

168.0

595.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402497

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402497

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402497

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402578

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402578

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000402578

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000403097

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000403097

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000403097

493_574

162.0

589.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000406641

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000406641

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000406641

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000407526

166_250

110.0

537.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000407526

290_399

110.0

537.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000407526

493_574

110.0

537.0

Domain

SH2

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000439599

166_250

162.0

589.0

Domain

Ras-associating

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000439599

290_399

162.0

589.0

Domain

Hgene

GRB10

chr7:50737419

chr7:50537869

ENST00000439599

493_574

162.0

589.0

Domain

SH2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000357936

58_178

347.0

600.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000426377

58_178

269.0

520.6666666666666

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000431062

58_178

254.0

479.3333333333333

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000444124

58_178

347.0

546.3333333333334

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000357936

58_178

347.0

600.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000426377

58_178

269.0

520.6666666666666

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000431062

58_178

254.0

479.3333333333333

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000444124

58_178

347.0

546.3333333333334

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000357936

58_178

347.0

600.0

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000426377

58_178

269.0

520.6666666666666

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000431062

58_178

254.0

479.3333333333333

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000444124

58_178

347.0

546.3333333333334

Region

Note=2 X approximate tandem repeats

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000357936

118_178

347.0

600.0

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000357936

58_115

347.0

600.0

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000426377

118_178

269.0

520.6666666666666

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000426377

58_115

269.0

520.6666666666666

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000431062

118_178

254.0

479.3333333333333

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000431062

58_115

254.0

479.3333333333333

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000444124

118_178

347.0

546.3333333333334

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537868

ENST00000444124

58_115

347.0

546.3333333333334

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000357936

118_178

347.0

600.0

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000357936

58_115

347.0

600.0

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000426377

118_178

269.0

520.6666666666666

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000426377

58_115

269.0

520.6666666666666

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000431062

118_178

254.0

479.3333333333333

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000431062

58_115

254.0

479.3333333333333

Repeat

Note=1

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000444124

118_178

347.0

546.3333333333334

Repeat

Note=2

Tgene

DDC

chr7:50737418

chr7:50537869

ENST00000444124

58_115

347.0

546.3333333333334

Repeat

Note=1

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000357936

118_178

347.0

600.0

Repeat

Note=2

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000357936

58_115

347.0

600.0

Repeat

Note=1

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000426377

118_178

269.0

520.6666666666666

Repeat

Note=2

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000426377

58_115

269.0

520.6666666666666

Repeat

Note=1

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000431062

118_178

254.0

479.3333333333333

Repeat

Note=2

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000431062

58_115

254.0

479.3333333333333

Repeat

Note=1

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000444124

118_178

347.0

546.3333333333334

Repeat

Note=2

Tgene

DDC

chr7:50737419

chr7:50537869

ENST00000444124

58_115

347.0

546.3333333333334

Repeat

Note=1

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GRB10
DDC

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to GRB10-DDC

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to GRB10-DDC

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source