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Fusion Protein:AKT1-ITPK1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: AKT1-ITPK1 | FusionPDB ID: 3466 | FusionGDB2.0 ID: 3466 | Hgene | Tgene | Gene symbol | AKT1 | ITPK1 | Gene ID | 207 | 3705 |
| Gene name | AKT serine/threonine kinase 1 | inositol-tetrakisphosphate 1-kinase | |
| Synonyms | AKT|CWS6|PKB|PKB-ALPHA|PRKBA|RAC|RAC-ALPHA | ITRPK1 | |
| Cytomap | 14q32.33 | 14q32.12 | |
| Type of gene | protein-coding | protein-coding | |
| Description | RAC-alpha serine/threonine-protein kinaseAKT1mPKB alphaRAC-PK-alphaprotein kinase B alphaproto-oncogene c-Aktrac protein kinase alphaserine-threonine protein kinasev-akt murine thymoma viral oncogene homolog 1v-akt murine thymoma viral oncogene-l | inositol-tetrakisphosphate 1-kinaseinositol 1,3,4-trisphosphate 5/6-kinaseins(1,3,4)P(3) 5/6-kinase | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | Q96B36 | Q13572 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000349310, ENST00000402615, ENST00000407796, ENST00000554581, ENST00000554848, ENST00000555528, ENST00000544168, ENST00000554192, ENST00000554585, ENST00000555458, | ENST00000555495, ENST00000556954, ENST00000267615, ENST00000354313, ENST00000556603, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 10 X 6 X 4=240 | 9 X 8 X 7=504 |
| # samples | 10 | 8 | |
| ** MAII score | log2(10/240*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/504*10)=-2.65535182861255 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: AKT1 [Title/Abstract] AND ITPK1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | AKT1(105258935)-ITPK1(93542964), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF. AKT1-ITPK1 seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF. AKT1-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a cell metabolism gene due to the frame-shifted ORF. AKT1-ITPK1 seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | AKT1 | GO:0001934 | positive regulation of protein phosphorylation | 19057511 |
| Hgene | AKT1 | GO:0006468 | protein phosphorylation | 11994271|14749367|23431171 |
| Hgene | AKT1 | GO:0007173 | epidermal growth factor receptor signaling pathway | 20878056 |
| Hgene | AKT1 | GO:0016310 | phosphorylation | 20333297 |
| Hgene | AKT1 | GO:0018105 | peptidyl-serine phosphorylation | 16139227 |
| Hgene | AKT1 | GO:0018107 | peptidyl-threonine phosphorylation | 20605787 |
| Hgene | AKT1 | GO:0030307 | positive regulation of cell growth | 19203586 |
| Hgene | AKT1 | GO:0032079 | positive regulation of endodeoxyribonuclease activity | 20605787 |
| Hgene | AKT1 | GO:0033138 | positive regulation of peptidyl-serine phosphorylation | 19667065 |
| Hgene | AKT1 | GO:0035556 | intracellular signal transduction | 14749367 |
| Hgene | AKT1 | GO:0035655 | interleukin-18-mediated signaling pathway | 21321938 |
| Hgene | AKT1 | GO:0043066 | negative regulation of apoptotic process | 19203586 |
| Hgene | AKT1 | GO:0043536 | positive regulation of blood vessel endothelial cell migration | 20011604 |
| Hgene | AKT1 | GO:0048661 | positive regulation of smooth muscle cell proliferation | 21321938 |
| Hgene | AKT1 | GO:0051091 | positive regulation of DNA-binding transcription factor activity | 19057511 |
| Hgene | AKT1 | GO:0070141 | response to UV-A | 18483258 |
| Fusion gene breakpoints across AKT1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across ITPK1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | STAD | TCGA-HU-A4GN-01A | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000402615 | AKT1 | chr14 | 105258935 | - | ENST00000267615 | ITPK1 | chr14 | 93542964 | - | 7324 | 1527 | 1087 | 2676 | 529 |
| ENST00000402615 | AKT1 | chr14 | 105258935 | - | ENST00000354313 | ITPK1 | chr14 | 93542964 | - | 3946 | 1527 | 2064 | 616 | 482 |
| ENST00000402615 | AKT1 | chr14 | 105258935 | - | ENST00000556603 | ITPK1 | chr14 | 93542964 | - | 4485 | 1527 | 1087 | 2676 | 529 |
| ENST00000555528 | AKT1 | chr14 | 105258935 | - | ENST00000267615 | ITPK1 | chr14 | 93542964 | - | 6496 | 699 | 259 | 1848 | 529 |
| ENST00000555528 | AKT1 | chr14 | 105258935 | - | ENST00000354313 | ITPK1 | chr14 | 93542964 | - | 3118 | 699 | 259 | 1548 | 429 |
| ENST00000555528 | AKT1 | chr14 | 105258935 | - | ENST00000556603 | ITPK1 | chr14 | 93542964 | - | 3657 | 699 | 259 | 1848 | 529 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000402615 | ENST00000267615 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.004019531 | 0.9959805 |
| ENST00000402615 | ENST00000354313 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.003742648 | 0.9962573 |
| ENST00000402615 | ENST00000556603 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.005585109 | 0.9944149 |
| ENST00000555528 | ENST00000267615 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.00419804 | 0.995802 |
| ENST00000555528 | ENST00000354313 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.005226501 | 0.99477357 |
| ENST00000555528 | ENST00000556603 | AKT1 | chr14 | 105258935 | - | ITPK1 | chr14 | 93542964 | - | 0.007237264 | 0.99276274 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >3466_3466_1_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000267615_length(amino acids)=529AA_BP=146 MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL -------------------------------------------------------------- >3466_3466_2_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000354313_length(amino acids)=482AA_BP=1 MDHGVGLANHEHLVQDGVVVDEILDHAGWLDGVQALLVEHDSHLVRVGAMSHSGFANEWESQAVLLQQPHGVIPAQARELHEGWRADPVV FHVGLNLPDELIGLGAVKQGSDGRERVQDDGLRVGIDVLLEPVHQLQGLAIILVGFKDDVSQLVDDDVQGALLLDRPAKVQLHNLHPSLP RLCSQPSFTIATSLMVPEAPATLTRSSQAGAPRAQLAWPQPLMHQLTGCLLQAAPLTSLTQAGSAFPKPLVTDGPVCSPCPWCSYPWILG QGTGLLPAPQTRKAKKFKHEEDRTRMQATGANGSPEPSSASPKTSWEKPQAPPKPQRPCRSESGSFIWPTCTGRLRFCQAQCWALETKRG SDKSVSEEHPVQGGYRPIITAVGRQQVSGGALDRPPPCSGPPANPHLSTLYPLILHGFLISPLMDELLGIPQNPVPTSPTTGIPRKSTSH -------------------------------------------------------------- >3466_3466_3_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000402615_ITPK1_chr14_93542964_ENST00000556603_length(amino acids)=529AA_BP=146 MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL -------------------------------------------------------------- >3466_3466_4_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000267615_length(amino acids)=529AA_BP=146 MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL -------------------------------------------------------------- >3466_3466_5_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000354313_length(amino acids)=429AA_BP=146 MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT -------------------------------------------------------------- >3466_3466_6_AKT1-ITPK1_AKT1_chr14_105258935_ENST00000555528_ITPK1_chr14_93542964_ENST00000556603_length(amino acids)=529AA_BP=146 MWFRRGLGFLPGGFWACAGGLWTPVCASGLHPGPVFLMFEFLCFPSLGSREEPCALSQDPWVGTPWTGRANGAICHQGLREGRASLGQRS QRGCLEEAACQLVHQRLWPGQLGSGSASLRGARERRGSLGHHERRGYCEGGLAAQTRKRGMEVVQLNLSRPIEEQGPLDVIIHKLTDVIL EADQNDSQSLELVHRFQEYIDAHPETIVLDPLPAIRTLLDRSKSYELIRKIEAYMEDDRICSPPFMELTSLCGDDTMRLLEKNGLTFPFI CKTRVAHGTNSHEMAIVFNQEGLNAIQPPCVVQNFINHNAVLYKVFVVGESYTVVQRPSLKNFSAGTSDRESIFFNSHNVSKPESSSVLT ELDKIEGVFERPSDEVIRELSRALRQALGVSLFGIDIIINNQTGQHAVIDINAFPGYEGVSEFFTDLLNHIATVLQGQSTAMAATGDVAL -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:105258935/chr14:93542964) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| AKT1 | ITPK1 |
| FUNCTION: Subunit of mTORC1, which regulates cell growth and survival in response to nutrient and hormonal signals. mTORC1 is activated in response to growth factors or amino acids. Growth factor-stimulated mTORC1 activation involves a AKT1-mediated phosphorylation of TSC1-TSC2, which leads to the activation of the RHEB GTPase that potently activates the protein kinase activity of mTORC1. Amino acid-signaling to mTORC1 requires its relocalization to the lysosomes mediated by the Ragulator complex and the Rag GTPases. Activated mTORC1 up-regulates protein synthesis by phosphorylating key regulators of mRNA translation and ribosome synthesis. mTORC1 phosphorylates EIF4EBP1 and releases it from inhibiting the elongation initiation factor 4E (eiF4E). mTORC1 phosphorylates and activates S6K1 at 'Thr-389', which then promotes protein synthesis by phosphorylating PDCD4 and targeting it for degradation. Within mTORC1, AKT1S1 negatively regulates mTOR activity in a manner that is dependent on its phosphorylation state and binding to 14-3-3 proteins. Inhibits RHEB-GTP-dependent mTORC1 activation. Substrate for AKT1 phosphorylation, but can also be activated by AKT1-independent mechanisms. May also play a role in nerve growth factor-mediated neuroprotection. {ECO:0000269|PubMed:16174443, ECO:0000269|PubMed:17277771, ECO:0000269|PubMed:17386266}. | FUNCTION: Kinase that can phosphorylate various inositol polyphosphate such as Ins(3,4,5,6)P4 or Ins(1,3,4)P3. Phosphorylates Ins(3,4,5,6)P4 at position 1 to form Ins(1,3,4,5,6)P5. This reaction is thought to have regulatory importance, since Ins(3,4,5,6)P4 is an inhibitor of plasma membrane Ca(2+)-activated Cl(-) channels, while Ins(1,3,4,5,6)P5 is not. Also phosphorylates Ins(1,3,4)P3 on O-5 and O-6 to form Ins(1,3,4,6)P4, an essential molecule in the hexakisphosphate (InsP6) pathway. Also acts as an inositol polyphosphate phosphatase that dephosphorylate Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 to Ins(1,3,4)P3, and Ins(1,3,4,5,6)P5 to Ins(3,4,5,6)P4. May also act as an isomerase that interconverts the inositol tetrakisphosphate isomers Ins(1,3,4,5)P4 and Ins(1,3,4,6)P4 in the presence of ADP and magnesium. Probably acts as the rate-limiting enzyme of the InsP6 pathway. Modifies TNF-alpha-induced apoptosis by interfering with the activation of TNFRSF1A-associated death domain (PubMed:11909533, PubMed:12925536, PubMed:17616525). Plays an important role in MLKL-mediated necroptosis. Produces highly phosphorylated inositol phosphates such as inositolhexakisphosphate (InsP6) which bind to MLKL mediating the release of an N-terminal auto-inhibitory region leading to its activation. Essential for activated phospho-MLKL to oligomerize and localize to the cell membrane during necroptosis (PubMed:17616525). {ECO:0000269|PubMed:11909533, ECO:0000269|PubMed:12925536, ECO:0000269|PubMed:17616525}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000267615 | 1 | 11 | 117_325 | 31.666666666666668 | 415.0 | Domain | ATP-grasp | |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000354313 | 1 | 11 | 117_325 | 31.666666666666668 | 315.0 | Domain | ATP-grasp | |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000556603 | 1 | 11 | 117_325 | 31.666666666666668 | 415.0 | Domain | ATP-grasp | |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000267615 | 1 | 11 | 188_199 | 31.666666666666668 | 415.0 | Nucleotide binding | Note=ATP | |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000354313 | 1 | 11 | 188_199 | 31.666666666666668 | 315.0 | Nucleotide binding | Note=ATP | |
| Tgene | ITPK1 | chr14:105258935 | chr14:93542964 | ENST00000556603 | 1 | 11 | 188_199 | 31.666666666666668 | 415.0 | Nucleotide binding | Note=ATP |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 150_408 | 15.333333333333334 | 481.0 | Domain | Protein kinase |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 409_480 | 15.333333333333334 | 481.0 | Domain | AGC-kinase C-terminal |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 5_108 | 15.333333333333334 | 481.0 | Domain | PH |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 156_164 | 15.333333333333334 | 481.0 | Nucleotide binding | ATP |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000349310 | - | 3 | 15 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000402615 | - | 2 | 14 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000407796 | - | 2 | 14 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554581 | - | 1 | 13 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000554848 | - | 2 | 14 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 14_19 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 228_230 | 15.333333333333334 | 481.0 | Region | Note=Inhibitor binding |
| Hgene | AKT1 | chr14:105258935 | chr14:93542964 | ENST00000555528 | - | 2 | 14 | 23_25 | 15.333333333333334 | 481.0 | Region | Note=Inositol-(1%2C3%2C4%2C5)-tetrakisphosphate binding |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| AKT1 | |
| ITPK1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to AKT1-ITPK1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to AKT1-ITPK1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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