UTHEALTH HOME    ABOUT SBMI    A-Z    WEBMAIL    INSIDE THE UNIVERSITY
FusionGDB Logo

Home

Download

Statistics

Examples

Help

Contact

Terms of Use
Center for Computational Systems Medicine level1
leaf

Fusion Gene Summary

leaf

Fusion Gene Sample Information

leaf

Fusion ORF Analysis

leaf

Fusion Amino Acid Sequences

leaf

Fusion Protein Functional Features

leaf

Fusion Protein-Protein Interaction

leaf

Related drugs with this fusion protein

leaf

Related disease with this fusion protein

Fusion Protein:GRID1-MBNL1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GRID1-MBNL1
FusionPDB ID: 34746
FusionGDB2.0 ID: 34746
HgeneTgene
Gene symbol

GRID1

MBNL1

Gene ID

2894

4154

Gene nameglutamate ionotropic receptor delta type subunit 1muscleblind like splicing regulator 1
SynonymsGluD1EXP|MBNL
Cytomap

10q23.1-q23.2

3q25.1-q25.2

Type of geneprotein-codingprotein-coding
Descriptionglutamate receptor ionotropic, delta-1gluR delta-1 subunitglutamate receptor delta-1 subunitmuscleblind-like protein 1muscleblind-liketriplet-expansion RNA-binding protein
Modification date2020031320200327
UniProtAcc

Q9ULK0

Q9NR56

Ensembl transtripts involved in fusion geneENST idsENST00000327946, ENST00000536331, 
ENST00000552278, 		ENST00000461436, 
ENST00000282486, ENST00000282488, 
ENST00000324196, ENST00000324210, 
ENST00000355460, ENST00000357472, 
ENST00000463374, ENST00000485509, 
ENST00000485910, ENST00000492948, 
ENST00000493459, ENST00000498502, 
ENST00000545754, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score10 X 8 X 6=48028 X 14 X 6=2352
# samples 1128
** MAII scorelog2(11/480*10)=-2.12553088208386
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(28/2352*10)=-3.0703893278914
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GRID1 [Title/Abstract] AND MBNL1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GRID1(87898576)-MBNL1(152132730), # samples:1
Anticipated loss of major functional domain due to fusion event.GRID1-MBNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRID1-MBNL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRID1-MBNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRID1-MBNL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneMBNL1

GO:0008380

RNA splicing

18335541

TgeneMBNL1

GO:0043484

regulation of RNA splicing

15257297|16946708


check buttonFusion gene breakpoints across GRID1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across MBNL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


Top

Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8210-01AGRID1chr10

87898576

-MBNL1chr3

152132730

+


Top

Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000327946GRID1chr1087898576-ENST00000282488MBNL1chr3152132730+4960812861546486
ENST00000327946GRID1chr1087898576-ENST00000282486MBNL1chr3152132730+5218812861804572
ENST00000327946GRID1chr1087898576-ENST00000355460MBNL1chr3152132730+5165812861750554
ENST00000327946GRID1chr1087898576-ENST00000493459MBNL1chr3152132730+4693812861840584
ENST00000327946GRID1chr1087898576-ENST00000324210MBNL1chr3152132730+5184812861786566
ENST00000327946GRID1chr1087898576-ENST00000498502MBNL1chr3152132730+5107812861684532
ENST00000327946GRID1chr1087898576-ENST00000545754MBNL1chr3152132730+4996812861582498
ENST00000327946GRID1chr1087898576-ENST00000357472MBNL1chr3152132730+5105812861666526
ENST00000327946GRID1chr1087898576-ENST00000324196MBNL1chr3152132730+5074812861660524
ENST00000327946GRID1chr1087898576-ENST00000485910MBNL1chr3152132730+4384812861546486
ENST00000327946GRID1chr1087898576-ENST00000463374MBNL1chr3152132730+5219812861804572
ENST00000327946GRID1chr1087898576-ENST00000492948MBNL1chr3152132730+1692812861666526
ENST00000327946GRID1chr1087898576-ENST00000485509MBNL1chr3152132730+1661812861660525

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000327946ENST00000282488GRID1chr1087898576-MBNL1chr3152132730+0.0001783820.9998216
ENST00000327946ENST00000282486GRID1chr1087898576-MBNL1chr3152132730+0.0003642210.9996358
ENST00000327946ENST00000355460GRID1chr1087898576-MBNL1chr3152132730+0.0004100720.99959
ENST00000327946ENST00000493459GRID1chr1087898576-MBNL1chr3152132730+0.0005047830.99949515
ENST00000327946ENST00000324210GRID1chr1087898576-MBNL1chr3152132730+0.0003983020.99960166
ENST00000327946ENST00000498502GRID1chr1087898576-MBNL1chr3152132730+0.0002544010.99974555
ENST00000327946ENST00000545754GRID1chr1087898576-MBNL1chr3152132730+0.0001850190.99981505
ENST00000327946ENST00000357472GRID1chr1087898576-MBNL1chr3152132730+0.0003037110.9996964
ENST00000327946ENST00000324196GRID1chr1087898576-MBNL1chr3152132730+0.0004116460.9995883
ENST00000327946ENST00000485910GRID1chr1087898576-MBNL1chr3152132730+0.0002038610.9997962
ENST00000327946ENST00000463374GRID1chr1087898576-MBNL1chr3152132730+0.0003649230.9996351
ENST00000327946ENST00000492948GRID1chr1087898576-MBNL1chr3152132730+0.0056734410.99432653
ENST00000327946ENST00000485509GRID1chr1087898576-MBNL1chr3152132730+0.0083203180.9916797

Top

Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34746_34746_1_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000282486_length(amino acids)=572AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA
AAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTS

--------------------------------------------------------------

>34746_34746_2_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000282488_length(amino acids)=486AA_BP=242
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQ
AKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSA

--------------------------------------------------------------

>34746_34746_3_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000324196_length(amino acids)=524AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA

--------------------------------------------------------------

>34746_34746_4_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000324210_length(amino acids)=566AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA
AAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVVPMVHGATPATVSAATTSATSVPF

--------------------------------------------------------------

>34746_34746_5_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000355460_length(amino acids)=554AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA
AAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTSATSVPFAATATANQIPII

--------------------------------------------------------------

>34746_34746_6_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000357472_length(amino acids)=526AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA

--------------------------------------------------------------

>34746_34746_7_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000463374_length(amino acids)=572AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA
AAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSAATTS

--------------------------------------------------------------

>34746_34746_8_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000485509_length(amino acids)=525AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA

--------------------------------------------------------------

>34746_34746_9_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000485910_length(amino acids)=486AA_BP=242
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQ
AKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPVPMVHGATPATVSA

--------------------------------------------------------------

>34746_34746_10_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000492948_length(amino acids)=526AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA

--------------------------------------------------------------

>34746_34746_11_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000493459_length(amino acids)=584AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA
AAMTQSAVKSLKRPLEATFDLGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVVPMVHG

--------------------------------------------------------------

>34746_34746_12_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000498502_length(amino acids)=532AA_BP=365
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVPMFSVAPSLATNASAAAFNPYLGPVSPSLVPAEILPTAPMLVTGNPGVPVPAAAAAAAQKL
MRTDRLEVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQAKIKAAQYQVNQAAAAQAAATA

--------------------------------------------------------------

>34746_34746_13_GRID1-MBNL1_GRID1_chr10_87898576_ENST00000327946_MBNL1_chr3_152132730_ENST00000545754_length(amino acids)=498AA_BP=242
MEALTLWLLPWICQCVSVRADSIIHIGAIFEENAAKDDRVFQLAVSDLSLNDDILQSEKITYSIKVIEANNPFQAVQEACDLMTQGILAL
VTSTGCASANALQSLTDAMHIPHLFVQRNPGGSPRTACHLNPSPDGEAYTLASRPPVRLNDVMLRLVTELRWQKFVMFYDSEYDIRGLQS
FLDQASRLGLDVSLQKVDKNISHVFTSLFTTMKTEELNRYRDTLRRAILLLSPQGAHSFINEGRCSRENCKYLHPPPHLKTQLEINGRNN
LIQQKNMAMLAQQMQLANAMMPGAPLQPVVCREYQRGNCNRGENDCRFAHPADSTMIDTNDNTVTVCMDYIKGRCSREKCKYFHPPAHLQ
AKIKAAQYQVNQAAAAQAAATAAAMGIPQAVLPPLPKRPALEKTNGATAVFNTGIFQYQQALANMQLQQHTAFLPPGSILCMTPATSVVP

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:87898576/chr3:152132730)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRID1

Q9ULK0

MBNL1

Q9NR56

FUNCTION: Receptor for glutamate. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. The postsynaptic actions of Glu are mediated by a variety of receptors that are named according to their selective agonists.FUNCTION: Mediates pre-mRNA alternative splicing regulation. Acts either as activator or repressor of splicing on specific pre-mRNA targets. Inhibits cardiac troponin-T (TNNT2) pre-mRNA exon inclusion but induces insulin receptor (IR) pre-mRNA exon inclusion in muscle. Antagonizes the alternative splicing activity pattern of CELF proteins. Regulates the TNNT2 exon 5 skipping through competition with U2AF2. Inhibits the formation of the spliceosome A complex on intron 4 of TNNT2 pre-mRNA. Binds to the stem-loop structure within the polypyrimidine tract of TNNT2 intron 4 during spliceosome assembly. Binds to the 5'-YGCU(U/G)Y-3'consensus sequence. Binds to the IR RNA. Binds to expanded CUG repeat RNA, which folds into a hairpin structure containing GC base pairs and bulged, unpaired U residues. {ECO:0000269|PubMed:10970838, ECO:0000269|PubMed:15257297, ECO:0000269|PubMed:16946708, ECO:0000269|PubMed:18335541, ECO:0000269|PubMed:19470458}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneMBNL1chr10:87898576chr3:152132730ENST00000282486110179_20758.01169.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST00000282486110215_24158.01169.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000028248818179_20758.01083.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000028248818215_24158.01083.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000032419608179_20758.01151.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000032419608215_24158.01151.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST00000324210110179_20758.01466.0Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST00000324210110215_24158.01466.0Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000035546019179_20758.01294.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000035546019215_24158.01294.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000035747208179_20758.01153.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000035747208215_24158.01153.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000046337409179_20758.01292.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000046337409215_24158.01292.6666666666667Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000048550907179_20758.0341.0Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000048550907215_24158.0341.0Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000048591007179_20758.01014.3333333333334Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000048591007215_24158.01014.3333333333334Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000049294807179_20758.0343.0Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000049294807215_24158.0343.0Zinc fingerC3H1-type 4
TgeneMBNL1chr10:87898576chr3:152132730ENST0000054575408179_20758.01125.6666666666667Zinc fingerC3H1-type 3
TgeneMBNL1chr10:87898576chr3:152132730ENST0000054575408215_24158.01125.6666666666667Zinc fingerC3H1-type 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-41621_562242.01010.0Topological domainExtracellular
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416584_637242.01010.0Topological domainCytoplasmic
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416659_830242.01010.0Topological domainExtracellular
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416852_1009242.01010.0Topological domainCytoplasmic
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416563_583242.01010.0TransmembraneHelical
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416638_658242.01010.0TransmembraneHelical
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-416831_851242.01010.0TransmembraneHelical
TgeneMBNL1chr10:87898576chr3:152132730ENST0000028248611013_4158.01169.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST0000028248611047_7358.01169.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000002824881813_4158.01083.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000002824881847_7358.01083.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000003241960813_4158.01151.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000003241960847_7358.01151.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST0000032421011013_4158.01466.0Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST0000032421011047_7358.01466.0Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000003554601913_4158.01294.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000003554601947_7358.01294.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000003574720813_4158.01153.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000003574720847_7358.01153.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000004633740913_4158.01292.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000004633740947_7358.01292.6666666666667Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000004855090713_4158.0341.0Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000004855090747_7358.0341.0Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000004859100713_4158.01014.3333333333334Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000004859100747_7358.01014.3333333333334Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000004929480713_4158.0343.0Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000004929480747_7358.0343.0Zinc fingerC3H1-type 2
TgeneMBNL1chr10:87898576chr3:152132730ENST000005457540813_4158.01125.6666666666667Zinc fingerC3H1-type 1
TgeneMBNL1chr10:87898576chr3:152132730ENST000005457540847_7358.01125.6666666666667Zinc fingerC3H1-type 2


Top

Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GRID1
MBNL1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneGRID1chr10:87898576chr3:152132730ENST00000327946-41621_436242.01010.0CBLN1


Top

Related Drugs to GRID1-MBNL1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

Top

Related Diseases to GRID1-MBNL1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource