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Fusion Protein:GRIK2-GPC1 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: GRIK2-GPC1 | FusionPDB ID: 34787 | FusionGDB2.0 ID: 34787 | Hgene | Tgene | Gene symbol | GRIK2 | GPC1 | Gene ID | 2901 | 2817 |
| Gene name | glutamate ionotropic receptor kainate type subunit 5 | glypican 1 | |
| Synonyms | EAA2|GRIK2|GluK5|KA2 | glypican | |
| Cytomap | 19q13.2 | 2q37.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2 | glypican-1epididymis secretory sperm binding proteinglypican proteoglycan 1 | |
| Modification date | 20200313 | 20200315 | |
| UniProtAcc | Q13002 | P35052 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000318991, ENST00000358361, ENST00000369137, ENST00000369138, ENST00000413795, ENST00000421544, ENST00000369134, | ENST00000466624, ENST00000264039, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 9 X 4 X 6=216 | 2 X 2 X 2=8 |
| # samples | 10 | 2 | |
| ** MAII score | log2(10/216*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(2/8*10)=1.32192809488736 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: GRIK2 [Title/Abstract] AND GPC1 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | GRIK2(101847268)-GPC1(241398447), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | GRIK2-GPC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GRIK2-GPC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Tgene | GPC1 | GO:0030200 | heparan sulfate proteoglycan catabolic process | 12732622 |
| Fusion gene breakpoints across GRIK2 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across GPC1 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | SKCM | TCGA-D3-A2JP-06A | GRIK2 | chr6 | 101847268 | - | GPC1 | chr2 | 241398447 | + |
| ChimerDB4 | SKCM | TCGA-D3-A2JP-06A | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000413795 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3902 | 605 | 391 | 2115 | 574 |
| ENST00000369138 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3902 | 605 | 391 | 2115 | 574 |
| ENST00000421544 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3902 | 605 | 391 | 2115 | 574 |
| ENST00000358361 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3897 | 600 | 386 | 2110 | 574 |
| ENST00000318991 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3412 | 115 | 0 | 1625 | 541 |
| ENST00000369137 | GRIK2 | chr6 | 101847268 | + | ENST00000264039 | GPC1 | chr2 | 241398447 | + | 3412 | 115 | 0 | 1625 | 541 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000413795 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016747687 | 0.9832523 |
| ENST00000369138 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016747687 | 0.9832523 |
| ENST00000421544 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016747687 | 0.9832523 |
| ENST00000358361 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016558968 | 0.983441 |
| ENST00000318991 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016787095 | 0.9832129 |
| ENST00000369137 | ENST00000264039 | GRIK2 | chr6 | 101847268 | + | GPC1 | chr2 | 241398447 | + | 0.016787095 | 0.9832129 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >34787_34787_1_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000318991_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=541AA_BP=38 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSF DDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAE ALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLD AEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEK LVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRL RSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRW -------------------------------------------------------------- >34787_34787_2_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000358361_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=574AA_BP=71 MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEME ENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLA EFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLV YCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCG NPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLA NQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQ -------------------------------------------------------------- >34787_34787_3_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000369137_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=541AA_BP=38 MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEMEENLANRSHAELETALRDSSRVLQAMLATQLRSF DDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLAEFWARLLERLFKQLHPQLLLPDDYLDCLGKQAE ALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLVYCAHCLGVPGARPCPDYCRNVLKGCLANQADLD AEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCGNPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEK LVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLANQINNPEVEVDITKPDMTIRQQIMQLKIMTNRL RSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQEGQKTSAASCPQPPTFLLPLLLFLALTVARPRW -------------------------------------------------------------- >34787_34787_4_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000369138_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=574AA_BP=71 MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEME ENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLA EFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLV YCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCG NPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLA NQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQ -------------------------------------------------------------- >34787_34787_5_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000413795_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=574AA_BP=71 MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEME ENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLA EFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLV YCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCG NPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLA NQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQ -------------------------------------------------------------- >34787_34787_6_GRIK2-GPC1_GRIK2_chr6_101847268_ENST00000421544_GPC1_chr2_241398447_ENST00000264039_length(amino acids)=574AA_BP=71 MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGEHLRICPQGYTCCTSEME ENLANRSHAELETALRDSSRVLQAMLATQLRSFDDHFQHLLNDSERTLQATFPGAFGELYTQNARAFRDLYSELRLYYRGANLHLEETLA EFWARLLERLFKQLHPQLLLPDDYLDCLGKQAEALRPFGEAPRELRLRATRAFVAARSFVQGLGVASDVVRKVAQVPLGPECSRAVMKLV YCAHCLGVPGARPCPDYCRNVLKGCLANQADLDAEWRNLLDSMVLITDKFWGTSGVESVIGSVHTWLAEAINALQDNRDTLTAKVIQGCG NPKVNPQGPGPEEKRRRGKLAPRERPPSGTLEKLVSEAKAQLRDVQDFWISLPGTLCSEKMALSTASDDRCWNGMARGRYLPEVMGDGLA NQINNPEVEVDITKPDMTIRQQIMQLKIMTNRLRSAYNGNDVDFQDASDDGSGSGSGDGCLDDLCSRKVSRKSSSSRTPLTHALPGLSEQ -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:101847268/chr2:241398447) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| GRIK2 | GPC1 |
| FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:28180184}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250|UniProtKB:P39087, ECO:0000269|PubMed:31474366}. | FUNCTION: Cell surface proteoglycan that bears heparan sulfate. Binds, via the heparan sulfate side chains, alpha-4 (V) collagen and participates in Schwann cell myelination (By similarity). May act as a catalyst in increasing the rate of conversion of prion protein PRPN(C) to PRNP(Sc) via associating (via the heparan sulfate side chains) with both forms of PRPN, targeting them to lipid rafts and facilitating their interaction. Required for proper skeletal muscle differentiation by sequestering FGF2 in lipid rafts preventing its binding to receptors (FGFRs) and inhibiting the FGF-mediated signaling. {ECO:0000250, ECO:0000269|PubMed:19936054, ECO:0000269|PubMed:21642435}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 516_518 | 38.333333333333336 | 870.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 689_690 | 38.333333333333336 | 870.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 516_518 | 38.333333333333336 | 833.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 689_690 | 38.333333333333336 | 833.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 516_518 | 38.333333333333336 | 1270.3333333333333 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 689_690 | 38.333333333333336 | 1270.3333333333333 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 516_518 | 38.333333333333336 | 1247.3333333333333 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 689_690 | 38.333333333333336 | 1247.3333333333333 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 516_518 | 38.333333333333336 | 909.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 689_690 | 38.333333333333336 | 909.0 | Region | Glutamate binding |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 32_561 | 38.333333333333336 | 870.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 583_635 | 38.333333333333336 | 870.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 657_819 | 38.333333333333336 | 870.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 841_908 | 38.333333333333336 | 870.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 32_561 | 38.333333333333336 | 833.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 583_635 | 38.333333333333336 | 833.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 657_819 | 38.333333333333336 | 833.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 841_908 | 38.333333333333336 | 833.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 32_561 | 38.333333333333336 | 1270.3333333333333 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 583_635 | 38.333333333333336 | 1270.3333333333333 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 657_819 | 38.333333333333336 | 1270.3333333333333 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 841_908 | 38.333333333333336 | 1270.3333333333333 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 32_561 | 38.333333333333336 | 1247.3333333333333 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 583_635 | 38.333333333333336 | 1247.3333333333333 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 657_819 | 38.333333333333336 | 1247.3333333333333 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 841_908 | 38.333333333333336 | 1247.3333333333333 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 32_561 | 38.333333333333336 | 909.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 583_635 | 38.333333333333336 | 909.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 657_819 | 38.333333333333336 | 909.0 | Topological domain | Extracellular |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 841_908 | 38.333333333333336 | 909.0 | Topological domain | Cytoplasmic |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 562_582 | 38.333333333333336 | 870.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 636_656 | 38.333333333333336 | 870.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000318991 | + | 1 | 16 | 820_840 | 38.333333333333336 | 870.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 562_582 | 38.333333333333336 | 833.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 636_656 | 38.333333333333336 | 833.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369137 | + | 1 | 15 | 820_840 | 38.333333333333336 | 833.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 562_582 | 38.333333333333336 | 1270.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 636_656 | 38.333333333333336 | 1270.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000369138 | + | 1 | 17 | 820_840 | 38.333333333333336 | 1270.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 562_582 | 38.333333333333336 | 1247.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 636_656 | 38.333333333333336 | 1247.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000413795 | + | 1 | 17 | 820_840 | 38.333333333333336 | 1247.3333333333333 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 562_582 | 38.333333333333336 | 909.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 636_656 | 38.333333333333336 | 909.0 | Transmembrane | Helical |
| Hgene | GRIK2 | chr6:101847268 | chr2:241398447 | ENST00000421544 | + | 1 | 16 | 820_840 | 38.333333333333336 | 909.0 | Transmembrane | Helical |
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Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| GRIK2 | |
| GPC1 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
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Related Drugs to GRIK2-GPC1 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
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Related Diseases to GRIK2-GPC1 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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