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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:GRIK2-PRKD3

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: GRIK2-PRKD3
	FusionPDB ID: 34789
	FusionGDB2.0 ID: 34789
		Hgene	Tgene
	Gene symbol	GRIK2	PRKD3
	Gene ID	2901	23683
	Gene name	glutamate ionotropic receptor kainate type subunit 5	protein kinase D3
	Synonyms	EAA2\|GRIK2\|GluK5\|KA2	EPK2\|PKC-NU\|PKD3\|PRKCN\|nPKC-NU
	Cytomap	19q13.2	2p22.2
	Type of gene	protein-coding	protein-coding
	Description	glutamate receptor ionotropic, kainate 5excitatory amino acid receptor 2glutamate receptor KA2	serine/threonine-protein kinase D3protein kinase C nu typeprotein kinase EPK2
	Modification date	20200313	20200329
	UniProtAcc	Q13002	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000318991, ENST00000358361, ENST00000369134, ENST00000369137, ENST00000369138, ENST00000413795, ENST00000421544,	ENST00000477132, ENST00000234179, ENST00000379066,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	9 X 4 X 6=216	2 X 2 X 2=8
	# samples	10	2
	** MAII score	log2(10/216*10)=-1.11103131238874 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(2/8*10)=1.32192809488736
Context (manual curation of fusion genes in FusionPDB)	PubMed: GRIK2 [Title/Abstract] AND PRKD3 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	GRIK2(102134228)-PRKD3(37520414), # samples:1
Anticipated loss of major functional domain due to fusion event.	GRIK2-PRKD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GRIK2-PRKD3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GRIK2-PRKD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GRIK2-PRKD3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner

Gene

GO ID

GO term

PubMed ID

Fusion gene breakpoints across GRIK2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across PRKD3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	ERR315356	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000413795	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6501	1441	391	3825	1144
ENST00000413795	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6498	1441	391	3825	1144
ENST00000369138	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6501	1441	391	3825	1144
ENST00000369138	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6498	1441	391	3825	1144
ENST00000421544	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6501	1441	391	3825	1144
ENST00000421544	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6498	1441	391	3825	1144
ENST00000358361	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6496	1436	386	3820	1144
ENST00000358361	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6493	1436	386	3820	1144
ENST00000318991	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6011	951	0	3335	1111
ENST00000318991	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6008	951	0	3335	1111
ENST00000369137	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6011	951	0	3335	1111
ENST00000369137	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6008	951	0	3335	1111
ENST00000369134	GRIK2	chr6	102134228	+	ENST00000379066	PRKD3	chr2	37520414	-	6014	954	150	3338	1062
ENST00000369134	GRIK2	chr6	102134228	+	ENST00000234179	PRKD3	chr2	37520414	-	6011	954	150	3338	1062

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000413795	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.99995124
ENST00000413795	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.9999511
ENST00000369138	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.99995124
ENST00000369138	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.9999511
ENST00000421544	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.99995124
ENST00000421544	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.88E-05	0.9999511
ENST00000358361	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.80E-05	0.99995196
ENST00000358361	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	4.81E-05	0.99995196
ENST00000318991	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	2.58E-05	0.99997425
ENST00000318991	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	2.58E-05	0.99997413
ENST00000369137	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	2.58E-05	0.99997425
ENST00000369137	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	2.58E-05	0.99997413
ENST00000369134	ENST00000379066	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	3.14E-05	0.9999685
ENST00000369134	ENST00000234179	GRIK2	chr6	102134228	+	PRKD3	chr2	37520414	-	3.15E-05	0.9999685

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34789_34789_1_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000318991_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1111AA_BP=317
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFE
ASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYR
YSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV
VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQ
PEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPR
DCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKH
TKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGE
NNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGI
VYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFM
VTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVS
LSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDD

--------------------------------------------------------------

>34789_34789_2_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000318991_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1111AA_BP=317
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFE
ASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYR
YSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV
VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQ
PEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPR
DCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKH
TKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGE
NNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGI
VYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFM
VTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVS
LSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDD

--------------------------------------------------------------

>34789_34789_3_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000358361_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_4_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000358361_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_5_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369134_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1062AA_BP=268
MGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVS
DNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFD
CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFP
ECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGC
GLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHS
YTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPED
KMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYK
EIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGK
DHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNL
ECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIG
EKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMR

--------------------------------------------------------------

>34789_34789_6_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369134_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1062AA_BP=268
MGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVS
DNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFD
CSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFP
ECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGC
GLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHS
YTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPED
KMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYK
EIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGK
DHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNL
ECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIG
EKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMR

--------------------------------------------------------------

>34789_34789_7_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369137_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1111AA_BP=317
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFE
ASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYR
YSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV
VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQ
PEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPR
DCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKH
TKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGE
NNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGI
VYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFM
VTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVS
LSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDD

--------------------------------------------------------------

>34789_34789_8_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369137_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1111AA_BP=317
MKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAFRFAVNTINRNRTLLPNTTLTYDTQKINLYDSFE
ASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYVSLYPDFSSLSRAILDLVQFFKWKTVTVVYDDST
GLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAGILKQALAMGMMTEYYHYIFTTLDLFALDVEPYR
YSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMYDKILLFRHDMNSENILQLITSADEIHEGDLVEV
VLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRCAFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQ
PEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQYCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPR
DCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPSDLDVERDEEAVKTISPSTSNNIPLMRVVQSIKH
TKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEILRISSPRDFTNISQGSNPHCFEIITDTMVYFVGE
NNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTSISVSNCQIQENVDISTVYQIFADEVLGSGQFGI
VYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPERVFVVMEKLHGDMLEMILSSEKSRLPERITKFM
VTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSVVGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVS
LSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKSLSHPWLQDYQTWLDLREFETRIGERYITHESDD

--------------------------------------------------------------

>34789_34789_9_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369138_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_10_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000369138_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_11_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000413795_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_12_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000413795_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_13_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000421544_PRKD3_chr2_37520414_ENST00000234179_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

>34789_34789_14_GRIK2-PRKD3_GRIK2_chr6_102134228_ENST00000421544_PRKD3_chr2_37520414_ENST00000379066_length(amino acids)=1144AA_BP=350
MRSPLDASSFLPEPRSRTLDRGSGCRACGHRNTMKIIFPILSNPVFRRTVKLLLCLLWIGYSQGTTHVLRFGGIFEYVESGPMGAEELAF
RFAVNTINRNRTLLPNTTLTYDTQKINLYDSFEASKKACDQLSLGVAAIFGPSHSSSANAVQSICNALGVPHIQTRWKHQVSDNKDSFYV
SLYPDFSSLSRAILDLVQFFKWKTVTVVYDDSTGLIRLQELIKAPSRYNLRLKIRQLPADTKDAKPLLKEMKRGKEFHVIFDCSHEMAAG
ILKQALAMGMMTEYYHYIFTTLDLFALDVEPYRYSGVNMTGFRILNTENTQVSSIIEKWSMERLQAPPKPDSGLLDGFMTFPECGFFGMY
DKILLFRHDMNSENILQLITSADEIHEGDLVEVVLSALATVEDFQIRPHTLYVHSYKAPTFCDYCGEMLWGLVRQGLKCEGCGLNYHKRC
AFKIPNNCSGVRKRRLSNVSLPGPGLSVPRPLQPEYVALPSEESHVHQEPSKRIPSWSGRPIWMEKMVMCRVKVPHTFAVHSYTRPTICQ
YCKRLLKGLFRQGMQCKDCKFNCHKRCASKVPRDCLGEVTFNGEPSSLGTDTDIPMDIDNNDINSDSSRGLDDTEEPSPPEDKMFFLDPS
DLDVERDEEAVKTISPSTSNNIPLMRVVQSIKHTKRKSSTMVKEGWMVHYTSRDNLRKRHYWRLDSKCLTLFQNESGSKYYKEIPLSEIL
RISSPRDFTNISQGSNPHCFEIITDTMVYFVGENNGDSSHNPVLAATGVGLDVAQSWEKAIRQALMPVTPQASVCTSPGQGKDHKDLSTS
ISVSNCQIQENVDISTVYQIFADEVLGSGQFGIVYGGKHRKTGRDVAIKVIDKMRFPTKQESQLRNEVAILQNLHHPGIVNLECMFETPE
RVFVVMEKLHGDMLEMILSSEKSRLPERITKFMVTQILVALRNLHFKNIVHCDLKPENVLLASAEPFPQVKLCDFGFARIIGEKSFRRSV
VGTPAYLAPEVLRSKGYNRSLDMWSVGVIIYVSLSGTFPFNEDEDINDQIQNAAFMYPPNPWREISGEAIDLINNLLQVKMRKRYSVDKS

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:102134228/chr2:37520414)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
GRIK2 Q13002	.
FUNCTION: Ionotropic glutamate receptor. L-glutamate acts as an excitatory neurotransmitter at many synapses in the central nervous system. Binding of the excitatory neurotransmitter L-glutamate induces a conformation change, leading to the opening of the cation channel, and thereby converts the chemical signal to an electrical impulse. The receptor then desensitizes rapidly and enters a transient inactive state, characterized by the presence of bound agonist (PubMed:28180184). Modulates cell surface expression of NETO2 (By similarity). {ECO:0000250\|UniProtKB:P39087, ECO:0000269\|PubMed:28180184}.; FUNCTION: Independent of its ionotropic glutamate receptor activity, acts as a thermoreceptor conferring sensitivity to cold temperatures (PubMed:31474366). Functions in dorsal root ganglion neurons (By similarity). {ECO:0000250\|UniProtKB:P39087, ECO:0000269\|PubMed:31474366}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000234179

416_532

96.0

891.0

Domain

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000234179

576_832

96.0

891.0

Domain

Protein kinase

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000379066

416_532

96.0

891.0

Domain

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000379066

576_832

96.0

891.0

Domain

Protein kinase

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000234179

582_590

96.0

891.0

Nucleotide binding

ATP

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000379066

582_590

96.0

891.0

Nucleotide binding

ATP

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000234179

154_204

96.0

891.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000234179

271_321

96.0

891.0

Zinc finger

Phorbol-ester/DAG-type 2

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000379066

154_204

96.0

891.0

Zinc finger

Phorbol-ester/DAG-type 1

Tgene

PRKD3

chr6:102134228

chr2:37520414

ENST00000379066

271_321

96.0

891.0

Zinc finger

Phorbol-ester/DAG-type 2

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

516_518

317.0

870.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

689_690

317.0

870.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

516_518

317.0

833.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

689_690

317.0

833.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

516_518

317.0

1270.3333333333333

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

689_690

317.0

1270.3333333333333

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

516_518

317.0

1247.3333333333333

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

689_690

317.0

1247.3333333333333

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

516_518

317.0

909.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

689_690

317.0

909.0

Region

Glutamate binding

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

32_561

317.0

870.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

583_635

317.0

870.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

657_819

317.0

870.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

841_908

317.0

870.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

32_561

317.0

833.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

583_635

317.0

833.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

657_819

317.0

833.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

841_908

317.0

833.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

32_561

317.0

1270.3333333333333

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

583_635

317.0

1270.3333333333333

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

657_819

317.0

1270.3333333333333

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

841_908

317.0

1270.3333333333333

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

32_561

317.0

1247.3333333333333

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

583_635

317.0

1247.3333333333333

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

657_819

317.0

1247.3333333333333

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

841_908

317.0

1247.3333333333333

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

32_561

317.0

909.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

583_635

317.0

909.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

657_819

317.0

909.0

Topological domain

Extracellular

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

841_908

317.0

909.0

Topological domain

Cytoplasmic

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

562_582

317.0

870.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

636_656

317.0

870.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000318991

820_840

317.0

870.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

562_582

317.0

833.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

636_656

317.0

833.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369137

820_840

317.0

833.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

562_582

317.0

1270.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

636_656

317.0

1270.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000369138

820_840

317.0

1270.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

562_582

317.0

1247.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

636_656

317.0

1247.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000413795

820_840

317.0

1247.3333333333333

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

562_582

317.0

909.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

636_656

317.0

909.0

Transmembrane

Helical

Hgene

GRIK2

chr6:102134228

chr2:37520414

ENST00000421544

820_840

317.0

909.0

Transmembrane

Helical

Top

Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
GRIK2
PRKD3

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to GRIK2-PRKD3

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to GRIK2-PRKD3

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source