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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GRM3-CASR

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GRM3-CASR
FusionPDB ID: 34900
FusionGDB2.0 ID: 34900
HgeneTgene
Gene symbol

GRM3

CASR

Gene ID

2913

846

Gene nameglutamate metabotropic receptor 3calcium sensing receptor
SynonymsGLUR3|GPRC1C|MGLUR3|mGlu3CAR|EIG8|FHH|FIH|GPRC2A|HHC|HHC1|HYPOC1|NSHPT|PCAR1|hCasR
Cytomap

7q21.11-q21.12

3q13.33-q21.1

Type of geneprotein-codingprotein-coding
Descriptionmetabotropic glutamate receptor 3glutamate receptor, metabotropic 3extracellular calcium-sensing receptorparathyroid Ca(2+)-sensing receptor 1parathyroid cell calcium-sensing receptor 1
Modification date2020031320200313
UniProtAcc

Q14832

P41180

Ensembl transtripts involved in fusion geneENST idsENST00000361669, ENST00000394720, 
ENST00000439827, ENST00000536043, 
ENST00000546348, 		ENST00000296154, 
ENST00000490131, ENST00000498619, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score4 X 5 X 1=208 X 9 X 7=504
# samples 515
** MAII scorelog2(5/20*10)=1.32192809488736
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0		log2(15/504*10)=-1.74846123300404
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GRM3 [Title/Abstract] AND CASR [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GRM3(86479793)-CASR(122003403), # samples:1
Anticipated loss of major functional domain due to fusion event.GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
GRM3-CASR seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneCASR

GO:0005513

detection of calcium ion

27434672

TgeneCASR

GO:0006874

cellular calcium ion homeostasis

27434672

TgeneCASR

GO:0007186

G protein-coupled receptor signaling pathway

27434672

TgeneCASR

GO:0070509

calcium ion import

20846291


check buttonFusion gene breakpoints across GRM3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CASR (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChiTaRS5.0N/AAX542233GRM3chr7

86479793

+CASRchr3

122003403

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000361669GRM3chr786479793+ENST00000498619CASRchr3122003403+54963557105441911045
ENST00000546348GRM3chr786479793+ENST00000498619CASRchr3122003403+355616173742251625
ENST00000536043GRM3chr786479793+ENST00000498619CASRchr3122003403+416622271532861902

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000361669ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0006526370.9993474
ENST00000546348ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0016233090.9983767
ENST00000536043ENST00000498619GRM3chr786479793+CASRchr3122003403+0.0010735240.99892646

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>34900_34900_1_GRM3-CASR_GRM3_chr7_86479793_ENST00000361669_CASR_chr3_122003403_ENST00000498619_length(amino acids)=1045AA_BP=769
MAPPLISPRGTETGFMKMLTRLQVLTLALFSKGFLLSLGDHNFLRREIKIEGDLVLGGLFPINEKGTGTEECGRINEDRGIQRLEAMLFA
IDEINKDDYLLPGVKLGVHILDTCSRDTYALEQSLEFVRASLTKVDEAEYMCPDGSYAIQENIPLLIAGVIGGSYSSVSIQVANLLRLFQ
IPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVASEGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKS
YDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQESIIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNN
HRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVYAMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYL
LKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGD
VCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELC
YILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSV
WLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSD
YRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQ
QPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDL

--------------------------------------------------------------

>34900_34900_2_GRM3-CASR_GRM3_chr7_86479793_ENST00000536043_CASR_chr3_122003403_ENST00000498619_length(amino acids)=902AA_BP=626
MSQSPGAGSPPPLPPRSAPVPARSCRCEVANLLRLFQIPQISYASTSAKLSDKSRYDYFARTVPPDFYQAKAMAEILRFFNWTYVSTVAS
EGDYGETGIEAFEQEARLRNICIATAEKVGRSNIRKSYDSVIRELLQKPNARVVVLFMRSDDSRELIAAASRANASFTWVASDGWGAQES
IIKGSEHVAYGAITLELASQPVRQFDRYFQSLNPYNNHRNPWFRDFWEQKFQCSLQNKRNHRRVCDKHLAIDSSNYEQESKIMFVVNAVY
AMAHALHKMQRTLCPNTTKLCDAMKILDGKKLYKDYLLKINFTAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAE
TLSLDVNSIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAI
GPVTIACLGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIAR
IFDGVKNGAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKT
RKCPENFNEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSR
KRSSSLGGSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNA
MAHRNSTHQNSLEAQKSSDTLTRHEPLLPLQCGETDLDLTVQETGLQGPVGGDQRPEVEDPEELSPALVVSSSQSFVISGGGSTVTENVV

--------------------------------------------------------------

>34900_34900_3_GRM3-CASR_GRM3_chr7_86479793_ENST00000546348_CASR_chr3_122003403_ENST00000498619_length(amino acids)=625AA_BP=349
MCRMRRTNHEPEPGCRLTAAAATAVSSSSCQELSVRAPFNPNKDADSIVKFDTFGDGMGRYNVFNFQNVGGKYSYLKVGHWAETLSLDVN
SIHWSRNSVPTSQCSDPCAPNEMKNMQPGDVCCWICIPCEPYEYLADEFTCMDCGSGQWPTADLTGCYDLPEDYIRWEDAWAIGPVTIAC
LGFMCTCMVVTVFIKHNNTPLVKASGRELCYILLFGVGLSYCMTFFFIAKPSPVICALRRLGLGSSFAICYSALLTKTNCIARIFDGVKN
GAQRPKFISPSSQVFICLGLILVQIVMVSVWLILEAPGTRRYTLAEKRETVILKCNVKDSSMLISLTYDVILVILCTVYAFKTRKCPENF
NEAKFIGFTMYTTCIIWLAFLPIFYVTSSDYRVVTHRLHLNRFSVSGTGTTYSQSIEEVRCSTAAHAFKVAARATLRRSNVSRKRSSSLG
GSTGSTPSSSISSKSNSEDPFPQPERQKQQQPLALTQQEQQQQPLTLPQQQRSQQQPRCKQKVIFGSGTVTFSLSFDEPQKNAMAHRNST

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:86479793/chr3:122003403)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GRM3

Q14832

CASR

P41180

FUNCTION: G-protein coupled receptor for glutamate. Ligand binding causes a conformation change that triggers signaling via guanine nucleotide-binding proteins (G proteins) and modulates the activity of down-stream effectors. Signaling inhibits adenylate cyclase activity. {ECO:0000269|PubMed:8840013}.FUNCTION: G-protein-coupled receptor that senses changes in the extracellular concentration of calcium ions and plays a key role in maintaining calcium homeostasis (PubMed:7759551, PubMed:8702647, PubMed:8636323, PubMed:8878438, PubMed:17555508, PubMed:19789209, PubMed:21566075, PubMed:22114145, PubMed:23966241, PubMed:25292184, PubMed:25104082, PubMed:26386835, PubMed:25766501, PubMed:22789683). Senses fluctuations in the circulating calcium concentration and modulates the production of parathyroid hormone (PTH) in parathyroid glands (By similarity). The activity of this receptor is mediated by a G-protein that activates a phosphatidylinositol-calcium second messenger system (PubMed:7759551). The G-protein-coupled receptor activity is activated by a co-agonist mechanism: aromatic amino acids, such as Trp or Phe, act concertedly with divalent cations, such as calcium or magnesium, to achieve full receptor activation (PubMed:27434672, PubMed:27386547). {ECO:0000250|UniProtKB:Q9QY96, ECO:0000269|PubMed:17555508, ECO:0000269|PubMed:19789209, ECO:0000269|PubMed:21566075, ECO:0000269|PubMed:22114145, ECO:0000269|PubMed:22789683, ECO:0000269|PubMed:23966241, ECO:0000269|PubMed:25104082, ECO:0000269|PubMed:25292184, ECO:0000269|PubMed:25766501, ECO:0000269|PubMed:26386835, ECO:0000269|PubMed:27386547, ECO:0000269|PubMed:27434672, ECO:0000269|PubMed:7759551, ECO:0000269|PubMed:8636323, ECO:0000269|PubMed:8702647, ECO:0000269|PubMed:8878438}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406189_32401079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr7:86479793chr3:122003403ENST000002961540622_18801079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406415_41701079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406542_61201079.0RegionCysteine-rich (CR)
TgeneCASRchr7:86479793chr3:122003403ENST000002961540666_7001079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107189_32401079.0RegionLigand-binding 2 (LB2)
TgeneCASRchr7:86479793chr3:122003403ENST000004901310722_18801079.0RegionLigand-binding 1 (LB1)
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107415_41701079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107542_61201079.0RegionCysteine-rich (CR)
TgeneCASRchr7:86479793chr3:122003403ENST000004901310766_7001079.0RegionAnion binding
TgeneCASRchr7:86479793chr3:122003403ENST000002961540620_61201079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406636_64901079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406671_68101079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406701_72401079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406746_76901079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406793_80501079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406829_83601079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406863_107801079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST000004901310720_61201079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107636_64901079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107671_68101079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107701_72401079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107746_76901079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107793_80501079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107829_83601079.0Topological domainExtracellular
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107863_107801079.0Topological domainCytoplasmic
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406613_63501079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406650_67001079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406682_70001079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406725_74501079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406770_79201079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406806_82801079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr7:86479793chr3:122003403ENST0000029615406837_86201079.0TransmembraneHelical%3B Name%3D7
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107613_63501079.0TransmembraneHelical%3B Name%3D1
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107650_67001079.0TransmembraneHelical%3B Name%3D2
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107682_70001079.0TransmembraneHelical%3B Name%3D3
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107725_74501079.0TransmembraneHelical%3B Name%3D4
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107770_79201079.0TransmembraneHelical%3B Name%3D5
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107806_82801079.0TransmembraneHelical%3B Name%3D6
TgeneCASRchr7:86479793chr3:122003403ENST0000049013107837_86201079.0TransmembraneHelical%3B Name%3D7

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16172_1740880.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15172_1740536.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15172_1740538.0RegionGlutamate binding
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+1623_5760880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16600_6130880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16635_6450880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16665_6880880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16710_7340880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16757_7690880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16793_8020880.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16829_8790880.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+1523_5760536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15600_6130536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15635_6450536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15665_6880536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15710_7340536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15757_7690536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15793_8020536.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15829_8790536.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+1523_5760538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15600_6130538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15635_6450538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15665_6880538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15710_7340538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15757_7690538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15793_8020538.0Topological domainExtracellular
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15829_8790538.0Topological domainCytoplasmic
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16577_5990880.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16614_6340880.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16646_6640880.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16689_7090880.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16735_7560880.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16770_7920880.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000361669+16803_8280880.0TransmembraneHelical%3B Name%3D7
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15577_5990536.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15614_6340536.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15646_6640536.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15689_7090536.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15735_7560536.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15770_7920536.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000394720+15803_8280536.0TransmembraneHelical%3B Name%3D7
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15577_5990538.0TransmembraneHelical%3B Name%3D1
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15614_6340538.0TransmembraneHelical%3B Name%3D2
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15646_6640538.0TransmembraneHelical%3B Name%3D3
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15689_7090538.0TransmembraneHelical%3B Name%3D4
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15735_7560538.0TransmembraneHelical%3B Name%3D5
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15770_7920538.0TransmembraneHelical%3B Name%3D6
HgeneGRM3chr7:86479793chr3:122003403ENST00000439827+15803_8280538.0TransmembraneHelical%3B Name%3D7


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GRM3
CASR


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GRM3-CASR


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GRM3-CASR


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource