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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:AKT3-CDC14A

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: AKT3-CDC14A
FusionPDB ID: 3496
FusionGDB2.0 ID: 3496
HgeneTgene
Gene symbol

AKT3

CDC14A

Gene ID

10000

8556

Gene nameAKT serine/threonine kinase 3cell division cycle 14A
SynonymsMPPH|MPPH2|PKB-GAMMA|PKBG|PRKBG|RAC-PK-gamma|RAC-gamma|STK-2DFNB105|DFNB32|DFNB35|cdc14|hCDC14
Cytomap

1q43-q44

1p21.2

Type of geneprotein-codingprotein-coding
DescriptionRAC-gamma serine/threonine-protein kinasePKB gammaRAC-gamma serine/threonine protein kinasev-akt murine thymoma viral oncogene homolog 3 (protein kinase B, gamma)dual specificity protein phosphatase CDC14ACDC10 (cell division cycle 10, S. cerevisiae, homolog)CDC14 cell division cycle 14 homolog A
Modification date2020031320200313
UniProtAcc

Q9Y243

Q9UNH5

Ensembl transtripts involved in fusion geneENST idsENST00000263826, ENST00000336199, 
ENST00000366539, ENST00000366540, 
ENST00000492957, 		ENST00000469387, 
ENST00000336454, ENST00000361544, 
ENST00000370124, ENST00000370125, 
ENST00000542213, ENST00000544534, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score18 X 15 X 7=18906 X 6 X 5=180
# samples 216
** MAII scorelog2(21/1890*10)=-3.16992500144231
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(6/180*10)=-1.58496250072116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: AKT3 [Title/Abstract] AND CDC14A [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)AKT3(244006427)-CDC14A(100856288), # samples:2
Anticipated loss of major functional domain due to fusion event.AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
AKT3-CDC14A seems lost the major protein functional domain in Hgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneAKT3

GO:0043536

positive regulation of blood vessel endothelial cell migration

28254819

HgeneAKT3

GO:1905564

positive regulation of vascular endothelial cell proliferation

28254819


check buttonFusion gene breakpoints across AKT3 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CDC14A (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4SKCMTCGA-D3-A3ML-06AAKT3chr1

244006427

-CDC14Achr1

100856288

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000336199AKT3chr1244006427-ENST00000542213CDC14Achr1100856288+18541121211767548
ENST00000336199AKT3chr1244006427-ENST00000370125CDC14Achr1100856288+35891125971592331
ENST00000336199AKT3chr1244006427-ENST00000361544CDC14Achr1100856288+18491121211767548
ENST00000336199AKT3chr1244006427-ENST00000370124CDC14Achr1100856288+13261121211047308
ENST00000336199AKT3chr1244006427-ENST00000336454CDC14Achr1100856288+36781121211680519
ENST00000336199AKT3chr1244006427-ENST00000544534CDC14Achr1100856288+18181121211728535
ENST00000366539AKT3chr1244006427-ENST00000542213CDC14Achr1100856288+19892472561902548
ENST00000366539AKT3chr1244006427-ENST00000370125CDC14Achr1100856288+37242477321727331
ENST00000366539AKT3chr1244006427-ENST00000361544CDC14Achr1100856288+19842472561902548
ENST00000366539AKT3chr1244006427-ENST00000370124CDC14Achr1100856288+14612472561182308
ENST00000366539AKT3chr1244006427-ENST00000336454CDC14Achr1100856288+38132472561815519
ENST00000366539AKT3chr1244006427-ENST00000544534CDC14Achr1100856288+19532472561863535
ENST00000263826AKT3chr1244006427-ENST00000542213CDC14Achr1100856288+18691271361782548
ENST00000263826AKT3chr1244006427-ENST00000370125CDC14Achr1100856288+36041276121607331
ENST00000263826AKT3chr1244006427-ENST00000361544CDC14Achr1100856288+18641271361782548
ENST00000263826AKT3chr1244006427-ENST00000370124CDC14Achr1100856288+13411271361062308
ENST00000263826AKT3chr1244006427-ENST00000336454CDC14Achr1100856288+36931271361695519
ENST00000263826AKT3chr1244006427-ENST00000544534CDC14Achr1100856288+18331271361743535

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000336199ENST00000542213AKT3chr1244006427-CDC14Achr1100856288+0.0276453850.9723546
ENST00000336199ENST00000370125AKT3chr1244006427-CDC14Achr1100856288+0.0020339570.99796605
ENST00000336199ENST00000361544AKT3chr1244006427-CDC14Achr1100856288+0.0274527610.97254723
ENST00000336199ENST00000370124AKT3chr1244006427-CDC14Achr1100856288+0.192468080.80753195
ENST00000336199ENST00000336454AKT3chr1244006427-CDC14Achr1100856288+0.0021042840.9978957
ENST00000336199ENST00000544534AKT3chr1244006427-CDC14Achr1100856288+0.056897670.94310236
ENST00000366539ENST00000542213AKT3chr1244006427-CDC14Achr1100856288+0.0344470780.9655529
ENST00000366539ENST00000370125AKT3chr1244006427-CDC14Achr1100856288+0.0025440350.997456
ENST00000366539ENST00000361544AKT3chr1244006427-CDC14Achr1100856288+0.0341870230.965813
ENST00000366539ENST00000370124AKT3chr1244006427-CDC14Achr1100856288+0.204033640.7959663
ENST00000366539ENST00000336454AKT3chr1244006427-CDC14Achr1100856288+0.0026394690.9973605
ENST00000366539ENST00000544534AKT3chr1244006427-CDC14Achr1100856288+0.0712106450.9287893
ENST00000263826ENST00000542213AKT3chr1244006427-CDC14Achr1100856288+0.03196410.9680359
ENST00000263826ENST00000370125AKT3chr1244006427-CDC14Achr1100856288+0.0021502490.9978498
ENST00000263826ENST00000361544AKT3chr1244006427-CDC14Achr1100856288+0.031649850.9683501
ENST00000263826ENST00000370124AKT3chr1244006427-CDC14Achr1100856288+0.257976470.74202347
ENST00000263826ENST00000336454AKT3chr1244006427-CDC14Achr1100856288+0.0022215890.99777836
ENST00000263826ENST00000544534AKT3chr1244006427-CDC14Achr1100856288+0.06536290.93463707

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>3496_3496_1_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000336454_length(amino acids)=519AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

--------------------------------------------------------------

>3496_3496_2_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000361544_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

--------------------------------------------------------------

>3496_3496_3_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000370124_length(amino acids)=308AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR

--------------------------------------------------------------

>3496_3496_4_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000370125_length(amino acids)=331AA_BP=
MNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSIN
KILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAV
TLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNN

--------------------------------------------------------------

>3496_3496_5_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000542213_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

--------------------------------------------------------------

>3496_3496_6_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000263826_CDC14A_chr1_100856288_ENST00000544534_length(amino acids)=535AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

--------------------------------------------------------------

>3496_3496_7_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000336454_length(amino acids)=519AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

--------------------------------------------------------------

>3496_3496_8_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000361544_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

--------------------------------------------------------------

>3496_3496_9_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000370124_length(amino acids)=308AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR

--------------------------------------------------------------

>3496_3496_10_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000370125_length(amino acids)=331AA_BP=
MNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSIN
KILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAV
TLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNN

--------------------------------------------------------------

>3496_3496_11_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000542213_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

--------------------------------------------------------------

>3496_3496_12_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000336199_CDC14A_chr1_100856288_ENST00000544534_length(amino acids)=535AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

--------------------------------------------------------------

>3496_3496_13_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000336454_length(amino acids)=519AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

--------------------------------------------------------------

>3496_3496_14_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000361544_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

--------------------------------------------------------------

>3496_3496_15_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000370124_length(amino acids)=308AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR

--------------------------------------------------------------

>3496_3496_16_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000370125_length(amino acids)=331AA_BP=
MNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNRPSSEGSIN
KILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLSSSLQGSAV
TLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTTRNYPELNN

--------------------------------------------------------------

>3496_3496_17_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000542213_length(amino acids)=548AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT
RNYPELNNNQYNRSSNSNGGNLNSPPGPHSAKTEEHTTILRPSYTGLSSSSARFLSRSIPVSAQTPPPGPQNPECNFCALPSQPRLPPKK

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>3496_3496_18_AKT3-CDC14A_AKT3_chr1_244006427_ENST00000366539_CDC14A_chr1_100856288_ENST00000544534_length(amino acids)=535AA_BP=
MSRKKIVHYTCFDQRKRANAAFLIGAYAVIYLKKTPEEAYRALLSGSNPPYLPFRDASFGNCTYNLTILDCLQGIRKGLQHGFFDFETFD
VDEYEHYERVENGDFNWIVPGKFLAFSGPHPKSKIENGYPLHAPEAYFPYFKKHNVTAVVRLNKKIYEAKRFTDAGFEHYDLFFIDGSTP
SDNIVRRFLNICENTEGAIAVHCKAGLGRTGTLIACYVMKHYRFTHAEIIAWIRICRPGSIIGPQQHFLEEKQASLWVQGDIFRSKLKNR
PSSEGSINKILSGLDDMSIGGNLSKTQNMERFGEDNLEDDDVEMKNGITQGDKLRALKSQRQPRTSPSCAFRSDDTKGHPRAVSQPFRLS
SSLQGSAVTLKTSKMALSPSATAKRINRTSLSSGATVRSFSINSRLASSLGNLNAATDDPENKKTSSSSKAGFTASPFTNLLNGSSQPTT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:244006427/chr1:100856288)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
AKT3

Q9Y243

CDC14A

Q9UNH5

FUNCTION: AKT3 is one of 3 closely related serine/threonine-protein kinases (AKT1, AKT2 and AKT3) called the AKT kinase, and which regulate many processes including metabolism, proliferation, cell survival, growth and angiogenesis. This is mediated through serine and/or threonine phosphorylation of a range of downstream substrates. Over 100 substrate candidates have been reported so far, but for most of them, no isoform specificity has been reported. AKT3 is the least studied AKT isoform. It plays an important role in brain development and is crucial for the viability of malignant glioma cells. AKT3 isoform may also be the key molecule in up-regulation and down-regulation of MMP13 via IL13. Required for the coordination of mitochondrial biogenesis with growth factor-induced increases in cellular energy demands. Down-regulation by RNA interference reduces the expression of the phosphorylated form of BAD, resulting in the induction of caspase-dependent apoptosis. {ECO:0000269|PubMed:18524868, ECO:0000269|PubMed:21191416}.FUNCTION: Dual-specificity phosphatase. Required for centrosome separation and productive cytokinesis during cell division. Dephosphorylates SIRT2 around early anaphase. May dephosphorylate the APC subunit FZR1/CDH1, thereby promoting APC-FZR1 dependent degradation of mitotic cyclins and subsequent exit from mitosis. Required for normal hearing (PubMed:29293958). {ECO:0000269|PubMed:11901424, ECO:0000269|PubMed:12134069, ECO:0000269|PubMed:17488717, ECO:0000269|PubMed:29293958, ECO:0000269|PubMed:9367992}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneCDC14Achr1:244006427chr1:100856288ENST00000336454216179_33672.0595.0DomainTyrosine-protein phosphatase
TgeneCDC14Achr1:244006427chr1:100856288ENST00000361544215179_33672.0624.0DomainTyrosine-protein phosphatase
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370124211179_33672.0384.0DomainTyrosine-protein phosphatase
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370125215179_33672.0837.3333333333334DomainTyrosine-protein phosphatase
TgeneCDC14Achr1:244006427chr1:100856288ENST00000544534217179_33672.0607.0DomainTyrosine-protein phosphatase
TgeneCDC14Achr1:244006427chr1:100856288ENST00000336454216163_17672.0595.0RegionNote=Linker
TgeneCDC14Achr1:244006427chr1:100856288ENST00000336454216177_34372.0595.0RegionNote=B
TgeneCDC14Achr1:244006427chr1:100856288ENST00000361544215163_17672.0624.0RegionNote=Linker
TgeneCDC14Achr1:244006427chr1:100856288ENST00000361544215177_34372.0624.0RegionNote=B
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370124211163_17672.0384.0RegionNote=Linker
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370124211177_34372.0384.0RegionNote=B
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370125215163_17672.0837.3333333333334RegionNote=Linker
TgeneCDC14Achr1:244006427chr1:100856288ENST00000370125215177_34372.0837.3333333333334RegionNote=B
TgeneCDC14Achr1:244006427chr1:100856288ENST00000544534217163_17672.0607.0RegionNote=Linker
TgeneCDC14Achr1:244006427chr1:100856288ENST00000544534217177_34372.0607.0RegionNote=B

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneAKT3chr1:244006427chr1:100856288ENST00000263826-113148_40515.333333333333334480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:100856288ENST00000263826-113406_47915.333333333333334480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:100856288ENST00000263826-1135_10715.333333333333334480.0DomainPH
HgeneAKT3chr1:244006427chr1:100856288ENST00000336199-114148_40515.333333333333334476.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:100856288ENST00000336199-114406_47915.333333333333334476.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:100856288ENST00000336199-1145_10715.333333333333334476.0DomainPH
HgeneAKT3chr1:244006427chr1:100856288ENST00000366539-214148_40515.333333333333334480.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:100856288ENST00000366539-214406_47915.333333333333334480.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:100856288ENST00000366539-2145_10715.333333333333334480.0DomainPH
HgeneAKT3chr1:244006427chr1:100856288ENST00000366540-214148_40515.333333333333334466.0DomainProtein kinase
HgeneAKT3chr1:244006427chr1:100856288ENST00000366540-214406_47915.333333333333334466.0DomainAGC-kinase C-terminal
HgeneAKT3chr1:244006427chr1:100856288ENST00000366540-2145_10715.333333333333334466.0DomainPH
HgeneAKT3chr1:244006427chr1:100856288ENST00000263826-113154_16215.333333333333334480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:100856288ENST00000336199-114154_16215.333333333333334476.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:100856288ENST00000366539-214154_16215.333333333333334480.0Nucleotide bindingATP
HgeneAKT3chr1:244006427chr1:100856288ENST00000366540-214154_16215.333333333333334466.0Nucleotide bindingATP
TgeneCDC14Achr1:244006427chr1:100856288ENST000003364542167_16272.0595.0RegionNote=A
TgeneCDC14Achr1:244006427chr1:100856288ENST000003615442157_16272.0624.0RegionNote=A
TgeneCDC14Achr1:244006427chr1:100856288ENST000003701242117_16272.0384.0RegionNote=A
TgeneCDC14Achr1:244006427chr1:100856288ENST000003701252157_16272.0837.3333333333334RegionNote=A
TgeneCDC14Achr1:244006427chr1:100856288ENST000005445342177_16272.0607.0RegionNote=A


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
AKT3
CDC14A


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to AKT3-CDC14A


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to AKT3-CDC14A


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource