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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GSK3B-ATP11B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GSK3B-ATP11B
FusionPDB ID: 35031
FusionGDB2.0 ID: 35031
HgeneTgene
Gene symbol

GSK3B

ATP11B

Gene ID

2932

23200

Gene nameglycogen synthase kinase 3 betaATPase phospholipid transporting 11B (putative)
Synonyms-ATPIF|ATPIR
Cytomap

3q13.33

3q26.33

Type of geneprotein-codingprotein-coding
Descriptionglycogen synthase kinase-3 betaGSK-3 betaGSK3beta isoformserine/threonine-protein kinase GSK3Bprobable phospholipid-transporting ATPase IFATPase IRATPase, class VI, type 11BP4-ATPase flippase complex alpha subunit ATP11Btruncated ATPase 11B protein
Modification date2020031520200313
UniProtAcc

C14orf129

Q9Y2G3

Ensembl transtripts involved in fusion geneENST idsENST00000264235, ENST00000316626, 
ENST00000473886, 
ENST00000482794, 
ENST00000493826, ENST00000323116, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score31 X 22 X 12=818412 X 11 X 4=528
# samples 3614
** MAII scorelog2(36/8184*10)=-4.50673733341565
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(14/528*10)=-1.91511110241349
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GSK3B [Title/Abstract] AND ATP11B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GSK3B(119720893)-ATP11B(182631649), # samples:2
Anticipated loss of major functional domain due to fusion event.GSK3B-ATP11B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSK3B-ATP11B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSK3B

GO:0005977

glycogen metabolic process

8638126

HgeneGSK3B

GO:0006468

protein phosphorylation

11035810|16315267|20937854

HgeneGSK3B

GO:0006983

ER overload response

14744935

HgeneGSK3B

GO:0018105

peptidyl-serine phosphorylation

8638126|11104755|11955436|14744935|17139249

HgeneGSK3B

GO:0018107

peptidyl-threonine phosphorylation

11955436|17139249|25897075

HgeneGSK3B

GO:0031175

neuron projection development

19830702

HgeneGSK3B

GO:0031334

positive regulation of protein complex assembly

8638126

HgeneGSK3B

GO:0032091

negative regulation of protein binding

16890161

HgeneGSK3B

GO:0032436

positive regulation of proteasomal ubiquitin-dependent protein catabolic process

19364825

HgeneGSK3B

GO:0035556

intracellular signal transduction

14749367

HgeneGSK3B

GO:0043066

negative regulation of apoptotic process

14744935

HgeneGSK3B

GO:0046777

protein autophosphorylation

23184662

HgeneGSK3B

GO:0046827

positive regulation of protein export from nucleus

14744935

HgeneGSK3B

GO:1901215

negative regulation of neuron death

19830702

HgeneGSK3B

GO:1901216

positive regulation of neuron death

18508033

HgeneGSK3B

GO:2000300

regulation of synaptic vesicle exocytosis

17989287


check buttonFusion gene breakpoints across GSK3B (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across ATP11B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-G9-6333-01AGSK3Bchr3

119720893

-ATP11Bchr3

182631649

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000264235GSK3Bchr3119720893-ENST00000323116ATP11Bchr3182631649+501212656421214
ENST00000316626GSK3Bchr3119720893-ENST00000323116ATP11Bchr3182631649+4261514232729165

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000264235ENST00000323116GSK3Bchr3119720893-ATP11Bchr3182631649+0.0070547540.99294525
ENST00000316626ENST00000323116GSK3Bchr3119720893-ATP11Bchr3182631649+0.0069310060.99306905

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35031_35031_1_GSK3B-ATP11B_GSK3B_chr3_119720893_ENST00000264235_ATP11B_chr3_182631649_ENST00000323116_length(amino acids)=214AA_BP=
MIENEYFEYYIFLGDFFSESMKKGSGGRITSLTLEEKGGWVGGREREGGGGSEMRRETLQLRQAAGSGGLTAGARRTRGRRSRESVRGGR
WRWRRLLSSLRQEQLQAAAGSSGHGGGGGSSLQTPGSGSSTVPHSPGTWEPGNRFRPSGPPPPSAATARPPSRPSALLGARSGSVRALPQ

--------------------------------------------------------------

>35031_35031_2_GSK3B-ATP11B_GSK3B_chr3_119720893_ENST00000316626_ATP11B_chr3_182631649_ENST00000323116_length(amino acids)=165AA_BP=94
MSGRPRTTSFAESCKPVQQPSAFGSMKVSRDKDGSKVTTVVATPGQGPDRPQEVSYTDTKVIGNGSFGVVYQAKLCDSGELVAIKKVLQD

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:119720893/chr3:182631649)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSK3B

C14orf129

ATP11B

Q9Y2G3

139FUNCTION: Catalytic component of a P4-ATPase flippase complex which catalyzes the hydrolysis of ATP coupled to the transport of aminophospholipids, phosphatidylserines (PS) and phosphatidylethanolamines (PE), from the outer to the inner leaflet of intracellular membranes (PubMed:30018401). May contribute to the maintenance of membrane lipid asymmetry in endosome compartment (PubMed:30018401). {ECO:0000269|PubMed:30018401}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000264235-21162_7094.0421.0Nucleotide bindingATP
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000316626-21262_7094.0434.0Nucleotide bindingATP
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061021_10250196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061048_10650196.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606105_2890196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061091_11770196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061_550196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606312_3410196.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606360_8760196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST000004938260678_820196.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606899_9100196.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606931_9600196.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606983_9970196.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061026_10470196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000493826061066_10900196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606290_3110196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606342_3590196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000004938260656_770196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000004938260683_1040196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606877_8980196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606911_9300196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606961_9820196.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000049382606998_10200196.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000264235-21156_34094.0421.0DomainProtein kinase
HgeneGSK3Bchr3:119720893chr3:182631649ENST00000316626-21256_34094.0434.0DomainProtein kinase
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301021_10251106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301048_10651106.01178.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730105_2891106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301091_11771106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301_551106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730312_3411106.01178.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730360_8761106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116273078_821106.01178.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730899_9101106.01178.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730931_9601106.01178.0Topological domainCytoplasmic
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730983_9971106.01178.0Topological domainExtracellular
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301026_10471106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST0000032311627301066_10901106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730290_3111106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730342_3591106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116273056_771106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST00000323116273083_1041106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730877_8981106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730911_9301106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730961_9821106.01178.0TransmembraneHelical
TgeneATP11Bchr3:119720893chr3:182631649ENST000003231162730998_10201106.01178.0TransmembraneHelical


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GSK3B
ATP11B


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GSK3B-ATP11B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GSK3B-ATP11B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource