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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GSN-CNTRL

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GSN-CNTRL
FusionPDB ID: 35063
FusionGDB2.0 ID: 35063
HgeneTgene
Gene symbol

GSN

CNTRL

Gene ID

2934

11064

Gene namegelsolincentriolin
SynonymsADF|AGELCEP1|CEP110|FAN|bA165P4.1
Cytomap

9q33.2

9q33.2

Type of geneprotein-codingprotein-coding
Descriptiongelsolinactin-depolymerizing factorbrevinepididymis secretory sperm binding proteincentriolin110 kDa centrosomal proteinbA165P4.1 (ortholog of mouse Ma2a8)bA165P4.2 (centrosomal protein 1)centriole associated proteincentrosomal protein 110kDacentrosomal protein of 110 kDa
Modification date2020032920200313
UniProtAcc

P06396

Q7Z7A1

Ensembl transtripts involved in fusion geneENST idsENST00000341272, ENST00000373808, 
ENST00000373818, ENST00000373823, 
ENST00000394353, ENST00000412819, 
ENST00000436847, ENST00000449733, 
ENST00000545652, ENST00000373806, 
ENST00000373807, ENST00000485767, 
ENST00000373844, ENST00000373845, 
ENST00000373847, ENST00000373850, 
ENST00000238341, ENST00000373855, 
ENST00000373865, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score21 X 16 X 8=26883 X 3 X 2=18
# samples 243
** MAII scorelog2(24/2688*10)=-3.48542682717024
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/18*10)=0.736965594166206
effective Gene in Pan-Cancer Fusion Genes (eGinPCFGs).
DoF>8 and MAII>0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GSN [Title/Abstract] AND CNTRL [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GSN(124065343)-CNTRL(123852553), # samples:1
Anticipated loss of major functional domain due to fusion event.GSN-CNTRL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSN-CNTRL seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSN-CNTRL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GSN-CNTRL seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GSN-CNTRL seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
GSN-CNTRL seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSN

GO:0030041

actin filament polymerization

3020431

HgeneGSN

GO:0051014

actin filament severing

3020431


check buttonFusion gene breakpoints across GSN (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CNTRL (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-BR-8683-01AGSNchr9

124065343

+CNTRLchr9

123852553

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000373823GSNchr9124065343+ENST00000373865CNTRLchr9123852553+2720125613272718464
ENST00000373808GSNchr9124065343+ENST00000373865CNTRLchr9123852553+19424785491940464
ENST00000436847GSNchr9124065343+ENST00000373865CNTRLchr9123852553+21066427132104464
ENST00000449733GSNchr9124065343+ENST00000373865CNTRLchr9123852553+21476837542145464
ENST00000412819GSNchr9124065343+ENST00000373865CNTRLchr9123852553+21146507212112464
ENST00000394353GSNchr9124065343+ENST00000373865CNTRLchr9123852553+20976337042095464
ENST00000341272GSNchr9124065343+ENST00000373865CNTRLchr9123852553+20355716422033464
ENST00000545652GSNchr9124065343+ENST00000373865CNTRLchr9123852553+19945306011992464
ENST00000373818GSNchr9124065343+ENST00000373865CNTRLchr9123852553+20375736442035464

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000373823ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0288989280.97110105
ENST00000373808ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0173081530.9826918
ENST00000436847ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0081373110.99186265
ENST00000449733ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0053443860.9946556
ENST00000412819ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0114676510.9885323
ENST00000394353ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0105218950.98947805
ENST00000341272ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0196013540.9803986
ENST00000545652ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0168828610.9831171
ENST00000373818ENST00000373865GSNchr9124065343+CNTRLchr9123852553+0.0033296910.9966703

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35063_35063_1_GSN-CNTRL_GSN_chr9_124065343_ENST00000341272_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_2_GSN-CNTRL_GSN_chr9_124065343_ENST00000373808_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_3_GSN-CNTRL_GSN_chr9_124065343_ENST00000373818_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_4_GSN-CNTRL_GSN_chr9_124065343_ENST00000373823_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_5_GSN-CNTRL_GSN_chr9_124065343_ENST00000394353_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_6_GSN-CNTRL_GSN_chr9_124065343_ENST00000412819_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_7_GSN-CNTRL_GSN_chr9_124065343_ENST00000436847_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_8_GSN-CNTRL_GSN_chr9_124065343_ENST00000449733_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

>35063_35063_9_GSN-CNTRL_GSN_chr9_124065343_ENST00000545652_CNTRL_chr9_123852553_ENST00000373865_length(amino acids)=464AA_BP=
MALIKSLNLSLSKDGGKKFKYIENLEKCVKLEVLNLSYNLIGKIEKLDKLLKLRELNLSYNKISKIEGIENMCNLQKLNLAGNEIEHIPV
WLGKKLKSLRVLNLKGNKISSLQDISKLKPLQDLISLILVENPVVTLPHYLQFTIFHLRSLESLEGQPVTTQDRQEAFERFSLEEVERLE
RDLEKKMIETEELKSKQTRFLEEIKNQDKLNKSLKEEAMLQKQSCEELKSDLNTKNELLKQKTIELTRACQKQYELEQELAFYKIDAKFE
PLNYYPSEYAEIDKAPDESPYIGKSRYKRNMFATESYIIDSAQAVQIKKMEPDEQLRNDHMNLRGHTPLDTQLEDKEKKISAAQTRLSEL
HDEIEKAEQQILRATEEFKQLEEAIQLKKISEAGKDLLYKQLSGRLQLVNKLRQEALDLELQMEKQKQEIAGKQKEIKDLQIAIDSLDSK

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr9:124065343/chr9:123852553)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSN

P06396

CNTRL

Q7Z7A1

FUNCTION: Calcium-regulated, actin-modulating protein that binds to the plus (or barbed) ends of actin monomers or filaments, preventing monomer exchange (end-blocking or capping). It can promote the assembly of monomers into filaments (nucleation) as well as sever filaments already formed. Plays a role in ciliogenesis. {ECO:0000269|PubMed:20393563}.FUNCTION: Involved in cell cycle progression and cytokinesis. During the late steps of cytokinesis, anchors exocyst and SNARE complexes at the midbody, thereby allowing secretory vesicle-mediated abscission. {ECO:0000269|PubMed:12732615, ECO:0000269|PubMed:16213214}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317123_126168.0783.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317162_169168.0783.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519123_126128.0743.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519123_126128.0743.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+31776_126168.0783.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+51976_126128.0743.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+51976_126128.0743.0RepeatNote=Gelsolin-like 1
TgeneCNTRLchr9:124065343chr9:123852553ENST000002383410421317_225572.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042267_34372.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042435_79972.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042851_110172.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738500331317_225501774.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033267_34301774.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033435_79901774.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033851_110101774.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738552441317_225572.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244267_34372.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244435_79972.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244851_110172.333333333333332326.0Coiled coilOntology_term=ECO:0000255
TgeneCNTRLchr9:124065343chr9:123852553ENST000002383410421147_115072.333333333333332326.0Compositional biasNote=Poly-Pro
TgeneCNTRLchr9:124065343chr9:123852553ENST000002383410421236_130772.333333333333332326.0Compositional biasNote=Pro-rich
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042956_95972.333333333333332326.0Compositional biasNote=Poly-Lys
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738500331147_115001774.0Compositional biasNote=Poly-Pro
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738500331236_130701774.0Compositional biasNote=Pro-rich
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033956_95901774.0Compositional biasNote=Poly-Lys
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738552441147_115072.333333333333332326.0Compositional biasNote=Poly-Pro
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738552441236_130772.333333333333332326.0Compositional biasNote=Pro-rich
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244956_95972.333333333333332326.0Compositional biasNote=Poly-Lys
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042228_26672.333333333333332326.0DomainNote=LRRCT
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033228_26601774.0DomainNote=LRRCT
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244228_26672.333333333333332326.0DomainNote=LRRCT
TgeneCNTRLchr9:124065343chr9:123852553ENST000002383410421948_211872.333333333333332326.0RegionNote=Required for centrosome localization
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738500331948_211801774.0RegionNote=Required for centrosome localization
TgeneCNTRLchr9:124065343chr9:123852553ENST000003738552441948_211872.333333333333332326.0RegionNote=Required for centrosome localization
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042126_14772.333333333333332326.0RepeatNote=LRR 1
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042148_16972.333333333333332326.0RepeatNote=LRR 2
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042170_19172.333333333333332326.0RepeatNote=LRR 3
TgeneCNTRLchr9:124065343chr9:123852553ENST00000238341042194_21572.333333333333332326.0RepeatNote=LRR 4
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033126_14701774.0RepeatNote=LRR 1
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033148_16901774.0RepeatNote=LRR 2
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033170_19101774.0RepeatNote=LRR 3
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373850033194_21501774.0RepeatNote=LRR 4
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244126_14772.333333333333332326.0RepeatNote=LRR 1
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244148_16972.333333333333332326.0RepeatNote=LRR 2
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244170_19172.333333333333332326.0RepeatNote=LRR 3
TgeneCNTRLchr9:124065343chr9:123852553ENST00000373855244194_21572.333333333333332326.0RepeatNote=LRR 4

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418123_126117.0732.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418162_169117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418188_196117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418434_782117.0732.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+41853_176117.0732.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317123_126117.0732.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317162_169117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317188_196117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317434_782117.0732.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+31753_176117.0732.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317188_196168.0783.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317434_782168.0783.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+31753_176168.0783.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125123_126117.0732.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125162_169117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125188_196117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125434_782117.0732.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+112553_176117.0732.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519162_169128.0743.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519188_196128.0743.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519434_782128.0743.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+51953_176128.0743.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519123_126117.0732.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519162_169117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519188_196117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519434_782117.0732.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+51953_176117.0732.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519162_169128.0743.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519188_196128.0743.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519434_782128.0743.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+51953_176128.0743.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519123_126117.0732.0RegionNote=Actin-actin interfilament contact point
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519162_169117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519188_196117.0732.0RegionPolyphosphoinositide binding
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519434_782117.0732.0RegionActin-binding%2C Ca-sensitive
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+51953_176117.0732.0RegionActin-severing
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418198_238117.0732.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418314_356117.0732.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418453_504117.0732.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418576_616117.0732.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+418679_721117.0732.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000341272+41876_126117.0732.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317198_238117.0732.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317314_356117.0732.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317453_504117.0732.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317576_616117.0732.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+317679_721117.0732.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000373808+31776_126117.0732.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317198_238168.0783.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317314_356168.0783.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317453_504168.0783.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317576_616168.0783.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000373818+317679_721168.0783.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125198_238117.0732.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125314_356117.0732.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125453_504117.0732.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125576_616117.0732.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+1125679_721117.0732.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000373823+112576_126117.0732.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519198_238128.0743.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519314_356128.0743.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519453_504128.0743.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519576_616128.0743.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000394353+519679_721128.0743.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519198_238117.0732.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519314_356117.0732.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519453_504117.0732.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519576_616117.0732.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+519679_721117.0732.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000412819+51976_126117.0732.0RepeatNote=Gelsolin-like 1
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519198_238128.0743.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519314_356128.0743.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519453_504128.0743.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519576_616128.0743.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000436847+519679_721128.0743.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519198_238117.0732.0RepeatNote=Gelsolin-like 2
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519314_356117.0732.0RepeatNote=Gelsolin-like 3
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519453_504117.0732.0RepeatNote=Gelsolin-like 4
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519576_616117.0732.0RepeatNote=Gelsolin-like 5
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+519679_721117.0732.0RepeatNote=Gelsolin-like 6
HgeneGSNchr9:124065343chr9:123852553ENST00000449733+51976_126117.0732.0RepeatNote=Gelsolin-like 1


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GSN
CNTRL


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GSN-CNTRL


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GSN-CNTRL


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource