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Fusion Protein:ABCG1-BACE2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: ABCG1-BACE2 | FusionPDB ID: 351 | FusionGDB2.0 ID: 351 | Hgene | Tgene | Gene symbol | ABCG1 | BACE2 | Gene ID | 9619 | 25825 |
| Gene name | ATP binding cassette subfamily G member 1 | beta-secretase 2 | |
| Synonyms | ABC8|WHITE1 | AEPLC|ALP56|ASP1|ASP21|BAE2|CDA13|CEAP1|DRAP | |
| Cytomap | 21q22.3 | 21q22.2-q22.3 | |
| Type of gene | protein-coding | protein-coding | |
| Description | ATP-binding cassette sub-family G member 1ABC transporter 8ATP-binding cassette transporter 8ATP-binding cassette transporter member 1 of subfamily GATP-binding cassette, sub-family G (WHITE), member 1homolog of Drosophila whitewhite protein homolog | beta-secretase 256 kDa aspartic-like proteaseDown syndrome region aspartic proteaseSLCO3A1/BACE2 fusionaspartyl protease 1beta-site APP-cleaving enzyme 2beta-site amyloid beta A4 precursor protein-cleaving enzyme 2memapsin-1membrane-associated asp | |
| Modification date | 20200329 | 20200313 | |
| UniProtAcc | P45844 | Q9Y5Z0 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000462050, ENST00000340588, ENST00000343687, ENST00000347800, ENST00000361802, ENST00000398437, ENST00000398449, ENST00000398457, | ENST00000328735, ENST00000330333, ENST00000347667, ENST00000466122, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 8 X 7 X 4=224 | 14 X 9 X 8=1008 |
| # samples | 7 | 14 | |
| ** MAII score | log2(7/224*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(14/1008*10)=-2.84799690655495 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: ABCG1 [Title/Abstract] AND BACE2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | ABCG1(43708422)-BACE2(42598193), # samples:3 | ||
| Anticipated loss of major functional domain due to fusion event. | ABCG1-BACE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCG1-BACE2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. ABCG1-BACE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. ABCG1-BACE2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | ABCG1 | GO:0008203 | cholesterol metabolic process | 15994327 |
| Hgene | ABCG1 | GO:0033344 | cholesterol efflux | 15994327 |
| Hgene | ABCG1 | GO:0033993 | response to lipid | 16556852 |
| Hgene | ABCG1 | GO:0034436 | glycoprotein transport | 17293612 |
| Hgene | ABCG1 | GO:0042632 | cholesterol homeostasis | 15994327 |
| Hgene | ABCG1 | GO:0042987 | amyloid precursor protein catabolic process | 17293612 |
| Hgene | ABCG1 | GO:0050714 | positive regulation of protein secretion | 17293612 |
| Hgene | ABCG1 | GO:1902004 | positive regulation of amyloid-beta formation | 17293612 |
| Tgene | BACE2 | GO:0006509 | membrane protein ectodomain proteolysis | 10591213 |
| Fusion gene breakpoints across ABCG1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across BACE2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | UCEC | TCGA-B5-A3FB-01A | ABCG1 | chr21 | 43708422 | - | BACE2 | chr21 | 42598193 | + |
| ChimerDB4 | UCEC | TCGA-B5-A3FB-01A | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000398457 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3539 | 1490 | 239 | 2368 | 709 |
| ENST00000398457 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3708 | 1490 | 239 | 2734 | 831 |
| ENST00000398457 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9479 | 1490 | 239 | 2584 | 781 |
| ENST00000347800 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3343 | 1294 | 43 | 2172 | 709 |
| ENST00000347800 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3512 | 1294 | 43 | 2538 | 831 |
| ENST00000347800 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9283 | 1294 | 43 | 2388 | 781 |
| ENST00000398449 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3418 | 1369 | 145 | 2247 | 700 |
| ENST00000398449 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3587 | 1369 | 145 | 2613 | 822 |
| ENST00000398449 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9358 | 1369 | 145 | 2463 | 772 |
| ENST00000361802 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3454 | 1405 | 145 | 2283 | 712 |
| ENST00000361802 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3623 | 1405 | 145 | 2649 | 834 |
| ENST00000361802 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9394 | 1405 | 145 | 2499 | 784 |
| ENST00000343687 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3457 | 1408 | 151 | 2286 | 711 |
| ENST00000343687 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3626 | 1408 | 151 | 2652 | 833 |
| ENST00000343687 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9397 | 1408 | 151 | 2502 | 783 |
| ENST00000398437 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3895 | 1846 | 148 | 2724 | 858 |
| ENST00000398437 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 4064 | 1846 | 148 | 3090 | 980 |
| ENST00000398437 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9835 | 1846 | 148 | 2940 | 930 |
| ENST00000340588 | ABCG1 | chr21 | 43708422 | + | ENST00000328735 | BACE2 | chr21 | 42598193 | + | 3633 | 1584 | 0 | 2462 | 820 |
| ENST00000340588 | ABCG1 | chr21 | 43708422 | + | ENST00000330333 | BACE2 | chr21 | 42598193 | + | 3802 | 1584 | 0 | 2828 | 942 |
| ENST00000340588 | ABCG1 | chr21 | 43708422 | + | ENST00000347667 | BACE2 | chr21 | 42598193 | + | 9573 | 1584 | 0 | 2678 | 892 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000398457 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001913465 | 0.9980866 |
| ENST00000398457 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000902934 | 0.9990971 |
| ENST00000398457 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.00030073 | 0.99969935 |
| ENST00000347800 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.005222251 | 0.9947778 |
| ENST00000347800 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.002519337 | 0.9974807 |
| ENST00000347800 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000987869 | 0.9990121 |
| ENST00000398449 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.002437001 | 0.997563 |
| ENST00000398449 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001387649 | 0.9986123 |
| ENST00000398449 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000327658 | 0.9996724 |
| ENST00000361802 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.002223308 | 0.9977767 |
| ENST00000361802 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001225993 | 0.998774 |
| ENST00000361802 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000305309 | 0.9996947 |
| ENST00000343687 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001800909 | 0.99819916 |
| ENST00000343687 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000946718 | 0.9990533 |
| ENST00000343687 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000284011 | 0.999716 |
| ENST00000398437 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001173141 | 0.9988268 |
| ENST00000398437 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000417391 | 0.9995826 |
| ENST00000398437 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000249501 | 0.99975055 |
| ENST00000340588 | ENST00000328735 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.001437296 | 0.99856275 |
| ENST00000340588 | ENST00000330333 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000538286 | 0.9994617 |
| ENST00000340588 | ENST00000347667 | ABCG1 | chr21 | 43708422 | + | BACE2 | chr21 | 42598193 | + | 0.000308413 | 0.9996916 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >351_351_1_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000340588_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=820AA_BP=528 MVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAPGHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTA TAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSSIVIMPPSNRPLKASAASCTWSVQVQGGPHHLGVVAISGK VLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYI MQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC FQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVR AVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNF AVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAK PSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYN ADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQKLQVLQCL -------------------------------------------------------------- >351_351_2_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000340588_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=942AA_BP=528 MVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAPGHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTA TAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSSIVIMPPSNRPLKASAASCTWSVQVQGGPHHLGVVAISGK VLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYI MQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC FQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVR AVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNF AVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAK PSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYN ADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMG AGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALM -------------------------------------------------------------- >351_351_3_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000340588_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=892AA_BP=528 MVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAPGHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTA TAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSSIVIMPPSNRPLKASAASCTWSVQVQGGPHHLGVVAISGK VLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYI MQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASC FQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVR AVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNF AVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAK PSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYN ADKAIVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEI -------------------------------------------------------------- >351_351_4_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000343687_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=711AA_BP=419 MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEF RDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLM KGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERS STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV -------------------------------------------------------------- >351_351_5_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000343687_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=833AA_BP=419 MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEF RDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLM KGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERS STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV FDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNAL VIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFR -------------------------------------------------------------- >351_351_6_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000343687_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=783AA_BP=419 MRISLPRAPERDGGVSASSLLDTVTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEF RDLSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLL PHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLM KGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMC DSDHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERS STYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIP NVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKV FDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVAS -------------------------------------------------------------- >351_351_7_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000347800_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=709AA_BP=2 MPPCETCLSPSAMIMRLPQPHGTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD -------------------------------------------------------------- >351_351_8_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000347800_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=831AA_BP=2 MPPCETCLSPSAMIMRLPQPHGTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD AVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVI GATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQ -------------------------------------------------------------- >351_351_9_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000347800_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=781AA_BP=2 MPPCETCLSPSAMIMRLPQPHGTNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD AVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNC -------------------------------------------------------------- >351_351_10_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000361802_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=712AA_BP=420 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTER SSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANI PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQK -------------------------------------------------------------- >351_351_11_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000361802_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=834AA_BP=420 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTER SSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANI PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQK VFDAVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNA LVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPF -------------------------------------------------------------- >351_351_12_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000361802_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=784AA_BP=420 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTER SSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANI PNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQK VFDAVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVA -------------------------------------------------------------- >351_351_13_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398437_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=858AA_BP=566 MLAVQQTEHLPACPPARRWSSNFCPESTEGGPSLLGLRDMVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAP GHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTATAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSS IVIMPPSNRPLASAASCTWSVQVQGGPHHLGVVAISGKVLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGK STLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRT GSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL VPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGC HSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKG FNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSL YKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNS -------------------------------------------------------------- >351_351_14_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398437_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=980AA_BP=566 MLAVQQTEHLPACPPARRWSSNFCPESTEGGPSLLGLRDMVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAP GHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTATAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSS IVIMPPSNRPLASAASCTWSVQVQGGPHHLGVVAISGKVLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGK STLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRT GSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL VPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGC HSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKG FNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSL YKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLIPEFSDGFWTGSQLACWTNS ETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAG -------------------------------------------------------------- >351_351_15_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398437_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=930AA_BP=566 MLAVQQTEHLPACPPARRWSSNFCPESTEGGPSLLGLRDMVRRGWSVCTAILLARLWCLVPTHTFLSEYPEAAEYPHPGWVYWLQMAVAP GHLRAWVMRNNVTTNIPSAFSGTLTHEEKAVLTVFTGTATAVHVQVAALASAKLESSVFVTDCVSCKIENVCDSALQGKRVPMSGLQGSS IVIMPPSNRPLASAASCTWSVQVQGGPHHLGVVAISGKVLSAAHGAGRAYGWGFPGDPMEEGYKTLLKGISGKFNSGELVAIMGPSGAGK STLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRT GSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNL VPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGDAEVNPFLWHRPSEEVKQTKRLKGLRKDSSSMEGC HSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVTVKYTQGSWTGFVGEDLVTIPKG FNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAGLPVAGSGTNGGSLVLGGIEPSL YKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARASLLYIQPMMGAGLNYECYRFGI SPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIV -------------------------------------------------------------- >351_351_16_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398449_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=700AA_BP=408 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVT VKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAG LPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARA -------------------------------------------------------------- >351_351_17_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398449_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=822AA_BP=408 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVT VKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAG LPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARA SLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFY VIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQRRPRDPEVV -------------------------------------------------------------- >351_351_18_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398449_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=772AA_BP=408 MACLMAAFSVGTAMNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRDLSYSVPEGP WWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPHLTVQEAMMV SAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKGLAQGGRSII CTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDSDHKRDLGGD AEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSSTYRSKGFDVT VKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNVFSMQMCGAG LPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFDAVVEAVARA SLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEP -------------------------------------------------------------- >351_351_19_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398457_BACE2_chr21_42598193_ENST00000328735_length(amino acids)=709AA_BP=417 MCQELFLMLGTQGWTKQRKPCPQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD -------------------------------------------------------------- >351_351_20_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398457_BACE2_chr21_42598193_ENST00000330333_length(amino acids)=831AA_BP=417 MCQELFLMLGTQGWTKQRKPCPQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD AVVEAVARASLIPEFSDGFWTGSQLACWTNSETPWSYFPKISIYLRDENSSRSFRITILPQLYIQPMMGAGLNYECYRFGISPSTNALVI GATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNCVPAQSLSEPILWIVSYALMSVCGAILLVLIVLLLLPFRCQ -------------------------------------------------------------- >351_351_21_ABCG1-BACE2_ABCG1_chr21_43708422_ENST00000398457_BACE2_chr21_42598193_ENST00000347667_length(amino acids)=781AA_BP=417 MCQELFLMLGTQGWTKQRKPCPQNASSYSAEMTEPKSVCVSVDEVVSSNMEATETDLLNGHLKKVDNNLTEAQRFSSLPRRAAVNIEFRD LSYSVPEGPWWRKKGYKTLLKGISGKFNSGELVAIMGPSGAGKSTLMNILAGYRETGMKGAVLINGLPRDLRCFRKVSCYIMQDDMLLPH LTVQEAMMVSAHLKLQEKDEGRREMVKEILTALGLLSCANTRTGSLSGGQRKRLAIALELVNNPPVMFFDEPTSGLDSASCFQVVSLMKG LAQGGRSIICTIHQPSAKLFELFDQLYVLSQGQCVYRGKVCNLVPYLRDLGLNCPTYHNPADFVMEVASGEYGDQNSRLVRAVREGMCDS DHKRDLGGDAEVNPFLWHRPSEEDSSSMEGCHSFSASCLTQFCILFKRTFLSIMRDSLQILVDTGSSNFAVAGTPHSYIDTYFDTERSST YRSKGFDVTVKYTQGSWTGFVGEDLVTIPKGFNTSFLVNIATIFESENFFLPGIKWNGILGLAYATLAKPSSSLETFFDSLVTQANIPNV FSMQMCGAGLPVAGSGTNGGSLVLGGIEPSLYKGDIWYTPIKEEWYYQIEILKLEIGGQSLNLDCREYNADKAIVDSGTTLLRLPQKVFD AVVEAVARASLLYIQPMMGAGLNYECYRFGISPSTNALVIGATVMEGFYVIFDRAQKRVGFAASPCAEIAGAAVSEISGPFSTEDVASNC -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr21:43708422/chr21:42598193) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| ABCG1 | BACE2 |
| FUNCTION: Catalyzes the efflux of phospholipids such as sphingomyelin, cholesterol and its oxygenated derivatives like 7beta-hydroxycholesterol and this transport is coupled to hydrlysis of ATP (PubMed:17408620, PubMed:24576892). The lipid efflux is ALB-dependent (PubMed:16702602). Is an active component of the macrophage lipid export complex. Could also be involved in intracellular lipid transport processes. The role in cellular lipid homeostasis may not be limited to macrophages. Prevents cell death by transporting cytotoxic 7beta-hydroxycholesterol (PubMed:17408620). {ECO:0000269|PubMed:16702602, ECO:0000269|PubMed:17408620, ECO:0000269|PubMed:24576892}. | FUNCTION: Responsible for the proteolytic processing of the amyloid precursor protein (APP). Cleaves APP, between residues 690 and 691, leading to the generation and extracellular release of beta-cleaved soluble APP, and a corresponding cell-associated C-terminal fragment which is later released by gamma-secretase. It has also been shown that it can cleave APP between residues 671 and 672. Responsible also for the proteolytic processing of CLTRN in pancreatic beta cells (PubMed:21907142). {ECO:0000269|PubMed:10591213, ECO:0000269|PubMed:11083922, ECO:0000269|PubMed:11423558, ECO:0000269|PubMed:15857888, ECO:0000269|PubMed:16816112, ECO:0000269|PubMed:21907142}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 77_317 | 419.0 | 678.0 | Domain | ABC transporter |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 77_317 | 405.0 | 664.0 | Domain | ABC transporter |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 77_317 | 420.0 | 679.0 | Domain | ABC transporter |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 77_317 | 408.0 | 667.0 | Domain | ABC transporter |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 77_317 | 410.0 | 669.0 | Domain | ABC transporter |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 118_125 | 419.0 | 678.0 | Nucleotide binding | ATP |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 118_125 | 405.0 | 664.0 | Nucleotide binding | ATP |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 118_125 | 420.0 | 679.0 | Nucleotide binding | ATP |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 118_125 | 408.0 | 667.0 | Nucleotide binding | ATP |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 118_125 | 410.0 | 669.0 | Nucleotide binding | ATP |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000328735 | 0 | 8 | 495_518 | 104.0 | 397.0 | Topological domain | Cytoplasmic | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000330333 | 0 | 9 | 495_518 | 104.0 | 519.0 | Topological domain | Cytoplasmic | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000347667 | 0 | 8 | 495_518 | 104.0 | 469.0 | Topological domain | Cytoplasmic | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000328735 | 0 | 8 | 474_494 | 104.0 | 397.0 | Transmembrane | Helical | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000330333 | 0 | 9 | 474_494 | 104.0 | 519.0 | Transmembrane | Helical | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000347667 | 0 | 8 | 474_494 | 104.0 | 469.0 | Transmembrane | Helical |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 415_673 | 419.0 | 678.0 | Domain | Note=ABC transmembrane type-2 |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 415_673 | 405.0 | 664.0 | Domain | Note=ABC transmembrane type-2 |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 415_673 | 420.0 | 679.0 | Domain | Note=ABC transmembrane type-2 |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 415_673 | 408.0 | 667.0 | Domain | Note=ABC transmembrane type-2 |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 415_673 | 410.0 | 669.0 | Domain | Note=ABC transmembrane type-2 |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 1_426 | 419.0 | 678.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 446_456 | 419.0 | 678.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 478_506 | 419.0 | 678.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 526_533 | 419.0 | 678.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 556_567 | 419.0 | 678.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 587_649 | 419.0 | 678.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 670_678 | 419.0 | 678.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 1_426 | 405.0 | 664.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 446_456 | 405.0 | 664.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 478_506 | 405.0 | 664.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 526_533 | 405.0 | 664.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 556_567 | 405.0 | 664.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 587_649 | 405.0 | 664.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 670_678 | 405.0 | 664.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 1_426 | 420.0 | 679.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 446_456 | 420.0 | 679.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 478_506 | 420.0 | 679.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 526_533 | 420.0 | 679.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 556_567 | 420.0 | 679.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 587_649 | 420.0 | 679.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 670_678 | 420.0 | 679.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 1_426 | 408.0 | 667.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 446_456 | 408.0 | 667.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 478_506 | 408.0 | 667.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 526_533 | 408.0 | 667.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 556_567 | 408.0 | 667.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 587_649 | 408.0 | 667.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 670_678 | 408.0 | 667.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 1_426 | 410.0 | 669.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 446_456 | 410.0 | 669.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 478_506 | 410.0 | 669.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 526_533 | 410.0 | 669.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 556_567 | 410.0 | 669.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 587_649 | 410.0 | 669.0 | Topological domain | Extracellular |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 670_678 | 410.0 | 669.0 | Topological domain | Cytoplasmic |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 427_445 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 457_477 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 507_525 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 534_555 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 568_586 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000343687 | + | 10 | 15 | 650_669 | 419.0 | 678.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 427_445 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 457_477 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 507_525 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 534_555 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 568_586 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000347800 | + | 10 | 15 | 650_669 | 405.0 | 664.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 427_445 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 457_477 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 507_525 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 534_555 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 568_586 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000361802 | + | 10 | 15 | 650_669 | 420.0 | 679.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 427_445 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 457_477 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 507_525 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 534_555 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 568_586 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398449 | + | 10 | 15 | 650_669 | 408.0 | 667.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 427_445 | 410.0 | 669.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 457_477 | 410.0 | 669.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 507_525 | 410.0 | 669.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 534_555 | 410.0 | 669.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 568_586 | 410.0 | 669.0 | Transmembrane | Helical |
| Hgene | ABCG1 | chr21:43708422 | chr21:42598193 | ENST00000398457 | + | 11 | 16 | 650_669 | 410.0 | 669.0 | Transmembrane | Helical |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000328735 | 0 | 8 | 92_429 | 104.0 | 397.0 | Domain | Peptidase A1 | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000330333 | 0 | 9 | 92_429 | 104.0 | 519.0 | Domain | Peptidase A1 | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000347667 | 0 | 8 | 92_429 | 104.0 | 469.0 | Domain | Peptidase A1 | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000328735 | 0 | 8 | 21_473 | 104.0 | 397.0 | Topological domain | Extracellular | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000330333 | 0 | 9 | 21_473 | 104.0 | 519.0 | Topological domain | Extracellular | |
| Tgene | BACE2 | chr21:43708422 | chr21:42598193 | ENST00000347667 | 0 | 8 | 21_473 | 104.0 | 469.0 | Topological domain | Extracellular |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| ABCG1 | |
| BACE2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to ABCG1-BACE2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to ABCG1-BACE2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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