UTHEALTH HOME ABOUT SBMI A-Z WEBMAIL INSIDE THE UNIVERSITY |
![]() |
|||||||
|
Fusion Protein:GSTP1-KRT14 |
Fusion Protein Summary |
![]() |
Fusion partner gene information | Fusion gene name: GSTP1-KRT14 | FusionPDB ID: 35136 | FusionGDB2.0 ID: 35136 | Hgene | Tgene | Gene symbol | GSTP1 | KRT14 | Gene ID | 2950 | 3861 |
Gene name | glutathione S-transferase pi 1 | keratin 14 | |
Synonyms | DFN7|FAEES3|GST3|GSTP|HEL-S-22|PI | CK14|EBS3|EBS4|K14|NFJ | |
Cytomap | 11q13.2 | 17q21.2 | |
Type of gene | protein-coding | protein-coding | |
Description | glutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase III | keratin, type I cytoskeletal 14cytokeratin 14keratin 14, type I | |
Modification date | 20200329 | 20200313 | |
UniProtAcc | P09211 | P02533 | |
Ensembl transtripts involved in fusion gene | ENST ids | ENST00000498765, ENST00000398603, ENST00000398606, | ENST00000167586, |
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 16 X 13 X 5=1040 | 19 X 28 X 6=3192 |
# samples | 16 | 23 | |
** MAII score | log2(16/1040*10)=-2.70043971814109 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(23/3192*10)=-3.79475488527797 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
Context (manual curation of fusion genes in FusionPDB) | PubMed: GSTP1 [Title/Abstract] AND KRT14 [Title/Abstract] AND fusion [Title/Abstract] | ||
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | GSTP1(67352630)-KRT14(39739709), # samples:1 | ||
Anticipated loss of major functional domain due to fusion event. | GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. |
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
![]() |
Partner | Gene | GO ID | GO term | PubMed ID |
Hgene | GSTP1 | GO:0006469 | negative regulation of protein kinase activity | 16636664 |
Hgene | GSTP1 | GO:0006749 | glutathione metabolic process | 1540159 |
Hgene | GSTP1 | GO:0006805 | xenobiotic metabolic process | 1540159 |
Hgene | GSTP1 | GO:0009890 | negative regulation of biosynthetic process | 18962899 |
Hgene | GSTP1 | GO:0032691 | negative regulation of interleukin-1 beta production | 18962899 |
Hgene | GSTP1 | GO:0032720 | negative regulation of tumor necrosis factor production | 18962899 |
Hgene | GSTP1 | GO:0043407 | negative regulation of MAP kinase activity | 11408560 |
Hgene | GSTP1 | GO:0043508 | negative regulation of JUN kinase activity | 16636664 |
Hgene | GSTP1 | GO:0043651 | linoleic acid metabolic process | 16624487 |
Hgene | GSTP1 | GO:0051771 | negative regulation of nitric-oxide synthase biosynthetic process | 18962899 |
Hgene | GSTP1 | GO:0070373 | negative regulation of ERK1 and ERK2 cascade | 11408560 |
Hgene | GSTP1 | GO:0071638 | negative regulation of monocyte chemotactic protein-1 production | 18962899 |
Hgene | GSTP1 | GO:2001237 | negative regulation of extrinsic apoptotic signaling pathway | 16636664 |
Tgene | KRT14 | GO:0007568 | aging | 21916889 |
Tgene | KRT14 | GO:0042633 | hair cycle | 21916889 |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
![]() * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
![]() |
Top |
Fusion Gene Sample Information |
![]() |
![]() * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
ChimerDB4 | HNSC | TCGA-CV-A6K1 | GSTP1 | chr11 | 67352630 | + | KRT14 | chr17 | 39739709 | - |
Top |
Fusion ORF Analysis |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
ENST00000398606 | GSTP1 | chr11 | 67352630 | + | ENST00000167586 | KRT14 | chr17 | 39739709 | - | 1085 | 563 | 218 | 928 | 236 |
ENST00000398603 | GSTP1 | chr11 | 67352630 | + | ENST00000167586 | KRT14 | chr17 | 39739709 | - | 938 | 416 | 71 | 781 | 236 |
![]() |
Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
ENST00000398606 | ENST00000167586 | GSTP1 | chr11 | 67352630 | + | KRT14 | chr17 | 39739709 | - | 0.011458299 | 0.9885417 |
ENST00000398603 | ENST00000167586 | GSTP1 | chr11 | 67352630 | + | KRT14 | chr17 | 39739709 | - | 0.010695524 | 0.9893044 |
Top |
Fusion Amino Acid Sequences |
![]() |
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >35136_35136_1_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398603_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21 MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR -------------------------------------------------------------- >35136_35136_2_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398606_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21 MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR -------------------------------------------------------------- |
Top |
Fusion Protein Functional Features |
![]() Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:67352630/chr17:39739709) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
![]() |
![]() |
Hgene | Tgene |
GSTP1 | KRT14 |
FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}. | FUNCTION: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}. |
![]() |
- Retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 423_472 | 351.0 | 473.0 | Region | Note=Tail |
- Not-retained protein feature among the 13 regional features. |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
Hgene | GSTP1 | chr11:67352630 | chr17:39739709 | ENST00000398606 | + | 1 | 7 | 2_81 | 0 | 211.0 | Domain | Note=GST N-terminal |
Hgene | GSTP1 | chr11:67352630 | chr17:39739709 | ENST00000398606 | + | 1 | 7 | 83_204 | 0 | 211.0 | Domain | Note=GST C-terminal |
Hgene | GSTP1 | chr11:67352630 | chr17:39739709 | ENST00000398606 | + | 1 | 7 | 52_53 | 0 | 211.0 | Region | Glutathione binding |
Hgene | GSTP1 | chr11:67352630 | chr17:39739709 | ENST00000398606 | + | 1 | 7 | 65_66 | 0 | 211.0 | Region | Glutathione binding |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 115_426 | 351.0 | 473.0 | Domain | IF rod | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 115_150 | 351.0 | 473.0 | Region | Note=Coil 1A | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 151_168 | 351.0 | 473.0 | Region | Note=Linker 1 | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 169_260 | 351.0 | 473.0 | Region | Note=Coil 1B | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 1_114 | 351.0 | 473.0 | Region | Note=Head | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 261_283 | 351.0 | 473.0 | Region | Note=Linker 12 | |
Tgene | KRT14 | chr11:67352630 | chr17:39739709 | ENST00000167586 | 4 | 8 | 284_422 | 351.0 | 473.0 | Region | Note=Coil 2 |
Top |
Fusion Protein-Protein Interaction |
![]() |
![]() |
Gene | PPI interactors |
![]() |
Gene | STRING network |
GSTP1 | |
KRT14 |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
![]() |
Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
Top |
Related Drugs to GSTP1-KRT14 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to GSTP1-KRT14 |
![]() (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
Hgene | Tgene | Disease | Source | PMID |
![]() (DisGeNet 4.0) |
Partner | Gene | Disease ID | Disease name | # pubmeds | Source |