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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:GSTP1-KRT14

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: GSTP1-KRT14
FusionPDB ID: 35136
FusionGDB2.0 ID: 35136
HgeneTgene
Gene symbol

GSTP1

KRT14

Gene ID

2950

3861

Gene nameglutathione S-transferase pi 1keratin 14
SynonymsDFN7|FAEES3|GST3|GSTP|HEL-S-22|PICK14|EBS3|EBS4|K14|NFJ
Cytomap

11q13.2

17q21.2

Type of geneprotein-codingprotein-coding
Descriptionglutathione S-transferase PGST class-piGSTP1-1deafness, X-linked 7epididymis secretory protein Li 22fatty acid ethyl ester synthase IIIkeratin, type I cytoskeletal 14cytokeratin 14keratin 14, type I
Modification date2020032920200313
UniProtAcc

P09211

P02533

Ensembl transtripts involved in fusion geneENST idsENST00000498765, ENST00000398603, 
ENST00000398606, 
ENST00000167586, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score16 X 13 X 5=104019 X 28 X 6=3192
# samples 1623
** MAII scorelog2(16/1040*10)=-2.70043971814109
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
log2(23/3192*10)=-3.79475488527797
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: GSTP1 [Title/Abstract] AND KRT14 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)GSTP1(67352630)-KRT14(39739709), # samples:1
Anticipated loss of major functional domain due to fusion event.GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
GSTP1-KRT14 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneGSTP1

GO:0006469

negative regulation of protein kinase activity

16636664

HgeneGSTP1

GO:0006749

glutathione metabolic process

1540159

HgeneGSTP1

GO:0006805

xenobiotic metabolic process

1540159

HgeneGSTP1

GO:0009890

negative regulation of biosynthetic process

18962899

HgeneGSTP1

GO:0032691

negative regulation of interleukin-1 beta production

18962899

HgeneGSTP1

GO:0032720

negative regulation of tumor necrosis factor production

18962899

HgeneGSTP1

GO:0043407

negative regulation of MAP kinase activity

11408560

HgeneGSTP1

GO:0043508

negative regulation of JUN kinase activity

16636664

HgeneGSTP1

GO:0043651

linoleic acid metabolic process

16624487

HgeneGSTP1

GO:0051771

negative regulation of nitric-oxide synthase biosynthetic process

18962899

HgeneGSTP1

GO:0070373

negative regulation of ERK1 and ERK2 cascade

11408560

HgeneGSTP1

GO:0071638

negative regulation of monocyte chemotactic protein-1 production

18962899

HgeneGSTP1

GO:2001237

negative regulation of extrinsic apoptotic signaling pathway

16636664

TgeneKRT14

GO:0007568

aging

21916889

TgeneKRT14

GO:0042633

hair cycle

21916889


check buttonFusion gene breakpoints across GSTP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KRT14 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-CV-A6K1GSTP1chr11

67352630

+KRT14chr17

39739709

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)
BP loci
(transcript)
Predicted start
(transcript)
Predicted stop
(transcript)
Seq length
(amino acids)
ENST00000398606GSTP1chr1167352630+ENST00000167586KRT14chr1739739709-1085563218928236
ENST00000398603GSTP1chr1167352630+ENST00000167586KRT14chr1739739709-93841671781236

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000398606ENST00000167586GSTP1chr1167352630+KRT14chr1739739709-0.0114582990.9885417
ENST00000398603ENST00000167586GSTP1chr1167352630+KRT14chr1739739709-0.0106955240.9893044

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35136_35136_1_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398603_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21
MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA
ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR

--------------------------------------------------------------

>35136_35136_2_GSTP1-KRT14_GSTP1_chr11_67352630_ENST00000398606_KRT14_chr17_39739709_ENST00000167586_length(amino acids)=236AA_BP=21
MEFRRRSLRHHAALHRGLFPSSRPLRGPAHAAGRSGPELEGGGGDRGDVAGGLTQSLLPIRAAPQVPGRRPHPVPVQYHPASPGPHPWEA
ALVDMVNDGVEDLRCKYISLIYTNYKASLENSLEETKGRYCMQLAQIQEMIGSVEEQLAQLRCEMEQQNQEYKILLDVKTRLEQEIATYR

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr11:67352630/chr17:39739709)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
GSTP1

P09211

KRT14

P02533

FUNCTION: Conjugation of reduced glutathione to a wide number of exogenous and endogenous hydrophobic electrophiles. Involved in the formation of glutathione conjugates of both prostaglandin A2 (PGA2) and prostaglandin J2 (PGJ2) (PubMed:9084911). Participates in the formation of novel hepoxilin regioisomers (PubMed:21046276). Regulates negatively CDK5 activity via p25/p35 translocation to prevent neurodegeneration. {ECO:0000269|PubMed:21046276, ECO:0000269|PubMed:21668448, ECO:0000269|PubMed:9084911}.FUNCTION: The nonhelical tail domain is involved in promoting KRT5-KRT14 filaments to self-organize into large bundles and enhances the mechanical properties involved in resilience of keratin intermediate filaments in vitro. {ECO:0000269|PubMed:11724817}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648423_472351.0473.0RegionNote=Tail

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneGSTP1chr11:67352630chr17:39739709ENST00000398606+172_810211.0DomainNote=GST N-terminal
HgeneGSTP1chr11:67352630chr17:39739709ENST00000398606+1783_2040211.0DomainNote=GST C-terminal
HgeneGSTP1chr11:67352630chr17:39739709ENST00000398606+1752_530211.0RegionGlutathione binding
HgeneGSTP1chr11:67352630chr17:39739709ENST00000398606+1765_660211.0RegionGlutathione binding
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648115_426351.0473.0DomainIF rod
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648115_150351.0473.0RegionNote=Coil 1A
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648151_168351.0473.0RegionNote=Linker 1
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648169_260351.0473.0RegionNote=Coil 1B
TgeneKRT14chr11:67352630chr17:39739709ENST00000167586481_114351.0473.0RegionNote=Head
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648261_283351.0473.0RegionNote=Linker 12
TgeneKRT14chr11:67352630chr17:39739709ENST0000016758648284_422351.0473.0RegionNote=Coil 2


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
GSTP1
KRT14


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to GSTP1-KRT14


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to GSTP1-KRT14


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource