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Fusion Protein:HAT1-DYNC1I2 |
Fusion Protein Summary |
 Fusion gene summary |
| Fusion partner gene information | Fusion gene name: HAT1-DYNC1I2 | FusionPDB ID: 35627 | FusionGDB2.0 ID: 35627 | Hgene | Tgene | Gene symbol | HAT1 | DYNC1I2 | Gene ID | 8520 | 1781 |
| Gene name | histone acetyltransferase 1 | dynein cytoplasmic 1 intermediate chain 2 | |
| Synonyms | KAT1 | DIC74|DNCI2|IC2|NEDMIBA | |
| Cytomap | 2q31.1 | 2q31.1 | |
| Type of gene | protein-coding | protein-coding | |
| Description | histone acetyltransferase type B catalytic subunit | cytoplasmic dynein 1 intermediate chain 2DH IC-2dynein intermediate chain 2, cytosolicdynein, cytoplasmic, intermediate polypeptide 2testis tissue sperm-binding protein Li 66n | |
| Modification date | 20200320 | 20200315 | |
| UniProtAcc | O14929 | Q13409 | |
| Ensembl transtripts involved in fusion gene | ENST ids | ENST00000264108, ENST00000392584, ENST00000460481, | ENST00000263811, ENST00000340296, ENST00000358002, ENST00000397119, ENST00000409197, ENST00000409317, ENST00000409453, ENST00000409773, ENST00000410079, ENST00000508530, ENST00000534253, |
| Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0) | * DoF score | 6 X 6 X 4=144 | 8 X 8 X 4=256 |
| # samples | 6 | 8 | |
| ** MAII score | log2(6/144*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | log2(8/256*10)=-1.67807190511264 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0 | |
| Context (manual curation of fusion genes in FusionPDB) | PubMed: HAT1 [Title/Abstract] AND DYNC1I2 [Title/Abstract] AND fusion [Title/Abstract] | ||
| Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0) | HAT1(172803303)-DYNC1I2(172571838), # samples:1 | ||
| Anticipated loss of major functional domain due to fusion event. | HAT1-DYNC1I2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HAT1-DYNC1I2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HAT1-DYNC1I2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HAT1-DYNC1I2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. | ||
| * DoF score (Degree of Frequency) = # partners X # break points X # cancer types ** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10) |
| Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez |
| Partner | Gene | GO ID | GO term | PubMed ID |
| Hgene | HAT1 | GO:0006335 | DNA replication-dependent nucleosome assembly | 14718166 |
| Hgene | HAT1 | GO:0006336 | DNA replication-independent nucleosome assembly | 14718166 |
| Hgene | HAT1 | GO:0043967 | histone H4 acetylation | 22615379 |
| Fusion gene breakpoints across HAT1 (5'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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| Fusion gene breakpoints across DYNC1I2 (3'-gene) * Click on the image to open the UCSC genome browser with custom track showing this image in a new window. |
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Fusion Gene Sample Information |
| Fusion gene information from FusionGDB2.0. |
| Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0) * All genome coordinats were lifted-over on hg19. * Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser. |
| Source | Disease | Sample | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand |
| ChimerDB4 | LUAD | TCGA-44-3918-01A | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + |
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Fusion ORF Analysis |
| Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | Seq length (transcript) | BP loci (transcript) | Predicted start (transcript) | Predicted stop (transcript) | Seq length (amino acids) |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000340296 | DYNC1I2 | chr2 | 172571838 | + | 2268 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000534253 | DYNC1I2 | chr2 | 172571838 | + | 2266 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000263811 | DYNC1I2 | chr2 | 172571838 | + | 2266 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000397119 | DYNC1I2 | chr2 | 172571838 | + | 2266 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000410079 | DYNC1I2 | chr2 | 172571838 | + | 1846 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000508530 | DYNC1I2 | chr2 | 172571838 | + | 2265 | 224 | 36 | 1742 | 568 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000409197 | DYNC1I2 | chr2 | 172571838 | + | 2268 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000409317 | DYNC1I2 | chr2 | 172571838 | + | 1868 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000409773 | DYNC1I2 | chr2 | 172571838 | + | 2273 | 224 | 36 | 1745 | 569 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000409453 | DYNC1I2 | chr2 | 172571838 | + | 2274 | 224 | 36 | 1742 | 568 |
| ENST00000264108 | HAT1 | chr2 | 172803303 | + | ENST00000358002 | DYNC1I2 | chr2 | 172571838 | + | 1973 | 224 | 36 | 1745 | 569 |
| DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated. |
| Henst | Tenst | Hgene | Hchr | Hbp | Hstrand | Tgene | Tchr | Tbp | Tstrand | No-coding score | Coding score |
| ENST00000264108 | ENST00000340296 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000315868 | 0.9996841 |
| ENST00000264108 | ENST00000534253 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000323578 | 0.99967647 |
| ENST00000264108 | ENST00000263811 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000323578 | 0.99967647 |
| ENST00000264108 | ENST00000397119 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000323578 | 0.99967647 |
| ENST00000264108 | ENST00000410079 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000637064 | 0.999363 |
| ENST00000264108 | ENST00000508530 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000289394 | 0.9997106 |
| ENST00000264108 | ENST00000409197 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000315868 | 0.9996841 |
| ENST00000264108 | ENST00000409317 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000616486 | 0.99938345 |
| ENST00000264108 | ENST00000409773 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000314223 | 0.99968576 |
| ENST00000264108 | ENST00000409453 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.000288726 | 0.9997112 |
| ENST00000264108 | ENST00000358002 | HAT1 | chr2 | 172803303 | + | DYNC1I2 | chr2 | 172571838 | + | 0.00054803 | 0.99945194 |
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Fusion Amino Acid Sequences |
| For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones. |
| >FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP >35627_35627_1_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000263811_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_2_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000340296_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_3_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000358002_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_4_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000397119_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_5_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000409197_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_6_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000409317_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_7_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000409453_length(amino acids)=568AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEIAVPRNDE -------------------------------------------------------------- >35627_35627_8_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000409773_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_9_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000410079_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- >35627_35627_10_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000508530_length(amino acids)=568AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEIAVPRNDE -------------------------------------------------------------- >35627_35627_11_HAT1-DYNC1I2_HAT1_chr2_172803303_ENST00000264108_DYNC1I2_chr2_172571838_ENST00000534253_length(amino acids)=569AA_BP=63 MAGFGAMEKFLVEYKSAVEKKLAEYKCNTNTAIELKLVRFPEDLENDIRTFFPEYTHQLFGDERGPIKLGMAKITQVDFPPREIVTYTKE TQTPVMAQPKEDEEEDDDVVAPKPPIEPEEEKTLKKDEENDSKAPPHELTEEEKQQILHSEEFLSFFDHSTRIVERALSEQINIFFDYSG RDLEDKEGEIQAGAKLSLNRQFFDERWSKHRVVSCLDWSSQYPELLVASYNNNEDAPHEPDGVALVWNMKYKKTTPEYVFHCQSAVMSAT FAKFHPNLVVGGTYSGQIVLWDNRSNKRTPVQRTPLSAAAHTHPVYCVNVVGTQNAHNLISISTDGKICSWSLDMLSHPQDSMELVHKQS KAVAVTSMSFPVGDVNNFVVGSEEGSVYTACRHGSKAGISEMFEGHQGPITGIHCHAAVGAVDFSHLFVTSSFDWTVKLWTTKNNKPLYS FEDNADYVYDVMWSPTHPALFACVDGMGRLDLWNLNNDTEVPTASISVEGNPALNRVRWTHSGREIAVGDSEGQIVIYDVGEQIAVPRND -------------------------------------------------------------- |
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Fusion Protein Functional Features |
| Four levels of functional features of fusion genes Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:172803303/chr2:172571838) - FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels. - How to search 1. Put your fusion gene symbol. 2. Press the tab key until there will be shown the breakpoint information filled. 4. Go down and press 'Search' tab twice. 4. Go down to have the hyperlink of the search result. 5. Click the hyperlink. 6. See the FGviewer result for your fusion gene. |
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| Main function of each fusion partner protein. (from UniProt) |
| Hgene | Tgene |
| HAT1 | DYNC1I2 |
| FUNCTION: Histone acetyltransferase that plays a role in different biological processes including cell cycle progression, glucose metabolism, histone production or DNA damage repair (PubMed:31278053, PubMed:20953179, PubMed:23653357, PubMed:32081014). Coordinates histone production and acetylation via H4 promoter binding (PubMed:31278053). Acetylates histone H4 at 'Lys-5' (H4K5ac) and 'Lys-12' (H4K12ac) and, to a lesser extent, histone H2A at 'Lys-5' (H2AK5ac) (PubMed:22615379, PubMed:11585814). Drives H4 production by chromatin binding to support chromatin replication and acetylation. Since transcription of H4 genes is tightly coupled to S-phase, plays an important role in S-phase entry and progression (PubMed:31278053). Promotes homologous recombination in DNA repair by facilitating histone turnover and incorporation of acetylated H3.3 at sites of double-strand breaks (PubMed:23653357). In addition, acetylates other substrates such as chromatin-related proteins (PubMed:32081014). Acetylates also RSAD2 which mediates the interaction of ubiquitin ligase UBE4A with RSAD2 leading to RSAD2 ubiquitination and subsequent degradation (PubMed:31812350). {ECO:0000269|PubMed:11585814, ECO:0000269|PubMed:20953179, ECO:0000269|PubMed:22615379, ECO:0000269|PubMed:23653357, ECO:0000269|PubMed:31278053, ECO:0000269|PubMed:31812350, ECO:0000269|PubMed:32081014}.; FUNCTION: (Microbial infection) Contributes to hepatitis B virus (HBV) replication by acetylating histone H4 at the sites of 'Lys-5' and 'Lys-12' on the covalently closed circular DNA (cccDNA) minichromosome leading to its accumulation within the host cell. {ECO:0000269|PubMed:31695772}. | FUNCTION: Acts as one of several non-catalytic accessory components of the cytoplasmic dynein 1 complex that are thought to be involved in linking dynein to cargos and to adapter proteins that regulate dynein function (PubMed:31079899). Cytoplasmic dynein 1 acts as a motor for the intracellular retrograde motility of vesicles and organelles along microtubules (PubMed:31079899). The intermediate chains mediate the binding of dynein to dynactin via its 150 kDa component (p150-glued) DCTN1 (By similarity). Involved in membrane-transport, such as Golgi apparatus, late endosomes and lysosomes (By similarity). {ECO:0000250|UniProtKB:Q62871, ECO:0000269|PubMed:31079899}. |
| Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at * Minus value of BPloci means that the break pointn is located before the CDS. |
| - Retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 277_326 | 125.66666666666667 | 633.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 330_370 | 125.66666666666667 | 633.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 379_420 | 125.66666666666667 | 633.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 429_469 | 125.66666666666667 | 633.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 474_519 | 125.66666666666667 | 633.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 522_562 | 125.66666666666667 | 633.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000263811 | 4 | 17 | 568_607 | 125.66666666666667 | 633.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 277_326 | 105.66666666666667 | 613.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 330_370 | 105.66666666666667 | 613.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 379_420 | 105.66666666666667 | 613.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 429_469 | 105.66666666666667 | 613.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 474_519 | 105.66666666666667 | 613.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 522_562 | 105.66666666666667 | 613.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000340296 | 3 | 16 | 568_607 | 105.66666666666667 | 613.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 277_326 | 131.66666666666666 | 639.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 330_370 | 131.66666666666666 | 639.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 379_420 | 131.66666666666666 | 639.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 429_469 | 131.66666666666666 | 639.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 474_519 | 131.66666666666666 | 639.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 522_562 | 131.66666666666666 | 639.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000397119 | 5 | 18 | 568_607 | 131.66666666666666 | 639.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 277_326 | 105.66666666666667 | 613.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 330_370 | 105.66666666666667 | 613.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 379_420 | 105.66666666666667 | 613.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 429_469 | 105.66666666666667 | 613.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 474_519 | 105.66666666666667 | 613.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 522_562 | 105.66666666666667 | 613.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409197 | 3 | 16 | 568_607 | 105.66666666666667 | 613.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 277_326 | 125.66666666666667 | 633.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 330_370 | 125.66666666666667 | 633.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 379_420 | 125.66666666666667 | 633.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 429_469 | 125.66666666666667 | 633.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 474_519 | 125.66666666666667 | 633.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 522_562 | 125.66666666666667 | 633.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409317 | 4 | 17 | 568_607 | 125.66666666666667 | 633.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 277_326 | 131.66666666666666 | 638.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 330_370 | 131.66666666666666 | 638.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 379_420 | 131.66666666666666 | 638.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 429_469 | 131.66666666666666 | 638.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 474_519 | 131.66666666666666 | 638.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 522_562 | 131.66666666666666 | 638.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409453 | 5 | 18 | 568_607 | 131.66666666666666 | 638.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 277_326 | 131.66666666666666 | 639.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 330_370 | 131.66666666666666 | 639.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 379_420 | 131.66666666666666 | 639.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 429_469 | 131.66666666666666 | 639.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 474_519 | 131.66666666666666 | 639.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 522_562 | 131.66666666666666 | 639.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000409773 | 5 | 18 | 568_607 | 131.66666666666666 | 639.0 | Repeat | Note=WD 7 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 277_326 | 105.66666666666667 | 612.0 | Repeat | Note=WD 1 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 330_370 | 105.66666666666667 | 612.0 | Repeat | Note=WD 2 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 379_420 | 105.66666666666667 | 612.0 | Repeat | Note=WD 3 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 429_469 | 105.66666666666667 | 612.0 | Repeat | Note=WD 4 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 474_519 | 105.66666666666667 | 612.0 | Repeat | Note=WD 5 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 522_562 | 105.66666666666667 | 612.0 | Repeat | Note=WD 6 | |
| Tgene | DYNC1I2 | chr2:172803303 | chr2:172571838 | ENST00000508530 | 3 | 16 | 568_607 | 105.66666666666667 | 612.0 | Repeat | Note=WD 7 |
| - Not-retained protein feature among the 13 regional features. |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Protein feature | Protein feature note |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000264108 | + | 3 | 11 | 241_243 | 62.666666666666664 | 420.0 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000264108 | + | 3 | 11 | 248_254 | 62.666666666666664 | 420.0 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000392584 | + | 1 | 10 | 241_243 | 0 | 335.0 | Region | Acetyl-CoA binding |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000392584 | + | 1 | 10 | 248_254 | 0 | 335.0 | Region | Acetyl-CoA binding |
Top |
Fusion Protein-Protein Interaction |
| Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in |
| Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160) |
| Gene | PPI interactors |
| Protein-protein interactors based on sequence similarity (STRING) |
| Gene | STRING network |
| HAT1 | |
| DYNC1I2 |
| - Retained interactions in fusion protein (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Still interaction with |
| - Lost interactions due to fusion (protein functional feature from UniProt). |
| Partner | Gene | Hbp | Tbp | ENST | Strand | BPexon | TotalExon | Protein feature loci | *BPloci | TotalLen | Interaction lost with |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000392584 | + | 1 | 10 | 62_64 | 0 | 335.0 | histone H4 N-terminus |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000264108 | + | 3 | 11 | 225_227 | 62.666666666666664 | 420.0 | histone H4 N-terminus |
| Hgene | HAT1 | chr2:172803303 | chr2:172571838 | ENST00000392584 | + | 1 | 10 | 225_227 | 0 | 335.0 | histone H4 N-terminus |
Top |
Related Drugs to HAT1-DYNC1I2 |
| Drugs used for this fusion-positive patient. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Drug | Source | PMID |
Top |
Related Diseases to HAT1-DYNC1I2 |
| Diseases that have this fusion gene. (Manual curation of PubMed, 04-30-2022 + MyCancerGenome) |
| Hgene | Tgene | Disease | Source | PMID |
| Diseases associated with fusion partners. (DisGeNet 4.0) |
| Partner | Gene | Disease ID | Disease name | # pubmeds | Source |
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