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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HDLBP-TMC1

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HDLBP-TMC1
FusionPDB ID: 35937
FusionGDB2.0 ID: 35937
HgeneTgene
Gene symbol

HDLBP

TMC1

Gene ID

3069

117531

Gene namehigh density lipoprotein binding proteintransmembrane channel like 1
SynonymsHBP|PRO2900|VGLDFNA36|DFNB11|DFNB7
Cytomap

2q37.3

9q21.13

Type of geneprotein-codingprotein-coding
DescriptionvigilinHDL-binding proteintransmembrane channel-like protein 1transmembrane cochlear-expressed protein 1transmembrane, cochlear expressed, 1
Modification date2020031320200313
UniProtAcc

Q00341

.
Ensembl transtripts involved in fusion geneENST idsENST00000310931, ENST00000391975, 
ENST00000391976, ENST00000427183, 
ENST00000476807, 		ENST00000486417, 
ENST00000297784, ENST00000340019, 
ENST00000396237, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score26 X 24 X 10=62408 X 7 X 4=224
# samples 309
** MAII scorelog2(30/6240*10)=-4.37851162325373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(9/224*10)=-1.31550182572793
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HDLBP [Title/Abstract] AND TMC1 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HDLBP(242186471)-TMC1(75445367), # samples:3
HDLBP(242186470)-TMC1(75445366), # samples:3
Anticipated loss of major functional domain due to fusion event.HDLBP-TMC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HDLBP-TMC1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HDLBP-TMC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HDLBP-TMC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HDLBP-TMC1 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HDLBP (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMC1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-HC-A631-01AHDLBPchr2

242186470

-TMC1chr9

75445366

+
ChimerDB4PRADTCGA-HC-A631-01AHDLBPchr2

242186471

-TMC1chr9

75445367

+
ChimerDB4PRADTCGA-HC-A631HDLBPchr2

242186470

-TMC1chr9

75445366

+
ChimerDB4PRADTCGA-HC-A631HDLBPchr2

242186471

-TMC1chr9

75445367

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000391976HDLBPchr2242186471-ENST00000297784TMC1chr975445367+264321112692536755
ENST00000391976HDLBPchr2242186471-ENST00000340019TMC1chr975445367+264321112692536755
ENST00000391976HDLBPchr2242186471-ENST00000396237TMC1chr975445367+235321112692350694
ENST00000310931HDLBPchr2242186471-ENST00000297784TMC1chr975445367+272521933512618755
ENST00000310931HDLBPchr2242186471-ENST00000340019TMC1chr975445367+272521933512618755
ENST00000310931HDLBPchr2242186471-ENST00000396237TMC1chr975445367+243521933512432694
ENST00000427183HDLBPchr2242186471-ENST00000297784TMC1chr975445367+244719151962340714
ENST00000427183HDLBPchr2242186471-ENST00000340019TMC1chr975445367+244719151962340714
ENST00000427183HDLBPchr2242186471-ENST00000396237TMC1chr975445367+215719151962154653
ENST00000391976HDLBPchr2242186470-ENST00000297784TMC1chr975445366+264321112692536755
ENST00000391976HDLBPchr2242186470-ENST00000340019TMC1chr975445366+264321112692536755
ENST00000391976HDLBPchr2242186470-ENST00000396237TMC1chr975445366+235321112692350694
ENST00000310931HDLBPchr2242186470-ENST00000297784TMC1chr975445366+272521933512618755
ENST00000310931HDLBPchr2242186470-ENST00000340019TMC1chr975445366+272521933512618755
ENST00000310931HDLBPchr2242186470-ENST00000396237TMC1chr975445366+243521933512432694
ENST00000427183HDLBPchr2242186470-ENST00000297784TMC1chr975445366+244719151962340714
ENST00000427183HDLBPchr2242186470-ENST00000340019TMC1chr975445366+244719151962340714
ENST00000427183HDLBPchr2242186470-ENST00000396237TMC1chr975445366+215719151962154653

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000391976ENST00000297784HDLBPchr2242186471-TMC1chr975445367+0.0078267380.9921733
ENST00000391976ENST00000340019HDLBPchr2242186471-TMC1chr975445367+0.0078267380.9921733
ENST00000391976ENST00000396237HDLBPchr2242186471-TMC1chr975445367+0.32364930.6763507
ENST00000310931ENST00000297784HDLBPchr2242186471-TMC1chr975445367+0.0075317420.9924683
ENST00000310931ENST00000340019HDLBPchr2242186471-TMC1chr975445367+0.0075317420.9924683
ENST00000310931ENST00000396237HDLBPchr2242186471-TMC1chr975445367+0.344705670.65529436
ENST00000427183ENST00000297784HDLBPchr2242186471-TMC1chr975445367+0.0046194390.99538064
ENST00000427183ENST00000340019HDLBPchr2242186471-TMC1chr975445367+0.0046194390.99538064
ENST00000427183ENST00000396237HDLBPchr2242186471-TMC1chr975445367+0.197291020.802709
ENST00000391976ENST00000297784HDLBPchr2242186470-TMC1chr975445366+0.0078267380.9921733
ENST00000391976ENST00000340019HDLBPchr2242186470-TMC1chr975445366+0.0078267380.9921733
ENST00000391976ENST00000396237HDLBPchr2242186470-TMC1chr975445366+0.32364930.6763507
ENST00000310931ENST00000297784HDLBPchr2242186470-TMC1chr975445366+0.0075317420.9924683
ENST00000310931ENST00000340019HDLBPchr2242186470-TMC1chr975445366+0.0075317420.9924683
ENST00000310931ENST00000396237HDLBPchr2242186470-TMC1chr975445366+0.344705670.65529436
ENST00000427183ENST00000297784HDLBPchr2242186470-TMC1chr975445366+0.0046194390.99538064
ENST00000427183ENST00000340019HDLBPchr2242186470-TMC1chr975445366+0.0046194390.99538064
ENST00000427183ENST00000396237HDLBPchr2242186470-TMC1chr975445366+0.197291020.802709

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>35937_35937_1_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000310931_TMC1_chr9_75445366_ENST00000297784_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_2_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000310931_TMC1_chr9_75445366_ENST00000340019_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_3_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000310931_TMC1_chr9_75445366_ENST00000396237_length(amino acids)=694AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS

--------------------------------------------------------------

>35937_35937_4_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000391976_TMC1_chr9_75445366_ENST00000297784_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_5_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000391976_TMC1_chr9_75445366_ENST00000340019_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_6_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000391976_TMC1_chr9_75445366_ENST00000396237_length(amino acids)=694AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS

--------------------------------------------------------------

>35937_35937_7_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000427183_TMC1_chr9_75445366_ENST00000297784_length(amino acids)=714AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

>35937_35937_8_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000427183_TMC1_chr9_75445366_ENST00000340019_length(amino acids)=714AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

>35937_35937_9_HDLBP-TMC1_HDLBP_chr2_242186470_ENST00000427183_TMC1_chr9_75445366_ENST00000396237_length(amino acids)=653AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

>35937_35937_10_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000310931_TMC1_chr9_75445367_ENST00000297784_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_11_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000310931_TMC1_chr9_75445367_ENST00000340019_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_12_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000310931_TMC1_chr9_75445367_ENST00000396237_length(amino acids)=694AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS

--------------------------------------------------------------

>35937_35937_13_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000391976_TMC1_chr9_75445367_ENST00000297784_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_14_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000391976_TMC1_chr9_75445367_ENST00000340019_length(amino acids)=755AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL

--------------------------------------------------------------

>35937_35937_15_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000391976_TMC1_chr9_75445367_ENST00000396237_length(amino acids)=694AA_BP=614
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS

--------------------------------------------------------------

>35937_35937_16_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000427183_TMC1_chr9_75445367_ENST00000297784_length(amino acids)=714AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

>35937_35937_17_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000427183_TMC1_chr9_75445367_ENST00000340019_length(amino acids)=714AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

>35937_35937_18_HDLBP-TMC1_HDLBP_chr2_242186471_ENST00000427183_TMC1_chr9_75445367_ENST00000396237_length(amino acids)=653AA_BP=573
MHLAERDRWLFVATVMMHFVSIKSGFPGLCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACL
ESAQEPSGAWGNKIRPIKASVITQVFHVPLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIV
ARLQTQASATVAIPKEHHRFVIGKNGEKLQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFH
PFIAGPYNRLVGEIMQETGTRINIPPPSVNRTEIVFTGEKEQLAQAVARIKKIYEEKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQ
MPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINIDHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRI
EGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIREIRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKM
VADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGSESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRA

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr2:242186471/chr9:75445367)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HDLBP

Q00341

.
FUNCTION: Appears to play a role in cell sterol metabolism. It may function to protect cells from over-accumulation of cholesterol.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528158_229573.01236.0DomainKH 1
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528230_302573.01236.0DomainKH 2
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528303_371573.01236.0DomainKH 3
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528372_442573.01236.0DomainKH 4
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528443_514573.01236.0DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528158_229606.01269.0DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528230_302606.01269.0DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528303_371606.01269.0DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528372_442606.01269.0DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528443_514606.01269.0DomainKH 5
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528515_588606.01269.0DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528158_229573.01236.0DomainKH 1
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528230_302573.01236.0DomainKH 2
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528303_371573.01236.0DomainKH 3
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528372_442573.01236.0DomainKH 4
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528443_514573.01236.0DomainKH 5
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620749_757709.6666666666666761.0Compositional biasNote=Poly-Ala
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024721_760709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923721_760709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620721_760709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024721_760709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923721_760709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620721_760709.6666666666666761.0Topological domainCytoplasmic

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186470chr9:75445366ENST00000310931-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391975-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186470chr9:75445366ENST00000391976-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-15281060_1134573.01236.0DomainKH 13
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-15281135_1209573.01236.0DomainKH 14
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528515_588573.01236.0DomainKH 6
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528589_660573.01236.0DomainKH 7
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528661_734573.01236.0DomainKH 8
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528735_807573.01236.0DomainKH 9
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528808_880573.01236.0DomainKH 10
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528881_979573.01236.0DomainKH 11
HgeneHDLBPchr2:242186470chr9:75445366ENST00000427183-1528980_1059573.01236.0DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000310931-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391975-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-15281060_1134606.01269.0DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-15281135_1209606.01269.0DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528589_660606.01269.0DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528661_734606.01269.0DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528735_807606.01269.0DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528808_880606.01269.0DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528881_979606.01269.0DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000391976-1528980_1059606.01269.0DomainKH 12
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-15281060_1134573.01236.0DomainKH 13
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-15281135_1209573.01236.0DomainKH 14
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528515_588573.01236.0DomainKH 6
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528589_660573.01236.0DomainKH 7
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528661_734573.01236.0DomainKH 8
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528735_807573.01236.0DomainKH 9
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528808_880573.01236.0DomainKH 10
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528881_979573.01236.0DomainKH 11
HgeneHDLBPchr2:242186471chr9:75445367ENST00000427183-1528980_1059573.01236.0DomainKH 12
TgeneTMC1chr2:242186470chr9:75445366ENST0000029778420244_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186470chr9:75445366ENST0000034001919234_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186470chr9:75445366ENST0000039623716204_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST0000029778420244_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST0000034001919234_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186471chr9:75445367ENST0000039623716204_178709.6666666666666761.0Compositional biasNote=Arg/Asp/Glu/Lys-rich (highly charged)
TgeneTMC1chr2:242186470chr9:75445366ENST0000029778420241_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST0000034001919231_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST0000039623716201_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST0000029778420241_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST0000034001919231_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST0000039623716201_199709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620221_272709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620294_365709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620387_440709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620462_634709.6666666666666761.0Topological domainCytoplasmic
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620656_699709.6666666666666761.0Topological domainExtracellular
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000002977842024700_720709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003400191923700_720709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186470chr9:75445366ENST000003962371620700_720709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000002977842024700_720709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003400191923700_720709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620200_220709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620273_293709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620366_386709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620441_461709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620635_655709.6666666666666761.0TransmembraneHelical
TgeneTMC1chr2:242186471chr9:75445367ENST000003962371620700_720709.6666666666666761.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1520_HDLBP_242186471_TMC1_75445367_ranked_0.pdbHDLBP242186470242186471ENST00000396237TMC1chr975445367+
MCVGVRSTMSSVAVLTQESFAEHRSGLVPQQIKVATLNSEEESDPPTYKDAFPPLPEKAACLESAQEPSGAWGNKIRPIKASVITQVFHV
PLEERKYKDMNQFGEGEQAKICLEIMQRTGAHLELSLAKDQGLSIMVSGKLDAVMKARKDIVARLQTQASATVAIPKEHHRFVIGKNGEK
LQDLELKTATKIQIPRPDDPSNQIKITGTKEGIEKARHEVLLISAEQDKRAVERLEVEKAFHPFIAGPYNRLVGEIMQETGTRINIPPPS
VNRTEIVFTGEKEQLAQAVARIKKIYEEKKKKTTTIAVEVKKSQHKYVIGPKGNSLQEILERTGVSVEIPPSDSISETVILRGEPEKLGQ
ALTEVYAKANSFTVSSVAAPSWLHRFIIGKKGQNLAKITQQMPKVHIEFTEGEDKITLEGPTEDVNVAQEQIEGMVKDLINRMDYVEINI
DHKFHRHLIGKSGANINRIKDQYKVSVRIPPDSEKSNLIRIEGDPQGVQQAKRELLELASRMENERTKDLIIEQRFHRTIIGQKGERIRE
IRDKFPEVIINFPDPAQKSDIVQLRGPKNEVEKCTKYMQKMVADLVENSYSISVPIFKQFHKNIIGKGGANIKKFGHLLSQCYCQGPEGS
ESGSQKEDENASFGEQNAKQENGSCTSSCSCWSPVISILRAQKRYTLPCCLKVMQYVNAQRTSTVELLFSCSTLDGFSRSCWPIKASSVL
755


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HDLBP_pLDDT.png
all structure
all structure
TMC1_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HDLBP
TMC1


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HDLBP-TMC1


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HDLBP-TMC1


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource