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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HERC2-TMEM145

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HERC2-TMEM145
FusionPDB ID: 36168
FusionGDB2.0 ID: 36168
HgeneTgene
Gene symbol

HERC2

TMEM145

Gene ID

8924

284339

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 2transmembrane protein 145
SynonymsD15F37S1|MRT38|SHEP1|jdf2|p528-
Cytomap

15q13.1

19q13.2

Type of geneprotein-codingprotein-coding
DescriptionE3 ubiquitin-protein ligase HERC2HECT-type E3 ubiquitin transferase HERC2hect domain and RCC1-like domain-containing protein 2hect domain and RLD 2probable E3 ubiquitin-protein ligase HERC2transmembrane protein 145
Modification date2020031320200313
UniProtAcc

O95714

.
Ensembl transtripts involved in fusion geneENST idsENST00000261609, ENST00000563945, 
ENST00000301204, ENST00000598766, 
ENST00000601020, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 12 X 9=15121 X 2 X 1=2
# samples 152
** MAII scorelog2(15/1512*10)=-3.33342373372519
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(2/2*10)=3.32192809488736
Context (manual curation of fusion genes in FusionPDB)

PubMed: HERC2 [Title/Abstract] AND TMEM145 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HERC2(28544548)-TMEM145(42818424), # samples:2
HERC2(28544547)-TMEM145(42818423), # samples:2
Anticipated loss of major functional domain due to fusion event.HERC2-TMEM145 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC2-TMEM145 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHERC2

GO:0006974

cellular response to DNA damage stimulus

22508508

HgeneHERC2

GO:0016567

protein ubiquitination

20304803


check buttonFusion gene breakpoints across HERC2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across TMEM145 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-V1-A8WS-01AHERC2chr15

28544548

-TMEM145chr19

42818424

+
ChimerDB4PRADTCGA-V1-A8WSHERC2chr15

28544547

-TMEM145chr19

42818423

+
ChimerDB4PRADTCGA-V1-A8WSHERC2chr15

28544548

-TMEM145chr19

42818424

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000261609HERC2chr1528544548-ENST00000301204TMEM145chr1942818424+19032961821657491
ENST00000261609HERC2chr1528544548-ENST00000598766TMEM145chr1942818424+21872961821642486
ENST00000261609HERC2chr1528544548-ENST00000601020TMEM145chr1942818424+6482964700157
ENST00000261609HERC2chr1528544547-ENST00000301204TMEM145chr1942818423+19032961821657491
ENST00000261609HERC2chr1528544547-ENST00000598766TMEM145chr1942818423+21872961821642486
ENST00000261609HERC2chr1528544547-ENST00000601020TMEM145chr1942818423+6482964700157

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000261609ENST00000301204HERC2chr1528544548-TMEM145chr1942818424+0.0114023540.98859763
ENST00000261609ENST00000598766HERC2chr1528544548-TMEM145chr1942818424+0.024966840.97503316
ENST00000261609ENST00000601020HERC2chr1528544548-TMEM145chr1942818424+0.102286980.89771307
ENST00000261609ENST00000301204HERC2chr1528544547-TMEM145chr1942818423+0.0114023540.98859763
ENST00000261609ENST00000598766HERC2chr1528544547-TMEM145chr1942818423+0.024966840.97503316
ENST00000261609ENST00000601020HERC2chr1528544547-TMEM145chr1942818423+0.102286980.89771307

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36168_36168_1_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000301204_length(amino acids)=491AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKD
CLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFI
LIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRI
SHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHFPEKQPFYVPFFAAYTLWFFAV
PVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISDSV

--------------------------------------------------------------

>36168_36168_2_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000598766_length(amino acids)=486AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPELPVPNISGLQAKCCQNILLYFDDPSQW
PAVYKAGDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSVRERWWYIALSKCGGDGLQLEYEMVLTNGKSF
WTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFS
SSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSL
RHFPEKQPFYVPFFAAYTLWFFAVPVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLILPFLFCIPTAFPTLLDLSTLPLPLPKFCH

--------------------------------------------------------------

>36168_36168_3_HERC2-TMEM145_HERC2_chr15_28544547_ENST00000261609_TMEM145_chr19_42818423_ENST00000601020_length(amino acids)=157AA_BP=1
MTPWPGSPCPLPCTRLATGMGHQNRGGCSDSTWPQGSGNGSPVGRNPRGNKILSGTPSPFLGGSSPFWVDSVPVYTISPSLTISFHRPQS

--------------------------------------------------------------

>36168_36168_4_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000301204_length(amino acids)=491AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKD
CLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFI
LIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRI
SHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHFPEKQPFYVPFFAAYTLWFFAV
PVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISDSV

--------------------------------------------------------------

>36168_36168_5_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000598766_length(amino acids)=486AA_BP=38
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPELPVPNISGLQAKCCQNILLYFDDPSQW
PAVYKAGDKDCLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSVRERWWYIALSKCGGDGLQLEYEMVLTNGKSF
WTRHFSADEFGILETDVTFLLIFILIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFS
SSFLIFLLMLILLGKGFTVTRGRISHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSL
RHFPEKQPFYVPFFAAYTLWFFAVPVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLILPFLFCIPTAFPTLLDLSTLPLPLPKFCH

--------------------------------------------------------------

>36168_36168_6_HERC2-TMEM145_HERC2_chr15_28544548_ENST00000261609_TMEM145_chr19_42818424_ENST00000601020_length(amino acids)=157AA_BP=1
MTPWPGSPCPLPCTRLATGMGHQNRGGCSDSTWPQGSGNGSPVGRNPRGNKILSGTPSPFLGGSSPFWVDSVPVYTISPSLTISFHRPQS

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr15:28544548/chr19:42818424)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC2

O95714

.
FUNCTION: E3 ubiquitin-protein ligase that regulates ubiquitin-dependent retention of repair proteins on damaged chromosomes. Recruited to sites of DNA damage in response to ionizing radiation (IR) and facilitates the assembly of UBE2N and RNF8 promoting DNA damage-induced formation of 'Lys-63'-linked ubiquitin chains. Acts as a mediator of binding specificity between UBE2N and RNF8. Involved in the maintenance of RNF168 levels. E3 ubiquitin-protein ligase that promotes the ubiquitination and proteasomal degradation of XPA which influences the circadian oscillation of DNA excision repair activity. By controlling the steady-state expression of the IGF1R receptor, indirectly regulates the insulin-like growth factor receptor signaling pathway (PubMed:26692333). {ECO:0000269|PubMed:20023648, ECO:0000269|PubMed:20304803, ECO:0000269|PubMed:22508508, ECO:0000269|PubMed:26692333}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015175_19540.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015207_22740.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015241_26140.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015282_30240.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015318_33840.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015349_36940.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544547chr19:42818423ENST00000301204015381_40140.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015175_19540.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015207_22740.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015241_26140.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015282_30240.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015318_33840.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015349_36940.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST00000301204015381_40140.0494.0TransmembraneHelical

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393948_98062.3333333333333364835.0Coiled coilOntology_term=ECO:0000255
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393948_98062.3333333333333364835.0Coiled coilOntology_term=ECO:0000255
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3931207_128362.3333333333333364835.0DomainCytochrome b5 heme-binding
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3931859_193262.3333333333333364835.0DomainMIB/HERC2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932759_293662.3333333333333364835.0DomainDOC
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934457_479462.3333333333333364835.0DomainHECT
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931207_128362.3333333333333364835.0DomainCytochrome b5 heme-binding
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3931859_193262.3333333333333364835.0DomainMIB/HERC2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932759_293662.3333333333333364835.0DomainDOC
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934457_479462.3333333333333364835.0DomainHECT
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932958_300962.3333333333333364835.0RepeatRCC1 2-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933010_306462.3333333333333364835.0RepeatRCC1 2-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933065_311662.3333333333333364835.0RepeatRCC1 2-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933118_316862.3333333333333364835.0RepeatRCC1 2-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933171_322262.3333333333333364835.0RepeatRCC1 2-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933224_327462.3333333333333364835.0RepeatRCC1 2-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933275_332662.3333333333333364835.0RepeatRCC1 2-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3933951_400262.3333333333333364835.0RepeatRCC1 3-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934004_405662.3333333333333364835.0RepeatRCC1 3-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934058_410862.3333333333333364835.0RepeatRCC1 3-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934110_416262.3333333333333364835.0RepeatRCC1 3-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393415_46162.3333333333333364835.0RepeatRCC1 1-1
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934164_421462.3333333333333364835.0RepeatRCC1 3-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934216_426662.3333333333333364835.0RepeatRCC1 3-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3934268_431862.3333333333333364835.0RepeatRCC1 3-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393462_51262.3333333333333364835.0RepeatRCC1 1-2
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393513_56862.3333333333333364835.0RepeatRCC1 1-3
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393569_62062.3333333333333364835.0RepeatRCC1 1-4
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393623_67462.3333333333333364835.0RepeatRCC1 1-5
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393675_72662.3333333333333364835.0RepeatRCC1 1-6
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-393728_77862.3333333333333364835.0RepeatRCC1 1-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932958_300962.3333333333333364835.0RepeatRCC1 2-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933010_306462.3333333333333364835.0RepeatRCC1 2-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933065_311662.3333333333333364835.0RepeatRCC1 2-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933118_316862.3333333333333364835.0RepeatRCC1 2-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933171_322262.3333333333333364835.0RepeatRCC1 2-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933224_327462.3333333333333364835.0RepeatRCC1 2-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933275_332662.3333333333333364835.0RepeatRCC1 2-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3933951_400262.3333333333333364835.0RepeatRCC1 3-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934004_405662.3333333333333364835.0RepeatRCC1 3-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934058_410862.3333333333333364835.0RepeatRCC1 3-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934110_416262.3333333333333364835.0RepeatRCC1 3-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393415_46162.3333333333333364835.0RepeatRCC1 1-1
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934164_421462.3333333333333364835.0RepeatRCC1 3-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934216_426662.3333333333333364835.0RepeatRCC1 3-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3934268_431862.3333333333333364835.0RepeatRCC1 3-7
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393462_51262.3333333333333364835.0RepeatRCC1 1-2
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393513_56862.3333333333333364835.0RepeatRCC1 1-3
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393569_62062.3333333333333364835.0RepeatRCC1 1-4
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393623_67462.3333333333333364835.0RepeatRCC1 1-5
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393675_72662.3333333333333364835.0RepeatRCC1 1-6
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-393728_77862.3333333333333364835.0RepeatRCC1 1-7
HgeneHERC2chr15:28544547chr19:42818423ENST00000261609-3932702_274962.3333333333333364835.0Zinc fingerZZ-type
HgeneHERC2chr15:28544548chr19:42818424ENST00000261609-3932702_274962.3333333333333364835.0Zinc fingerZZ-type
TgeneTMEM145chr15:28544547chr19:42818423ENST000003012040159_2940.0494.0TransmembraneHelical
TgeneTMEM145chr15:28544548chr19:42818424ENST000003012040159_2940.0494.0TransmembraneHelical


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1033_HERC2_28544548_TMEM145_42818424_1033_HERC2_28544548_TMEM145_42818424_ranked_0.pdbHERC22854454728544548ENST00000601020TMEM145chr1942818424+
MHSQEMGSVVCGMKWLKMEKLYTLEQNQPRTESSLLEKDWVFLTRFCFLSDYGRLDFRFRYPEAKCCQNILLYFDDPSQWPAVYKAGDKD
CLAKESVIRPENNQVINLTTQYAWSGCQVVSEEGTRYLSCSSGRSFRSGDGLQLEYEMVLTNGKSFWTRHFSADEFGILETDVTFLLIFI
LIFFLSCYFGYLLKGRQLLHTTYKMFMAAAGVEVLSLLFFCIYWGQYATDGIGNESVKILAKLLFSSSFLIFLLMLILLGKGFTVTRGRI
SHAGSVKLSVYMTLYTLTHVVLLIYEAEFFDPGQVLYTYESPAGYGLIGLQVAAYVWFCYAVLVSLRHFPEKQPFYVPFFAAYTLWFFAV
PVMALIANFGIPKWAREKIVNGIQLGIHLYAHGVFLIMTRPSAANKNFPYHVRTSQIASAGVPGPGGSQSADKAFPQHVYGNVTFISDSV
491


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HERC2_pLDDT.png
all structure
all structure
TMEM145_pLDDT.png
all structure
all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HERC2
TMEM145


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HERC2-TMEM145


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HERC2-TMEM145


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource