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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HERC4-CTNNA3

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HERC4-CTNNA3
FusionPDB ID: 36177
FusionGDB2.0 ID: 36177
HgeneTgene
Gene symbol

HERC4

CTNNA3

Gene ID

26091

29119

Gene nameHECT and RLD domain containing E3 ubiquitin protein ligase 4catenin alpha 3
Synonyms-ARVD13|VR22
Cytomap

10q21.3

10q21.3

Type of geneprotein-codingprotein-coding
Descriptionprobable E3 ubiquitin-protein ligase HERC4HECT domain and RCC1-like domain-containing protein 4HECT-type E3 ubiquitin transferase HERC4hect domain and RLD 4catenin alpha-3alpha-T-cateninalpha-catenin-like proteincatenin (cadherin-associated protein), alpha 3
Modification date2020032720200313
UniProtAcc

Q5GLZ8

Q9UI47

Ensembl transtripts involved in fusion geneENST idsENST00000395187, ENST00000277817, 
ENST00000373700, ENST00000395198, 
ENST00000412272, ENST00000480158, 
ENST00000492996, 		ENST00000373744, 
ENST00000433211, ENST00000373735, 
ENST00000545309, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score12 X 13 X 6=93623 X 20 X 6=2760
# samples 1525
** MAII scorelog2(15/936*10)=-2.64154602908752
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(25/2760*10)=-3.46466826700344
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HERC4 [Title/Abstract] AND CTNNA3 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HERC4(69749968)-CTNNA3(67680375), # samples:1
HERC4(69748420)-CTNNA3(67748555), # samples:1
Anticipated loss of major functional domain due to fusion event.HERC4-CTNNA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC4-CTNNA3 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC4-CTNNA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC4-CTNNA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HERC4-CTNNA3 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF.
HERC4-CTNNA3 seems lost the major protein functional domain in Tgene partner, which is a tumor suppressor due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID

check buttonFusion gene breakpoints across HERC4 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across CTNNA3 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4HNSCTCGA-BB-7861-01AHERC4chr10

69748420

-CTNNA3chr10

67748555

-
ChimerDB4HNSCTCGA-BB-7861-01AHERC4chr10

69749968

-CTNNA3chr10

67680375

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000277817HERC4chr1069749968-ENST00000433211CTNNA3chr1067680375-989817984951976493
ENST00000412272HERC4chr1069749968-ENST00000373744CTNNA3chr1067680375-248018812482059603
ENST00000395198HERC4chr1069749968-ENST00000373744CTNNA3chr1067680375-248018812482059603
ENST00000373700HERC4chr1069749968-ENST00000373744CTNNA3chr1067680375-254519463132124603
ENST00000412272HERC4chr1069748420-ENST00000433211CTNNA3chr1067748555-1039520542482083611
ENST00000412272HERC4chr1069748420-ENST00000373744CTNNA3chr1067748555-289420542482083611
ENST00000395198HERC4chr1069748420-ENST00000433211CTNNA3chr1067748555-1039520542482083611
ENST00000395198HERC4chr1069748420-ENST00000373744CTNNA3chr1067748555-289420542482083611
ENST00000373700HERC4chr1069748420-ENST00000433211CTNNA3chr1067748555-1046021193132148611
ENST00000373700HERC4chr1069748420-ENST00000373744CTNNA3chr1067748555-295921193132148611

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000277817ENST00000433211HERC4chr1069749968-CTNNA3chr1067680375-0.0001969230.9998031
ENST00000412272ENST00000373744HERC4chr1069749968-CTNNA3chr1067680375-0.000128680.99987125
ENST00000395198ENST00000373744HERC4chr1069749968-CTNNA3chr1067680375-0.000128680.99987125
ENST00000373700ENST00000373744HERC4chr1069749968-CTNNA3chr1067680375-0.0001339390.999866
ENST00000412272ENST00000433211HERC4chr1069748420-CTNNA3chr1067748555-8.11E-050.99991894
ENST00000412272ENST00000373744HERC4chr1069748420-CTNNA3chr1067748555-0.0002464910.99975353
ENST00000395198ENST00000433211HERC4chr1069748420-CTNNA3chr1067748555-8.11E-050.99991894
ENST00000395198ENST00000373744HERC4chr1069748420-CTNNA3chr1067748555-0.0002464910.99975353
ENST00000373700ENST00000433211HERC4chr1069748420-CTNNA3chr1067748555-8.22E-050.99991775
ENST00000373700ENST00000373744HERC4chr1069748420-CTNNA3chr1067748555-0.0002422910.9997577

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36177_36177_1_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000373700_CTNNA3_chr10_67748555_ENST00000373744_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_2_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000373700_CTNNA3_chr10_67748555_ENST00000433211_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_3_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000395198_CTNNA3_chr10_67748555_ENST00000373744_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_4_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000395198_CTNNA3_chr10_67748555_ENST00000433211_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_5_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000412272_CTNNA3_chr10_67748555_ENST00000373744_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_6_HERC4-CTNNA3_HERC4_chr10_69748420_ENST00000412272_CTNNA3_chr10_67748555_ENST00000433211_length(amino acids)=611AA_BP=
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_7_HERC4-CTNNA3_HERC4_chr10_69749968_ENST00000277817_CTNNA3_chr10_67680375_ENST00000433211_length(amino acids)=493AA_BP=434
MCVDSLVRICSGLSYGRIRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTSPQLLKSLLGIPFMQVAAGGA
HSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGGYGQLGHNSTSHEINPRKVFE
LMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEEYFCVKRIFSGGDQSFSHYSS
PQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYRTGTRFSGVDMNAARLLFHKL
IQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAPLKVLVGQCHIPDPSSQKFNE

--------------------------------------------------------------

>36177_36177_8_HERC4-CTNNA3_HERC4_chr10_69749968_ENST00000373700_CTNNA3_chr10_67680375_ENST00000373744_length(amino acids)=603AA_BP=544
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_9_HERC4-CTNNA3_HERC4_chr10_69749968_ENST00000395198_CTNNA3_chr10_67680375_ENST00000373744_length(amino acids)=603AA_BP=544
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

>36177_36177_10_HERC4-CTNNA3_HERC4_chr10_69749968_ENST00000412272_CTNNA3_chr10_67680375_ENST00000373744_length(amino acids)=603AA_BP=544
MLCWGNASFGQLGLGGIDEEIVLEPRKSDFFINKRVRDVGCGLRHTVFVLDDGTVYTCGCNDLGQLGHEKSRKKPEQVVALDAQNIVAVS
CGEAHTLALNDKGQVYAWGLDSDGQLGLVGSEECIRVPRNIKSLSDIQIVQVACGYYHSLALSKASEVFCWGQNKYGQLGLGTDCKKQTS
PQLLKSLLGIPFMQVAAGGAHSFVLTLSGAIFGWGRNKFGQLGLNDENDRYVPNLLKSLRSQKIVYICCGEDHTAALTKEGGVFTFGAGG
YGQLGHNSTSHEINPRKVFELMGSIVTEIACGRQHTSAFVPSSGRIYSFGLGGNGQLGTGSTSNRKSPFTVKGNWYPYNGQCLPDIDSEE
YFCVKRIFSGGDQSFSHYSSPQNCGPPDDFRCPNPTKQIWTVNEALIQKWLSYPSGRFPVEIANEIDGTFSSSGCLNGSFLAVSNDDHYR
TGTRFSGVDMNAARLLFHKLIQPDHPQISQQVAASLEKNLIPKLTSSLPDVEALRFYLTLPECPLMSDSNNFTTIAIPFGTALVNLEKAP

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:69749968/chr10:67680375)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HERC4

Q5GLZ8

CTNNA3

Q9UI47

FUNCTION: Probable E3 ubiquitin-protein ligase involved in either protein trafficking or in the distribution of cellular structures. Required for spermatozoon maturation and fertility, and for the removal of the cytoplasmic droplet of the spermatozoon. E3 ubiquitin-protein ligases accept ubiquitin from an E2 ubiquitin-conjugating enzyme in the form of a thioester and then directly transfer it to targeted substrates. {ECO:0000250|UniProtKB:Q6PAV2}.FUNCTION: May be involved in formation of stretch-resistant cell-cell adhesion complexes. {ECO:0000303|PubMed:11590244}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424730_1057548.6666666666666123.66666666666667DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324730_1057491.0123.66666666666667DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223102_154492.0948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223156_207492.0948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-12231_51492.0948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223208_259492.0948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223261_311492.0948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223313_368492.0948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-122352_101492.0948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525102_154602.01050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525156_207602.01050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-15251_51602.01050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525208_259602.01050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525261_311602.01050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525313_368602.01050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-152552_101602.01050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424102_154548.6666666666666123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424156_207548.6666666666666123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-14241_51548.6666666666666123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424208_259548.6666666666666123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424261_311548.6666666666666123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-1424313_368548.6666666666666123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000395187-142452_101548.6666666666666123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526102_154602.01058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526156_207602.01058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-15261_51602.01058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526208_259602.01058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526261_311602.01058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526313_368602.01058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-152652_101602.01058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524102_154602.0980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524156_207602.0980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-15241_51602.0980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524208_259602.0980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524261_311602.0980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524313_368602.0980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-152452_101602.0980.0RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123102_154434.3333333333333948.0RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123156_207434.3333333333333948.0RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-11231_51434.3333333333333948.0RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123208_259434.3333333333333948.0RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123261_311434.3333333333333948.0RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123313_368434.3333333333333948.0RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-112352_101434.3333333333333948.0RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425102_154544.33333333333341050.0RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425156_207544.33333333333341050.0RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-14251_51544.33333333333341050.0RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425208_259544.33333333333341050.0RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425261_311544.33333333333341050.0RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425313_368544.33333333333341050.0RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-142552_101544.33333333333341050.0RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324102_154491.0123.66666666666667RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324156_207491.0123.66666666666667RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-13241_51491.0123.66666666666667RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324208_259491.0123.66666666666667RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324261_311491.0123.66666666666667RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-1324313_368491.0123.66666666666667RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000395187-132452_101491.0123.66666666666667RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426102_154544.33333333333341058.0RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426156_207544.33333333333341058.0RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-14261_51544.33333333333341058.0RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426208_259544.33333333333341058.0RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426261_311544.33333333333341058.0RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426313_368544.33333333333341058.0RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-142652_101544.33333333333341058.0RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424102_154544.3333333333334980.0RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424156_207544.3333333333334980.0RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-14241_51544.3333333333334980.0RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424208_259544.3333333333334980.0RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424261_311544.3333333333334980.0RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424313_368544.3333333333334980.0RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-142452_101544.3333333333334980.0RepeatNote=RCC1 2

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHERC4chr10:69748420chr10:67748555ENST00000277817-1223730_1057492.0948.0DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000373700-1525730_1057602.01050.0DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000395198-1526730_1057602.01058.0DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000412272-1524730_1057602.0980.0DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000277817-1123730_1057434.3333333333333948.0DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000373700-1425730_1057544.33333333333341050.0DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000395198-1426730_1057544.33333333333341058.0DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000412272-1424730_1057544.3333333333334980.0DomainHECT
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14730_10570111.0DomainHECT
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69748420chr10:67748555ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14102_1540111.0RepeatNote=RCC1 3
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14156_2070111.0RepeatNote=RCC1 4
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-141_510111.0RepeatNote=RCC1 1
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14208_2590111.0RepeatNote=RCC1 5
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14261_3110111.0RepeatNote=RCC1 6
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-14313_3680111.0RepeatNote=RCC1 7
HgeneHERC4chr10:69749968chr10:67680375ENST00000492996-1452_1010111.0RepeatNote=RCC1 2
TgeneCTNNA3chr10:69748420chr10:67748555ENST000003737441317325_379719.6666666666666896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69748420chr10:67748555ENST00000373744131774_111719.6666666666666896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69748420chr10:67748555ENST000004332111418325_379719.6666666666666896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69748420chr10:67748555ENST00000433211141874_111719.6666666666666896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69749968chr10:67680375ENST000003737441517325_379800.0896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69749968chr10:67680375ENST00000373744151774_111800.0896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69749968chr10:67680375ENST000004332111618325_379800.0896.0Coiled coilOntology_term=ECO:0000255
TgeneCTNNA3chr10:69749968chr10:67680375ENST00000433211161874_111800.0896.0Coiled coilOntology_term=ECO:0000255


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HERC4
CTNNA3


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HERC4-CTNNA3


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HERC4-CTNNA3


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource