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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HHAT-KIF5B

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HHAT-KIF5B
FusionPDB ID: 36266
FusionGDB2.0 ID: 36266
HgeneTgene
Gene symbol

HHAT

KIF5B

Gene ID

55733

3799

Gene namehedgehog acyltransferasekinesin family member 5B
SynonymsMART2|SKI1|SknHEL-S-61|KINH|KNS|KNS1|UKHC
Cytomap

1q32.2

10p11.22

Type of geneprotein-codingprotein-coding
Descriptionprotein-cysteine N-palmitoyltransferase HHATmelanoma antigen recognized by T-cells 2skinny hedgehog protein 1kinesin-1 heavy chainconventional kinesin heavy chainepididymis secretory protein Li 61kinesin 1 (110-120kD)kinesin heavy chainubiquitous kinesin heavy chain
Modification date2020031320200313
UniProtAcc

Q9HCP6

P33176

Ensembl transtripts involved in fusion geneENST idsENST00000261458, ENST00000308852, 
ENST00000367010, ENST00000391905, 
ENST00000413764, ENST00000537898, 
ENST00000541565, ENST00000545154, 
ENST00000545781, ENST00000367009, 
ENST00000493889, ENST00000302418, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score8 X 8 X 3=19211 X 12 X 5=660
# samples 812
** MAII scorelog2(8/192*10)=-1.26303440583379
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(12/660*10)=-2.4594316186373
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HHAT [Title/Abstract] AND KIF5B [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)KIF5B(32337392)-HHAT(210637849), # samples:3
HHAT(210591669)-KIF5B(32329385), # samples:1
Anticipated loss of major functional domain due to fusion event.HHAT-KIF5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HHAT-KIF5B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HHAT-KIF5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HHAT-KIF5B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
KIF5B-HHAT seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
TgeneKIF5B

GO:0042391

regulation of membrane potential

19675065

TgeneKIF5B

GO:0043268

positive regulation of potassium ion transport

19675065

TgeneKIF5B

GO:0047496

vesicle transport along microtubule

28426968

TgeneKIF5B

GO:1903078

positive regulation of protein localization to plasma membrane

19675065


check buttonFusion gene breakpoints across HHAT (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across KIF5B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4PRADTCGA-VN-A88L-01AHHATchr1

210591669

-KIF5Bchr10

32329385

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000541565HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-582662117632981040
ENST00000413764HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-6237103217637091177
ENST00000391905HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-6303109816737751202
ENST00000537898HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-610890316735801137
ENST00000545154HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-616996410536411178
ENST00000545781HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-60878822335591178
ENST00000308852HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-618898326236601132
ENST00000261458HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-6256105112037281202
ENST00000367010HHATchr1210591669-ENST00000302418KIF5Bchr1032329385-628810837437601228

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000541565ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0002044260.9997956
ENST00000413764ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001625740.9998374
ENST00000391905ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001665450.99983346
ENST00000537898ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001740860.9998259
ENST00000545154ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001318460.99986815
ENST00000545781ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001474360.99985254
ENST00000308852ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001642870.9998357
ENST00000261458ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001563360.9998436
ENST00000367010ENST00000302418HHATchr1210591669-KIF5Bchr1032329385-0.0001723950.9998276

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36266_36266_1_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000261458_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1202AA_BP=310
MPSPPPGTARRNSQRRHREPSCQGAMLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWME
WGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEV
KRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLA
LGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYS
MDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLIN
VKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVIC
CSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFT
VDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAEN
DASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGN
NDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE
ESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEH
EKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQ
LTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPA

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>36266_36266_2_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000308852_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1132AA_BP=240
MKFTKSPEDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLL
TWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEF
IKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHD
PEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRH
VAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSK
MTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNG
ETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLA
STRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRA
AEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEA
KIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLIT
DLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDD
TGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNM

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>36266_36266_3_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000367010_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1228AA_BP=336
MASSPASGTAAGSCELWSSWQYRRCACLPAVTPGTLKNSQRRHREPSCQGAMLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQE
FELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQ
FRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPI
LSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTM
EGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDE
GKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYV
PYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENEL
NRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLD
QEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTN
HQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLR
ISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEA
KAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSA
EIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEA

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>36266_36266_4_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000391905_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1202AA_BP=310
MPSPPPGTARRNSQRRHREPSCQGAMLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWME
WGKQWLVWLLLGHMVVSQMATLLARKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEV
KRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLA
LGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYS
MDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLIN
VKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVIC
CSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFT
VDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAEN
DASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGN
NDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLE
ESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEH
EKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQ
LTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPA

--------------------------------------------------------------

>36266_36266_5_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000413764_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1177AA_BP=285
MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLAR
KHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLYY
TSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAI
YSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLL
DVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSE
KVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIK
NTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDA
ERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKS
QEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISK
MKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKE
HLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRRE
QARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKR
LRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAVR

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>36266_36266_6_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000537898_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1137AA_BP=245
MPSPPPGTARRNSQRRHREPSCQGAMLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWME
WGKQWLVWLLLGHMVVSQMATLLARKRRWYKTENEYYLLQFTLTVRCLYYTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPIL
SFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTME
GKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEG
KSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVP
YRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELN
RWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQ
EELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNH
QKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRI
SQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAK
AKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAE
IDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAV

--------------------------------------------------------------

>36266_36266_7_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000541565_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1040AA_BP=148
MLPRWELALYLLASLGFHFYSFYEVYKVSREHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLAR
KMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHAIYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPE
GMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDLLDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVA
VTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGSEKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMT
RILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTIKNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGET
VPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTDAERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLAST
RRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQKSQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAE
MMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYISKMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKI
KSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEKEHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDL
QDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRREQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTG
GSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEKRLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMAR

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>36266_36266_8_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000545154_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1178AA_BP=286
MSLGLGSAERGVLGTRGARERCRRRRPGQPGEHEEELDQEFELETDTLFGGLKKDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLA
RKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLY
YTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHA
IYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDL
LDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGS
EKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTI
KNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTD
AERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQK
SQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYIS
KMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEK
EHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRR
EQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEK
RLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAV

--------------------------------------------------------------

>36266_36266_9_HHAT-KIF5B_HHAT_chr1_210591669_ENST00000545781_KIF5B_chr10_32329385_ENST00000302418_length(amino acids)=1178AA_BP=286
MLLQRAAPGERGWRPGEARSRRRCRWDSEVPKEGCWELAARVNVAVAAARDSPEDATDFEWSFWMEWGKQWLVWLLLGHMVVSQMATLLA
RKHRPWILMLYGMWACWCVLGTPGVAMVLLHTTISFCVAQFRSQLLTWLCSLLLLSTLRLQGVEEVKRRWYKTENEYYLLQFTLTVRCLY
YTSFSLELCWQQLPAASTSYSFPWMLAYVFYYPVLHNGPILSFSEFIKQMQQQEHDSLKASLCVLALGLGRLLCWWWLAELMAHLMYMHA
IYSSIPLLETVSCWTLDVLEGYNGTIFAYGQTSSGKTHTMEGKLHDPEGMGIIPRIVQDIFNYIYSMDENLEFHIKVSYFEIYLDKIRDL
LDVSKTNLSVHEDKNRVPYVKGCTERFVCSPDEVMDTIDEGKSNRHVAVTNMNEHSSRSHSIFLINVKQENTQTEQKLSGKLYLVDLAGS
EKVSKTGAEGAVLDEAKNINKSLSALGNVISALAEGSTYVPYRDSKMTRILQDSLGGNCRTTIVICCSPSSYNESETKSTLLFGQRAKTI
KNTVCVNVELTAEQWKKKYEKEKEKNKILRNTIQWLENELNRWRNGETVPIDEQFDKEKANLEAFTVDKDITLTNDKPATAIGVIGNFTD
AERRKCEEEIAKLYKQLDDKDEEINQQSQLVEKLKTQMLDQEELLASTRRDQDNMQAELNRLQAENDASKEEVKEVLQALEELAVNYDQK
SQEVEDKTKEYELLSDELNQKSATLASIDAELQKLKEMTNHQKKRAAEMMASLLKDLAEIGIAVGNNDVKQPEGTGMIDEEFTVARLYIS
KMKSEVKTMVKRCKQLESTQTESNKKMEENEKELAACQLRISQHEAKIKSLTEYLQNVEQKKRQLEESVDALSEELVQLRAQEKVHEMEK
EHLNKVQTANEVKQAVEQQIQSHRETHQKQISSLRDEVEAKAKLITDLQDQNQKMMLEQERLRVEHEKLKATDQEKSRKLHELTVMQDRR
EQARQDLKGLEETVAKELQTLHNLRKLFVQDLATRVKKSAEIDSDDTGGSAAQKQKISFLENNLEQLTKVHKQLVRDNADLRCELPKLEK
RLRATAERVKALESALKEAKENASRDRKRYQQEVDRIKEAVRSKNMARRGHSAQIAKPIRPGQHPAASPTHPSAIRGGGAFVQNSQPVAV

--------------------------------------------------------------

Top

Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr1:32337392/chr10:210637849)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HHAT

Q9HCP6

KIF5B

P33176

FUNCTION: Negatively regulates N-terminal palmitoylation of SHH by HHAT/SKN. {ECO:0000250}.FUNCTION: Microtubule-dependent motor required for normal distribution of mitochondria and lysosomes. Can induce formation of neurite-like membrane protrusions in non-neuronal cells in a ZFYVE27-dependent manner (By similarity). Regulates centrosome and nuclear positioning during mitotic entry. During the G2 phase of the cell cycle in a BICD2-dependent manner, antagonizes dynein function and drives the separation of nuclei and centrosomes (PubMed:20386726). Required for anterograde axonal transportation of MAPK8IP3/JIP3 which is essential for MAPK8IP3/JIP3 function in axon elongation (By similarity). Through binding with PLEKHM2 and ARL8B, directs lysosome movement toward microtubule plus ends (Probable). Involved in NK cell-mediated cytotoxicity. Drives the polarization of cytolytic granules and microtubule-organizing centers (MTOCs) toward the immune synapse between effector NK lymphocytes and target cells (PubMed:24088571). {ECO:0000250|UniProtKB:Q2PQA9, ECO:0000250|UniProtKB:Q61768, ECO:0000269|PubMed:20386726, ECO:0000269|PubMed:24088571, ECO:0000305|PubMed:22172677, ECO:0000305|PubMed:24088571}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712203_217285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-71295_119285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712203_217285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-71295_119285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712203_217285.3333333333333519.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-71295_119285.3333333333333519.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712203_217285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-71295_119285.3333333333333494.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611203_217220.33333333333334429.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-61195_119220.33333333333334429.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-51095_119148.33333333333334357.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611203_217286.3333333333333495.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-61195_119286.3333333333333495.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712120_131285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712149_162285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712184_202285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-7121_5285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712218_243285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-71223_67285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712272_281285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-71285_94285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712120_131285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712149_162285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712184_202285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-7121_5285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712218_243285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-71223_67285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712272_281285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-71285_94285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712120_131285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712149_162285.3333333333333519.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712184_202285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-7121_5285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712218_243285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-71223_67285.3333333333333519.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712272_281285.3333333333333519.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-71285_94285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712120_131285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712149_162285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712184_202285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-7121_5285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712218_243285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-71223_67285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712272_281285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-71285_94285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611120_131220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611149_162220.33333333333334429.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611184_202220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-6111_5220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-61123_67220.33333333333334429.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-61185_94220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510120_131148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-5101_5148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-51023_67148.33333333333334357.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-51085_94148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611120_131286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611149_162286.3333333333333495.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611184_202286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-6111_5286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611218_243286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-61123_67286.3333333333333495.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611272_281286.3333333333333495.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-61185_94286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712132_148285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712163_183285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712244_271285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-71268_84285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-7126_22285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712132_148285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712163_183285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712244_271285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-71268_84285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-7126_22285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712132_148285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712163_183285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712244_271285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-71268_84285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-7126_22285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712132_148285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712163_183285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712244_271285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-71268_84285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-7126_22285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611132_148220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611163_183220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-61168_84220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-6116_22220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510132_148148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-51068_84148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-5106_22148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611132_148286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611163_183286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611244_271286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-61168_84286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-6116_22286.3333333333333495.0TransmembraneHelical
TgeneKIF5Bchr1:210591669chr10:32329385ENST00000302418126329_91471.333333333333331626.0Coiled coil.
TgeneKIF5Bchr1:210591669chr10:32329385ENST0000030241812685_9271.333333333333331626.0Nucleotide bindingNote=ATP
TgeneKIF5Bchr1:210591669chr10:32329385ENST00000302418126915_96371.333333333333331626.0RegionNote=Globular

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510203_217148.33333333333334357.0IntramembraneOntology_term=ECO:0000255
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712448_455285.3333333333333494.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712448_455285.3333333333333494.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712448_455285.3333333333333519.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712448_455285.3333333333333494.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611448_455220.33333333333334429.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510448_455148.33333333333334357.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611448_455286.3333333333333495.0RegionGTP-binding
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712311_363285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712381_383285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712400_427285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712449_462285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712482_493285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712311_363285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712381_383285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712400_427285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712449_462285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712482_493285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712311_363285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712381_383285.3333333333333519.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712400_427285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712449_462285.3333333333333519.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712482_493285.3333333333333519.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712311_363285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712381_383285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712400_427285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712449_462285.3333333333333494.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712482_493285.3333333333333494.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611218_243220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611272_281220.33333333333334429.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611311_363220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611381_383220.33333333333334429.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611400_427220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611449_462220.33333333333334429.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611482_493220.33333333333334429.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510149_162148.33333333333334357.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510184_202148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510218_243148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510272_281148.33333333333334357.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510311_363148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510381_383148.33333333333334357.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510400_427148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510449_462148.33333333333334357.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510482_493148.33333333333334357.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611311_363286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611381_383286.3333333333333495.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611400_427286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611449_462286.3333333333333495.0Topological domainLumenal
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611482_493286.3333333333333495.0Topological domainCytoplasmic
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712282_310285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712364_380285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712384_399285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712428_448285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000261458-712463_481285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712282_310285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712364_380285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712384_399285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712428_448285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000367010-712463_481285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712282_310285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712364_380285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712384_399285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712428_448285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000391905-712463_481285.3333333333333519.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712282_310285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712364_380285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712384_399285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712428_448285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000413764-712463_481285.3333333333333494.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611244_271220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611282_310220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611364_380220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611384_399220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611428_448220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000537898-611463_481220.33333333333334429.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510163_183148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510244_271148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510282_310148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510364_380148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510384_399148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510428_448148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000541565-510463_481148.33333333333334357.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611282_310286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611364_380286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611384_399286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611428_448286.3333333333333495.0TransmembraneHelical
HgeneHHATchr1:210591669chr10:32329385ENST00000545154-611463_481286.3333333333333495.0TransmembraneHelical
TgeneKIF5Bchr1:210591669chr10:32329385ENST000003024181268_32571.333333333333331626.0DomainKinesin motor


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
KIF5BYWHAG, YWHAB, YWHAQ, YWHAZ, VDAC1, NME2, SFN, DTNB, SNAP23, SNAP25, KLC1, KLC2, KIF5C, YWHAH, USPL1, MARK2, MEPCE, FYCO1, RAPGEF2, APC, SPG20, CDC5L, GSK3B, NDRG1, SIRT7, RANBP2, KIAA0368, KLC4, ZBTB8B, KDM1A, MCCC1, EXOC7, DHX9, TWF1, SRP68, RNF168, YWHAE, CFTR, ACACA, CAST, COPE, COPS5, AKAP2, DIAPH1, ELP2, EPB41L1, NUP50, RNF20, PSMA2, PSMA4, PSMA5, PSMB3, PSMB4, PSMB5, PSMB6, PSMB7, PSME1, PTPN23, RABGAP1, SMEK2, TRIM25, STAU1, AURKB, HUWE1, PRKAR2B, VPS52, TAX1BP1, ZBTB8A, CUL7, EZH2, ABCE1, TRAK2, CCDC101, SYNE4, DTNBP1, NUP43, KPTN, AZIN1, TRIP6, CHRNA9, RPS6KB2, KIF1A, LSM2, NTRK1, MED4, L1TD1, KLC3, NHS, POU1F1, TUBA1A, OGT, SQSTM1, XPR1, NCOR1, TRAK1, KIDINS220, SLC38A10, Klc2, Klc4, Klc3, FOXQ1, Ostm1, CDH1, MYCL, COG6, EXOC1, MAP7D2, HOMER1, DLST, SOD1, BRCA1, ZNF598, EGLN3, CTNNB1, HSPA8, HDAC4, EFTUD2, ESR2, HEXIM1, PIK3R1, KDM6B, MYC, CDK9, KIAA1429, Bach1, GBF1, RFFL, HOOK1, HOOK3, BMH1, BMH2, BIRC3, LMBR1L, TRIM28, MEOX2, POU6F2, FHL2, CCDC136, LBX1, CDR2, BAG4, HSF2BP, POLR2G, GCC1, PRKAR1B, PLEKHA4, PPIB, MYO5A, KIF14, IFI16, PYHIN1, SUMO2, Rnf183, BRD4, Apc2, ORF6, SCGN, TP53, WDR5, NAA40, TPM3, SYCE1, NPEPPS, BRK1, PRPS2, HVCN1, C15orf59, HSPA2, NUP62, S100A2, CLSTN1, EP300, FGD5,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HHAT
KIF5Ball structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HHAT-KIF5B


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HHAT-KIF5B


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneKIF5BC0007131Non-Small Cell Lung Carcinoma1CTD_human
TgeneKIF5BC0011849Diabetes Mellitus1CTD_human