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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HIBADH-ST7

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HIBADH-ST7
	FusionPDB ID: 36295
	FusionGDB2.0 ID: 36295
		Hgene	Tgene
	Gene symbol	HIBADH	ST7
	Gene ID	11112	93655
	Gene name	3-hydroxyisobutyrate dehydrogenase	ST7 overlapping transcript 3
	Synonyms	NS5ATP1	NCRNA00026\|ST7\|ST7OT3
	Cytomap	7p15.2	7q31.2
	Type of gene	protein-coding	ncRNA
	Description	3-hydroxyisobutyrate dehydrogenase, mitochondrial3'-hydroxyisobutyrate dehydrogenaseepididymis secretory sperm binding protein	ST7 overlapping transcript 3 (non-coding RNA)ST7 overlapping transcript 3 (non-protein coding)suppression of tumorigenicity 7
	Modification date	20200313	20200313
	UniProtAcc	P31937	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000265395,	ENST00000393443, ENST00000393444, ENST00000393447, ENST00000465133, ENST00000487459, ENST00000265437, ENST00000323984, ENST00000393446, ENST00000393449, ENST00000393451, ENST00000422922, ENST00000432298,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	5 X 4 X 5=100	13 X 10 X 8=1040
	# samples	7	14
	** MAII score	log2(7/100*10)=-0.514573172829758 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(14/1040*10)=-2.89308479608349 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HIBADH [Title/Abstract] AND ST7 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HIBADH(27702316)-ST7(116759614), # samples:1
Anticipated loss of major functional domain due to fusion event.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIBADH	GO:0006574	valine catabolic process	16466957

Fusion gene breakpoints across HIBADH (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ST7 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	STAD	TCGA-IN-A6RL	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000393446	ST7	chr7	116759614	+	1875	298	13	1635	540
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000265437	ST7	chr7	116759614	+	2749	298	13	1821	602
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000393451	ST7	chr7	116759614	+	1975	298	13	1728	571
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000393449	ST7	chr7	116759614	+	2029	298	13	1782	589
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000323984	ST7	chr7	116759614	+	2044	298	13	1797	594
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000432298	ST7	chr7	116759614	+	2044	298	13	1797	594
ENST00000265395	HIBADH	chr7	27702316	-	ENST00000422922	ST7	chr7	116759614	+	1975	298	13	1728	571

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000265395	ENST00000393446	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.0017725	0.99822754
ENST00000265395	ENST00000265437	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.002851502	0.99714845
ENST00000265395	ENST00000393451	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.002382575	0.9976174
ENST00000265395	ENST00000393449	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.003311801	0.9966882
ENST00000265395	ENST00000323984	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.003338711	0.9966613
ENST00000265395	ENST00000432298	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.003338711	0.9966613
ENST00000265395	ENST00000422922	HIBADH	chr7	27702316	-	ST7	chr7	116759614	+	0.002382575	0.9976174

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36295_36295_1_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000265437_length(amino acids)=602AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTI
AEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALL
ELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHI
LKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLC

--------------------------------------------------------------

>36295_36295_2_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000323984_length(amino acids)=594AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTI
AEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALL
ELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHI
LKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLC

--------------------------------------------------------------

>36295_36295_3_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000393446_length(amino acids)=540AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQ
LQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKS
ATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVE
GALNLLHCTWEGTFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKAFLSTLFAPLNFVMEKVESILPSSLWHQLTRI

--------------------------------------------------------------

>36295_36295_4_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000393449_length(amino acids)=589AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTI
AEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALL
ELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHI
LKRGDSEAIAYAFFHLAHWKRVEGALNLLHSFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAM

--------------------------------------------------------------

>36295_36295_5_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000393451_length(amino acids)=571AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQ
LQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKS
ATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVE
GALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKA

--------------------------------------------------------------

>36295_36295_6_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000422922_length(amino acids)=571AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINECATAYILLAEEEATTIAEAEKLFKQALKAGDGCYRRSQQ
LQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALLELQAYADVQAVLAKYDDISLPKS
ATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHILKRGDSEAIAYAFFHLAHWKRVE
GALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLCSFTAMLALLTHQFPELMGVFAKA

--------------------------------------------------------------

>36295_36295_7_HIBADH-ST7_HIBADH_chr7_27702316_ENST00000265395_ST7_chr7_116759614_ENST00000432298_length(amino acids)=594AA_BP=95
MPRQAAPLGSALLPSRVGTRPRAVRARARAPFSVGEPASPAAHARSLWALREAAEVTAGRGAGAAWQPPYGSSELPPVSGTGAGGCGRQP
AALQRIFEWWYFRKYGTSFIEQVSVSHLRPLLGGVDNNSSNNSNSSNGDSDSNRQSVSECKVWRNPLNLFRGAEYNRYTWVTGREPLTYY
DMNLSAQDHQTFFTCDSDHLRPADAIMQKAWRERNPQARISAAHEALEINEIRSRVEVPLIASSTIWEIKLLPKCATAYILLAEEEATTI
AEAEKLFKQALKAGDGCYRRSQQLQHHGSQYEAQHRRDTNVLVYIKRRLAMCARRLGRTREAVKMMRDLMKEFPLLSMFNIHENLLEALL
ELQAYADVQAVLAKYDDISLPKSATICYTAALLKARAVSDKFSPEAASRRGLSTAEMNAVEAIHRAVEFNPHVPKYLLEMKSLILPPEHI
LKRGDSEAIAYAFFHLAHWKRVEGALNLLHCTWEGTFRMIPYPLEKGHLFYPYPICTETADRELLPSFHEVSVYPKKELPFFILFTAGLC

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:27702316/chr7:116759614)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIBADH P31937	.
	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000265437

512_532

78.0

586.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393443

512_532

28.0

500.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393443

62_82

28.0

500.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393451

512_532

78.0

555.0

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIBADH

chr7:27702316

chr7:116759614

ENST00000265395

103_104

30.333333333333332

337.0

Nucleotide binding

NAD

Hgene

HIBADH

chr7:27702316

chr7:116759614

ENST00000265395

40_68

30.333333333333332

337.0

Nucleotide binding

NAD

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000265437

15_35

78.0

586.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000265437

62_82

78.0

586.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393443

15_35

28.0

500.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393451

15_35

78.0

555.0

Transmembrane

Helical

Tgene

ST7

chr7:27702316

chr7:116759614

ENST00000393451

62_82

78.0

555.0

Transmembrane

Helical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HIBADH
ST7

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HIBADH-ST7

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HIBADH-ST7

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source