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Center for Computational Systems Medicine level2
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein Structure

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pLDDT scores

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Ramachandran Plot of Fusion Protein Structure

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HIF1A-PRKCH

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HIF1A-PRKCH
FusionPDB ID: 36343
FusionGDB2.0 ID: 36343
HgeneTgene
Gene symbol

HIF1A

PRKCH

Gene ID

3091

5583

Gene namehypoxia inducible factor 1 subunit alphaprotein kinase C eta
SynonymsHIF-1-alpha|HIF-1A|HIF-1alpha|HIF1|HIF1-ALPHA|MOP1|PASD8|bHLHe78PKC-L|PKCL|PRKCL|nPKC-eta
Cytomap

14q23.2

14q23.1

Type of geneprotein-codingprotein-coding
Descriptionhypoxia-inducible factor 1-alphaARNT interacting proteinPAS domain-containing protein 8basic-helix-loop-helix-PAS protein MOP1class E basic helix-loop-helix protein 78hypoxia inducible factor 1 alpha subunithypoxia inducible factor 1, alpha subunit protein kinase C eta type
Modification date2020032920200313
UniProtAcc

Q9NWT6

.
Ensembl transtripts involved in fusion geneENST idsENST00000323441, ENST00000337138, 
ENST00000394997, ENST00000539097, 
ENST00000557538, ENST00000557206, 
ENST00000555082, ENST00000332981, 
ENST00000556245, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score14 X 11 X 10=154017 X 18 X 11=3366
# samples 2427
** MAII scorelog2(24/1540*10)=-2.68182403997375
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(27/3366*10)=-3.64000386427912
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HIF1A [Title/Abstract] AND PRKCH [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HIF1A(62207906)-PRKCH(61995793), # samples:4
Anticipated loss of major functional domain due to fusion event.HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a cell metabolism gene due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.
HIF1A-PRKCH seems lost the major protein functional domain in Tgene partner, which is a kinase due to the frame-shifted ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHIF1A

GO:0001666

response to hypoxia

8756616|9887100|11782478|15261140|18419598

HgeneHIF1A

GO:0006355

regulation of transcription, DNA-templated

11782478|15261140

HgeneHIF1A

GO:0010468

regulation of gene expression

18419598

HgeneHIF1A

GO:0010573

vascular endothelial growth factor production

12958148

HgeneHIF1A

GO:0010575

positive regulation of vascular endothelial growth factor production

8756616

HgeneHIF1A

GO:0010628

positive regulation of gene expression

15459207|24244340

HgeneHIF1A

GO:0032364

oxygen homeostasis

16956324

HgeneHIF1A

GO:0043619

regulation of transcription from RNA polymerase II promoter in response to oxidative stress

8089148|8387214

HgeneHIF1A

GO:0045893

positive regulation of transcription, DNA-templated

8089148|9887100|25043030

HgeneHIF1A

GO:0045944

positive regulation of transcription by RNA polymerase II

11573933

HgeneHIF1A

GO:0046886

positive regulation of hormone biosynthetic process

1448077

HgeneHIF1A

GO:0061419

positive regulation of transcription from RNA polymerase II promoter in response to hypoxia

22735262

HgeneHIF1A

GO:0071456

cellular response to hypoxia

11573933|19528298|20889502

HgeneHIF1A

GO:1902895

positive regulation of pri-miRNA transcription by RNA polymerase II

19782034

HgeneHIF1A

GO:1903377

negative regulation of oxidative stress-induced neuron intrinsic apoptotic signaling pathway

24899725


check buttonFusion gene breakpoints across HIF1A (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across PRKCH (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4LUADTCGA-44-2668-01AHIF1Achr14

62207905

+PRKCHchr14

61995792

+
ChimerDB4LUADTCGA-44-2668-01AHIF1Achr14

62207906

-PRKCHchr14

61995793

+
ChimerDB4LUADTCGA-44-2668-01AHIF1Achr14

62207906

+PRKCHchr14

61995793

+
ChimerDB4LUADTCGA-44-2668-01BHIF1Achr14

62207905

+PRKCHchr14

61991769

+
ChimerDB4LUADTCGA-44-2668-01BHIF1Achr14

62207905

+PRKCHchr14

61995792

+
ChimerDB4LUADTCGA-44-2668-01BHIF1Achr14

62207906

+PRKCHchr14

61995793

+
ChimerDB4LUADTCGA-44-2668-01BHIF1Achr14

62211426

+PRKCHchr14

61968341

+
ChimerDB4LUADTCGA-44-2668HIF1Achr14

62207906

+PRKCHchr14

61995792

+
ChimerDB4OVTCGA-20-0987-01AHIF1Achr14

62162557

-PRKCHchr14

61909829

+
ChimerDB4STADTCGA-HU-A4GH-01AHIF1Achr14

62162557

-PRKCHchr14

61857943

+
ChimerDB4STADTCGA-HU-A4GH-01AHIF1Achr14

62162557

+PRKCHchr14

61857943

+
ChimerDB4STADTCGA-HU-A4GHHIF1Achr14

62162557

+PRKCHchr14

61857942

+
ChimerDB4UCECTCGA-EO-A22U-01AHIF1Achr14

62162557

-PRKCHchr14

61995793

+
ChiTaRS5.0N/ADB202604HIF1Achr14

62162558

+PRKCHchr14

61952220

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000394997HIF1Achr1462207906+ENST00000332981PRKCHchr1461995792+412523612652979904
ENST00000394997HIF1Achr1462207906+ENST00000555082PRKCHchr1461995792+412523612652979904
ENST00000337138HIF1Achr1462207906+ENST00000332981PRKCHchr1461995792+412223582652976903
ENST00000337138HIF1Achr1462207906+ENST00000555082PRKCHchr1461995792+412223582652976903
ENST00000323441HIF1Achr1462207906+ENST00000332981PRKCHchr1461995792+38852121282739903
ENST00000323441HIF1Achr1462207906+ENST00000555082PRKCHchr1461995792+38852121282739903
ENST00000557538HIF1Achr1462207906+ENST00000332981PRKCHchr1461995792+415823942293012927
ENST00000557538HIF1Achr1462207906+ENST00000555082PRKCHchr1461995792+415823942293012927
ENST00000539097HIF1Achr1462207906+ENST00000332981PRKCHchr1461995792+415823942293012927
ENST00000539097HIF1Achr1462207906+ENST00000555082PRKCHchr1461995792+415823942293012927
ENST00000394997HIF1Achr1462207906+ENST00000332981PRKCHchr1461995793+412523612652979904
ENST00000394997HIF1Achr1462207906+ENST00000555082PRKCHchr1461995793+412523612652979904
ENST00000337138HIF1Achr1462207906+ENST00000332981PRKCHchr1461995793+412223582652976903
ENST00000337138HIF1Achr1462207906+ENST00000555082PRKCHchr1461995793+412223582652976903
ENST00000323441HIF1Achr1462207906+ENST00000332981PRKCHchr1461995793+38852121282739903
ENST00000323441HIF1Achr1462207906+ENST00000555082PRKCHchr1461995793+38852121282739903
ENST00000557538HIF1Achr1462207906+ENST00000332981PRKCHchr1461995793+415823942293012927
ENST00000557538HIF1Achr1462207906+ENST00000555082PRKCHchr1461995793+415823942293012927
ENST00000539097HIF1Achr1462207906+ENST00000332981PRKCHchr1461995793+415823942293012927
ENST00000539097HIF1Achr1462207906+ENST00000555082PRKCHchr1461995793+415823942293012927
ENST00000394997HIF1Achr1462162557-ENST00000332981PRKCHchr1461995793+2064300265918217
ENST00000394997HIF1Achr1462162557-ENST00000555082PRKCHchr1461995793+2064300265918217
ENST00000337138HIF1Achr1462162557-ENST00000332981PRKCHchr1461995793+2064300265918217
ENST00000337138HIF1Achr1462162557-ENST00000555082PRKCHchr1461995793+2064300265918217
ENST00000323441HIF1Achr1462162557-ENST00000332981PRKCHchr1461995793+18276328681217
ENST00000323441HIF1Achr1462162557-ENST00000555082PRKCHchr1461995793+18276328681217
ENST00000394997HIF1Achr1462207905+ENST00000332981PRKCHchr1461995792+412523612652979904
ENST00000394997HIF1Achr1462207905+ENST00000555082PRKCHchr1461995792+412523612652979904
ENST00000337138HIF1Achr1462207905+ENST00000332981PRKCHchr1461995792+412223582652976903
ENST00000337138HIF1Achr1462207905+ENST00000555082PRKCHchr1461995792+412223582652976903
ENST00000323441HIF1Achr1462207905+ENST00000332981PRKCHchr1461995792+38852121282739903
ENST00000323441HIF1Achr1462207905+ENST00000555082PRKCHchr1461995792+38852121282739903
ENST00000557538HIF1Achr1462207905+ENST00000332981PRKCHchr1461995792+415823942293012927
ENST00000557538HIF1Achr1462207905+ENST00000555082PRKCHchr1461995792+415823942293012927
ENST00000539097HIF1Achr1462207905+ENST00000332981PRKCHchr1461995792+415823942293012927
ENST00000539097HIF1Achr1462207905+ENST00000555082PRKCHchr1461995792+415823942293012927

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000394997ENST00000332981HIF1Achr1462207906+PRKCHchr1461995792+0.0003503870.99964964
ENST00000394997ENST00000555082HIF1Achr1462207906+PRKCHchr1461995792+0.0003503870.99964964
ENST00000337138ENST00000332981HIF1Achr1462207906+PRKCHchr1461995792+0.0003470030.999653
ENST00000337138ENST00000555082HIF1Achr1462207906+PRKCHchr1461995792+0.0003470030.999653
ENST00000323441ENST00000332981HIF1Achr1462207906+PRKCHchr1461995792+0.0003648560.9996351
ENST00000323441ENST00000555082HIF1Achr1462207906+PRKCHchr1461995792+0.0003648560.9996351
ENST00000557538ENST00000332981HIF1Achr1462207906+PRKCHchr1461995792+7.89E-050.9999211
ENST00000557538ENST00000555082HIF1Achr1462207906+PRKCHchr1461995792+7.89E-050.9999211
ENST00000539097ENST00000332981HIF1Achr1462207906+PRKCHchr1461995792+7.89E-050.9999211
ENST00000539097ENST00000555082HIF1Achr1462207906+PRKCHchr1461995792+7.89E-050.9999211
ENST00000394997ENST00000332981HIF1Achr1462207906+PRKCHchr1461995793+0.0003503870.99964964
ENST00000394997ENST00000555082HIF1Achr1462207906+PRKCHchr1461995793+0.0003503870.99964964
ENST00000337138ENST00000332981HIF1Achr1462207906+PRKCHchr1461995793+0.0003470030.999653
ENST00000337138ENST00000555082HIF1Achr1462207906+PRKCHchr1461995793+0.0003470030.999653
ENST00000323441ENST00000332981HIF1Achr1462207906+PRKCHchr1461995793+0.0003648560.9996351
ENST00000323441ENST00000555082HIF1Achr1462207906+PRKCHchr1461995793+0.0003648560.9996351
ENST00000557538ENST00000332981HIF1Achr1462207906+PRKCHchr1461995793+7.89E-050.9999211
ENST00000557538ENST00000555082HIF1Achr1462207906+PRKCHchr1461995793+7.89E-050.9999211
ENST00000539097ENST00000332981HIF1Achr1462207906+PRKCHchr1461995793+7.89E-050.9999211
ENST00000539097ENST00000555082HIF1Achr1462207906+PRKCHchr1461995793+7.89E-050.9999211
ENST00000394997ENST00000332981HIF1Achr1462162557-PRKCHchr1461995793+0.0010892440.9989108
ENST00000394997ENST00000555082HIF1Achr1462162557-PRKCHchr1461995793+0.0010892440.9989108
ENST00000337138ENST00000332981HIF1Achr1462162557-PRKCHchr1461995793+0.0010892440.9989108
ENST00000337138ENST00000555082HIF1Achr1462162557-PRKCHchr1461995793+0.0010892440.9989108
ENST00000323441ENST00000332981HIF1Achr1462162557-PRKCHchr1461995793+0.0009468440.9990532
ENST00000323441ENST00000555082HIF1Achr1462162557-PRKCHchr1461995793+0.0009468440.9990532
ENST00000394997ENST00000332981HIF1Achr1462207905+PRKCHchr1461995792+0.0003503870.99964964
ENST00000394997ENST00000555082HIF1Achr1462207905+PRKCHchr1461995792+0.0003503870.99964964
ENST00000337138ENST00000332981HIF1Achr1462207905+PRKCHchr1461995792+0.0003470030.999653
ENST00000337138ENST00000555082HIF1Achr1462207905+PRKCHchr1461995792+0.0003470030.999653
ENST00000323441ENST00000332981HIF1Achr1462207905+PRKCHchr1461995792+0.0003648560.9996351
ENST00000323441ENST00000555082HIF1Achr1462207905+PRKCHchr1461995792+0.0003648560.9996351
ENST00000557538ENST00000332981HIF1Achr1462207905+PRKCHchr1461995792+7.89E-050.9999211
ENST00000557538ENST00000555082HIF1Achr1462207905+PRKCHchr1461995792+7.89E-050.9999211
ENST00000539097ENST00000332981HIF1Achr1462207905+PRKCHchr1461995792+7.89E-050.9999211
ENST00000539097ENST00000555082HIF1Achr1462207905+PRKCHchr1461995792+7.89E-050.9999211

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36343_36343_1_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000323441_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_2_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000323441_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_3_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000337138_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_4_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000337138_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_5_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000394997_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_6_HIF1A-PRKCH_HIF1A_chr14_62162557_ENST00000394997_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=217AA_BP=12
MEGAGGANDKKKDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEA
ENEDDLFEAILNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDP

--------------------------------------------------------------

>36343_36343_7_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000323441_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_8_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000323441_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_9_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000337138_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_10_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000337138_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_11_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000394997_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_12_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000394997_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_13_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000539097_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_14_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000539097_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_15_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000557538_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_16_HIF1A-PRKCH_HIF1A_chr14_62207905_ENST00000557538_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_17_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000323441_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_18_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000323441_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_19_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000323441_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_20_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000323441_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_21_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000337138_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_22_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000337138_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_23_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000337138_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_24_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000337138_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=903AA_BP=695
MEGAGGANDKKKISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMNC
FYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRGR
TMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEEL
LGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTECV
LKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLAM
SPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKLF
AEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTKD
RMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFGM
CKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFMT
KNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSPE

--------------------------------------------------------------

>36343_36343_25_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000394997_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_26_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000394997_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_27_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000394997_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_28_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000394997_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=904AA_BP=696
MEGAGGANDKKNRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISYLRVRKLLDAGDLDIEDDMKAQMN
CFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVKKGKEQNTQRSFFLRMKCTLTSRG
RTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRHSLDMKFSYCDERITELMGYEPEE
LLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIVCVNYVVSGIIQHDLIFSLQQTEC
VLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLEEVPLYNDVMLPSPNEKLQNINLA
MSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSPSEYCFYVDSDMVNEFKLELVEKL
FAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQIQEPTANATTTTATTDELKTVTK
DRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALSQRDLKLDNVLLDHEGHCKLADFG
MCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAILNDEVVYPTWLHEDATGILKSFM
TKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLTPIDEGHLPMINQDEFRNFSYVSP

--------------------------------------------------------------

>36343_36343_29_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000539097_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_30_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000539097_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_31_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000539097_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_32_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000539097_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_33_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000557538_PRKCH_chr14_61995792_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_34_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000557538_PRKCH_chr14_61995792_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

--------------------------------------------------------------

>36343_36343_35_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000557538_PRKCH_chr14_61995793_ENST00000332981_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

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>36343_36343_36_HIF1A-PRKCH_HIF1A_chr14_62207906_ENST00000557538_PRKCH_chr14_61995793_ENST00000555082_length(amino acids)=927AA_BP=719
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr14:62207906/chr14:61995793)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HIF1A

Q9NWT6

.
FUNCTION: Hydroxylates HIF-1 alpha at 'Asn-803' in the C-terminal transactivation domain (CAD). Functions as an oxygen sensor and, under normoxic conditions, the hydroxylation prevents interaction of HIF-1 with transcriptional coactivators including Cbp/p300-interacting transactivator. Involved in transcriptional repression through interaction with HIF1A, VHL and histone deacetylases. Hydroxylates specific Asn residues within ankyrin repeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A and several other ARD-containing proteins. Also hydroxylates Asp and His residues within ARDs of ANK1 and TNKS2, respectively. Negatively regulates NOTCH1 activity, accelerating myogenic differentiation. Positively regulates ASB4 activity, promoting vascular differentiation. {ECO:0000269|PubMed:12042299, ECO:0000269|PubMed:12080085, ECO:0000269|PubMed:17003112, ECO:0000269|PubMed:17573339, ECO:0000269|PubMed:18299578, ECO:0000269|PubMed:19245366, ECO:0000269|PubMed:21177872, ECO:0000269|PubMed:21251231}.FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214615_621697.6666666666666736.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215615_621697.6666666666666827.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215615_621721.6666666666666851.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214615_621697.6666666666666736.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215615_621697.6666666666666827.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215615_621721.6666666666666851.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214615_621697.6666666666666736.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215615_621697.6666666666666827.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215615_621721.6666666666666851.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+121417_70697.6666666666666736.0DomainbHLH
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214228_298697.6666666666666736.0DomainPAS 2
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214302_345697.6666666666666736.0DomainNote=PAC
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+121485_158697.6666666666666736.0DomainPAS 1
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+121517_70697.6666666666666827.0DomainbHLH
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215228_298697.6666666666666827.0DomainPAS 2
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215302_345697.6666666666666827.0DomainNote=PAC
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+121585_158697.6666666666666827.0DomainPAS 1
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+121517_70721.6666666666666851.0DomainbHLH
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215228_298721.6666666666666851.0DomainPAS 2
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215302_345721.6666666666666851.0DomainNote=PAC
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+121585_158721.6666666666666851.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+121417_70697.6666666666666736.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214228_298697.6666666666666736.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214302_345697.6666666666666736.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+121485_158697.6666666666666736.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+121517_70697.6666666666666827.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215228_298697.6666666666666827.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215302_345697.6666666666666827.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+121585_158697.6666666666666827.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+121517_70721.6666666666666851.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215228_298721.6666666666666851.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215302_345721.6666666666666851.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+121585_158721.6666666666666851.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121417_70697.6666666666666736.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214228_298697.6666666666666736.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214302_345697.6666666666666736.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121485_158697.6666666666666736.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121517_70697.6666666666666827.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215228_298697.6666666666666827.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215302_345697.6666666666666827.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121585_158697.6666666666666827.0DomainPAS 1
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121517_70721.6666666666666851.0DomainbHLH
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215228_298721.6666666666666851.0DomainPAS 2
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215302_345721.6666666666666851.0DomainNote=PAC
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121585_158721.6666666666666851.0DomainPAS 1
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215718_721721.6666666666666851.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215718_721721.6666666666666851.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215718_721721.6666666666666851.0MotifNuclear localization signal
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214170_191697.6666666666666736.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+121421_30697.6666666666666736.0RegionDNA-binding
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214380_417697.6666666666666736.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214401_603697.6666666666666736.0RegionNote=ODD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214531_575697.6666666666666736.0RegionNote=NTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214556_572697.6666666666666736.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215170_191697.6666666666666827.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+121521_30697.6666666666666827.0RegionDNA-binding
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215380_417697.6666666666666827.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215401_603697.6666666666666827.0RegionNote=ODD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215531_575697.6666666666666827.0RegionNote=NTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215556_572697.6666666666666827.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215170_191721.6666666666666851.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+121521_30721.6666666666666851.0RegionDNA-binding
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215380_417721.6666666666666851.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215401_603721.6666666666666851.0RegionNote=ODD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215531_575721.6666666666666851.0RegionNote=NTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215556_572721.6666666666666851.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214170_191697.6666666666666736.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+121421_30697.6666666666666736.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214380_417697.6666666666666736.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214401_603697.6666666666666736.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214531_575697.6666666666666736.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214556_572697.6666666666666736.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215170_191697.6666666666666827.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+121521_30697.6666666666666827.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215380_417697.6666666666666827.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215401_603697.6666666666666827.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215531_575697.6666666666666827.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215556_572697.6666666666666827.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215170_191721.6666666666666851.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+121521_30721.6666666666666851.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215380_417721.6666666666666851.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215401_603721.6666666666666851.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215531_575721.6666666666666851.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215556_572721.6666666666666851.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214170_191697.6666666666666736.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+121421_30697.6666666666666736.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214380_417697.6666666666666736.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214401_603697.6666666666666736.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214531_575697.6666666666666736.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214556_572697.6666666666666736.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215170_191697.6666666666666827.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+121521_30697.6666666666666827.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215380_417697.6666666666666827.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215401_603697.6666666666666827.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215531_575697.6666666666666827.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215556_572697.6666666666666827.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215170_191721.6666666666666851.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+121521_30721.6666666666666851.0RegionDNA-binding
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215380_417721.6666666666666851.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215401_603721.6666666666666851.0RegionNote=ODD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215531_575721.6666666666666851.0RegionNote=NTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215556_572721.6666666666666851.0RegionNote=C-terminal VHL recognition site
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981914615_683477.6666666666667684.0DomainAGC-kinase C-terminal
TgenePRKCHchr14:62207905chr14:61995792ENST00000332981914615_683477.6666666666667684.0DomainAGC-kinase C-terminal
TgenePRKCHchr14:62207906chr14:61995792ENST00000332981914615_683477.6666666666667684.0DomainAGC-kinase C-terminal
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981914615_683477.6666666666667684.0DomainAGC-kinase C-terminal

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114615_62111.666666666666666736.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115615_62111.666666666666666827.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115615_6210851.0Compositional biasNote=Poly-Thr
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-11417_7011.666666666666666736.0DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114228_29811.666666666666666736.0DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114302_34511.666666666666666736.0DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-11485_15811.666666666666666736.0DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-11517_7011.666666666666666827.0DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115228_29811.666666666666666827.0DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115302_34511.666666666666666827.0DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-11585_15811.666666666666666827.0DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-11517_700851.0DomainbHLH
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115228_2980851.0DomainPAS 2
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115302_3450851.0DomainNote=PAC
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-11585_1580851.0DomainPAS 1
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114718_72111.666666666666666736.0MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115718_72111.666666666666666827.0MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115718_7210851.0MotifNuclear localization signal
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214718_721697.6666666666666736.0MotifNuclear localization signal
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215718_721697.6666666666666827.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214718_721697.6666666666666736.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215718_721697.6666666666666827.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214718_721697.6666666666666736.0MotifNuclear localization signal
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215718_721697.6666666666666827.0MotifNuclear localization signal
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114170_19111.666666666666666736.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-11421_3011.666666666666666736.0RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114380_41711.666666666666666736.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114401_60311.666666666666666736.0RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114531_57511.666666666666666736.0RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114556_57211.666666666666666736.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114576_78511.666666666666666736.0RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-114786_82611.666666666666666736.0RegionNote=CTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115170_19111.666666666666666827.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-11521_3011.666666666666666827.0RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115380_41711.666666666666666827.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115401_60311.666666666666666827.0RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115531_57511.666666666666666827.0RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115556_57211.666666666666666827.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115576_78511.666666666666666827.0RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-115786_82611.666666666666666827.0RegionNote=CTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115170_1910851.0RegionRequired for heterodimer formation with ARNT
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-11521_300851.0RegionDNA-binding
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115380_4170851.0RegionNote=N-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115401_6030851.0RegionNote=ODD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115531_5750851.0RegionNote=NTAD
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115556_5720851.0RegionNote=C-terminal VHL recognition site
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115576_7850851.0RegionNote=ID
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-115786_8260851.0RegionNote=CTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214576_785697.6666666666666736.0RegionNote=ID
HgeneHIF1Achr14:62207905chr14:61995792ENST00000323441+1214786_826697.6666666666666736.0RegionNote=CTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215576_785697.6666666666666827.0RegionNote=ID
HgeneHIF1Achr14:62207905chr14:61995792ENST00000337138+1215786_826697.6666666666666827.0RegionNote=CTAD
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215576_785721.6666666666666851.0RegionNote=ID
HgeneHIF1Achr14:62207905chr14:61995792ENST00000539097+1215786_826721.6666666666666851.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214576_785697.6666666666666736.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995792ENST00000323441+1214786_826697.6666666666666736.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215576_785697.6666666666666827.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995792ENST00000337138+1215786_826697.6666666666666827.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215576_785721.6666666666666851.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995792ENST00000539097+1215786_826721.6666666666666851.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214576_785697.6666666666666736.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000323441+1214786_826697.6666666666666736.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215576_785697.6666666666666827.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000337138+1215786_826697.6666666666666827.0RegionNote=CTAD
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215576_785721.6666666666666851.0RegionNote=ID
HgeneHIF1Achr14:62207906chr14:61995793ENST00000539097+1215786_826721.6666666666666851.0RegionNote=CTAD
TgenePRKCHchr14:62162557chr14:61995793ENST000003329819141_118477.6666666666667684.0DomainC2
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981914355_614477.6666666666667684.0DomainProtein kinase
TgenePRKCHchr14:62207905chr14:61995792ENST000003329819141_118477.6666666666667684.0DomainC2
TgenePRKCHchr14:62207905chr14:61995792ENST00000332981914355_614477.6666666666667684.0DomainProtein kinase
TgenePRKCHchr14:62207906chr14:61995792ENST000003329819141_118477.6666666666667684.0DomainC2
TgenePRKCHchr14:62207906chr14:61995792ENST00000332981914355_614477.6666666666667684.0DomainProtein kinase
TgenePRKCHchr14:62207906chr14:61995793ENST000003329819141_118477.6666666666667684.0DomainC2
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981914355_614477.6666666666667684.0DomainProtein kinase
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981914361_369477.6666666666667684.0Nucleotide bindingATP
TgenePRKCHchr14:62207905chr14:61995792ENST00000332981914361_369477.6666666666667684.0Nucleotide bindingATP
TgenePRKCHchr14:62207906chr14:61995792ENST00000332981914361_369477.6666666666667684.0Nucleotide bindingATP
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981914361_369477.6666666666667684.0Nucleotide bindingATP
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981914171_222477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62162557chr14:61995793ENST00000332981914245_295477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCHchr14:62207905chr14:61995792ENST00000332981914171_222477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62207905chr14:61995792ENST00000332981914245_295477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCHchr14:62207906chr14:61995792ENST00000332981914171_222477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62207906chr14:61995792ENST00000332981914245_295477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 2
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981914171_222477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 1
TgenePRKCHchr14:62207906chr14:61995793ENST00000332981914245_295477.6666666666667684.0Zinc fingerPhorbol-ester/DAG-type 2


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Fusion Protein Structures

check button PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.
Fusion protein PDB link (fusion AA seq ID in FusionPDB)HgeneHchrHbpHstrandTgeneTchrTbpTstrandAA seqLen(AA seq)
PDB file >>>1721_HIF1A_62207906_PRKCH_61995793_ranked_0.pdbHIF1A6220790562207906ENST00000555082PRKCHchr1461995793+
MSSQCRSLENKFVFLKEGLGNSKPEELEEIRIENGRISSERRKEKSRDAARSRRSKESEVFYELAHQLPLPHNVSSHLDKASVMRLTISY
LRVRKLLDAGDLDIEDDMKAQMNCFYLKALDGFVMVLTDDGDMIYISDNVNKYMGLTQFELTGHSVFDFTHPCDHEEMREMLTHRNGLVK
KGKEQNTQRSFFLRMKCTLTSRGRTMNIKSATWKVLHCTGHIHVYDTNSNQPQCGYKKPPMTCLVLICEPIPHPSNIEIPLDSKTFLSRH
SLDMKFSYCDERITELMGYEPEELLGRSIYEYYHALDSDHLTKTHHDMFTKGQVTTGQYRMLAKRGGYVWVETQATVIYNTKNSQPQCIV
CVNYVVSGIIQHDLIFSLQQTECVLKPVESSDMKMTQLFTKVESEDTSSLFDKLKKEPDALTLLAPAAGDTIISLDFGSNDTETDDQQLE
EVPLYNDVMLPSPNEKLQNINLAMSPLPTAETPKPLRSSADPALNQEVALKLEPNPESLELSFTMPQIQDQTPSPSDGSTRQSSPEPNSP
SEYCFYVDSDMVNEFKLELVEKLFAEDTEAKNPFSTQDTDLDLEMLAPYIPMDDDFQLRSFDQLSPLESSSASPESASPQSTVTVFQQTQ
IQEPTANATTTTATTDELKTVTKDRMEDIKILIASPSPTHIHKETTSATSSPYRDTQSRTASPNRAGKGVIEQTEKSHPRSPNVLSVALS
QRDLKLDNVLLDHEGHCKLADFGMCKEGICNGVTTATFCGTPDYIAPEILQEMLYGPAVDWWAMGVLLYEMLCGHAPFEAENEDDLFEAI
LNDEVVYPTWLHEDATGILKSFMTKNPTMRLGSLTQGGEHAILRHPFFKEIDWAQLNHRQIEPPFRPRIKSREDVSNFDPDFIKEEPVLT
927


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pLDDT score distribution

check button pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
HIF1A_pLDDT.png
all structure
all structure

all structure

check button pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.
all structure


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Ramachandran Plot of Fusion Protein Structure


check button Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.
Fusion AA seq ID in FusionPDB and their Ramachandran plots

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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HIF1A
PRKCH


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with
HgeneHIF1Achr14:62162557chr14:61995793ENST00000323441-1141_40111.666666666666666736.0TSGA10
HgeneHIF1Achr14:62162557chr14:61995793ENST00000337138-1151_40111.666666666666666827.0TSGA10
HgeneHIF1Achr14:62162557chr14:61995793ENST00000539097-1151_4010851.0TSGA10


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Related Drugs to HIF1A-PRKCH


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HIF1A-PRKCH


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource