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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HIP1-STYXL1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HIP1-STYXL1
	FusionPDB ID: 36393
	FusionGDB2.0 ID: 36393
		Hgene	Tgene
	Gene symbol	HIP1	STYXL1
	Gene ID	3092	51657
	Gene name	huntingtin interacting protein 1	serine/threonine/tyrosine interacting like 1
	Synonyms	HIP-I\|ILWEQ\|SHON\|SHONbeta\|SHONgamma	DUSP24\|MK-STYX\|MKSTYX
	Cytomap	7q11.23	7q11.23
	Type of gene	protein-coding	protein-coding
	Description	huntingtin-interacting protein 1huntingtin-interacting protein I	serine/threonine/tyrosine-interacting-like protein 1dual specificity phosphatase 24 (putative)dual specificity phosphatase inhibitor MK-STYXdual specificity protein phosphatase 24inactive dual specificity protein phosphatase MK-STYXmap kinase phospha
	Modification date	20200313	20200313
	UniProtAcc	O75146	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000336926, ENST00000434438, ENST00000479835,	ENST00000460184, ENST00000248600, ENST00000340062, ENST00000359697, ENST00000360591, ENST00000431581, ENST00000451157,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 9 X 5=270	8 X 7 X 6=336
	# samples	7	9
	** MAII score	log2(7/270*10)=-1.94753258010586 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(9/336*10)=-1.90046432644909 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HIP1 [Title/Abstract] AND STYXL1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HIP1(75368119)-STYXL1(75634722), # samples:2
Anticipated loss of major functional domain due to fusion event.	HIP1-STYXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIP1-STYXL1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIP1-STYXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIP1-STYXL1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIP1	GO:0006915	apoptotic process	11788820
Hgene	HIP1	GO:0006919	activation of cysteine-type endopeptidase activity involved in apoptotic process	11788820
Hgene	HIP1	GO:0042981	regulation of apoptotic process	11788820
Hgene	HIP1	GO:0048268	clathrin coat assembly	11577110\|11889126
Hgene	HIP1	GO:0050821	protein stabilization	14732715
Hgene	HIP1	GO:0097190	apoptotic signaling pathway	11007801
Tgene	STYXL1	GO:0032515	negative regulation of phosphoprotein phosphatase activity	24709986

Fusion gene breakpoints across HIP1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across STYXL1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	OV	TCGA-24-1558-01A	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-
ChimerDB4	OV	TCGA-24-1558	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000336926	HIP1	chr7	75368119	-	ENST00000248600	STYXL1	chr7	75634722	-	766	147	27	635	202
ENST00000336926	HIP1	chr7	75368119	-	ENST00000359697	STYXL1	chr7	75634722	-	762	147	27	635	202
ENST00000336926	HIP1	chr7	75368119	-	ENST00000340062	STYXL1	chr7	75634722	-	762	147	27	635	202
ENST00000336926	HIP1	chr7	75368119	-	ENST00000360591	STYXL1	chr7	75634722	-	761	147	27	635	202
ENST00000336926	HIP1	chr7	75368119	-	ENST00000431581	STYXL1	chr7	75634722	-	695	147	27	635	202
ENST00000336926	HIP1	chr7	75368119	-	ENST00000451157	STYXL1	chr7	75634722	-	1094	147	27	542	171
ENST00000434438	HIP1	chr7	75368119	-	ENST00000248600	STYXL1	chr7	75634722	-	760	141	21	629	202
ENST00000434438	HIP1	chr7	75368119	-	ENST00000359697	STYXL1	chr7	75634722	-	756	141	21	629	202
ENST00000434438	HIP1	chr7	75368119	-	ENST00000340062	STYXL1	chr7	75634722	-	756	141	21	629	202
ENST00000434438	HIP1	chr7	75368119	-	ENST00000360591	STYXL1	chr7	75634722	-	755	141	21	629	202
ENST00000434438	HIP1	chr7	75368119	-	ENST00000431581	STYXL1	chr7	75634722	-	689	141	21	629	202
ENST00000434438	HIP1	chr7	75368119	-	ENST00000451157	STYXL1	chr7	75634722	-	1088	141	21	536	171
ENST00000336926	HIP1	chr7	75368118	-	ENST00000248600	STYXL1	chr7	75634722	-	766	147	27	635	202
ENST00000336926	HIP1	chr7	75368118	-	ENST00000359697	STYXL1	chr7	75634722	-	762	147	27	635	202
ENST00000336926	HIP1	chr7	75368118	-	ENST00000340062	STYXL1	chr7	75634722	-	762	147	27	635	202
ENST00000336926	HIP1	chr7	75368118	-	ENST00000360591	STYXL1	chr7	75634722	-	761	147	27	635	202
ENST00000336926	HIP1	chr7	75368118	-	ENST00000431581	STYXL1	chr7	75634722	-	695	147	27	635	202
ENST00000336926	HIP1	chr7	75368118	-	ENST00000451157	STYXL1	chr7	75634722	-	1094	147	27	542	171
ENST00000434438	HIP1	chr7	75368118	-	ENST00000248600	STYXL1	chr7	75634722	-	760	141	21	629	202
ENST00000434438	HIP1	chr7	75368118	-	ENST00000359697	STYXL1	chr7	75634722	-	756	141	21	629	202
ENST00000434438	HIP1	chr7	75368118	-	ENST00000340062	STYXL1	chr7	75634722	-	756	141	21	629	202
ENST00000434438	HIP1	chr7	75368118	-	ENST00000360591	STYXL1	chr7	75634722	-	755	141	21	629	202
ENST00000434438	HIP1	chr7	75368118	-	ENST00000431581	STYXL1	chr7	75634722	-	689	141	21	629	202
ENST00000434438	HIP1	chr7	75368118	-	ENST00000451157	STYXL1	chr7	75634722	-	1088	141	21	536	171

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000336926	ENST00000248600	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.00312964	0.99687034
ENST00000336926	ENST00000359697	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.003278869	0.9967211
ENST00000336926	ENST00000340062	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.003278869	0.9967211
ENST00000336926	ENST00000360591	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.003332549	0.99666744
ENST00000336926	ENST00000431581	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.002206229	0.9977938
ENST00000336926	ENST00000451157	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.001667592	0.99833244
ENST00000434438	ENST00000248600	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.002812457	0.99718755
ENST00000434438	ENST00000359697	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.002962833	0.9970372
ENST00000434438	ENST00000340062	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.002962833	0.9970372
ENST00000434438	ENST00000360591	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.003011298	0.9969887
ENST00000434438	ENST00000431581	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.002068375	0.9979316
ENST00000434438	ENST00000451157	HIP1	chr7	75368119	-	STYXL1	chr7	75634722	-	0.001279315	0.9987207
ENST00000336926	ENST00000248600	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.00312964	0.99687034
ENST00000336926	ENST00000359697	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.003278869	0.9967211
ENST00000336926	ENST00000340062	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.003278869	0.9967211
ENST00000336926	ENST00000360591	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.003332549	0.99666744
ENST00000336926	ENST00000431581	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.002206229	0.9977938
ENST00000336926	ENST00000451157	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.001667592	0.99833244
ENST00000434438	ENST00000248600	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.002812457	0.99718755
ENST00000434438	ENST00000359697	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.002962833	0.9970372
ENST00000434438	ENST00000340062	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.002962833	0.9970372
ENST00000434438	ENST00000360591	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.003011298	0.9969887
ENST00000434438	ENST00000431581	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.002068375	0.9979316
ENST00000434438	ENST00000451157	HIP1	chr7	75368118	-	STYXL1	chr7	75634722	-	0.001279315	0.9987207

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36393_36393_1_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000248600_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_2_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000340062_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_3_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000359697_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_4_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000360591_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_5_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000431581_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_6_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000336926_STYXL1_chr7_75634722_ENST00000451157_length(amino acids)=171AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF

--------------------------------------------------------------

>36393_36393_7_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000248600_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_8_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000340062_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_9_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000359697_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_10_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000360591_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_11_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000431581_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_12_HIP1-STYXL1_HIP1_chr7_75368118_ENST00000434438_STYXL1_chr7_75634722_ENST00000451157_length(amino acids)=171AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF

--------------------------------------------------------------

>36393_36393_13_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000248600_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_14_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000340062_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_15_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000359697_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_16_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000360591_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_17_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000431581_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_18_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000336926_STYXL1_chr7_75634722_ENST00000451157_length(amino acids)=171AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF

--------------------------------------------------------------

>36393_36393_19_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000248600_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_20_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000340062_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

--------------------------------------------------------------

>36393_36393_21_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000359697_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

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>36393_36393_22_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000360591_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

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>36393_36393_23_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000431581_length(amino acids)=202AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF
AGDADKLLHIRIEDSPEAQILPFLRHMCHFIEIHHHLGSVILIFSTQGISRSCAAIIAYLMHSNEQTLQRSWAYVKKCKNNMCPNRGLVS

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>36393_36393_24_HIP1-STYXL1_HIP1_chr7_75368119_ENST00000434438_STYXL1_chr7_75634722_ENST00000451157_length(amino acids)=171AA_BP=39
MDRMASSMKQVPNPLPKVLSRRGVGAGLEAAERESFERTQELDAFQPYPIEIVPGKVFVGNFSQACDPKIQKDLKIKAHVNVSMDTGPFF

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:75368119/chr7:75634722)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIP1 O75146	.
FUNCTION: Component of clathrin-coated pits and vesicles, that may link the endocytic machinery to the actin cytoskeleton. Binds 3-phosphoinositides (via ENTH domain). May act through the ENTH domain to promote cell survival by stabilizing receptor tyrosine kinases following ligand-induced endocytosis. {ECO:0000269\|PubMed:11889126, ECO:0000269\|PubMed:14732715}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000248600

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000340062

159_302

55.0

218.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000359697

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000431581

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000248600

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000340062

159_302

55.0

218.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000359697

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000431581

159_302

151.0

314.0

Domain

Tyrosine-protein phosphatase

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000336926

368_644

40.0

1038.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000434438

368_644

40.0

987.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000336926

368_644

40.0

1038.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000434438

368_644

40.0

987.0

Coiled coil

Ontology_term=ECO:0000255

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000336926

32_160

40.0

1038.0

Domain

ENTH

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000336926

771_1012

40.0

1038.0

Domain

I/LWEQ

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000434438

32_160

40.0

987.0

Domain

ENTH

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000434438

771_1012

40.0

987.0

Domain

I/LWEQ

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000336926

32_160

40.0

1038.0

Domain

ENTH

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000336926

771_1012

40.0

1038.0

Domain

I/LWEQ

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000434438

32_160

40.0

987.0

Domain

ENTH

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000434438

771_1012

40.0

987.0

Domain

I/LWEQ

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000336926

410_491

40.0

1038.0

Region

Note=pDED

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000336926

867_924

40.0

1038.0

Region

Important for actin binding

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000434438

410_491

40.0

987.0

Region

Note=pDED

Hgene

HIP1

chr7:75368118

chr7:75634722

ENST00000434438

867_924

40.0

987.0

Region

Important for actin binding

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000336926

410_491

40.0

1038.0

Region

Note=pDED

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000336926

867_924

40.0

1038.0

Region

Important for actin binding

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000434438

410_491

40.0

987.0

Region

Note=pDED

Hgene

HIP1

chr7:75368119

chr7:75634722

ENST00000434438

867_924

40.0

987.0

Region

Important for actin binding

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000248600

27_138

151.0

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000340062

27_138

55.0

218.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000359697

27_138

151.0

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368118

chr7:75634722

ENST00000431581

27_138

151.0

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000248600

27_138

151.0

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000340062

27_138

55.0

218.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000359697

27_138

151.0

314.0

Domain

Rhodanese

Tgene

STYXL1

chr7:75368119

chr7:75634722

ENST00000431581

27_138

151.0

314.0

Domain

Rhodanese

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HIP1

CFH, PFDN1, RPS10, EIF6, HTT, HIP1R, CLTC, IFT57, CASP8, MAPK6, ITSN1, BFAR, FBXO25, HIP1, REL, DAZAP2, MAP3K1, CCDC67, NTRK1, TMEM17, GAK, MYH9, GTSE1, Calml3, SMURF1, EGFR, CPNE2, TRIM25, CLTB, Hip1r, Ap2b1, ACTA1, PDGFRB, CASP1, AP2A1, DVL2, ESR2, APAF1, CASP9, KIAA1429, MAB21L2, FAM168A, LNX1, SYT17, EHHADH, RAD23B, GLS2, FAM49B, TCEA2, CFAP53, TCEANC, RPRM, LITAF, PLEKHA4, PLEC, ESR1, SMAP2, CIT, UBASH3A, BCAR1, Rnf183, NUPR1, AP2B1, B3GAT1, CLTA, DIRAS3, GJD3, RHOB, STX6, STX7, DNAJC6, KXD1, PLCD3, ZFP1, C10orf88, UBC,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HIP1
STYXL1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HIP1-STYXL1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HIP1-STYXL1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HIP1	C0023893	Liver Cirrhosis, Experimental	1	CTD_human