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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HIRA-ADAM2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HIRA-ADAM2
	FusionPDB ID: 36428
	FusionGDB2.0 ID: 36428
		Hgene	Tgene
	Gene symbol	HIRA	ADAM2
	Gene ID	7290	2515
	Gene name	histone cell cycle regulator	ADAM metallopeptidase domain 2
	Synonyms	DGCR1\|TUP1\|TUPLE1	CRYN1\|CRYN2\|CT15\|FTNB\|PH-30b\|PH30\|PH30-beta
	Cytomap	22q11.21	8p11.22
	Type of gene	protein-coding	protein-coding
	Description	protein HIRADiGeorge critical region gene 1HIR histone cell cycle regulation defective homolog ATUP1-like enhancer of split protein 1histone regulator A	disintegrin and metalloproteinase domain-containing protein 2cancer/testis antigen 15fertilin subunit beta
	Modification date	20200313	20200313
	UniProtAcc	P54198	Q9UKF5
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000263208, ENST00000340170, ENST00000541063, ENST00000546308, ENST00000464189,	ENST00000523181, ENST00000265708, ENST00000347580, ENST00000379853, ENST00000521880,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	18 X 15 X 9=2430	7 X 8 X 4=224
	# samples	23	10
	** MAII score	log2(23/2430*10)=-3.40125054754877 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(10/224*10)=-1.16349873228288 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HIRA [Title/Abstract] AND ADAM2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HIRA(19393309)-ADAM2(39627094), # samples:3
Anticipated loss of major functional domain due to fusion event.	HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a epigenetic factor due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a essential gene due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Hgene partner, which is a tumor suppressor due to the frame-shifted ORF. HIRA-ADAM2 seems lost the major protein functional domain in Tgene partner, which is a IUPHAR drug target due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HIRA	GO:0006336	DNA replication-independent nucleosome assembly	14718166

Fusion gene breakpoints across HIRA (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ADAM2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LUAD	TCGA-44-8117-01A	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000541063	HIRA	chr22	19393309	-	ENST00000347580	ADAM2	chr8	39627094	-	1937	397	542	1576	344
ENST00000541063	HIRA	chr22	19393309	-	ENST00000379853	ADAM2	chr8	39627094	-	1847	397	542	1486	314
ENST00000541063	HIRA	chr22	19393309	-	ENST00000265708	ADAM2	chr8	39627094	-	1937	397	542	1576	344
ENST00000541063	HIRA	chr22	19393309	-	ENST00000521880	ADAM2	chr8	39627094	-	1452	397	542	1387	281
ENST00000546308	HIRA	chr22	19393309	-	ENST00000347580	ADAM2	chr8	39627094	-	2095	555	700	1734	344
ENST00000546308	HIRA	chr22	19393309	-	ENST00000379853	ADAM2	chr8	39627094	-	2005	555	700	1644	314
ENST00000546308	HIRA	chr22	19393309	-	ENST00000265708	ADAM2	chr8	39627094	-	2095	555	700	1734	344
ENST00000546308	HIRA	chr22	19393309	-	ENST00000521880	ADAM2	chr8	39627094	-	1610	555	700	1545	281

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000541063	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000387983	0.99961203
ENST00000541063	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.00168073	0.9983192
ENST00000541063	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000387983	0.99961203
ENST00000541063	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.001188296	0.9988117
ENST00000546308	ENST00000347580	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000513156	0.9994868
ENST00000546308	ENST00000379853	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.002234545	0.9977654
ENST00000546308	ENST00000265708	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.000513156	0.9994868
ENST00000546308	ENST00000521880	HIRA	chr22	19393309	-	ADAM2	chr8	39627094	-	0.001529105	0.99847084

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36428_36428_1_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000265708_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------

>36428_36428_2_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000347580_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------

>36428_36428_3_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000379853_length(amino acids)=314AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVC
RNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFL

--------------------------------------------------------------

>36428_36428_4_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000541063_ADAM2_chr8_39627094_ENST00000521880_length(amino acids)=281AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD

--------------------------------------------------------------

>36428_36428_5_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000265708_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------

>36428_36428_6_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000347580_length(amino acids)=344AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADNLQCGKLICKYVGKFLLQIPRATIIYANISGHL
CIAVEFASDHADSQKMWIKDGTSCGSNKVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNF

--------------------------------------------------------------

>36428_36428_7_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000379853_length(amino acids)=314AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEADGHLCIAVEFASDHADSQKMWIKDGTSCGSNKVC
RNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCHCSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFL

--------------------------------------------------------------

>36428_36428_8_HIRA-ADAM2_HIRA_chr22_19393309_ENST00000546308_ADAM2_chr8_39627094_ENST00000521880_length(amino acids)=281AA_BP=
MEAGEECDCGTEQDCALIGETCCDIATCRFKAGSNCAEGPCCENCLFMSKERMCRPSFEECDLPEYCNGSSASCPENHYVQTGHPCGLNQ
WICIDGVCMSGDKQCTDTFGKEVEFGPSECYSHLNSKTDVSGNCGISDSGYTQCEVCRNQRCVSSSYLGYDCTTDKCNDRGVCNNKKHCH
CSASYLPPDCSVQSDLWPGGSIDSGNFPPVAIPARLPERRYIENIYHSKPMRWPFFLFIPFFIIFCVLIAIMVKVNFQRKKWRTEDYSSD

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr22:19393309/chr8:39627094)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HIRA P54198	ADAM2 Q9UKF5
FUNCTION: Cooperates with ASF1A to promote replication-independent chromatin assembly. Required for the periodic repression of histone gene transcription during the cell cycle. Required for the formation of senescence-associated heterochromatin foci (SAHF) and efficient senescence-associated cell cycle exit. {ECO:0000269\|PubMed:12370293, ECO:0000269\|PubMed:14718166, ECO:0000269\|PubMed:15621527}.	FUNCTION: May be involved in spermatogenesis and fertilization. Seems to be a non catalytic metalloprotease-like protein.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

11_53

132.33333333333334

1018.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

68_107

132.33333333333334

1018.0

Repeat

Note=WD 2

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

11_53

132.33333333333334

811.0

Repeat

Note=WD 1

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

68_107

132.33333333333334

811.0

Repeat

Note=WD 2

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

477_606

342.6666666666667

788.6666666666666

Compositional bias

Note=Cys-rich

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

477_606

323.6666666666667

796.3333333333334

Compositional bias

Note=Cys-rich

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

384_473

342.6666666666667

788.6666666666666

Domain

Disintegrin

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

612_645

342.6666666666667

788.6666666666666

Domain

Note=EGF-like

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

384_473

323.6666666666667

796.3333333333334

Domain

Disintegrin

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

612_645

323.6666666666667

796.3333333333334

Domain

Note=EGF-like

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

708_735

342.6666666666667

788.6666666666666

Topological domain

Cytoplasmic

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

708_735

323.6666666666667

796.3333333333334

Topological domain

Cytoplasmic

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

687_707

342.6666666666667

788.6666666666666

Transmembrane

Helical

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

687_707

323.6666666666667

796.3333333333334

Transmembrane

Helical

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

408_412

132.33333333333334

1018.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

640_643

132.33333333333334

1018.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

805_808

132.33333333333334

1018.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

408_412

132.33333333333334

811.0

Compositional bias

Note=Poly-Gln

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

640_643

132.33333333333334

811.0

Compositional bias

Note=Poly-Lys

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

805_808

132.33333333333334

811.0

Compositional bias

Note=Poly-Val

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

439_475

132.33333333333334

1018.0

Region

Note=Required for repression of histone gene transcription

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

439_475

132.33333333333334

811.0

Region

Note=Required for repression of histone gene transcription

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

129_168

132.33333333333334

1018.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

172_211

132.33333333333334

1018.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

220_263

132.33333333333334

1018.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

266_322

132.33333333333334

1018.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000263208

326_367

132.33333333333334

1018.0

Repeat

Note=WD 7

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

129_168

132.33333333333334

811.0

Repeat

Note=WD 3

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

172_211

132.33333333333334

811.0

Repeat

Note=WD 4

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

220_263

132.33333333333334

811.0

Repeat

Note=WD 5

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

266_322

132.33333333333334

811.0

Repeat

Note=WD 6

Hgene

HIRA

chr22:19393309

chr8:39627094

ENST00000340170

326_367

132.33333333333334

811.0

Repeat

Note=WD 7

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

178_375

342.6666666666667

788.6666666666666

Domain

Peptidase M12B

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

178_375

323.6666666666667

796.3333333333334

Domain

Peptidase M12B

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000265708

175_686

342.6666666666667

788.6666666666666

Topological domain

Extracellular

Tgene

ADAM2

chr22:19393309

chr8:39627094

ENST00000347580

175_686

323.6666666666667

796.3333333333334

Topological domain

Extracellular

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HIRA
ADAM2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	421_479	132.33333333333334	1018.0	ASF1A
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	421_479	132.33333333333334	811.0	ASF1A
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	421_729	132.33333333333334	1018.0	CCNA1
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	421_729	132.33333333333334	811.0	CCNA1
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	593_826	132.33333333333334	1018.0	histone H2B
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	593_826	132.33333333333334	811.0	histone H2B
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	738_1017	132.33333333333334	1018.0	histone H4
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	738_1017	132.33333333333334	811.0	histone H4
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	594_739	132.33333333333334	1018.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000263208	-	5	25	740_828	132.33333333333334	1018.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	594_739	132.33333333333334	811.0	PAX3
Hgene	HIRA	chr22:19393309	chr8:39627094	ENST00000340170	-	5	21	740_828	132.33333333333334	811.0	PAX3

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Related Drugs to HIRA-ADAM2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HIRA-ADAM2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source