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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HK1-FUS

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HK1-FUS
FusionPDB ID: 36575
FusionGDB2.0 ID: 36575
HgeneTgene
Gene symbol

HK1

FUS

Gene ID

255061

2521

Gene nametachykinin precursor 4FUS RNA binding protein
SynonymsEK|HK-1|HK1|PPT-CALS6|ETM4|FUS1|HNRNPP2|POMP75|TLS
Cytomap

17q21.33

16p11.2

Type of geneprotein-codingprotein-coding
Descriptiontachykinin-4endokininpreprotachykinin-Ctachykinin 4 (hemokinin)RNA-binding protein FUS75 kDa DNA-pairing proteinfus-like proteinfused in sarcomafusion gene in myxoid liposarcomaheterogeneous nuclear ribonucleoprotein P2oncogene FUSoncogene TLStranslocated in liposarcoma protein
Modification date2020031320200329
UniProtAcc

P19367

P35637

Ensembl transtripts involved in fusion geneENST idsENST00000494253, ENST00000298649, 
ENST00000359426, ENST00000360289, 
ENST00000404387, ENST00000448642, 
ENST00000254108, ENST00000380244, 
ENST00000568685, ENST00000474990, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score15 X 16 X 5=120020 X 13 X 10=2600
# samples 2122
** MAII scorelog2(21/1200*10)=-2.51457317282976
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(22/2600*10)=-3.56293619439116
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)

PubMed: HK1 [Title/Abstract] AND FUS [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HK1(71103745)-FUS(31199646), # samples:1
Anticipated loss of major functional domain due to fusion event.HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
HK1-FUS seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHK1

GO:1902093

positive regulation of flagellated sperm motility

17437961

TgeneFUS

GO:0006355

regulation of transcription, DNA-templated

26124092

TgeneFUS

GO:0006357

regulation of transcription by RNA polymerase II

25453086

TgeneFUS

GO:0008380

RNA splicing

26124092

TgeneFUS

GO:0043484

regulation of RNA splicing

25453086|27731383

TgeneFUS

GO:0048255

mRNA stabilization

27378374

TgeneFUS

GO:0051260

protein homooligomerization

25453086

TgeneFUS

GO:1905168

positive regulation of double-strand break repair via homologous recombination

10567410


check buttonFusion gene breakpoints across HK1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across FUS (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4STADTCGA-FP-8211-01AHK1chr10

71103745

+FUSchr16

31199646

+


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000360289HK1chr1071103745+ENST00000254108FUSchr1631199646+18396894811470329
ENST00000360289HK1chr1071103745+ENST00000380244FUSchr1631199646+16356894811470329
ENST00000360289HK1chr1071103745+ENST00000568685FUSchr1631199646+16116894811473330
ENST00000448642HK1chr1071103745+ENST00000254108FUSchr1631199646+18707203891501370
ENST00000448642HK1chr1071103745+ENST00000380244FUSchr1631199646+16667203891501370
ENST00000448642HK1chr1071103745+ENST00000568685FUSchr1631199646+16427203891504371
ENST00000404387HK1chr1071103745+ENST00000254108FUSchr1631199646+138823801019339
ENST00000404387HK1chr1071103745+ENST00000380244FUSchr1631199646+118423801019339
ENST00000404387HK1chr1071103745+ENST00000568685FUSchr1631199646+116023801022340
ENST00000298649HK1chr1071103745+ENST00000254108FUSchr1631199646+14743241011105334
ENST00000298649HK1chr1071103745+ENST00000380244FUSchr1631199646+12703241011105334
ENST00000298649HK1chr1071103745+ENST00000568685FUSchr1631199646+12463241011108335
ENST00000359426HK1chr1071103745+ENST00000254108FUSchr1631199646+1480330501111353
ENST00000359426HK1chr1071103745+ENST00000380244FUSchr1631199646+1276330501111353
ENST00000359426HK1chr1071103745+ENST00000568685FUSchr1631199646+1252330501114354

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000360289ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0021162050.99788374
ENST00000360289ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0023915150.9976084
ENST00000360289ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0026537930.99734616
ENST00000448642ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0055281010.9944719
ENST00000448642ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0065354440.9934645
ENST00000448642ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0090644260.9909356
ENST00000404387ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0005558990.99944407
ENST00000404387ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0005899360.99941003
ENST00000404387ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0011564580.99884355
ENST00000298649ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0013623780.9986376
ENST00000298649ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0013932830.99860674
ENST00000298649ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0022286910.9977714
ENST00000359426ENST00000254108HK1chr1071103745+FUSchr1631199646+0.0014468160.9985532
ENST00000359426ENST00000380244HK1chr1071103745+FUSchr1631199646+0.0013924280.9986076
ENST00000359426ENST00000568685HK1chr1071103745+FUSchr1631199646+0.0019937210.9980063

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36575_36575_1_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000254108_length(amino acids)=334AA_BP=190
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNS
DNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRR
ADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGS

--------------------------------------------------------------

>36575_36575_2_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000380244_length(amino acids)=334AA_BP=190
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNS
DNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRR
ADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGS

--------------------------------------------------------------

>36575_36575_3_HK1-FUS_HK1_chr10_71103745_ENST00000298649_FUS_chr16_31199646_ENST00000568685_length(amino acids)=335AA_BP=191
MDCEHSLSLPCRGAEAWEIGIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDN
SDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATR
RADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGG

--------------------------------------------------------------

>36575_36575_4_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000254108_length(amino acids)=353AA_BP=209
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>36575_36575_5_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000380244_length(amino acids)=353AA_BP=209
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDW
FDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNE

--------------------------------------------------------------

>36575_36575_6_HK1-FUS_HK1_chr10_71103745_ENST00000359426_FUS_chr16_31199646_ENST00000568685_length(amino acids)=354AA_BP=210
MRRTDRPHACRPATPTASMIAAQLLAYYFTELKDDQVKKIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIP
DGSGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAID
WFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRN

--------------------------------------------------------------

>36575_36575_7_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000254108_length(amino acids)=329AA_BP=185
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTI
FVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNR
GGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGN

--------------------------------------------------------------

>36575_36575_8_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000380244_length(amino acids)=329AA_BP=185
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTI
FVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNR
GGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGN

--------------------------------------------------------------

>36575_36575_9_HK1-FUS_HK1_chr10_71103745_ENST00000360289_FUS_chr16_31199646_ENST00000568685_length(amino acids)=330AA_BP=186
MWWRGKMAKRALHDFIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDNSDNNT
IFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFN
RGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGG

--------------------------------------------------------------

>36575_36575_10_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000254108_length(amino acids)=339AA_BP=195
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
EQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVS
FATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGG

--------------------------------------------------------------

>36575_36575_11_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000380244_length(amino acids)=339AA_BP=195
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
EQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKVS
FATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPGG

--------------------------------------------------------------

>36575_36575_12_HK1-FUS_HK1_chr10_71103745_ENST00000404387_FUS_chr16_31199646_ENST00000568685_length(amino acids)=340AA_BP=196
MGQICQRESATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDFNPTATVKMLPTFVRSIPDGSGPRDQGSRHDS
AEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGEATVSFDDPPSAKAAIDWFDGKEFSGNPIKV
SFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDWKCPNPTCENMNFSWRNECNQCKAPKPDGPG

--------------------------------------------------------------

>36575_36575_13_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000254108_length(amino acids)=370AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGE
ATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDW
KCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGE

--------------------------------------------------------------

>36575_36575_14_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000380244_length(amino acids)=370AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKGE
ATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGDW
KCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRGE

--------------------------------------------------------------

>36575_36575_15_HK1-FUS_HK1_chr10_71103745_ENST00000448642_FUS_chr16_31199646_ENST00000568685_length(amino acids)=371AA_BP=9
MGQICQRESRQGLAMLPRLFLNPWRQVILLPQPPKVLGLQATAAEKPKLHLLAESEIDKYLYAMRLSDETLIDIMTRFRKEMKNGLSRDF
NPTATVKMLPTFVRSIPDGSGPRDQGSRHDSAEQDNSDNNTIFVQGLGENVTIESVADYFKQIGIIKTNKKTGQPMINLYTDRETGKLKG
EATVSFDDPPSAKAAIDWFDGKEFSGNPIKVSFATRRADFNRGGGNGRGGRGRGGPMGRGGYGGGGSGGGGRGGFPSGGGGGGGQQRAGD
WKCPNPTCENMNFSWRNECNQCKAPKPDGPGGGPGGSHMGGNYGDDRRGGRGGYDRGGYRGRGGDRGGFRGGRGGGDRGGFGPGKMDSRG

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr10:71103745/chr16:31199646)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HK1

P19367

FUS

P35637

FUNCTION: Catalyzes the phosphorylation of various hexoses, such as D-glucose, D-glucosamine, D-fructose, D-mannose and 2-deoxy-D-glucose, to hexose 6-phosphate (D-glucose 6-phosphate, D-glucosamine 6-phosphate, D-fructose 6-phosphate, D-mannose 6-phosphate and 2-deoxy-D-glucose 6-phosphate, respectively) (PubMed:1637300, PubMed:25316723, PubMed:27374331). Does not phosphorylate N-acetyl-D-glucosamine (PubMed:27374331). Mediates the initial step of glycolysis by catalyzing phosphorylation of D-glucose to D-glucose 6-phosphate (By similarity). Involved in innate immunity and inflammation by acting as a pattern recognition receptor for bacterial peptidoglycan (PubMed:27374331). When released in the cytosol, N-acetyl-D-glucosamine component of bacterial peptidoglycan inhibits the hexokinase activity of HK1 and causes its dissociation from mitochondrial outer membrane, thereby activating the NLRP3 inflammasome (PubMed:27374331). {ECO:0000250|UniProtKB:P05708, ECO:0000269|PubMed:1637300, ECO:0000269|PubMed:25316723, ECO:0000269|PubMed:27374331}.FUNCTION: DNA/RNA-binding protein that plays a role in various cellular processes such as transcription regulation, RNA splicing, RNA transport, DNA repair and damage response (PubMed:27731383). Binds to nascent pre-mRNAs and acts as a molecular mediator between RNA polymerase II and U1 small nuclear ribonucleoprotein thereby coupling transcription and splicing (PubMed:26124092). Binds also its own pre-mRNA and autoregulates its expression; this autoregulation mechanism is mediated by non-sense-mediated decay (PubMed:24204307). Plays a role in DNA repair mechanisms by promoting D-loop formation and homologous recombination during DNA double-strand break repair (PubMed:10567410). In neuronal cells, plays crucial roles in dendritic spine formation and stability, RNA transport, mRNA stability and synaptic homeostasis (By similarity). {ECO:0000250|UniProtKB:P56959, ECO:0000269|PubMed:10567410, ECO:0000269|PubMed:24204307, ECO:0000269|PubMed:26124092, ECO:0000269|PubMed:27731383}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+2181_1074.33333333333333917.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+2181_1075.33333333333333918.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+6221_1063.333333333333336906.0RegionMitochondrial-binding peptide (MBP)
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+3191_1079.33333333333333922.0RegionMitochondrial-binding peptide (MBP)
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615371_526266.3333333333333527.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615371_526265.3333333333333526.0Compositional biasNote=Arg/Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615285_371266.3333333333333527.0DomainRRM
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615285_371265.3333333333333526.0DomainRRM
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615422_453266.3333333333333527.0Zinc fingerRanBP2-type
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615422_453265.3333333333333526.0Zinc fingerRanBP2-type

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21816_45874.33333333333333917.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218464_90674.33333333333333917.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21816_45875.33333333333333918.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218464_90675.33333333333333918.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62216_45863.333333333333336906.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622464_90663.333333333333336906.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31916_45879.33333333333333922.0DomainHexokinase 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319464_90679.33333333333333922.0DomainHexokinase 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218425_42674.33333333333333917.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218532_53774.33333333333333917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218747_74874.33333333333333917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218784_78874.33333333333333917.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21884_8974.33333333333333917.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218425_42675.33333333333333918.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218532_53775.33333333333333918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218747_74875.33333333333333918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218784_78875.33333333333333918.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21884_8975.33333333333333918.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622425_42663.333333333333336906.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622532_53763.333333333333336906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622747_74863.333333333333336906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622784_78863.333333333333336906.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62284_8963.333333333333336906.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319425_42679.33333333333333922.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319532_53779.33333333333333922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319747_74879.33333333333333922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319784_78879.33333333333333922.0Nucleotide bindingATP 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31984_8979.33333333333333922.0Nucleotide bindingATP 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218172_17374.33333333333333917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218208_20974.33333333333333917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218208_44774.33333333333333917.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218291_29474.33333333333333917.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218413_41574.33333333333333917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218521_65574.33333333333333917.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218532_53674.33333333333333917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218603_60474.33333333333333917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218620_62174.33333333333333917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218656_65774.33333333333333917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218656_89574.33333333333333917.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218682_68374.33333333333333917.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21873_20774.33333333333333917.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+21884_9174.33333333333333917.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000298649+218861_86374.33333333333333917.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218172_17375.33333333333333918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218208_20975.33333333333333918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218208_44775.33333333333333918.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218291_29475.33333333333333918.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218413_41575.33333333333333918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218521_65575.33333333333333918.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218532_53675.33333333333333918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218603_60475.33333333333333918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218620_62175.33333333333333918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218656_65775.33333333333333918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218656_89575.33333333333333918.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218682_68375.33333333333333918.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21873_20775.33333333333333918.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+21884_9175.33333333333333918.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000359426+218861_86375.33333333333333918.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622172_17363.333333333333336906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622208_20963.333333333333336906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622208_44763.333333333333336906.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622291_29463.333333333333336906.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622413_41563.333333333333336906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622521_65563.333333333333336906.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622532_53663.333333333333336906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622603_60463.333333333333336906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622620_62163.333333333333336906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622656_65763.333333333333336906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622656_89563.333333333333336906.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622682_68363.333333333333336906.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62273_20763.333333333333336906.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+62284_9163.333333333333336906.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000360289+622861_86363.333333333333336906.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319172_17379.33333333333333922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319208_20979.33333333333333922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319208_44779.33333333333333922.0RegionHexokinase large subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319291_29479.33333333333333922.0RegionSubstrate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319413_41579.33333333333333922.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319521_65579.33333333333333922.0RegionHexokinase small subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319532_53679.33333333333333922.0RegionGlucose-6-phosphate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319603_60479.33333333333333922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319620_62179.33333333333333922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319656_65779.33333333333333922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319656_89579.33333333333333922.0RegionHexokinase large subdomain 2
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319682_68379.33333333333333922.0RegionSubstrate 2 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31973_20779.33333333333333922.0RegionHexokinase small subdomain 1
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+31984_9179.33333333333333922.0RegionGlucose-6-phosphate 1 binding
HgeneHK1chr10:71103745chr16:31199646ENST00000404387+319861_86379.33333333333333922.0RegionGlucose-6-phosphate 2 binding
TgeneFUSchr10:71103745chr16:31199646ENST00000254108615166_267266.3333333333333527.0Compositional biasNote=Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST000002541086151_165266.3333333333333527.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich
TgeneFUSchr10:71103745chr16:31199646ENST00000380244615166_267265.3333333333333526.0Compositional biasNote=Gly-rich
TgeneFUSchr10:71103745chr16:31199646ENST000003802446151_165265.3333333333333526.0Compositional biasNote=Gln/Gly/Ser/Tyr-rich


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors
FUSEIF6, USF2, PRMT1, PTBP2, SRRM1, SPI1, YBX1, ILF3, SF1, SRSF10, THRA, RXRA, RELA, OTUB1, ZMYM2, SARNP, TARDBP, Mapk13, DGCR8, Pds5a, Shoc2, Ccdc15, PCM1, SF3A2, SIRT7, SQSTM1, TDRD3, CUL3, CUL4A, CUL4B, CUL5, CUL2, CDK2, CUL1, COPS5, COPS6, DCUN1D1, CAND1, NEDD8, ARHGEF28, PA2G4, UBE2I, ATXN1L, GRB2, PIK3R2, HNRNPA3, NONO, EEF1A1, DYNC1H1, GSE1, MBD3, MRPS18B, SAP30BP, RPLP1, ESR1, FN1, VCAM1, TP63, IL7R, UBL4A, ITGA4, CTNNB1, ECM32, NAM8, SBP1, SKO1, VHR1, UPF1, LMNA, EWSR1, RBMX, PSMB7, ESRRA, MDH1, TAF15, SRSF9, SAFB2, TNIP1, KHDRBS3, NKD2, MAX, PARK2, SUV39H1, WBP4, HNRNPU, LARS, rev, RPA3, RPA2, RPA1, WWOX, HSPA5, VCP, SFPQ, YWHAZ, YWHAQ, PFN1, FASN, PGK1, CKB, ENO1, LDHB, PAICS, PHGDH, LDHA, GAPDH, PKM, ATXN2L, MTHFD1, ACACA, CA2, ALDOA, GPI, PYCRL, PFKL, PGM1, ABCA1, HPRT1, PM20D2, TKT, UBA1, PSMD12, CDH4, ANXA2P2, GNAS, PLCE1, TRPM4, SLC1A5, UBAP2, UBAP2L, LYZ, CKAP4, YPEL1, HIST4H4, H3F3A, H3F3B, HIST2H2BE, DDX42, HNRNPD, SYNCRIP, DHX40, SF3A1, SF3B3, SF3B4, SERBP1, FANCM, RAD54B, PCNA, PHB, TP73, RPL18, RPL9, RPS9, TBPL1, TRIP4, DNAJC10, SAE1, DLD, GOT2, ATP5A1, GSTP1, HARS2, SLC25A3, KPNA2, RAB7A, SPATA6, UACA, STATH, ANXA5, MAP3K3, UBC, TUBB, CFL1, TUBA1A, ACTB, HNRNPF, HNRNPH1, DHX15, CPSF6, SF3A3, HNRNPK, PSPC1, HNRNPL, RPS5, RPS8, RPL12, RPN2, EEF2, EEF1G, HSP90AA1, CCT5, CCT6A, HSP90AB1, CCT2, CCT4, HSP90B1, CCT3, CCT7, CCT8, HSPA8, PPIL4, TCP1, PDIA3, PPIA, SSBP1, GLUD1, ATP5B, HSPA9, ERAL1, TUFM, HSPD1, PYCR1, MDH2, ABCF2, KPNB1, PRDX1, ERP44, F7, ALB, ARMC6, ADCK5, CCDC88A, GPR101, ITK, DGKA, SLC22A11, HERC6, TUBA1B, MTSS1L, CEP112, COL18A1, SEC13, NAP1L1, SNRPD2, NCAPG2, RBBP4, FLJ22447, LSM12, NUDT21, DDX1, C14orf166, DDX5, HIVEP3, NCOA6, RAVER1, TCEB1, TXNL4B, TTI2, GEN1, RPL14, RPS14, NPM1, RPL11, RPL4, EIF4A1, PCBP2, ST13, NSDHL, MTAP, MAT2A, AHCY, OAT, BCS1L, SLC25A5, TIMM50, MYH10, GOLIM4, CSE1L, RAN, KLHL40, KLHL5, IGKV1-5, C6, GIMAP8, CDC5L, CEP78, DBF4B, AMOT, FAM71F1, MFGE8, FAM98A, C11orf70, RTCB, UFL1, LRRIQ4, NUPR1, CUL7, OBSL1, EZH2, SUZ12, BMI1, ABL1, CHEK1, SIK2, SRPK1, DBR1, LUZP4, UPF2, UPF3A, FAM58A, YEATS4, RPS6KB2, HNRNPA1, HSP104, FBXW11, ACAT1, ARMC1, C2orf49, DDX17, DNAJC7, EIF4H, AURKA, PTBP1, TOMM34, TXLNA, UFD1L, HNRNPDL, MEF2D, NAA50, NPLOC4, PFKP, PICALM, TARS, NTRK1, SCARNA22, TCF7L2, KIF22, EMC2, MATR3, MCM2, SNW1, RC3H1, EGFR, TRAF6, CRBN, KCTD6, RPS27, PSRC1, SMCO3, CYLD, TRIM25, BRCA1, HDAC6, WDR77, PCBP1, PPIE, YAP1, EFTUD2, AAR2, PIH1D1, NKX2-1, CHD3, CHD4, TNF, HEXIM1, MEPCE, LARP7, RUNX1, PPT1, CTDSPL2, AGR2, RECQL4, CDK9, ARID1A, SMARCA4, SMARCD1, DDIT3, SMARCC2, SMARCC1, SS18, SMARCB1, FLI1, TP53BP1, MDC1, METTL3, METTL14, KIAA1429, RC3H2, ATG16L1, LINC00470, AKT1, ACTC1, RBX1, MYC, MAPT, HIV2gp4, HIV2gp3, NR2C2, UBQLN2, HDAC2, ZFYVE21, XRCC6, DYNLT1, HIST1H4A, SNRNP70, SNRPA, SRSF1, SNRPB, SNRPC, SNRPD1, SNRPD3, RNU1-1, FUS, TRIM28, HNRNPA2B1, HNRNPR, PPP1R10, ILF2, DHX9, PABPC1, DDX3X, SRSF7, HNRNPM, HNRNPUL1, PABPC4, SF3B1, LARP1, PBRM1, THRAP3, MOV10, FAM120A, SKIV2L2, TOX, POLR2A, ELAVL1, SF3B2, STRBP, WDR82, HNRNPCL1, CCNT1, RBM14, U2SURP, DDX20, HIST1H1C, NUMA1, CCBL2, ZFR, ACIN1, CDC73, DDX23, SLTM, SRRT, IGF2BP3, ZC3H18, PRRC2A, HNRNPUL2, THOC1, AKAP8, BCLAF1, SRSF3, CHERP, INTS12, PAF1, PNN, PPFIA1, RBM10, SNRNP200, TOE1, TRA2B, HNRNPC, HNRNPA0, PPP1CC, CCAR1, DDX21, HNRNPAB, INTS6, POLR2B, PRPF6, RALY, RBM25, RBM7, SAFB, THOC5, XRN2, EBNA1BP2, HSPA1A, RBM39, STRAP, TRA2A, YBX3, ZCCHC8, GPATCH8, SMN1, SRSF5, CTR9, EIF4A3, GNL3, HNRNPH3, HP1BP3, NCBP1, PRPF19, RBM17, RRP9, THOC2, ZC3HAV1, EXOSC10, GEMIN6, XAB2, HSPB1, PABPN1, CAPRIN1, CCAR2, GEMIN4, INTS4, KHDRBS1, PLRG1, PRMT5, SRSF6, ZNF326, ADAR, ARID2, GEMIN5, PHF10, PURB, SMU1, TOX4, AQR, ITFG1, ARAF, BIRC3, NFX1, VPS15, VPS34, VPS38, VPS8, PEP3, VPS21, CDC48, UBX3, BRE5, UBP3, SOX2, EP300, CMTR1, ARIH2, PLEKHA4, PINK1, PRMT8, FANCD2, MIRLET7A1, MIRLET7A2, MIRLET7A3, MIRLET7B, MIRLET7C, MIRLET7D, MIRLET7E, MIRLET7F1, MIRLET7F2, MIRLET7G, MIRLET7I, MIR98, MIR1-1, MIR1-2, MIR7-1, MIR7-2, MIR7-3, MIR9-1, MIR9-2, MIR9-3, MIR10B, MIR15A, MIR15B, MIR16-1, MIR16-2, MIR17, MIR18A, MIR18B, MIR19A, MIR19B1, MIR19B2, MIR20A, MIR20B, MIR21, MIR25, MIR29A, MIR29B1, MIR29B2, MIR29C, MIR31, MIR34A, MIR34B, MIR34C, MIR92A1, MIR92A2, MIR93, MIR106A, MIR106B, MIR107, MIR122, MIR128-1, MIR128-2, MIR138-1, MIR138-2, MIR140, MIR141, MIR143, MIR145, MIR155, MIR199A1, MIR199A2, MIR200A, MIR200B, MIR200C, MIR205, MIR206, MIR214, MIR221, MIR222, MIR363, MIR429, MIR451A, ADAMTS9-AS2, MDM2, OPTN, PRKD1, HVCN1, CELF1, FUBP3, DUX4, DUX4L9, CIT, CHMP4B, ECT2, KIF14, KIF20A, KIF23, PRC1, MKI67, BRD4, NINL, RBM45, UCHL1, Apc2, FBP1, LGALS9, WDR76, EIF3F, CREBBP, vpr, RNF4, OGT, CD274, SPOP, DDRGK1, TP53, DDX39B, HIST1H2BG, USP15, FZR1, WDR5, NUDCD2, CPSF1, NUP43, BTF3, BSG, S, RCHY1, NBR1, BACH2, PDE4B, SIRT6,


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HK1
FUSall structure


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HK1-FUS


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HK1-FUS


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource
TgeneFUSC1842675AMYOTROPHIC LATERAL SCLEROSIS 6 (disorder)5UNIPROT
TgeneFUSC3468114Juvenile amyotrophic lateral sclerosis5ORPHANET
TgeneFUSC0002736Amyotrophic Lateral Sclerosis2CTD_human;ORPHANET
TgeneFUSC0206634Liposarcoma, Myxoid2CTD_human;ORPHANET
TgeneFUSC0393554Amyotrophic Lateral Sclerosis With Dementia1CTD_human
TgeneFUSC0497327Dementia1GENOMICS_ENGLAND
TgeneFUSC0543859Amyotrophic Lateral Sclerosis, Guam Form1CTD_human
TgeneFUSC3539195TREMOR, HEREDITARY ESSENTIAL, 41CTD_human;UNIPROT
TgeneFUSC3888102Frontotemporal Dementia With Motor Neuron Disease1ORPHANET