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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HLTF-WWTR1

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HLTF-WWTR1
	FusionPDB ID: 36742
	FusionGDB2.0 ID: 36742
		Hgene	Tgene
	Gene symbol	HLTF	WWTR1
	Gene ID	6596	25937
	Gene name	helicase like transcription factor	WW domain containing transcription regulator 1
	Synonyms	HIP116\|HIP116A\|HLTF1\|RNF80\|SMARCA3\|SNF2L3\|ZBU1	TAZ
	Cytomap	3q24	3q25.1
	Type of gene	protein-coding	protein-coding
	Description	helicase-like transcription factorDNA-binding protein/plasminogen activator inhibitor-1 regulatorRING finger protein 80RING-type E3 ubiquitin transferase HLTFSNF2-like 3SWI/SNF related, matrix associated, actin dependent regulator of chromatin, subfa	WW domain-containing transcription regulator protein 1transcriptional co-activator with PDZ-binding motif
	Modification date	20200322	20200313
	UniProtAcc	Q14527	.
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000310053, ENST00000392912, ENST00000465259, ENST00000494055, ENST00000481663,	ENST00000465804, ENST00000360632, ENST00000467467, ENST00000474080,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	6 X 7 X 4=168	10 X 8 X 9=720
	# samples	7	13
	** MAII score	log2(7/168*10)=-1.26303440583379 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(13/720*10)=-2.46948528330122 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HLTF [Title/Abstract] AND WWTR1 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HLTF(148756836)-WWTR1(149237006), # samples:1 HLTF(148777505)-WWTR1(149260324), # samples:1
Anticipated loss of major functional domain due to fusion event.	HLTF-WWTR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HLTF-WWTR1 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HLTF-WWTR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HLTF-WWTR1 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Tgene	WWTR1	GO:0008284	positive regulation of cell proliferation	18227151
Tgene	WWTR1	GO:0010718	positive regulation of epithelial to mesenchymal transition	18227151
Tgene	WWTR1	GO:0017145	stem cell division	18568018
Tgene	WWTR1	GO:0035329	hippo signaling	18227151\|20412773
Tgene	WWTR1	GO:0060390	regulation of SMAD protein signal transduction	18568018

Fusion gene breakpoints across HLTF (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across WWTR1 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	LIHC	TCGA-PD-A5DF-01A	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-
ChimerDB4	OV	TCGA-13-A5FT-01A	HLTF	chr3	148756836	-	WWTR1	chr3	149237006	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000465259	HLTF	chr3	148777505	-	ENST00000465804	WWTR1	chr3	149260324	-	5763	1558	24	2192	722
ENST00000465259	HLTF	chr3	148777505	-	ENST00000360632	WWTR1	chr3	149260324	-	2753	1558	24	2192	722
ENST00000465259	HLTF	chr3	148777505	-	ENST00000467467	WWTR1	chr3	149260324	-	2388	1558	24	2192	722
ENST00000310053	HLTF	chr3	148777505	-	ENST00000465804	WWTR1	chr3	149260324	-	5774	1569	32	2203	723
ENST00000310053	HLTF	chr3	148777505	-	ENST00000360632	WWTR1	chr3	149260324	-	2764	1569	32	2203	723
ENST00000310053	HLTF	chr3	148777505	-	ENST00000467467	WWTR1	chr3	149260324	-	2399	1569	32	2203	723
ENST00000392912	HLTF	chr3	148777505	-	ENST00000465804	WWTR1	chr3	149260324	-	5748	1543	6	2177	723
ENST00000392912	HLTF	chr3	148777505	-	ENST00000360632	WWTR1	chr3	149260324	-	2738	1543	6	2177	723
ENST00000392912	HLTF	chr3	148777505	-	ENST00000467467	WWTR1	chr3	149260324	-	2373	1543	6	2177	723
ENST00000494055	HLTF	chr3	148777505	-	ENST00000465804	WWTR1	chr3	149260324	-	5798	1593	56	2227	723
ENST00000494055	HLTF	chr3	148777505	-	ENST00000360632	WWTR1	chr3	149260324	-	2788	1593	56	2227	723
ENST00000494055	HLTF	chr3	148777505	-	ENST00000467467	WWTR1	chr3	149260324	-	2423	1593	56	2227	723

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000465259	ENST00000465804	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000273048	0.99972695
ENST00000465259	ENST00000360632	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000930272	0.99906975
ENST00000465259	ENST00000467467	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.001771754	0.99822825
ENST00000310053	ENST00000465804	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000232616	0.99976736
ENST00000310053	ENST00000360632	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000857833	0.99914217
ENST00000310053	ENST00000467467	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.001722216	0.9982778
ENST00000392912	ENST00000465804	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000225064	0.999775
ENST00000392912	ENST00000360632	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000782656	0.9992173
ENST00000392912	ENST00000467467	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.001525797	0.9984742
ENST00000494055	ENST00000465804	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000229857	0.9997701
ENST00000494055	ENST00000360632	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.000826721	0.9991732
ENST00000494055	ENST00000467467	HLTF	chr3	148777505	-	WWTR1	chr3	149260324	-	0.00163977	0.9983602

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36742_36742_1_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000310053_WWTR1_chr3_149260324_ENST00000360632_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_2_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000310053_WWTR1_chr3_149260324_ENST00000465804_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_3_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000310053_WWTR1_chr3_149260324_ENST00000467467_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_4_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000392912_WWTR1_chr3_149260324_ENST00000360632_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_5_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000392912_WWTR1_chr3_149260324_ENST00000465804_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_6_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000392912_WWTR1_chr3_149260324_ENST00000467467_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_7_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000465259_WWTR1_chr3_149260324_ENST00000360632_length(amino acids)=722AA_BP=511
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAGL
MSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSR
EQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLT

--------------------------------------------------------------

>36742_36742_8_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000465259_WWTR1_chr3_149260324_ENST00000465804_length(amino acids)=722AA_BP=511
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAGL
MSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSR
EQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLT

--------------------------------------------------------------

>36742_36742_9_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000465259_WWTR1_chr3_149260324_ENST00000467467_length(amino acids)=722AA_BP=511
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAGL
MSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHSR
EQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFLT

--------------------------------------------------------------

>36742_36742_10_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000494055_WWTR1_chr3_149260324_ENST00000360632_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_11_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000494055_WWTR1_chr3_149260324_ENST00000465804_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

>36742_36742_12_HLTF-WWTR1_HLTF_chr3_148777505_ENST00000494055_WWTR1_chr3_149260324_ENST00000467467_length(amino acids)=723AA_BP=512
MDSRRLTFQSCAPDPALGICPRLQGCGAWKEAYRGGSKTIQGSRGAPLVIPLSAMSWMFKRDPVWKYLQTVQYGVHGNFPRLSYPTFFPR
FEFQDVIPPDDFLTSDEEVDSVLFGSLRGHVVGLRYYTGVVNNNEMVALQRDPNNPYDKNAIKVNNVNGNQVGHLKKELAGALAYIMDNK
LAQIEGVVPFGANNAFTMPLHMTFWGKEENRKAVSDQLKKHGFKLGPAPKTLGFNLESGWGSGRAGPSYSMPVHAAVQMTTEQLKTEFDK
LFEDLKEDDKTHEMEPAEAIETPLLPHQKQALAWMVSRENSKELPPFWEQRNDLYYNTITNFSEKDRPENVHGGILADDMGLGKTLTAIA
VILTNFHDGRPLPIERVKKNLLKKEYNVNDDSMKLGGNNTSEKADGLSKDASRCSEQPSISDIKEKSKFRMSELSSSRPKRRKTAVQYIE
SSDSEEIETSELPQKMKGKLKNVQSETKGRAKAGSSKVIEDVAFACALTSSVPTTKKKMLKKVMNHQHQQQMAPSTLSQQNHPTQNPPAG
LMSMPNALTTQQQQQQKLRLQRIQMERERIRMRQEELMRQEAALCRQLPMEAETLAPVQAAVNPPTMTPDMRSITNNSSDPFLNGGPYHS
REQSTDSGLGLGCYSVPTTPEDFLSNVDEMDTGENAGQTPMNINPQQTRFPDFLDCLPGTNVDLGTLESEDLIPLFNDVESALNKSEPFL

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr3:148756836/chr3:149237006)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HLTF Q14527	.
FUNCTION: Has both helicase and E3 ubiquitin ligase activities. Possesses intrinsic ATP-dependent nucleosome-remodeling activity; This activity may be required for transcriptional activation or repression of specific target promoters (By similarity). These may include the SERPINE1 and HIV-1 promoters and the SV40 enhancer, to which this protein can bind directly. Plays a role in error-free postreplication repair (PRR) of damaged DNA and maintains genomic stability through acting as a ubiquitin ligase for 'Lys-63'-linked polyubiquitination of chromatin-bound PCNA. {ECO:0000250, ECO:0000269\|PubMed:10391891, ECO:0000269\|PubMed:18316726, ECO:0000269\|PubMed:18719106, ECO:0000269\|PubMed:7876228, ECO:0000269\|PubMed:8672239, ECO:0000269\|PubMed:9126292}.	FUNCTION: Might normally function as a transcriptional repressor. EWS-fusion-proteins (EFPS) may play a role in the tumorigenic process. They may disturb gene expression by mimicking, or interfering with the normal function of CTD-POLII within the transcription initiation complex. They may also contribute to an aberrant activation of the fusion protein target genes.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

38_287

458.3333333333333

1010.0

DNA binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

38_287

458.3333333333333

1161.6666666666667

DNA binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

38_287

457.3333333333333

1009.0

DNA binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

38_287

458.3333333333333

1040.6666666666667

DNA binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

294_301

458.3333333333333

1010.0

Nucleotide binding

ATP

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

294_301

458.3333333333333

1161.6666666666667

Nucleotide binding

ATP

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

294_301

457.3333333333333

1009.0

Nucleotide binding

ATP

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

294_301

458.3333333333333

1040.6666666666667

Nucleotide binding

ATP

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000360632

225_259

189.33333333333334

401.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000465804

225_259

189.33333333333334

401.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000467467

225_259

189.33333333333334

401.0

Coiled coil

Ontology_term=ECO:0000255

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000360632

194_241

189.33333333333334

401.0

Compositional bias

Note=Gln-rich

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000465804

194_241

189.33333333333334

401.0

Compositional bias

Note=Gln-rich

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000467467

194_241

189.33333333333334

401.0

Compositional bias

Note=Gln-rich

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

435_606

458.3333333333333

1010.0

Domain

Helicase ATP-binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

837_996

458.3333333333333

1010.0

Domain

Helicase C-terminal

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

435_606

458.3333333333333

1161.6666666666667

Domain

Helicase ATP-binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

837_996

458.3333333333333

1161.6666666666667

Domain

Helicase C-terminal

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

435_606

457.3333333333333

1009.0

Domain

Helicase ATP-binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

837_996

457.3333333333333

1009.0

Domain

Helicase C-terminal

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

435_606

458.3333333333333

1040.6666666666667

Domain

Helicase ATP-binding

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

837_996

458.3333333333333

1040.6666666666667

Domain

Helicase C-terminal

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

557_560

458.3333333333333

1010.0

Motif

Note=DEGH box

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

557_560

458.3333333333333

1161.6666666666667

Motif

Note=DEGH box

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

557_560

457.3333333333333

1009.0

Motif

Note=DEGH box

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

557_560

458.3333333333333

1040.6666666666667

Motif

Note=DEGH box

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000310053

760_801

458.3333333333333

1010.0

Zinc finger

RING-type

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000392912

760_801

458.3333333333333

1161.6666666666667

Zinc finger

RING-type

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000465259

760_801

457.3333333333333

1009.0

Zinc finger

RING-type

Hgene

HLTF

chr3:148777505

chr3:149260324

ENST00000494055

760_801

458.3333333333333

1040.6666666666667

Zinc finger

RING-type

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000360632

124_157

189.33333333333334

401.0

Domain

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000465804

124_157

189.33333333333334

401.0

Domain

Tgene

WWTR1

chr3:148777505

chr3:149260324

ENST00000467467

124_157

189.33333333333334

401.0

Domain

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HLTF
WWTR1

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Hgene	HLTF	chr3:148777505	chr3:149260324	ENST00000310053	-	13	25	925_1009	458.3333333333333	1010.0	SP1 and SP3
Hgene	HLTF	chr3:148777505	chr3:149260324	ENST00000392912	-	13	26	925_1009	458.3333333333333	1161.6666666666667	SP1 and SP3
Hgene	HLTF	chr3:148777505	chr3:149260324	ENST00000465259	-	13	25	925_1009	457.3333333333333	1009.0	SP1 and SP3
Hgene	HLTF	chr3:148777505	chr3:149260324	ENST00000494055	-	13	26	925_1009	458.3333333333333	1040.6666666666667	SP1 and SP3

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Related Drugs to HLTF-WWTR1

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HLTF-WWTR1

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner

Gene

Disease ID

Disease name

# pubmeds

Source