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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA1-ARIH2

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA1-ARIH2
	FusionPDB ID: 36799
	FusionGDB2.0 ID: 36799
		Hgene	Tgene
	Gene symbol	HMGA1	ARIH2
	Gene ID	3159	10425
	Gene name	high mobility group AT-hook 1	ariadne RBR E3 ubiquitin protein ligase 2
	Synonyms	HMG-R\|HMGA1A\|HMGIY	ARI2\|TRIAD1
	Cytomap	6p21.31	3p21.31
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMG-I/HMG-Yhigh mobility group protein A1high mobility group protein Rhigh-mobility group (nonhistone chromosomal) protein isoforms I and Ynonhistone chromosomal high-mobility group protein HMG-I/HMG-Y	E3 ubiquitin-protein ligase ARIH2RING-type E3 ubiquitin transferase ARIH2all-trans retinoic acid inducible RING fingerariadne homolog 2protein ariadne-2 homolog
	Modification date	20200315	20200313
	UniProtAcc	P17096	O95376
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000478214, ENST00000311487, ENST00000347617, ENST00000374116, ENST00000401473, ENST00000447654, ENST00000395004,	ENST00000356401, ENST00000449376, ENST00000490095,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	13 X 9 X 5=585	17 X 18 X 8=2448
	# samples	12	21
	** MAII score	log2(12/585*10)=-2.28540221886225 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(21/2448*10)=-3.54314232502653 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA1 [Title/Abstract] AND ARIH2 [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HMGA1(34211295)-ARIH2(49019092), # samples:1
Anticipated loss of major functional domain due to fusion event.	HMGA1-ARIH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA1-ARIH2 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA1-ARIH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA1-ARIH2 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA1	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA1	GO:0090402	oncogene-induced cell senescence	16901784
Tgene	ARIH2	GO:0000209	protein polyubiquitination	16118314\|19340006
Tgene	ARIH2	GO:0006511	ubiquitin-dependent protein catabolic process	16118314
Tgene	ARIH2	GO:0016567	protein ubiquitination	24076655
Tgene	ARIH2	GO:0048588	developmental cell growth	19340006
Tgene	ARIH2	GO:0070534	protein K63-linked ubiquitination	19340006
Tgene	ARIH2	GO:0070936	protein K48-linked ubiquitination	16118314\|19340006
Tgene	ARIH2	GO:0071425	hematopoietic stem cell proliferation	16118314\|19340006

Fusion gene breakpoints across HMGA1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across ARIH2 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	Non-Cancer	257N	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000447654	HMGA1	chr6	34211295	+	ENST00000356401	ARIH2	chr3	49019092	+	4096	759	270	983	237
ENST00000447654	HMGA1	chr6	34211295	+	ENST00000449376	ARIH2	chr3	49019092	+	1334	759	270	983	237
ENST00000401473	HMGA1	chr6	34211295	+	ENST00000356401	ARIH2	chr3	49019092	+	3823	486	3747	3070	225
ENST00000401473	HMGA1	chr6	34211295	+	ENST00000449376	ARIH2	chr3	49019092	+	1061	486	39	710	223
ENST00000311487	HMGA1	chr6	34211295	+	ENST00000356401	ARIH2	chr3	49019092	+	3856	519	39	743	234
ENST00000311487	HMGA1	chr6	34211295	+	ENST00000449376	ARIH2	chr3	49019092	+	1094	519	39	743	234
ENST00000347617	HMGA1	chr6	34211295	+	ENST00000356401	ARIH2	chr3	49019092	+	3709	372	3633	2956	225
ENST00000347617	HMGA1	chr6	34211295	+	ENST00000449376	ARIH2	chr3	49019092	+	947	372	39	596	185
ENST00000374116	HMGA1	chr6	34211295	+	ENST00000356401	ARIH2	chr3	49019092	+	3785	448	3709	3032	225
ENST00000374116	HMGA1	chr6	34211295	+	ENST00000449376	ARIH2	chr3	49019092	+	1023	448	892	338	184

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000447654	ENST00000356401	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.014377436	0.9856226
ENST00000447654	ENST00000449376	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.031948972	0.96805096
ENST00000401473	ENST00000356401	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.02000255	0.9799975
ENST00000401473	ENST00000449376	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.028527906	0.9714721
ENST00000311487	ENST00000356401	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.01409479	0.98590523
ENST00000311487	ENST00000449376	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.026599875	0.9734002
ENST00000347617	ENST00000356401	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.019336563	0.9806635
ENST00000347617	ENST00000449376	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.030120531	0.9698795
ENST00000374116	ENST00000356401	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.019137671	0.9808623
ENST00000374116	ENST00000449376	HMGA1	chr6	34211295	+	ARIH2	chr3	49019092	+	0.027436318	0.9725637

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36799_36799_1_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000311487_ARIH2_chr3_49019092_ENST00000356401_length(amino acids)=234AA_BP=160
MGLRAGAISGAGAAPRRHPHLLPAAAAAEPGRSSAPSTAAPGNPERAPQAGGRARASQPSLFHLLLREGKMSESSSKSSQPLASKQEKDG
TEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMESGPR

--------------------------------------------------------------

>36799_36799_2_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000311487_ARIH2_chr3_49019092_ENST00000449376_length(amino acids)=234AA_BP=160
MGLRAGAISGAGAAPRRHPHLLPAAAAAEPGRSSAPSTAAPGNPERAPQAGGRARASQPSLFHLLLREGKMSESSSKSSQPLASKQEKDG
TEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMESGPR

--------------------------------------------------------------

>36799_36799_3_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000347617_ARIH2_chr3_49019092_ENST00000356401_length(amino acids)=225AA_BP=
MFPMDWKLLEARARESLAYHCMPRCQAWGLAHLRSRGRAAEFRLAMYEASSSHRCPVHVAHSYGASTLPLSYLSLTLLPLLTPQMWTPLI
NPNLISCPSPLRLDSTLVSAPSCLFITLRAPVKLEFTLPYSTALHSHVCFGGVRRSQNGGVGTFISVLYHNPGIYLWWGMIQPVLRERRA

--------------------------------------------------------------

>36799_36799_4_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000347617_ARIH2_chr3_49019092_ENST00000449376_length(amino acids)=185AA_BP=111
MGLRAGAISGAGAAPRRPSQPSLFHLLLREGKMSESSSKSSQPLASKQEKDGTEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGA
AKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMESGPRKKLFEYQQAQLEAEIENLSWKVERADSYDRGDLENQMHIAEQRRRTLLK

--------------------------------------------------------------

>36799_36799_5_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000374116_ARIH2_chr3_49019092_ENST00000356401_length(amino acids)=225AA_BP=
MFPMDWKLLEARARESLAYHCMPRCQAWGLAHLRSRGRAAEFRLAMYEASSSHRCPVHVAHSYGASTLPLSYLSLTLLPLLTPQMWTPLI
NPNLISCPSPLRLDSTLVSAPSCLFITLRAPVKLEFTLPYSTALHSHVCFGGVRRSQNGGVGTFISVLYHNPGIYLWWGMIQPVLRERRA

--------------------------------------------------------------

>36799_36799_6_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000374116_ARIH2_chr3_49019092_ENST00000449376_length(amino acids)=184AA_BP=1
MKRGQFNMASTLVETKSEKRRKQKSTKRCCQCLSGVGPWLLPGVMKGRACSMQYGSRETLQPHLPHPGTSTSQLRCHGNLSAGFSSAAPL
YASGSPSPLCHSCLHAPLSMRGFRSQPPAEPAGIQTASSWVRTPCNMHMGRCIAGCIDTVFWVCPLVSFLELWWFSGSWQHPCFCFPLVG

--------------------------------------------------------------

>36799_36799_7_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000401473_ARIH2_chr3_49019092_ENST00000356401_length(amino acids)=225AA_BP=
MFPMDWKLLEARARESLAYHCMPRCQAWGLAHLRSRGRAAEFRLAMYEASSSHRCPVHVAHSYGASTLPLSYLSLTLLPLLTPQMWTPLI
NPNLISCPSPLRLDSTLVSAPSCLFITLRAPVKLEFTLPYSTALHSHVCFGGVRRSQNGGVGTFISVLYHNPGIYLWWGMIQPVLRERRA

--------------------------------------------------------------

>36799_36799_8_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000401473_ARIH2_chr3_49019092_ENST00000449376_length(amino acids)=223AA_BP=149
MGLRAGAISGAGAAPRRHPHLLPAAAAAEPGRSSAPSTAAPGNPERAPQAGGRARASQPSLFHLLLREGKMSESSSKSSQPLASKQEKDG
TEKRGRGRPRKQPPKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMESGPRKKLFEYQQAQL

--------------------------------------------------------------

>36799_36799_9_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000447654_ARIH2_chr3_49019092_ENST00000356401_length(amino acids)=237AA_BP=163
MGGEHAAAAVSERLCSLPVSDPHLLPAAAAAEPGRSSAPSTAAPGNPERAPQAGGRARASQPSLFHLLLREGKMSESSSKSSQPLASKQE
KDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMES

--------------------------------------------------------------

>36799_36799_10_HMGA1-ARIH2_HMGA1_chr6_34211295_ENST00000447654_ARIH2_chr3_49019092_ENST00000449376_length(amino acids)=237AA_BP=163
MGGEHAAAAVSERLCSLPVSDPHLLPAAAAAEPGRSSAPSTAAPGNPERAPQAGGRARASQPSLFHLLLREGKMSESSSKSSQPLASKQE
KDGTEKRGRGRPRKQPPVSPGTALVGSQKEPSEVPTPKRPRGRPKGSKNKGAAKTRKTTTTPGRKPRGRPKKLCRYTLQYTYPYAYYMES

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr6:34211295/chr3:49019092)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA1 P17096	ARIH2 O95376
FUNCTION: HMG-I/Y bind preferentially to the minor groove of A+T rich regions in double-stranded DNA. It is suggested that these proteins could function in nucleosome phasing and in the 3'-end processing of mRNA transcripts. They are also involved in the transcription regulation of genes containing, or in close proximity to A+T-rich regions.	FUNCTION: E3 ubiquitin-protein ligase, which catalyzes ubiquitination of target proteins together with ubiquitin-conjugating enzyme E2 UBE2L3 (PubMed:16118314, PubMed:17646546, PubMed:19340006, PubMed:24076655). Acts as an atypical E3 ubiquitin-protein ligase by working together with cullin-5-RING ubiquitin ligase complex (ECS complex, also named CRL5 complex) and initiating ubiquitination of ECS substrates: associates with ECS complex and specifically mediates addition of the first ubiquitin on ECS targets (By similarity). The initial ubiquitin is then elongated (By similarity). E3 ubiquitin-protein ligase activity is activated upon binding to neddylated form of the ECS complex (PubMed:24076655). Mediates 'Lys-6', 'Lys-48'- and 'Lys-63'-linked polyubiquitination (PubMed:16118314, PubMed:17646546, PubMed:19340006). May play a role in myelopoiesis (PubMed:19340006). {ECO:0000250\|UniProtKB:Q9Y4X5, ECO:0000269\|PubMed:16118314, ECO:0000269\|PubMed:17646546, ECO:0000269\|PubMed:19340006, ECO:0000269\|PubMed:24076655}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000311487

21_31

90.0

108.0

DNA binding

Note=A.T hook 1

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000311487

53_63

90.0

108.0

DNA binding

Note=A.T hook 2

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000311487

78_89

90.0

108.0

DNA binding

Note=A.T hook 3

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000347617

21_31

79.0

97.0

DNA binding

Note=A.T hook 1

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000347617

53_63

79.0

97.0

DNA binding

Note=A.T hook 2

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000374116

21_31

79.0

97.0

DNA binding

Note=A.T hook 1

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000374116

53_63

79.0

97.0

DNA binding

Note=A.T hook 2

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000401473

21_31

79.0

97.0

DNA binding

Note=A.T hook 1

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000401473

53_63

79.0

97.0

DNA binding

Note=A.T hook 2

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000447654

21_31

90.0

108.0

DNA binding

Note=A.T hook 1

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000447654

53_63

90.0

108.0

DNA binding

Note=A.T hook 2

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000447654

78_89

90.0

108.0

DNA binding

Note=A.T hook 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000311487

91_106

90.0

108.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000347617

91_106

79.0

97.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000374116

91_106

79.0

97.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000401473

91_106

79.0

97.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000447654

91_106

90.0

108.0

Compositional bias

Note=Glu-rich (acidic)

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000347617

78_89

79.0

97.0

DNA binding

Note=A.T hook 3

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000374116

78_89

79.0

97.0

DNA binding

Note=A.T hook 3

Hgene

HMGA1

chr6:34211295

chr3:49019092

ENST00000401473

78_89

79.0

97.0

DNA binding

Note=A.T hook 3

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

135_344

419.0

494.0

Region

TRIAD supradomain

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

359_493

419.0

494.0

Region

Ariadne domain

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

65_112

419.0

494.0

Region

UBA-like

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

135_344

419.0

494.0

Region

TRIAD supradomain

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

359_493

419.0

494.0

Region

Ariadne domain

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

65_112

419.0

494.0

Region

UBA-like

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

139_188

419.0

494.0

Zinc finger

RING-type 1

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

208_270

419.0

494.0

Zinc finger

IBR-type

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000356401

297_326

419.0

494.0

Zinc finger

RING-type 2%3B atypical

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

139_188

419.0

494.0

Zinc finger

RING-type 1

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

208_270

419.0

494.0

Zinc finger

IBR-type

Tgene

ARIH2

chr6:34211295

chr3:49019092

ENST00000449376

297_326

419.0

494.0

Zinc finger

RING-type 2%3B atypical

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HMGA1

EWSR1, SP1, CEBPB, ELF1, NFYA, POU3F1, ATF2, JUN, IRF1, BANF1, CHD1, PRMT6, NPM1, PARP1, PPARG, PRKCA, RARA, CREBBP, POU2F1, POU2F2, KAT2B, NFKB1, TP53, RN7SK, Stag2, ORC6, ORC2, HHV8GK18_gp81, CBX7, HDAC2, CDK2, TERF2, FN1, HSP90AA1, CSNK2A1, PAN2, CDK1, NCL, PSIP1, EIF2S2, RCC1, HNRNPD, PPP1R8, HNRNPAB, HNRNPDL, DNAJC8, HNRNPA1, HMGB1, HMGB3, HMGB2, SYNCRIP, CWC27, METAP2, SSB, PA2G4, OLA1, APEX1, ANXA2, GTF2F2, XRCC6, HNRNPL, HSPA1A, PTBP1, PCBP1, ANXA1, PCBP2, HTT, UPF2, UBE2I, NCOR2, CUL7, OBSL1, APP, SRPK2, AP4M1, EMC2, RACGAP1, ZSCAN5A, Csk, Fbl, Gspt1, Srp72, Kifc1, CREB1, NFATC1, FOXA1, FOXE1, HEMGN, TRIM29, PCGF1, DPPA4, NANOG, POU5F1, C4orf27, EGFR, CDC14B, G3BP1, EFTUD2, NKX2-1, RNF123, HIF1A, AGR2, EZH2, DCPS, GPC1, REST, PRKDC, TYK2, CDC25A, OXT, CSF3R, KCNQ4, CYP11B2, CDK5, EPHB2, ITGB7, MYC, HIC1, HIST1H3A, ATG16L1, RBX1, PRDM16, AGRN, VRK1, HIST1H4A, CMTR1, FANCD2, N, HCVgp1, ZC3H18, CAMK2A, FYN, MAP2K1, PEBP1, RALBP1, RPS6KA3, ARNTL, YKT6, CD72, TRIP10, HIST1H2AH, NSD1, AKAP9, RBFOX2, ARR3, ECT2L, ABCC8, CAMSAP1, COL13A1, ELP2, FBXO38, RNF214, PANX2, STRN4, KCND1, ROBO1, HIST2H3PS2, HIST2H2BC, ARHGEF10, DSP, HIST1H1B, HIST1H1D, SOX6, RGS6, LOC102724334, HIST2H2BE, MST1L, UHRF1BP1, ADCK1, HIST2H2AB, CFAP46, CNBD1, SEPT1, TTN, JPH2, ATXN3L, UNC79, PCLO, ACACB, NOP14, HIST1H2AB, RGS3, GTF2H3, HIST3H3, MURC, HIST2H2BF, PHF3, INPP5D, HIST1H2BH, SPEN, TXLNA, CIT, ANLN, CHMP4B, ECT2, KIF14, KIF20A, PRC1, C12orf65, C1QBP, GRSF1, ICT1, MRPL11, TSFM, ZNF263, MAFB, BRD4, FBP1, NEDD4, HMGB1P1, FKBP3, RBM8A, PARK7, TRIM37, CBX3, CENPA, HIST1H2BG, LMNB1, ZNF330, WDR5, NAA40, H2AFY, UBN2, HIST1H2AG, VRK3, WDR89, H2AFX, HIRA, PARP2, CABIN1, XPC, CD274, BTF3, SLFN11, JMJD6, Ube2i, Klc4, TAX1BP1, PER2,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA1
ARIH2

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

Top

Related Drugs to HMGA1-ARIH2

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

Top

Related Diseases to HMGA1-ARIH2

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA1	C0011860	Diabetes Mellitus, Non-Insulin-Dependent	1	CTD_human
Hgene	HMGA1	C0020456	Hyperglycemia	1	CTD_human
Hgene	HMGA1	C0021655	Insulin Resistance	1	CTD_human
Hgene	HMGA1	C0023269	leiomyosarcoma	1	CTD_human
Hgene	HMGA1	C0036341	Schizophrenia	1	PSYGENET
Hgene	HMGA1	C0042138	Uterine Neoplasms	1	CTD_human
Hgene	HMGA1	C0153567	Uterine Cancer	1	CTD_human
Hgene	HMGA1	C0205815	Leiomyosarcoma, Epithelioid	1	CTD_human
Hgene	HMGA1	C0205816	Leiomyosarcoma, Myxoid	1	CTD_human
Hgene	HMGA1	C0524620	Metabolic Syndrome X	1	CTD_human
Hgene	HMGA1	C0920563	Insulin Sensitivity	1	CTD_human
Hgene	HMGA1	C1855520	Hyperglycemia, Postprandial	1	CTD_human