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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA2-NFIB

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA2-NFIB
	FusionPDB ID: 36846
	FusionGDB2.0 ID: 36846
		Hgene	Tgene
	Gene symbol	HMGA2	NFIB
	Gene ID	8091	4781
	Gene name	high mobility group AT-hook 2	nuclear factor I B
	Synonyms	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9	CTF\|HMGIC/NFIB\|MACID\|NF-I/B\|NF1-B\|NFI-B\|NFI-RED\|NFIB2\|NFIB3
	Cytomap	12q14.3	9p23-p22.3
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C	nuclear factor 1 B-typeCCAAT-box-binding transcription factorTGGCA-binding proteinnuclear factor 1/B
	Modification date	20200329	20200313
	UniProtAcc	P52926	O00712
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000354636, ENST00000393577, ENST00000393578, ENST00000403681, ENST00000425208, ENST00000536545, ENST00000541363,	ENST00000380921, ENST00000380924, ENST00000543693, ENST00000380934, ENST00000380953, ENST00000380959, ENST00000397575, ENST00000397579, ENST00000397581,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 25 X 15=16125	13 X 23 X 8=2392
	# samples	43	17
	** MAII score	log2(43/16125*10)=-5.22881869049588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(17/2392*10)=-3.8146107380604 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA2 [Title/Abstract] AND NFIB [Title/Abstract] AND fusion [Title/Abstract]
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)
Anticipated loss of major functional domain due to fusion event.	HMGA2-NFIB seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-NFIB seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. HMGA2-NFIB seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-NFIB seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF. HMGA2-NFIB seems lost the major protein functional domain in Tgene partner, which is a transcription factor due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Hgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Hgene	HMGA2	GO:0006284	base-excision repair	19465398
Hgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Hgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Hgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Hgene	HMGA2	GO:0031052	chromosome breakage	19549901
Hgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Hgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Hgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Hgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Hgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Hgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Hgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Hgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Hgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Hgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Hgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Hgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Hgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Hgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Hgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Hgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Hgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Hgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Hgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Hgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Hgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642
Tgene	NFIB	GO:0045893	positive regulation of transcription, DNA-templated	30388402
Tgene	NFIB	GO:0045944	positive regulation of transcription by RNA polymerase II	9099724\|19540848

Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across NFIB (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerKB3	.	.	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-
ChimerKB3	.	.	HMGA2	chr12	66309307	+	NFIB	chr9	14307519	-
ChimerKB3	.	.	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	9088	1389	1140	2621	493
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	9083	1389	1140	2621	493
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	3584	1389	1140	2843	567
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	3670	1389	1140	3044	634
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	3669	1389	1140	3071	643
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	3417	1389	1140	2822	560
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8321	622	373	1854	493
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8316	622	373	1854	493
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	2817	622	373	2076	567
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	2903	622	373	2277	634
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	2902	622	373	2304	643
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	2650	622	373	2055	560
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8096	397	148	1629	493
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8091	397	148	1629	493
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	2592	397	148	1851	567
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	2678	397	148	2052	634
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	2677	397	148	2079	643
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	2425	397	148	1830	560
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8759	1060	811	2292	493
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8754	1060	811	2292	493
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	3255	1060	811	2514	567
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	3341	1060	811	2715	634
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	3340	1060	811	2742	643
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	3088	1060	811	2493	560
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8759	1060	811	2292	493
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8754	1060	811	2292	493
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	3255	1060	811	2514	567
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	3341	1060	811	2715	634
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	3340	1060	811	2742	643
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	3088	1060	811	2493	560
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8759	1060	811	2292	493
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8754	1060	811	2292	493
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	3255	1060	811	2514	567
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	3341	1060	811	2715	634
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	3340	1060	811	2742	643
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	3088	1060	811	2493	560
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000380934	NFIB	chr9	14307519	-	8759	1060	811	2292	493
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000380959	NFIB	chr9	14307519	-	8754	1060	811	2292	493
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000380953	NFIB	chr9	14307519	-	3255	1060	811	2514	567
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000397575	NFIB	chr9	14307519	-	3341	1060	811	2715	634
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000397581	NFIB	chr9	14307519	-	3340	1060	811	2742	643
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000397579	NFIB	chr9	14307519	-	3088	1060	811	2493	560
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000380934	NFIB	chr9	14307519	-	9121	1422	1140	2654	504
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000380959	NFIB	chr9	14307519	-	9116	1422	1140	2654	504
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000380953	NFIB	chr9	14307519	-	3617	1422	1140	2876	578
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000397575	NFIB	chr9	14307519	-	3703	1422	1140	3077	645
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000397581	NFIB	chr9	14307519	-	3702	1422	1140	3104	654
ENST00000403681	HMGA2	chr12	66345195	+	ENST00000397579	NFIB	chr9	14307519	-	3450	1422	1140	2855	571
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000380934	NFIB	chr9	14307519	-	8129	430	148	1662	504
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000380959	NFIB	chr9	14307519	-	8124	430	148	1662	504
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000380953	NFIB	chr9	14307519	-	2625	430	148	1884	578
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000397575	NFIB	chr9	14307519	-	2711	430	148	2085	645
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000397581	NFIB	chr9	14307519	-	2710	430	148	2112	654
ENST00000393577	HMGA2	chr12	66345195	+	ENST00000397579	NFIB	chr9	14307519	-	2458	430	148	1863	571

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst

Tenst

Hgene

Hchr

Hbp

Hstrand

Tgene

Tchr

Tbp

Tstrand

No-coding score

Coding score

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36846_36846_1_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_2_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_3_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_4_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_5_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_6_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000354636_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_7_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_8_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_9_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_10_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_11_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_12_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393577_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_13_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_14_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_15_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_16_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_17_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_18_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000393578_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_19_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_20_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_21_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_22_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_23_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_24_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000403681_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_25_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_26_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_27_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_28_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_29_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_30_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000425208_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_31_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_32_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_33_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_34_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_35_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_36_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000536545_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_37_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_38_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=567AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG

--------------------------------------------------------------

>36846_36846_39_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=493AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA

--------------------------------------------------------------

>36846_36846_40_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=634AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASG
TSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA

--------------------------------------------------------------

>36846_36846_41_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=560AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPAN

--------------------------------------------------------------

>36846_36846_42_HMGA2-NFIB_HMGA2_chr12_66232349_ENST00000541363_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=643AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFI
EALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLS
NPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQEQDSGQSGSPSH
NDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISIDENMEPSPTG
DFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA
PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASP
TATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLN

--------------------------------------------------------------

>36846_36846_43_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=504AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL

--------------------------------------------------------------

>36846_36846_44_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=578AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI

--------------------------------------------------------------

>36846_36846_45_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=504AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL

--------------------------------------------------------------

>36846_36846_46_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=645AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI
TTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYG

--------------------------------------------------------------

>36846_36846_47_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=571AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQ

--------------------------------------------------------------

>36846_36846_48_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000393577_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=654AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI
TTSTEGEAASPTATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPI

--------------------------------------------------------------

>36846_36846_49_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000380934_length(amino acids)=504AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL

--------------------------------------------------------------

>36846_36846_50_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000380953_length(amino acids)=578AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI

--------------------------------------------------------------

>36846_36846_51_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000380959_length(amino acids)=504AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL

--------------------------------------------------------------

>36846_36846_52_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000397575_length(amino acids)=645AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI
TTSTEAYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYG

--------------------------------------------------------------

>36846_36846_53_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000397579_length(amino acids)=571AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQ

--------------------------------------------------------------

>36846_36846_54_HMGA2-NFIB_HMGA2_chr12_66345195_ENST00000403681_NFIB_chr9_14307519_ENST00000397581_length(amino acids)=654AA_BP=93
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQK
KPAQDEFHPFIEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLLAKLRKDIRQEYREDFVLTV
TGKKHPCCVLSNPDQKGKIRRIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELDLFLAYYVQE
QDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTIS
IDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL
PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPI
TTSTEGEAASPTATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPI

--------------------------------------------------------------

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Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:/chr9:)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA2 P52926	NFIB O00712
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.	FUNCTION: Transcriptional activator of GFAP, essential for proper brain development (PubMed:30388402). Recognizes and binds the palindromic sequence 5'-TTGGCNNNNNGCCAA-3' present in viral and cellular promoters and in the origin of replication of adenovirus type 2. These proteins are individually capable of activating transcription and replication. {ECO:0000269\|PubMed:30388402}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (288) >>>288.pdbFusion protein BP residue: 83 CIF file (288) >>>288.cif	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFIEALLPHVRAI AYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLL AKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELD LFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISI DENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSA SPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA	493
3D view using mol* of 288 (AA BP:83)


PDB file (309) >>>309.pdbFusion protein BP residue: 93 CIF file (309) >>>309.cif	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQDEFHPF IEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKP EIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIR RIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQP HHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSG VFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSP PSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTM KKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQS	504
3D view using mol* of 309 (AA BP:93)


PDB file (409) >>>409.pdbFusion protein BP residue: 83 CIF file (409) >>>409.cif	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFIEALLPHVRAI AYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLL AKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELD LFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISI DENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSA SPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQLRICDWTMNQNG RHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIG	560
3D view using mol* of 409 (AA BP:83)


PDB file (418) >>>418.pdbFusion protein BP residue: 83 CIF file (418) >>>418.cif	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFIEALLPHVRAI AYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLL AKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELD LFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISI DENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSA SPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVP GHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASGTSQANRYVGL	567
3D view using mol* of 418 (AA BP:83)


PDB file (425) >>>425.pdbFusion protein BP residue: 93 CIF file (425) >>>425.cif	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQDEFHPF IEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKP EIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIR RIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQP HHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSG VFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSP PSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTM KKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQL RICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLVPFQVSNRTPILPA	571
3D view using mol* of 425 (AA BP:93)


PDB file (442) >>>442.pdbFusion protein BP residue: 93 CIF file (442) >>>442.cif	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQDEFHPF IEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKP EIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIR RIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQP HHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSG VFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSP PSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTM KKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQP NGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTAS	578
3D view using mol* of 442 (AA BP:93)


PDB file (506) >>>506.pdbFusion protein BP residue: 83 CIF file (506) >>>506.cif	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFIEALLPHVRAI AYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLL AKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELD LFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISI DENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSA SPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVP GHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTASGTSQANRYVGL SPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQSPGTWASLV	634
3D view using mol* of 506 (AA BP:83)


PDB file (515) >>>515.pdbFusion protein BP residue: 83 CIF file (515) >>>515.cif	HMGA2	chr12	66232349	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWDEFHPFIEALLPHVRAI AYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKPEIKQKWASRLL AKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIRRIDCLRQADKV WRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQPHHITVSVKELD LFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSGVFNVSELVRVS RTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSPPSSKRPKTISI DENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTMKKPEKPLFSSA SPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPLPFPTQAILPPA PSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQPNGSGQVVGKVP GHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAASPTATTYTASGT SQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGITWQ	643
3D view using mol* of 515 (AA BP:83)


PDB file (519) >>>519.pdbFusion protein BP residue: 93 CIF file (519) >>>519.cif	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQDEFHPF IEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKP EIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIR RIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQP HHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSG VFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSP PSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTM KKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQP NGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEAYTAS GTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPSTSEDTLGIT	645
3D view using mol* of 519 (AA BP:93)


PDB file (532) >>>532.pdbFusion protein BP residue: 93 CIF file (532) >>>532.cif	HMGA2	chr12	66345195	+	NFIB	chr9	14307519	-	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWPQQVVQKKPAQDEFHPF IEALLPHVRAIAYTWFNLQARKRKYFKKHEKRMSKDEERAVKDELLSEKP EIKQKWASRLLAKLRKDIRQEYREDFVLTVTGKKHPCCVLSNPDQKGKIR RIDCLRQADKVWRLDLVMVILFKGIPLESTDGERLMKSPHCTNPALCVQP HHITVSVKELDLFLAYYVQEQDSGQSGSPSHNDPAKNPPGYLEDSFVKSG VFNVSELVRVSRTPITQGTGVNFPIGEIPSQPYYHDMNSGVNLQRSLSSP PSSKRPKTISIDENMEPSPTGDFYPSPSSPAAGSRTWHERDQDMSSPTTM KKPEKPLFSSASPQDSSPRLSTFPQHHHPGIPGVAHSVISTRTPPPPSPL PFPTQAILPPAPSSYFSHPTIRYPPHLNPQDTLKNYVPSYDPSSPQTSQP NGSGQVVGKVPGHFTPVLAPSPHPSAVRPVTLSMTDTKPITTSTEGEAAS PTATTYTASGTSQANRYVGLSPRDPSFLHQQQLRICDWTMNQNGRHLYPS TSEDTLGITWQSPGTWASLVPFQVSNRTPILPANVQNYGLNIIGEPFLQA	654
3D view using mol* of 532 (AA BP:93)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_pLDDT.png

NFIB_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_NFIB_288_pLDDT.png (AA BP:83)

HMGA2_NFIB_288_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_NFIB_288_violinplot.png (AA BP:83)

HMGA2_NFIB_309_pLDDT.png (AA BP:93)

HMGA2_NFIB_309_pLDDT_and_active_sites.png (AA BP:93)

HMGA2_NFIB_309_violinplot.png (AA BP:93)

HMGA2_NFIB_409_pLDDT.png (AA BP:83)

HMGA2_NFIB_409_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_NFIB_409_violinplot.png (AA BP:83)

HMGA2_NFIB_418_pLDDT.png (AA BP:83)

HMGA2_NFIB_418_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_NFIB_418_violinplot.png (AA BP:83)

HMGA2_NFIB_425_pLDDT.png (AA BP:93)

HMGA2_NFIB_425_pLDDT_and_active_sites.png (AA BP:93)

HMGA2_NFIB_425_violinplot.png (AA BP:93)

HMGA2_NFIB_442_pLDDT.png (AA BP:93)

HMGA2_NFIB_442_pLDDT_and_active_sites.png (AA BP:93)

HMGA2_NFIB_442_violinplot.png (AA BP:93)

HMGA2_NFIB_506_pLDDT.png (AA BP:83)

HMGA2_NFIB_506_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_NFIB_506_violinplot.png (AA BP:83)

HMGA2_NFIB_515_pLDDT.png (AA BP:83)

HMGA2_NFIB_515_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_NFIB_515_violinplot.png (AA BP:83)

HMGA2_NFIB_519_pLDDT.png (AA BP:93)

HMGA2_NFIB_519_pLDDT_and_active_sites.png (AA BP:93)

HMGA2_NFIB_519_violinplot.png (AA BP:93)

HMGA2_NFIB_532_pLDDT.png (AA BP:93)

HMGA2_NFIB_532_pLDDT_and_active_sites.png (AA BP:93)

HMGA2_NFIB_532_violinplot.png (AA BP:93)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

HMGA2_NFIB_288.png

HMGA2_NFIB_309.png

HMGA2_NFIB_409.png

HMGA2_NFIB_418.png

HMGA2_NFIB_425.png

HMGA2_NFIB_442.png

HMGA2_NFIB_506.png

HMGA2_NFIB_515.png

HMGA2_NFIB_519.png

HMGA2_NFIB_532.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
288	0.976	174	1.026	545.713	0.705	0.608	0.739	0.44	0.855	0.515	1.123	Chain A: 100,104,107,108,111,112,114,115,121,122,1 24,127,215,216,217,218,219,252,255,256,257,259,260 ,261,262,263,264,275,276,277,278,281,287,288,289,2 90,291,292,293,294,296
309	0.96	117	0.984	401.996	0.69	0.636	0.81	0.492	1.035	0.476	0.612	Chain A: 115,118,119,122,123,125,126,132,133,135,1 38,210,212,226,228,229,230,268,271,272,293,296,297 ,298,299,300,301,302,303,304,305,307
409	0.997	105	1.037	380.73	0.688	0.654	0.792	0.48	0.905	0.53	0.804	Chain A: 104,107,108,111,112,114,115,121,122,127,1 99,201,215,217,218,253,254,257,260,261,285,287,288 ,289,290,291,292,293,296
418	0.929	431	1.051	207.172	0.71	0.414	0.384	0.293	0.421	0.696	1.175	Chain A: 99,102,103,131,132,135,136,137,138,139,14 2,294,295,297,298,299,301,302,303,304,306,307,308, 310,311,312,313,314,315,316,317
425	0.941	4003	1.058	2124.199	0.666	0.44	0.398	0.334	0.448	0.744	0.915	Chain A: 106,107,109,110,111,114,115,118,119,120,1 21,122,123,124,125,126,127,128,129,131,132,133,134 ,135,137,138,139,140,141,142,143,144,145,146,147,1 48,149,150,153,154,172,179,180,181,182,184,185,186 ,187,188,190,199,201,207,208,209,210,211,212,213,2 16,222,223,224,225,226,227,228,229,230,231,232,233 ,234,236,237,238,239,240,241,242,250,251,252,254,2 55,256,257,258,259,260,261,262,263,264,265,266,267 ,268,269,270,271,272,273,275,276,291,292,293,294,2 95,296,297,298,299,300,301,302,303,304,305,306,307 ,308,309,310,311,312,313,314,315,316,317,318,319,3 20,321,322,323,324,325,326,327,328,500,501,502,503 ,522,523,524,525,526,527,528,529,530,531,532,533,5 34,535,536,537,538,539,540,541,543,544,545,547,549 ,550,551,552,553,554,555,556,557,558,559,560,561,5 62,563,564,565,567
442	0.943	88	0.984	304.241	0.737	0.617	0.728	0.306	0.823	0.371	0.91	Chain A: 92,95,96,101,102,105,151,152,154,155,156, 158,159,160,162,163,166,204,205,206
506	1.005	262	1.038	769.692	0.551	0.68	0.87	0.601	0.95	0.633	0.873	Chain A: 96,98,168,169,170,171,173,174,175,211,212 ,214,215,225,227,228,229,239,240,241,242,243,244,2 45,246,251,296,297,300,301,617,618,619,620,621,622 ,623,624,625,626,628
515	0.992	114	1.002	354.319	0.581	0.686	0.966	0.426	1.07	0.398	0.588	Chain A: 81,82,83,85,86,87,90,94,102,106,140,143,1 44,145,147,148,149,151,152,154,155,193,194,195
519	1.029103	280	1.072832	953.197	0.615385	0.69015	0.850868	0.69991	0.862757	0.811249	0.982898	Chain A: 107,109,115,119,122,135,138,139,142,179,1 80,182,184,185,186,222,223,224,225,226,228,238,239 ,240,250,251,252,254,255,257,264,265,267,268,272,2 95,296,297,298,299,300,301,302,303,304,306,307,308 ,311,312,599,600,601,631,632,633,634,635,636,637,6 38,639
532	1.013	183	1.039	623.574	0.544	0.702	0.937	0.72	0.989	0.728	1.007	Chain A: 107,109,179,180,181,182,184,185,186,222,2 23,225,226,227,236,237,238,239,240,250,251,252,253 ,254,255,257,304,307,308,311,312,639,640,641,642,6 43,644,645,646

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB	ZINC ID	DrugBank ID	Drug name	Docking score	Glide gscore
409	ZINC000019632917	DB00475	Chlordiazepoxide	-6.92645	-6.97435
409	ZINC000150588351	DB11574	Elbasvir	-5.57596	-6.96746
409	ZINC000085537014	DB09065	Cobicistat	-6.20098	-6.73078
409	ZINC000003830946	DB01362	Iohexol	-6.69015	-6.69015
409	ZINC000029571072	DB06636	Isavuconazonium	-4.84027	-6.61257
409	ZINC000022448696	DB00224	Indinavir	-5.93504	-6.57694
409	ZINC000060183170	DB01421	Paromomycin	-5.47452	-6.55172
409	ZINC000003943279	DB06695	Dabigatran etexilate	-5.07852	-6.54972
409	ZINC000049841054	DB08889	Carfilzomib	-6.4926	-6.4951
409	ZINC000242437512	DB00798	Gentamicin	-6.26006	-6.44396
409	ZINC000004658290	DB01033	Mercaptopurine	-6.30202	-6.42482
409	ZINC000068204830	DB09102	Daclatasvir	-5.51024	-6.37904
409	ZINC000027990463	DB08827	Lomitapide	-6.36792	-6.37102
409	ZINC000096006020	DB01229	Paclitaxel	-6.34398	-6.34548
409	ZINC000096006023	DB06590	Ceftaroline fosamil	-5.99573	-6.29693
409	ZINC000003830943	DB01362	Iohexol	-6.26508	-6.26508
409	ZINC000253917094	DB00703	Methazolamide	-5.87663	-6.15953
409	ZINC000003830957	DB09156	Iopromide	-6.1009	-6.1009
409	ZINC000043200832	DB09075	Edoxaban	-5.42745	-6.09745
409	ZINC000026985532	DB01232	Saquinavir	-6.0666	-6.0798

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID	DrugBank ID	Drug name	Drug type	SMILES	Drug group
ZINC000019632917	DB00475	Chlordiazepoxide	Small molecule	CNC1=NC2=C(C=C(Cl)C=C2)C(C2=CC=CC=C2)=[N+]([O-])C1	Approved\|Illicit\|Investigational
ZINC000150588351	DB11574	Elbasvir	Small molecule	[H][C@]1(CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C)C1=NC=C(N1)C1=CC2=C(C=C1)N1[C@@H](OC3=C(C=CC(=C3)C3=CN=C(N3)[C@]3([H])CCCN3C(=O)[C@@H](NC(=O)OC)C(C)C)C1=C2)C1=CC=CC=C1	Approved
ZINC000085537014	DB09065	Cobicistat	Small molecule	CC(C)C1=NC(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](CC2=CC=CC=C2)NC(=O)OCC2=CN=CS2)CC2=CC=CC=C2)=CS1	Approved
ZINC000022448696	DB00224	Indinavir	Small molecule	CC(C)(C)NC(=O)[C@@H]1CN(CC2=CN=CC=C2)CCN1C[C@@H](O)C[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H]1[C@H](O)CC2=CC=CC=C12	Approved
ZINC000060183170	DB01421	Paromomycin	Small molecule	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	Approved\|Investigational
ZINC000003943279	DB06695	Dabigatran etexilate	Small molecule	CCCCCCOC(=O)N=C(N)C1=CC=C(NCC2=NC3=C(C=CC(=C3)C(=O)N(CCC(=O)OCC)C3=NC=CC=C3)N2C)C=C1	Approved
ZINC000049841054	DB08889	Carfilzomib	Small molecule	CC(C)C[C@H](NC(=O)[C@H](CCC1=CC=CC=C1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](CC1=CC=CC=C1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1	Approved\|Investigational
ZINC000004658290	DB01033	Mercaptopurine	Small molecule	S=C1N=CNC2=C1NC=N2	Approved
ZINC000068204830	DB09102	Daclatasvir	Small molecule	COC(=O)N[C@@H](C(C)C)C(=O)N1CCC[C@H]1C1=NC=C(N1)C1=CC=C(C=C1)C1=CC=C(C=C1)C1=CN=C(N1)[C@@H]1CCCN1C(=O)[C@@H](NC(=O)OC)C(C)C	Approved\|Investigational
ZINC000027990463	DB08827	Lomitapide	Small molecule	FC(F)(F)CNC(=O)C1(CCCCN2CCC(CC2)NC(=O)C2=C(C=CC=C2)C2=CC=C(C=C2)C(F)(F)F)C2=CC=CC=C2C2=CC=CC=C12	Approved\|Investigational
ZINC000096006020	DB01229	Paclitaxel	Small molecule	[H][C@]12[C@H](OC(=O)C3=CC=CC=C3)[C@]3(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)C4=CC=CC=C4)C4=CC=CC=C4)C(C)=C([C@@H](OC(C)=O)C(=O)[C@]1(C)[C@@H](O)C[C@H]1OC[C@@]21OC(C)=O)C3(C)C	Approved\|Vet_approved
ZINC000253917094	DB00703	Methazolamide	Small molecule	CN1N=C(SC1=NC(C)=O)S(N)(=O)=O	Approved
ZINC000003830957	DB09156	Iopromide	Small molecule	COCC(=O)NC1=C(I)C(C(=O)N(C)CC(O)CO)=C(I)C(C(=O)NCC(O)CO)=C1I	Approved
ZINC000043200832	DB09075	Edoxaban	Small molecule	CN(C)C(=O)[C@H]1CC[C@H](NC(=O)C(=O)NC2=NC=C(Cl)C=C2)[C@@H](C1)NC(=O)C1=NC2=C(CN(C)CC2)S1	Approved

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID	mol_MW	dipole	SASA	FOSA	FISA	PISA	WPSA	volume	donorHB	accptHB	IP	Human Oral Absorption	Percent Human Oral Absorption	Rule Of Five	Rule Of Three
ZINC000019632917	299.759	4.645	553.04	137.022	64.707	279.788	71.524	941.819	1	3	8.565	3	100	0	0
ZINC000019632917	299.759	5.502	549.003	118.965	74.766	283.82	71.453	935.577	1	3	8.408	3	100	0	0
ZINC000150588351	882.03	6.572	1345.74	717.517	186.345	441.878	0	2635.972	2.5	13.25	8.001	1	68.973	3	1
ZINC000150588351	882.03	15.581	1298.014	670.728	196.39	430.896	0	2598.655	2.5	13.25	8.107	1	65.891	3	1
ZINC000150588351	882.03	7.694	1389.327	750.107	173.462	465.758	0	2673.848	2.5	13.25	8.124	1	73.085	3	1
ZINC000150588351	882.03	2.219	1373.023	721.483	195.055	456.485	0	2655.192	2.5	13.25	8.091	1	68.497	3	1
ZINC000150588351	882.03	13.761	1347.364	706.26	205.501	435.603	0	2635.257	2.5	13.25	8.253	1	64.824	3	1
ZINC000150588351	882.03	6.922	1403.807	740.212	182.531	481.064	0	2678.744	2.5	13.25	8.307	1	71.991	3	1
ZINC000150588351	882.03	13.99	1367.982	729.766	188.685	449.531	0	2678.673	2.5	13.25	7.973	1	70.208	3	2
ZINC000150588351	882.03	10.656	1391.126	719.587	194.166	477.373	0	2673.624	2.5	13.25	7.937	1	69.244	3	2
ZINC000150588351	882.03	8.233	1375.056	718.117	197.908	459.032	0	2655.63	2.5	13.25	7.962	1	67.787	3	2
ZINC000085537014	776.023	3.562	1130.896	463.572	119.013	461.565	86.745	2316.712	2.25	12.95	9.035	1	60.052	3	2
ZINC000085537014	776.023	4.572	1189.952	539.169	118.37	441.217	91.196	2383.159	2.25	12.95	9.28	1	63.16	3	2
ZINC000003830946	821.143	5.327	787.47	294	369.208	9.789	114.474	1488.253	8	18.2	9.631	1	0	3	1
ZINC000022448696	613.798	6.954	1035.321	444.196	106.92	484.205	0	1983.74	4	13.9	8.672	1	60.656	1	1
ZINC000022448696	613.798	4.692	987.892	420.483	105.118	462.291	0	1950.085	4	13.9	9.459	1	57.593	1	1
ZINC000022448696	613.798	4.883	996.709	456.592	90.226	449.891	0	1954.069	4	13.9	9.026	1	61.724	1	1
ZINC000022448696	613.798	4.038	892.447	367.68	134.761	390.006	0	1866.081	4	13.9	9.424	1	49.06	1	2
ZINC000022448696	613.798	6.203	1015.231	403.285	139.932	472.014	0	1971.466	4	13.9	9.391	1	49.786	1	2
ZINC000060183170	615.634	6.469	852.379	333.487	518.892	0	0	1659.281	18	28.8	9.349	1	0	3	2
ZINC000060183170	615.634	3.96	880.798	394.277	486.521	0	0	1692.314	18	28.8	9.305	1	0	3	2
ZINC000060183170	615.634	5.103	837.174	322.647	514.527	0	0	1660.785	18	28.8	9.222	1	0	3	2
ZINC000060183170	615.634	2.705	864.842	336.076	528.766	0	0	1662.115	18	28.8	9.424	1	0	3	2
ZINC000060183170	615.634	5.505	857.834	356.773	501.061	0	0	1653.731	18	28.8	9.025	1	0	3	2
ZINC000060183170	615.634	4.108	857.637	355.734	501.903	0	0	1653.789	18	28.8	9.107	1	0	3	2
ZINC000060183170	615.634	7.059	842.213	356.118	486.095	0	0	1655.763	18	28.8	9.1	1	0	3	2
ZINC000060183170	615.634	7.013	831.783	339.851	491.933	0	0	1655.638	18	28.8	9.196	1	0	3	2
ZINC000060183170	615.634	9.322	830.127	345.166	484.961	0	0	1649.249	18	28.8	9.438	1	0	3	2
ZINC000060183170	615.634	6.26	774.039	316.84	457.199	0	0	1589.578	18	28.8	9.166	1	0	3	2
ZINC000060183170	615.634	7.054	839.2	337.172	502.027	0	0	1650.058	18	28.8	9.355	1	0	3	2
ZINC000003943279	627.742	4.667	1184.331	574.306	231.253	378.772	0	2103.011	2	11	8.55	1	58.304	3	1
ZINC000003943279	627.742	7.938	1170.006	572.981	237.303	359.722	0	2090.012	2	11	8.404	1	56.447	3	1
ZINC000003943279	627.742	6.121	1133.409	561.818	218.501	353.089	0	2055.355	2	11	8.475	1	59.143	3	1
ZINC000003943279	627.742	10.2	1166.266	573.103	235.814	357.349	0	2084.657	2	11	8.292	1	56.55	3	1
ZINC000003943279	627.742	9.595	1158.598	580.852	244.759	332.987	0	2079.282	2	11	8.313	1	54.32	3	1
ZINC000003943279	627.742	7.327	1178.116	572.965	232.033	373.118	0	2096.733	2	11	8.58	1	57.88	3	1
ZINC000003943279	627.742	9.958	1175.042	575.778	234.38	364.884	0	2092.735	2	11	8.327	1	57.186	3	1
ZINC000049841054	719.92	3.846	1117.468	721.003	99.711	296.754	0	2246.436	0.75	14.45	9.194	1	56.806	2	1
ZINC000242437512	477.6	4.42	736.106	507.577	228.529	0	0	1451.61	11	16.95	8.823	1	0	2	2
ZINC000242437512	477.6	7.632	797.695	579.34	218.355	0	0	1493.017	11	16.95	8.818	1	0	2	2
ZINC000242437512	477.6	7.606	792.016	579.15	212.867	0	0	1489.075	11	16.95	8.8	1	0	2	2
ZINC000242437512	477.6	8.648	749.075	523.524	225.551	0	0	1481.179	11	16.95	8.813	1	0	2	2
ZINC000242437512	477.6	3.326	703.139	480.59	222.549	0	0	1416.05	11	16.95	8.822	1	0	2	2
ZINC000004658290	152.173	0.253	317.034	0	116.169	124.004	76.86	478.242	2	4.5	8.913	3	76.928	0	0
ZINC000004658290	152.173	6.839	316.545	0	107.798	131.011	77.736	477.355	1.8	3.5	9.117	3	80.844	0	0
ZINC000004658290	152.173	8.404	316.811	0	116.585	123.822	76.404	477.905	2	4.5	8.685	3	76.837	0	0
ZINC000068204830	738.885	9.186	1185.225	698.369	189.608	297.248	0	2297.481	2.5	12.5	8.424	1	56.25	3	1
ZINC000068204830	738.885	12.728	1242.653	732.724	195.462	314.467	0	2325.851	2.5	12.5	8.586	1	56.993	3	1
ZINC000068204830	738.885	5.659	1215.343	718.68	189.061	307.602	0	2308.854	2.5	12.5	8.456	1	57.668	3	1
ZINC000068204830	738.885	3.036	1238.237	724.613	189.774	323.849	0	2337.465	2.5	12.5	8.529	1	58.588	3	1
ZINC000068204830	738.885	6.612	1209.345	719.031	182.477	307.837	0	2307.347	2.5	12.5	8.288	1	59.648	3	1
ZINC000068204830	738.885	4.849	1244.561	737.115	179.716	327.731	0	2332.759	2.5	12.5	8.571	1	60.798	3	1
ZINC000027990463	693.731	9.819	1082.565	277.602	57.032	525.312	222.618	2026.285	2	7	9.293	1	100	2	1
ZINC000027990463	693.731	5.182	1032.195	249.812	56.285	513.578	212.521	1985.783	2	7	9.074	1	100	2	1
ZINC000096006020	853.918	7.222	1008.963	367.497	222.021	419.445	0	2212.853	3	17.65	9.796	2	61.419	2	2
ZINC000003830943	821.143	2.11	797.152	329.149	341.979	8.796	117.227	1489.14	8	18.2	9.356	1	0	3	1
ZINC000253917094	236.263	8.14	439.923	174.514	223.625	11.407	30.377	699.037	2	8.5	9.678	2	54.127	0	0
ZINC000253917094	236.263	7.436	427.93	148.388	223.083	11.627	44.833	684.853	2	8.5	9.676	2	54.222	0	0
ZINC000003830957	791.116	18.635	789.873	365.18	274.531	12.737	137.425	1448.372	6	16.5	9.13	2	11.93	3	0
ZINC000043200832	548.058	9.441	913.361	465.639	180.782	154.069	112.871	1642.583	1.5	13.5	9.003	2	38.997	2	0
ZINC000043200832	548.058	6.463	912.632	460.161	190.9	150.844	110.726	1644.454	1.5	13.5	9.164	2	36.849	2	0
ZINC000043200832	548.058	9.846	916.93	470.459	180.251	153.57	112.65	1646.732	1.5	13.5	8.983	2	39.246	2	0
ZINC000026985532	670.85	2.992	1090.203	522.841	198.112	369.25	0	2103.734	5	13.7	8.881	2	23.062	3	2
ZINC000026985532	670.85	8.593	1062.24	515.596	176.807	369.837	0	2085.965	5	13.7	9.245	2	25.698	3	2
ZINC000026985532	670.85	2.719	1077.343	520.688	191.958	364.697	0	2094.541	5	13.7	8.976	2	25	3	2

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID	Smile	Surface Accessibility	Toxicity
ZINC000019632917	CNC1=Nc2ccc(Cl)cc2C(c2ccccc2)=[N+]([O-])C1	0.147320673	0.447326601
ZINC000150588351	COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1nc(-c2ccc3c(c2)O[C@@H](c2ccccc2)n2c-3cc3cc(-c4c[nH]c([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)n4)ccc32)c[nH]1)C(C)C	0.015875917	0.217012798
ZINC000085537014	CC(C)c1nc(CN(C)C(=O)N[C@@H](CCN2CCOCC2)C(=O)N[C@H](CC[C@H](Cc2ccccc2)NC(=O)OCc2cncs2)Cc2ccccc2)cs1	0.040386906	0.210921474
ZINC000003830946	CC(=O)N(C[C@@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@@H](O)CO)c1I	0.042332243	0.211666342
ZINC000029571072	CNCC(=O)OCc1cccnc1N(C)C(=O)O[C@H](C)[n+]1cnn(C[C@](O)(c2cc(F)ccc2F)[C@@H](C)c2nc(-c3ccc(C#N)cc3)cs2)c1	0.025416027	0.235213823
ZINC000022448696	CC(C)(C)NC(=O)[C@@H]1CN(Cc2cccnc2)CCN1C[C@@H](O)C[C@@H](Cc1ccccc1)C(=O)N[C@H]1c2ccccc2C[C@H]1O	0.045517594	0.324414178
ZINC000060183170	NC[C@@H]1O[C@H](O[C@@H]2[C@@H](CO)O[C@@H](O[C@@H]3[C@@H](O)[C@H](N)C[C@H](N)[C@H]3O[C@H]3O[C@H](CO)[C@@H](O)[C@H](O)[C@H]3N)[C@@H]2O)[C@H](N)[C@@H](O)[C@@H]1O	0.010995771	0.270848186
ZINC000003943279	CCCCCCOC(=O)/N=C(N)c1ccc(NCc2nc3cc(C(=O)N(CCC(=O)OCC)c4ccccn4)ccc3n2C)cc1	0.136066223	0.265677856
ZINC000049841054	CC(C)C[C@H](NC(=O)[C@H](CCc1ccccc1)NC(=O)CN1CCOCC1)C(=O)N[C@@H](Cc1ccccc1)C(=O)N[C@@H](CC(C)C)C(=O)[C@@]1(C)CO1	0.045831724	0.177798441
ZINC000242437512	CN[C@H](C)[C@@H]1CC[C@H](N)[C@H](O[C@H]2[C@H](O)[C@@H](O[C@@H]3OC[C@](C)(O)[C@H](NC)[C@@H]3O)[C@@H](N)C[C@H]2N)O1	0.013265241	0.371016745
ZINC000004658290	S=c1[nH]cnc2nc[nH]c12	0.101927094	0.621755098
ZINC000068204830	COC(=O)N[C@H](C(=O)N1CCC[C@H]1c1ncc(-c2ccc(-c3ccc(-c4cnc([C@@H]5CCCN5C(=O)[C@@H](NC(=O)OC)C(C)C)[nH]4)cc3)cc2)[nH]1)C(C)C	0.039971092	0.226481814
ZINC000027990463	O=C(NC1CCN(CCCCC2(C(=O)NCC(F)(F)F)c3ccccc3-c3ccccc32)CC1)c1ccccc1-c1ccc(C(F)(F)F)cc1	0.141091549	0.274261494
ZINC000096006020	CC(=O)O[C@H]1C(=O)[C@]2(C)[C@@H](O)C[C@H]3OC[C@@]3(OC(C)=O)[C@H]2[C@H](OC(=O)c2ccccc2)[C@]2(O)C[C@H](OC(=O)[C@H](O)[C@@H](NC(=O)c3ccccc3)c3ccccc3)C(C)=C1C2(C)C	0.007331142	0.303016135
ZINC000096006023	CCO/N=C(/C(=O)N[C@@H]1C(=O)N2C(C(=O)O)=C(Sc3nc(-c4cc[n+](C)cc4)cs3)CS[C@H]12)c1nsc(NP(=O)(O)O)n1	0.027233582	0.191312451
ZINC000003830943	CC(=O)N(C[C@H](O)CO)c1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)NC[C@H](O)CO)c1I	0.042332243	0.211666342
ZINC000253917094	CC(=O)N=c1sc(S(N)(=O)=O)nn1C	0.122096206	0.392164649
ZINC000003830957	COCC(=O)Nc1c(I)c(C(=O)NC[C@H](O)CO)c(I)c(C(=O)N(C)C[C@H](O)CO)c1I	0.060949553	0.263153665
ZINC000043200832	CN1CCc2nc(C(=O)N[C@@H]3C[C@@H](C(=O)N(C)C)CC[C@@H]3NC(=O)C(=O)Nc3ccc(Cl)cn3)sc2C1	0.053168582	0.122501005
ZINC000026985532	CC(C)(C)NC(=O)[C@@H]1C[C@H]2CCCC[C@@H]2CN1C[C@@H](O)[C@H](Cc1ccccc1)NC(=O)[C@H](CC(N)=O)NC(=O)c1ccc2ccccc2n1	0.039248776	0.333476835

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene

PPI interactors

HMGA2

RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA2
NFIB

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Interaction lost with

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Related Drugs to HMGA2-NFIB

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HMGA2-NFIB

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Disease

Source

PMID

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Hgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Hgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Hgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Hgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Hgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Hgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Hgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET
Tgene	NFIB	C0010606	Adenoid Cystic Carcinoma	1	CTD_human
Tgene	NFIB	C0221355	Macrocephaly	1	GENOMICS_ENGLAND
Tgene	NFIB	C0557874	Global developmental delay	1	GENOMICS_ENGLAND
Tgene	NFIB	C3714756	Intellectual Disability	1	GENOMICS_ENGLAND
Tgene	NFIB	C4748993	MACROCEPHALY, ACQUIRED, WITH IMPAIRED INTELLECTUAL DEVELOPMENT	1	GENOMICS_ENGLAND;UNIPROT