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	Fusion Gene Summary
	Fusion Gene Sample Information
	Fusion ORF Analysis
	Fusion Amino Acid Sequences
	Fusion Protein Functional Features
	Fusion Protein Structure
	pLDDT scores
	Ramachandran Plot of Fusion Protein Structure
	Potential Active Site Information
	Potentially Interacting Small Molecules through Virtual Screening
	Biochemical Features of Small Molecules with ADME
	Drug Toxicity Information
	Fusion Protein-Protein Interaction
	Related drugs with this fusion protein
	Related disease with this fusion protein

Fusion Protein:HMGA2-RAD51B

Fusion Protein Summary

Fusion gene summary

Fusion partner gene information	Fusion gene name: HMGA2-RAD51B
	FusionPDB ID: 36854
	FusionGDB2.0 ID: 36854
		Hgene	Tgene
	Gene symbol	HMGA2	RAD51B
	Gene ID	8091	5890
	Gene name	high mobility group AT-hook 2	RAD51 paralog B
	Synonyms	BABL\|HMGI-C\|HMGIC\|LIPO\|STQTL9	R51H2\|RAD51L1\|REC2
	Cytomap	12q14.3	14q24.1
	Type of gene	protein-coding	protein-coding
	Description	high mobility group protein HMGI-CHMGA2/KRT121P fusionhigh-mobility group (nonhistone chromosomal) protein isoform I-C	DNA repair protein RAD51 homolog 2RAD51 homolog BRecA-like proteinrecombination repair protein
	Modification date	20200329	20200313
	UniProtAcc	P52926	O15315
Ensembl transtripts involved in fusion gene	ENST ids	ENST00000403681, ENST00000354636, ENST00000393577, ENST00000393578, ENST00000425208, ENST00000536545, ENST00000541363,	ENST00000390683, ENST00000471583, ENST00000487270, ENST00000487861, ENST00000488612, ENST00000469165,
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)	* DoF score	43 X 25 X 15=16125	41 X 23 X 12=11316
	# samples	43	56
	** MAII score	log2(43/16125*10)=-5.22881869049588 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0	log2(56/11316*10)=-4.33679344445129 possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs). DoF>8 and MAII<0
Context (manual curation of fusion genes in FusionPDB)	PubMed: HMGA2 [Title/Abstract] AND RAD51B [Title/Abstract] AND fusion [Title/Abstract] Allelic knockout of novel splice variants of human recombination repair gene RAD51B in t(12;14) uterine leiomyomas (pmid: 9892177)
Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)	HMGA2(66232351)-RAD51B(68758600), # samples:3
Anticipated loss of major functional domain due to fusion event.	HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Hgene partner, which is a transcription factor due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Tgene partner, which is a CGC due to the frame-shifted ORF. HMGA2-RAD51B seems lost the major protein functional domain in Tgene partner, which is a essential gene due to the frame-shifted ORF.

* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez

Partner	Gene	GO ID	GO term	PubMed ID
Hgene	HMGA2	GO:0000122	negative regulation of transcription by RNA polymerase II	14627817
Hgene	HMGA2	GO:0002062	chondrocyte differentiation	21484705
Hgene	HMGA2	GO:0006284	base-excision repair	19465398
Hgene	HMGA2	GO:0007095	mitotic G2 DNA damage checkpoint	16061642
Hgene	HMGA2	GO:0010564	regulation of cell cycle process	14645522
Hgene	HMGA2	GO:0010628	positive regulation of gene expression	18832382
Hgene	HMGA2	GO:0031052	chromosome breakage	19549901
Hgene	HMGA2	GO:0031507	heterochromatin assembly	16901784
Hgene	HMGA2	GO:0035978	histone H2A-S139 phosphorylation	16061642
Hgene	HMGA2	GO:0035986	senescence-associated heterochromatin focus assembly	16901784
Hgene	HMGA2	GO:0035988	chondrocyte proliferation	21484705
Hgene	HMGA2	GO:0042769	DNA damage response, detection of DNA damage	19465398
Hgene	HMGA2	GO:0043065	positive regulation of apoptotic process	16061642
Hgene	HMGA2	GO:0043066	negative regulation of apoptotic process	19465398
Hgene	HMGA2	GO:0043392	negative regulation of DNA binding	14645522
Hgene	HMGA2	GO:0043922	negative regulation by host of viral transcription	17005673
Hgene	HMGA2	GO:0045869	negative regulation of single stranded viral RNA replication via double stranded DNA intermediate	17005673
Hgene	HMGA2	GO:0045892	negative regulation of transcription, DNA-templated	18832382
Hgene	HMGA2	GO:0045893	positive regulation of transcription, DNA-templated	15225648\|15755872\|17005673\|17324944\|17426251
Hgene	HMGA2	GO:0045944	positive regulation of transcription by RNA polymerase II	14645522\|18832382
Hgene	HMGA2	GO:0071158	positive regulation of cell cycle arrest	16061642
Hgene	HMGA2	GO:0071902	positive regulation of protein serine/threonine kinase activity	19549901
Hgene	HMGA2	GO:0090402	oncogene-induced cell senescence	16901784
Hgene	HMGA2	GO:2000648	positive regulation of stem cell proliferation	21484705
Hgene	HMGA2	GO:2000679	positive regulation of transcription regulatory region DNA binding	18832382
Hgene	HMGA2	GO:2000685	positive regulation of cellular response to X-ray	16061642
Hgene	HMGA2	GO:2001022	positive regulation of response to DNA damage stimulus	16061642\|19465398
Hgene	HMGA2	GO:2001033	negative regulation of double-strand break repair via nonhomologous end joining	19549901
Hgene	HMGA2	GO:2001038	regulation of cellular response to drug	16061642

Fusion gene breakpoints across HMGA2 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

Fusion gene breakpoints across RAD51B (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.

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Fusion Gene Sample Information

Fusion gene information from FusionGDB2.0.

Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.

Source	Disease	Sample	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand
ChimerDB4	leiomyoma	AF533653	HMGA2	chr12	66357844		RAD51B	chr14	68418832
ChimerKB3	.	.	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+
ChimerKB3	.	.	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+
ChimerKB3	.	.	HMGA2	chr12	66360071	+	RAD51B	chr14	68353737
ChiTaRS5.0	N/A	AF533653	HMGA2	chr12	66357844	+	RAD51B	chr14	68418832	+
ChiTaRS5.0	N/A	AY138857	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+
ChiTaRS5.0	N/A	AY138858	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+
ChiTaRS5.0	N/A	AY138859	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+
ChiTaRS5.0	N/A	AY138860	HMGA2	chr12	66357154	+	RAD51B	chr14	68758601	+

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Fusion ORF Analysis

Fusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	Seq length (transcript)	BP loci (transcript)	Predicted start (transcript)	Predicted stop (transcript)	Seq length (amino acids)
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	2229	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	2121	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	3181	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	2156	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	1734	1389	114	992	292
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1462	622	373	1143	256
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1354	622	373	918	181
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2414	622	373	1020	215
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1389	622	373	966	197
ENST00000541363	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	967	622	373	966	198
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1237	397	148	918	256
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1129	397	148	693	181
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2189	397	148	795	215
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1164	397	148	741	197
ENST00000393577	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	742	397	148	741	198
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232349	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	2229	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	2121	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	3181	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	2156	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1734	1389	114	992	292
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1462	622	373	1143	256
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1354	622	373	918	181
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2414	622	373	1020	215
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1389	622	373	966	197
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	967	622	373	966	198
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1237	397	148	918	256
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1129	397	148	693	181
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2189	397	148	795	215
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1164	397	148	741	197
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	742	397	148	741	198
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	2229	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	2121	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	3181	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	2156	1389	114	992	292
ENST00000403681	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1734	1389	114	992	292
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1462	622	373	1143	256
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1354	622	373	918	181
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2414	622	373	1020	215
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1389	622	373	966	197
ENST00000541363	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	967	622	373	966	198
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1237	397	148	918	256
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1129	397	148	693	181
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2189	397	148	795	215
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1164	397	148	741	197
ENST00000393577	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	742	397	148	741	198
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000393578	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000425208	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000536545	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000487861	RAD51B	chr14	68758600	+	1900	1060	811	1581	256
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000471583	RAD51B	chr14	68758600	+	1792	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000487270	RAD51B	chr14	68758600	+	2852	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000488612	RAD51B	chr14	68758600	+	1827	1060	1	663	220
ENST00000354636	HMGA2	chr12	66232351	+	ENST00000390683	RAD51B	chr14	68758600	+	1405	1060	1	663	220

DeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.

Henst	Tenst	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	No-coding score	Coding score
ENST00000403681	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.18883233	0.8111677
ENST00000403681	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.044306263	0.9556938
ENST00000403681	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.110473596	0.8895264
ENST00000403681	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.06483422	0.93516576
ENST00000403681	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.05298182	0.94701815
ENST00000541363	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.1671994	0.83280057
ENST00000541363	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.058965627	0.9410344
ENST00000541363	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.13071436	0.86928564
ENST00000541363	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.07941733	0.92058265
ENST00000541363	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.06977114	0.9302289
ENST00000393577	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.17646758	0.8235324
ENST00000393577	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.06104926	0.9389507
ENST00000393577	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.090914845	0.90908515
ENST00000393577	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.098512195	0.90148777
ENST00000393577	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.093537234	0.9064628
ENST00000393578	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.18470018	0.81529987
ENST00000393578	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.03632338	0.9636766
ENST00000393578	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.089867316	0.91013265
ENST00000393578	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.049283694	0.95071626
ENST00000393578	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.054416377	0.94558364
ENST00000425208	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.18470018	0.81529987
ENST00000425208	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.03632338	0.9636766
ENST00000425208	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.089867316	0.91013265
ENST00000425208	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.049283694	0.95071626
ENST00000425208	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.054416377	0.94558364
ENST00000536545	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.18470018	0.81529987
ENST00000536545	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.03632338	0.9636766
ENST00000536545	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.089867316	0.91013265
ENST00000536545	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.049283694	0.95071626
ENST00000536545	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.054416377	0.94558364
ENST00000354636	ENST00000487861	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.18470018	0.81529987
ENST00000354636	ENST00000471583	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.03632338	0.9636766
ENST00000354636	ENST00000487270	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.089867316	0.91013265
ENST00000354636	ENST00000488612	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.049283694	0.95071626
ENST00000354636	ENST00000390683	HMGA2	chr12	66232351	+	RAD51B	chr14	68758600	+	0.054416377	0.94558364

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Fusion Amino Acid Sequences

For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.

>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>36854_36854_1_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000354636_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_2_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000354636_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_3_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000354636_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_4_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000354636_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_5_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000354636_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_6_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393577_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=198AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_7_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393577_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=181AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEK

--------------------------------------------------------------

>36854_36854_8_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393577_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=215AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTF

--------------------------------------------------------------

>36854_36854_9_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393577_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_10_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393577_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=197AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_11_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393578_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_12_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393578_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_13_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393578_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_14_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393578_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_15_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000393578_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_16_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000403681_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_17_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000403681_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_18_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000403681_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_19_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000403681_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_20_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000403681_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_21_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000425208_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_22_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000425208_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_23_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000425208_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_24_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000425208_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_25_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000425208_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_26_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000536545_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_27_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000536545_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_28_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000536545_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_29_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000536545_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_30_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000536545_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_31_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000541363_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=198AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_32_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000541363_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=181AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEK

--------------------------------------------------------------

>36854_36854_33_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000541363_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=215AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTF

--------------------------------------------------------------

>36854_36854_34_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000541363_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_35_HMGA2-RAD51B_HMGA2_chr12_66232349_ENST00000541363_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=197AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_36_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000354636_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_37_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000354636_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_38_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000354636_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_39_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000354636_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_40_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000354636_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_41_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393577_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=198AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_42_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393577_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=181AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEK

--------------------------------------------------------------

>36854_36854_43_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393577_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=215AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTF

--------------------------------------------------------------

>36854_36854_44_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393577_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_45_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393577_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=197AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_46_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393578_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_47_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393578_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_48_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393578_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_49_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393578_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_50_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000393578_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_51_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000403681_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_52_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000403681_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_53_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000403681_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_54_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000403681_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_55_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000403681_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=292AA_BP=
MPLASSQAPWLGGPPGLPPPHTFLPAQPPPLYPPTIRGGHSPHHHPLPKRKRVHAHTPHTLTLTHTHTHSSHLNLGAGTQKTSSPGSARL
VQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLSLSLSLSLSLSLSLAGWGE
EEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPPAPTHRRRRHRQRLLLSSS

--------------------------------------------------------------

>36854_36854_56_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000425208_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_57_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000425208_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_58_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000425208_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_59_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000425208_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_60_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000425208_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_61_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000536545_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_62_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000536545_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_63_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000536545_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_64_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000536545_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_65_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000536545_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=220AA_BP=
LNLGAGTQKTSSPGSARLVQDSGASSPSPSDSPVPPLPAPATLGGAVPPTTLSSACAPCPTLSRRSLPILLCFPTAQGTFNLNLFSLSLS
LSLSLSLSLSLSLAGWGEEEEEFFPRLTFQGTQFTPSLFPFQAASEVLPVPATPDPNPREEPLRPQSLSSFSLASLLLLLPPPPPPPPPP

--------------------------------------------------------------

>36854_36854_66_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000541363_RAD51B_chr14_68758600_ENST00000390683_length(amino acids)=198AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

>36854_36854_67_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000541363_RAD51B_chr14_68758600_ENST00000471583_length(amino acids)=181AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQGQEK

--------------------------------------------------------------

>36854_36854_68_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000541363_RAD51B_chr14_68758600_ENST00000487270_length(amino acids)=215AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQETTF

--------------------------------------------------------------

>36854_36854_69_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000541363_RAD51B_chr14_68758600_ENST00000487861_length(amino acids)=256AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQVVRT

--------------------------------------------------------------

>36854_36854_70_HMGA2-RAD51B_HMGA2_chr12_66232351_ENST00000541363_RAD51B_chr14_68758600_ENST00000488612_length(amino acids)=197AA_BP=83
MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRGRPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQI
TTHLSGALASQADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQILIAKSPLAPFTSFVYTIKEEGLVLQEFWH

--------------------------------------------------------------

Top

Fusion Protein Functional Features

Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr12:66232351/chr14:68758600)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.

Main function of each fusion partner protein. (from UniProt)

Hgene	Tgene
HMGA2 P52926	RAD51B O15315
FUNCTION: Functions as a transcriptional regulator. Functions in cell cycle regulation through CCNA2. Plays an important role in chromosome condensation during the meiotic G2/M transition of spermatocytes. Plays a role in postnatal myogenesis, is involved in satellite cell activation (By similarity). Positively regulates IGF2 expression through PLAG1 and in a PLAG1-independent manner (PubMed:28796236). {ECO:0000250\|UniProtKB:P52927, ECO:0000269\|PubMed:14645522, ECO:0000269\|PubMed:28796236}.	FUNCTION: Involved in the homologous recombination repair (HRR) pathway of double-stranded DNA breaks arising during DNA replication or induced by DNA-damaging agents. May promote the assembly of presynaptic RAD51 nucleoprotein filaments. Binds single-stranded DNA and double-stranded DNA and has DNA-dependent ATPase activity. Part of the RAD21 paralog protein complex BCDX2 which acts in the BRCA1-BRCA2-dependent HR pathway. Upon DNA damage, BCDX2 acts downstream of BRCA2 recruitment and upstream of RAD51 recruitment. BCDX2 binds predominantly to the intersection of the four duplex arms of the Holliday junction and to junction of replication forks. The BCDX2 complex was originally reported to bind single-stranded DNA, single-stranded gaps in duplex DNA and specifically to nicks in duplex DNA. The BCDX2 subcomplex RAD51B:RAD51C exhibits single-stranded DNA-dependent ATPase activity suggesting an involvement in early stages of the HR pathway. {ECO:0000269\|PubMed:11751635, ECO:0000269\|PubMed:11751636, ECO:0000269\|PubMed:11842113, ECO:0000269\|PubMed:12441335, ECO:0000269\|PubMed:23108668, ECO:0000269\|PubMed:23149936}.

Retention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at
download page
* Minus value of BPloci means that the break pointn is located before the CDS.

- Retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000354636

24_34

83.0

107.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000354636

44_54

83.0

107.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000354636

71_82

83.0

107.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000393578

24_34

83.0

91.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000393578

44_54

83.0

91.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000393578

71_82

83.0

91.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000403681

24_34

83.0

110.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000403681

44_54

83.0

110.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000403681

71_82

83.0

110.0

DNA binding

Note=A.T hook 3

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000425208

24_34

83.0

93.0

DNA binding

Note=A.T hook 1

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000425208

44_54

83.0

93.0

DNA binding

Note=A.T hook 2

Hgene

HMGA2

chr12:66232351

chr14:68758600

ENST00000425208

71_82

83.0

93.0

DNA binding

Note=A.T hook 3

- Not-retained protein feature among the 13 regional features.

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Protein feature

Protein feature note

Tgene

RAD51B

chr12:66232351

chr14:68758600

ENST00000390683

108_115

252.0

367.0

Nucleotide binding

ATP

Tgene

RAD51B

chr12:66232351

chr14:68758600

ENST00000471583

108_115

252.0

351.0

Nucleotide binding

ATP

Tgene

RAD51B

chr12:66232351

chr14:68758600

ENST00000487270

108_115

252.0

385.0

Nucleotide binding

ATP

Tgene

RAD51B

chr12:66232351

chr14:68758600

ENST00000488612

108_115

252.0

495.6666666666667

Nucleotide binding

ATP

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Fusion Protein Structures

PDB and CIF files of the predicted fusion proteins
* Here we show the 3D structure of the fusion proteins using Mol*. AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100. Model confidence is shown from the pLDDT values per residue. pLDDT corresponds to the model’s prediction of its score on the local Distance Difference Test. It is a measure of local accuracy (from AlphfaFold website). To color code individual residues, we transformed individual PDB files into CIF format.

Fusion protein PDB link (fusion AA seq ID in FusionPDB)	Hgene	Hchr	Hbp	Hstrand	Tgene	Tchr	Tbp	Tstrand	AA seq	Len(AA seq)

PDB file (18) >>>18.pdbFusion protein BP residue: 83 CIF file (18) >>>18.cif	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQITTHLSGALAS QADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQ	181
3D view using mol* of 18 (AA BP:83)


PDB file (24) >>>24.pdbFusion protein BP residue: 83 CIF file (24) >>>24.cif	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQITTHLSGALAS QADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQ	197
3D view using mol* of 24 (AA BP:83)


PDB file (25) >>>25.pdbFusion protein BP residue: 83 CIF file (25) >>>25.cif	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQITTHLSGALAS QADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQ	198
3D view using mol* of 25 (AA BP:83)


PDB file (29) >>>29.pdbFusion protein BP residue: 83 CIF file (29) >>>29.cif	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQITTHLSGALAS QADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQ ILIAKSPLAPFTSFVYTIKEEGLVLQETTFCSVTQAELNWAPEILPPQPP	215
3D view using mol* of 29 (AA BP:83)


PDB file (45) >>>45.pdbFusion protein BP residue: 83 CIF file (45) >>>45.cif	HMGA2	chr12	66232349	+	RAD51B	chr14	68758600	+	MSARGEGAGQPSTSAQGQPAAPAPQKRGRGRPRKQQQEPTGEPSPKRPRG RPKGSKNKSPSKAAQKKAEATGEKRPRGRPRKWVILTNQITTHLSGALAS QADLVSPADDLSLSEGTSGSSCVIAALGNTWSHSVNTRLILQYLDSERRQ ILIAKSPLAPFTSFVYTIKEEGLVLQVVRTVARVSPRSECWSAADSHPSP TFLIPDVVLRKTRNPRLLPSVSMCPPQMHSTVLSSALPPTNWATGIRTET	256
3D view using mol* of 45 (AA BP:83)

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pLDDT score distribution

pLDDT score distribution of the predicted wild-type structures of two partner proteins from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_pLDDT.png

RAD51B_pLDDT.png

pLDDT score distribution of the predicted fusion protein structures from AlphaFold2
* AlphaFold produces a per-residue confidence score (pLDDT) between 0 and 100.

HMGA2_RAD51B_18_pLDDT.png (AA BP:83)

HMGA2_RAD51B_18_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_RAD51B_18_violinplot.png (AA BP:83)

HMGA2_RAD51B_24_pLDDT.png (AA BP:83)

HMGA2_RAD51B_24_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_RAD51B_24_violinplot.png (AA BP:83)

HMGA2_RAD51B_25_PAE.png (AA BP:83)

HMGA2_RAD51B_25_pLDDT.png (AA BP:83)

HMGA2_RAD51B_25_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_RAD51B_25_violinplot.png (AA BP:83)

HMGA2_RAD51B_29_PAE.png (AA BP:83)

HMGA2_RAD51B_29_pLDDT.png (AA BP:83)

HMGA2_RAD51B_29_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_RAD51B_29_violinplot.png (AA BP:83)

HMGA2_RAD51B_45_PAE.png (AA BP:83)

HMGA2_RAD51B_45_pLDDT.png (AA BP:83)

HMGA2_RAD51B_45_pLDDT_and_active_sites.png (AA BP:83)

HMGA2_RAD51B_45_violinplot.png (AA BP:83)

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Ramachandran Plot of Fusion Protein Structure

Ramachandran plot of the torsional angles - phi (φ)and psi (ψ) - of the residues (amino acids) contained in this fusion protein peptide.

Fusion AA seq ID in FusionPDB and their Ramachandran plots

HMGA2_RAD51B_18.png

HMGA2_RAD51B_24.png

HMGA2_RAD51B_25.png

HMGA2_RAD51B_29.png

HMGA2_RAD51B_45.png

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Potential Active Site Information

The potential binding sites of these fusion proteins were identified using SiteMap, a module of the Schrodinger suite.

Fusion AA seq ID in FusionPDB	Site score	Size	D score	Volume	Exposure	Enclosure	Contact	Phobic	Philic	Balance	Don/Acc	Residues
18	0.843	75	0.847	225.008	0.691	0.597	0.775	0.323	0.998	0.324	1.04	Chain A: 85,86,87,88,89,90,91,126,128,129,131,133, 135,136,137,138,139
24	0.8	64	0.762	197.911	0.67	0.618	0.824	0.242	1.107	0.218	0.835	Chain A: 150,153,154,155,156,159,160,161,162,163,1 64,165,175,177,179,180,181,182,183,184
25	0.817	69	0.805	199.283	0.648	0.61	0.818	0.216	1.048	0.206	0.88	Chain A: 150,153,154,155,156,159,160,161,162,163,1 64,165,177,179,180,181,182,183
29	0.914	64	0.877	217.462	0.475	0.789	1.123	0.877	1.068	0.821	0.769	Chain A: 87,88,89,90,123,124,125,126,127,128,129,1 30,131,132,133,141,143,149
45	1.043	214	1.1	765.233	0.558	0.684	0.914	1.284	0.768	1.671	0.753	Chain A: 85,87,88,89,121,122,123,124,125,137,139,1 41,151,153,154,155,156,159,160,161,162,164,166,168 ,169,172,173,174,175,178,200,202,203,204,205,206,2 07,208,209,210,211

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Potentially Interacting Small Molecules through Virtual Screening

The FDA-approved small molecule library molecules were subjected to virtual screening using the Glide.

Fusion AA seq ID in FusionPDB

ZINC ID

DrugBank ID

Drug name

Docking score

Glide gscore

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Drug information from DrugBank of the top 20 interacting small molecules.

ZINC ID

DrugBank ID

Drug name

Drug type

SMILES

Drug group

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Biochemical Features of Small Molecules

ADME (Absorption, Distribution, Metabolism, and Excretion) of drugs using QikProp(v3.9)

ZINC ID

mol_MW

dipole

SASA

FOSA

FISA

PISA

WPSA

volume

donorHB

accptHB

Human Oral Absorption

Percent Human Oral Absorption

Rule Of Five

Rule Of Three

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Drug Toxicity Information

Toxicity information of individual drugs using eToxPred

ZINC ID

Smile

Surface Accessibility

Toxicity

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Fusion Protein-Protein Interaction

Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in
ChiPPI page.

Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)

Gene	PPI interactors
HMGA2	RELA, NFKB1, PIAS3, RB1, PRMT6, NPM1, SMAD1, SMAD5, SMAD9, PRKCA, HDGF, PTBP1, APEX1, SYNCRIP, XRCC6, PSIP1, PA2G4, PCBP2, E4F1, OBSL1, HIST1H3A, CREB1, NFATC1, PCGF1, POU5F1, DLST, EZH2, SUZ12, MYC, TP53, MDM2, CSK, VRK1, HIST1H1B, PRKAG2, DUX4, DUX4L9, SYDE1, ARHGAP21, ARHGAP39, Plekhg5, ZNF263, MAFB, KAT2B, HIST1H2BG, LMNB1, NDUFAF7, CSNK2A1, LIG3, SUPT16H, VRK3, SP2, C1QBP, PARP2, TOP3A, CSNK2A2, XPC, RANBP17, PARP1, SUPV3L1, HIST2H2AC, HIST2H3PS2, KPNA4, USP7,
RAD51B	RAD51, RAD51C, RAD51D, XRCC2, SWSAP1, FAM9B, DKKL1, ARL4C, MUC20, ADAMTS4, HELQ, HNRNPL, SPDL1, BRCA1, TPT1, ABL1, MEOX2, RPAIN, ANAPC5, BAGE2, C15orf39, PRPF6, C5orf34, N4BP2L2, BANP, ANKHD1-EIF4EBP3, KLRC2, DSCC1, SATB2, ZNHIT6, PMS1, NUF2, APAF1, PRKACB, MAPRE2, CD300LB, PRKACG, TBC1D2B, MTR,

Protein-protein interactors based on sequence similarity (STRING)

Gene	STRING network
HMGA2
RAD51B

- Retained interactions in fusion protein (protein functional feature from UniProt).

Partner

Gene

Hbp

Tbp

ENST

Strand

BPexon

TotalExon

Protein feature loci

*BPloci

TotalLen

Still interaction with

- Lost interactions due to fusion (protein functional feature from UniProt).

Partner	Gene	Hbp	Tbp	ENST	Strand	BPexon	TotalExon	Protein feature loci	*BPloci	TotalLen	Interaction lost with
Tgene	RAD51B	chr12:66232351	chr14:68758600	ENST00000390683		5	10	1_75	252.0	367.0	RAD51C
Tgene	RAD51B	chr12:66232351	chr14:68758600	ENST00000471583		6	11	1_75	252.0	351.0	RAD51C
Tgene	RAD51B	chr12:66232351	chr14:68758600	ENST00000487270		6	11	1_75	252.0	385.0	RAD51C
Tgene	RAD51B	chr12:66232351	chr14:68758600	ENST00000488612		6	12	1_75	252.0	495.6666666666667	RAD51C

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Related Drugs to HMGA2-RAD51B

Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene

Tgene

Drug

Source

PMID

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Related Diseases to HMGA2-RAD51B

Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)

Hgene	Tgene	Disease	Source	PMID
HMGA2	RAD51B	Cancer Of Unknown Primary	MyCancerGenome
HMGA2	RAD51B	Colorectal Adenocarcinoma	MyCancerGenome
HMGA2	RAD51B	Invasive Breast Carcinoma	MyCancerGenome
HMGA2	RAD51B	Leiomyosarcoma	MyCancerGenome
HMGA2	RAD51B	Pancreatic Adenocarcinoma	MyCancerGenome

Diseases associated with fusion partners.
(DisGeNet 4.0)

Partner	Gene	Disease ID	Disease name	# pubmeds	Source
Hgene	HMGA2	C1519176	Salivary Gland Pleomorphic Adenoma	2	ORPHANET
Hgene	HMGA2	C0005612	Birth Weight	1	CTD_human
Hgene	HMGA2	C0006826	Malignant Neoplasms	1	CTD_human
Hgene	HMGA2	C0027626	Neoplasm Invasiveness	1	CTD_human
Hgene	HMGA2	C0027651	Neoplasms	1	CTD_human
Hgene	HMGA2	C0086692	Benign Neoplasm	1	CTD_human
Hgene	HMGA2	C0175693	Russell-Silver syndrome	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0473935	Radiolabeled somatostatin analog study	1	GENOMICS_ENGLAND
Hgene	HMGA2	C0796160	MENTAL RETARDATION, X-LINKED, SNYDER-ROBINSON TYPE	1	GENOMICS_ENGLAND
Hgene	HMGA2	C1096309	Myolipoma	1	GENOMICS_ENGLAND
Hgene	HMGA2	C4305140	12q14 microdeletion syndrome	1	ORPHANET
Tgene	RAD51B	C0006142	Malignant neoplasm of breast	1	CTD_human
Tgene	RAD51B	C0013146	Drug abuse	1	CTD_human
Tgene	RAD51B	C0013170	Drug habituation	1	CTD_human
Tgene	RAD51B	C0013222	Drug Use Disorders	1	CTD_human
Tgene	RAD51B	C0029231	Organic Mental Disorders, Substance-Induced	1	CTD_human
Tgene	RAD51B	C0038580	Substance Dependence	1	CTD_human
Tgene	RAD51B	C0038586	Substance Use Disorders	1	CTD_human
Tgene	RAD51B	C0236969	Substance-Related Disorders	1	CTD_human
Tgene	RAD51B	C0238033	Carcinoma of Male Breast	1	CTD_human
Tgene	RAD51B	C0242788	Breast Neoplasms, Male	1	CTD_human
Tgene	RAD51B	C0678222	Breast Carcinoma	1	CTD_human
Tgene	RAD51B	C0740858	Substance abuse problem	1	CTD_human
Tgene	RAD51B	C1257931	Mammary Neoplasms, Human	1	CTD_human
Tgene	RAD51B	C1458155	Mammary Neoplasms	1	CTD_human
Tgene	RAD51B	C1510472	Drug Dependence	1	CTD_human
Tgene	RAD51B	C4316881	Prescription Drug Abuse	1	CTD_human
Tgene	RAD51B	C4704874	Mammary Carcinoma, Human	1	CTD_human