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Center for Computational Systems Medicine level1
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Fusion Gene Summary

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Fusion Gene Sample Information

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Fusion ORF Analysis

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Fusion Amino Acid Sequences

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Fusion Protein Functional Features

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Fusion Protein-Protein Interaction

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Related drugs with this fusion protein

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Related disease with this fusion protein

Fusion Protein:HNRNPA2B1-HSD17B10

Fusion Protein Summary

check button Fusion gene summary
Fusion partner gene informationFusion gene name: HNRNPA2B1-HSD17B10
FusionPDB ID: 37079
FusionGDB2.0 ID: 37079
HgeneTgene
Gene symbol

HNRNPA2B1

HSD17B10

Gene ID

3181

3028

Gene nameheterogeneous nuclear ribonucleoprotein A2/B1hydroxysteroid 17-beta dehydrogenase 10
SynonymsHNRNPA2|HNRNPB1|HNRPA2|HNRPA2B1|HNRPB1|IBMPFD2|RNPA2|SNRPB117b-HSD10|ABAD|CAMR|DUPXp11.22|ERAB|HADH2|HCD2|HSD10MD|MHBD|MRPP2|MRX17|MRX31|MRXS10|SCHAD|SDR5C1
Cytomap

7p15.2

Xp11.22

Type of geneprotein-codingprotein-coding
Descriptionheterogeneous nuclear ribonucleoproteins A2/B1HNRNPA2B1/MYC fusionepididymis secretory sperm binding proteinhnRNP A2 / hnRNP B1nuclear ribonucleoprotein particle A2 protein3-hydroxyacyl-CoA dehydrogenase type-23-hydroxy-2-methylbutyryl-CoA dehydrogenaseAB-binding alcohol dehydrogenaseamyloid-beta peptide binding alcohol dehydrogenaseendoplasmic reticulum-associated amyloid beta-peptide-binding proteinmitochondrial RNas
Modification date2020031420200313
UniProtAcc

P22626

Q99714

Ensembl transtripts involved in fusion geneENST idsENST00000354667, ENST00000356674, 
ENST00000476233, 		ENST00000495986, 
ENST00000168216, ENST00000375298, 
ENST00000375304, 
Fusion gene scores for assessment (based on all fusion genes of FusionGDB 2.0)* DoF score43 X 37 X 14=222742 X 2 X 2=8
# samples 503
** MAII scorelog2(50/22274*10)=-5.47728875772656
possibly effective Gene in Pan-Cancer Fusion Genes (peGinPCFGs).
DoF>8 and MAII<0		log2(3/8*10)=1.90689059560852
Context (manual curation of fusion genes in FusionPDB)

PubMed: HNRNPA2B1 [Title/Abstract] AND HSD17B10 [Title/Abstract] AND fusion [Title/Abstract]

Most frequent breakpoint (based on all fusion genes of FusionGDB 2.0)HNRNPA2B1(26240192)-HSD17B10(53460833), # samples:2
Anticipated loss of major functional domain due to fusion event.HNRNPA2B1-HSD17B10 seems lost the major protein functional domain in Hgene partner, which is a CGC by not retaining the major functional domain in the partially deleted in-frame ORF.
HNRNPA2B1-HSD17B10 seems lost the major protein functional domain in Hgene partner, which is a essential gene by not retaining the major functional domain in the partially deleted in-frame ORF.
* DoF score (Degree of Frequency) = # partners X # break points X # cancer types
** MAII score (Major Active Isofusion Index) = log2(# samples/DoF score*10)

check button Gene ontology of each fusion partner gene with evidence of Inferred from Direct Assay (IDA) from Entrez
PartnerGeneGO IDGO termPubMed ID
HgeneHNRNPA2B1

GO:0006397

mRNA processing

2557628

HgeneHNRNPA2B1

GO:0006406

mRNA export from nucleus

10567417

HgeneHNRNPA2B1

GO:0031053

primary miRNA processing

26321680

HgeneHNRNPA2B1

GO:0050658

RNA transport

17004321

HgeneHNRNPA2B1

GO:1990428

miRNA transport

24356509

TgeneHSD17B10

GO:0051289

protein homotetramerization

25925575

TgeneHSD17B10

GO:0070901

mitochondrial tRNA methylation

25925575|28888424

TgeneHSD17B10

GO:0097745

mitochondrial tRNA 5'-end processing

24549042|25925575|28888424|29040705

TgeneHSD17B10

GO:1990180

mitochondrial tRNA 3'-end processing

29040705


check buttonFusion gene breakpoints across HNRNPA2B1 (5'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure

check buttonFusion gene breakpoints across HSD17B10 (3'-gene)
* Click on the image to open the UCSC genome browser with custom track showing this image in a new window.
all structure


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Fusion Gene Sample Information

check buttonFusion gene information from FusionGDB2.0.
check button Fusion gene information from two resources (ChiTars 5.0 and ChimerDB 4.0)
* All genome coordinats were lifted-over on hg19.
* Click on the break point to see the gene structure around the break point region using the UCSC Genome Browser.
SourceDiseaseSampleHgeneHchrHbpHstrandTgeneTchrTbpTstrand
ChimerDB4ACCTCGA-OU-A5PI-01AHNRNPA2B1chr7

26240192

-HSD17B10chrX

53460833

-
ChimerDB4ACCTCGA-OU-A5PIHNRNPA2B1chr7

26240191

-HSD17B10chrX

53460833

-


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Fusion ORF Analysis


check buttonFusion information from ORFfinder translation from full-length transcript sequence from FusionPDB.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandSeq length
(transcript)		BP loci
(transcript)		Predicted start
(transcript)		Predicted stop
(transcript)		Seq length
(amino acids)
ENST00000354667HNRNPA2B1chr726240192-ENST00000375304HSD17B10chrX53460833-1053175169906245
ENST00000354667HNRNPA2B1chr726240192-ENST00000168216HSD17B10chrX53460833-1080175169933254
ENST00000354667HNRNPA2B1chr726240192-ENST00000375298HSD17B10chrX53460833-96617561172179
ENST00000356674HNRNPA2B1chr726240192-ENST00000375304HSD17B10chrX53460833-1053175169906245
ENST00000356674HNRNPA2B1chr726240192-ENST00000168216HSD17B10chrX53460833-1080175169933254
ENST00000356674HNRNPA2B1chr726240192-ENST00000375298HSD17B10chrX53460833-96617561172179
ENST00000354667HNRNPA2B1chr726240191-ENST00000375304HSD17B10chrX53460833-1053175169906245
ENST00000354667HNRNPA2B1chr726240191-ENST00000168216HSD17B10chrX53460833-1080175169933254
ENST00000354667HNRNPA2B1chr726240191-ENST00000375298HSD17B10chrX53460833-96617561172179
ENST00000356674HNRNPA2B1chr726240191-ENST00000375304HSD17B10chrX53460833-1053175169906245
ENST00000356674HNRNPA2B1chr726240191-ENST00000168216HSD17B10chrX53460833-1080175169933254
ENST00000356674HNRNPA2B1chr726240191-ENST00000375298HSD17B10chrX53460833-96617561172179

check buttonDeepORF prediction of the coding potential based on the fusion transcript sequence of in-frame fusion genes. DeepORF is a coding potential classifier based on convolutional neural network by comparing the real Ribo-seq data. If the no-coding score < 0.5 and coding score > 0.5, then the in-frame fusion transcript is predicted as being likely translated.
HenstTenstHgeneHchrHbpHstrandTgeneTchrTbpTstrandNo-coding scoreCoding score
ENST00000354667ENST00000375304HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0040503580.9959496
ENST00000354667ENST00000168216HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0040274650.9959726
ENST00000354667ENST00000375298HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0069330810.9930669
ENST00000356674ENST00000375304HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0040503580.9959496
ENST00000356674ENST00000168216HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0040274650.9959726
ENST00000356674ENST00000375298HNRNPA2B1chr726240192-HSD17B10chrX53460833-0.0069330810.9930669
ENST00000354667ENST00000375304HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0040503580.9959496
ENST00000354667ENST00000168216HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0040274650.9959726
ENST00000354667ENST00000375298HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0069330810.9930669
ENST00000356674ENST00000375304HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0040503580.9959496
ENST00000356674ENST00000168216HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0040274650.9959726
ENST00000356674ENST00000375298HNRNPA2B1chr726240191-HSD17B10chrX53460833-0.0069330810.9930669

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Fusion Amino Acid Sequences


check button For individual full-length fusion transcript sequence from FusionPDB, we ran ORFfinder and chose the longest ORF among the all predicted ones.
>FusionGDB ID_FusionGDB isoform ID_FGname_Hgene_Hchr_Hbp_Henst_Tgene_Tchr_Tbp_Tenst_length(fusion AA) seq_BP

>37079_37079_1_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000354667_HSD17B10_chrX_53460833_ENST00000168216_length(amino acids)=254AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_2_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000354667_HSD17B10_chrX_53460833_ENST00000375298_length(amino acids)=179AA_BP=1
MAVLMMTPRWPPWSGSFWPISPATRRITLKVPMRFTSRTRWKSSKVWVWPFFKLYVLLATAMPAQLTATSTRPNFPFARARAVCTSFSEV

--------------------------------------------------------------

>37079_37079_3_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000354667_HSD17B10_chrX_53460833_ENST00000375304_length(amino acids)=245AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_4_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000356674_HSD17B10_chrX_53460833_ENST00000168216_length(amino acids)=254AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_5_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000356674_HSD17B10_chrX_53460833_ENST00000375298_length(amino acids)=179AA_BP=1
MAVLMMTPRWPPWSGSFWPISPATRRITLKVPMRFTSRTRWKSSKVWVWPFFKLYVLLATAMPAQLTATSTRPNFPFARARAVCTSFSEV

--------------------------------------------------------------

>37079_37079_6_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240191_ENST00000356674_HSD17B10_chrX_53460833_ENST00000375304_length(amino acids)=245AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_7_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000354667_HSD17B10_chrX_53460833_ENST00000168216_length(amino acids)=254AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_8_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000354667_HSD17B10_chrX_53460833_ENST00000375298_length(amino acids)=179AA_BP=1
MAVLMMTPRWPPWSGSFWPISPATRRITLKVPMRFTSRTRWKSSKVWVWPFFKLYVLLATAMPAQLTATSTRPNFPFARARAVCTSFSEV

--------------------------------------------------------------

>37079_37079_9_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000354667_HSD17B10_chrX_53460833_ENST00000375304_length(amino acids)=245AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_10_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000356674_HSD17B10_chrX_53460833_ENST00000168216_length(amino acids)=254AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

>37079_37079_11_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000356674_HSD17B10_chrX_53460833_ENST00000375298_length(amino acids)=179AA_BP=1
MAVLMMTPRWPPWSGSFWPISPATRRITLKVPMRFTSRTRWKSSKVWVWPFFKLYVLLATAMPAQLTATSTRPNFPFARARAVCTSFSEV

--------------------------------------------------------------

>37079_37079_12_HNRNPA2B1-HSD17B10_HNRNPA2B1_chr7_26240192_ENST00000356674_HSD17B10_chrX_53460833_ENST00000375304_length(amino acids)=245AA_BP=2
MEGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVA
SKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLA

--------------------------------------------------------------

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Fusion Protein Functional Features


check button Four levels of functional features of fusion genes
Go to FGviewer search page for the most frequent breakpoint (https://ccsmweb.uth.edu/FGviewer/chr7:26240192/chrX:53460833)
- FGviewer provides the online visualization of the retention search of the protein functional features across DNA, RNA, protein, and pathological levels.
- How to search
1. Put your fusion gene symbol.
2. Press the tab key until there will be shown the breakpoint information filled.
4. Go down and press 'Search' tab twice.
4. Go down to have the hyperlink of the search result.
5. Click the hyperlink.
6. See the FGviewer result for your fusion gene.
FGviewer

check buttonMain function of each fusion partner protein. (from UniProt)
HgeneTgene
HNRNPA2B1

P22626

HSD17B10

Q99714

FUNCTION: Heterogeneous nuclear ribonucleoprotein (hnRNP) that associates with nascent pre-mRNAs, packaging them into hnRNP particles. The hnRNP particle arrangement on nascent hnRNA is non-random and sequence-dependent and serves to condense and stabilize the transcripts and minimize tangling and knotting. Packaging plays a role in various processes such as transcription, pre-mRNA processing, RNA nuclear export, subcellular location, mRNA translation and stability of mature mRNAs (PubMed:19099192). Forms hnRNP particles with at least 20 other different hnRNP and heterogeneous nuclear RNA in the nucleus. Involved in transport of specific mRNAs to the cytoplasm in oligodendrocytes and neurons: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) or the A2RE11 (derivative 11 nucleotide oligonucleotide) sequence motifs present on some mRNAs, and promotes their transport to the cytoplasm (PubMed:10567417). Specifically binds single-stranded telomeric DNA sequences, protecting telomeric DNA repeat against endonuclease digestion (By similarity). Also binds other RNA molecules, such as primary miRNA (pri-miRNAs): acts as a nuclear 'reader' of the N6-methyladenosine (m6A) mark by specifically recognizing and binding a subset of nuclear m6A-containing pri-miRNAs. Binding to m6A-containing pri-miRNAs promotes pri-miRNA processing by enhancing binding of DGCR8 to pri-miRNA transcripts (PubMed:26321680). Involved in miRNA sorting into exosomes following sumoylation, possibly by binding (m6A)-containing pre-miRNAs (PubMed:24356509). Acts as a regulator of efficiency of mRNA splicing, possibly by binding to m6A-containing pre-mRNAs (PubMed:26321680). Plays also a role in the activation of the innate immune response (PubMed:31320558). Mechanistically, senses the presence of viral DNA in the nucleus, homodimerizes and is demethylated by JMJD6 (PubMed:31320558). In turn, translocates to the cytoplasm where it activates the TBK1-IRF3 pathway, leading to interferon alpha/beta production (PubMed:31320558). {ECO:0000250|UniProtKB:A7VJC2, ECO:0000269|PubMed:10567417, ECO:0000269|PubMed:24356509, ECO:0000269|PubMed:26321680, ECO:0000303|PubMed:19099192}.; FUNCTION: (Microbial infection) Involved in the transport of HIV-1 genomic RNA out of the nucleus, to the microtubule organizing center (MTOC), and then from the MTOC to the cytoplasm: acts by specifically recognizing and binding the A2RE (21 nucleotide hnRNP A2 response element) sequence motifs present on HIV-1 genomic RNA, and promotes its transport. {ECO:0000269|PubMed:15294897, ECO:0000269|PubMed:17004321}.FUNCTION: Mitochondrial dehydrogenase involved in pathways of fatty acid, branched-chain amino acid and steroid metabolism (PubMed:9553139, PubMed:10600649, PubMed:12917011, PubMed:20077426, PubMed:18996107, PubMed:19706438, PubMed:25925575, PubMed:26950678, PubMed:28888424). Acts as (S)-3-hydroxyacyl-CoA dehydrogenase in mitochondrial fatty acid beta-oxidation, a major degradation pathway of fatty acids. Catalyzes the third step in the beta-oxidation cycle, namely the reversible conversion of (S)-3-hydroxyacyl-CoA to 3-ketoacyl-CoA. Preferentially accepts straight medium- and short-chain acyl-CoA substrates with highest efficiency for (3S)-hydroxybutanoyl-CoA (PubMed:9553139, PubMed:10600649, PubMed:12917011, PubMed:25925575, PubMed:26950678). Acts as 3-hydroxy-2-methylbutyryl-CoA dehydrogenase in branched-chain amino acid catabolic pathway. Catalyzes the oxidation of 3-hydroxy-2-methylbutanoyl-CoA into 2-methyl-3-oxobutanoyl-CoA, a step in isoleucine degradation pathway (PubMed:20077426, PubMed:18996107, PubMed:19706438). Has hydroxysteroid dehydrogenase activity toward steroid hormones and bile acids. Catalyzes the oxidation of 3alpha-, 17beta-, 20beta- and 21-hydroxysteroids and 7alpha- and 7beta-hydroxy bile acids (PubMed:10600649, PubMed:12917011). Oxidizes allopregnanolone/brexanolone at the 3alpha-hydroxyl group, which is known to be critical for the activation of gamma-aminobutyric acid receptors (GABAARs) chloride channel (PubMed:19706438, PubMed:28888424). Has phospholipase C-like activity toward cardiolipin and its oxidized species. Likely oxidizes the 2'-hydroxyl in the head group of cardiolipin to form a ketone intermediate that undergoes nucleophilic attack by water and fragments into diacylglycerol, dihydroxyacetone and orthophosphate. Has higher affinity for cardiolipin with oxidized fatty acids and may degrade these species during the oxidative stress response to protect cells from apoptosis (PubMed:26338420). By interacting with intracellular amyloid-beta, it may contribute to the neuronal dysfunction associated with Alzheimer disease (AD) (PubMed:9338779). Essential for structural and functional integrity of mitochondria (PubMed:20077426). {ECO:0000269|PubMed:10600649, ECO:0000269|PubMed:12917011, ECO:0000269|PubMed:18996107, ECO:0000269|PubMed:19706438, ECO:0000269|PubMed:20077426, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26338420, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:9553139}.; FUNCTION: In addition to mitochondrial dehydrogenase activity, moonlights as a component of mitochondrial ribonuclease P, a complex that cleaves tRNA molecules in their 5'-ends (PubMed:18984158, PubMed:24549042, PubMed:25925575, PubMed:26950678, PubMed:28888424). Together with TRMT10C/MRPP1, forms a subcomplex of the mitochondrial ribonuclease P, named MRPP1-MRPP2 subcomplex, which displays functions that are independent of the ribonuclease P activity (PubMed:23042678, PubMed:29040705). The MRPP1-MRPP2 subcomplex catalyzes the formation of N(1)-methylguanine and N(1)-methyladenine at position 9 (m1G9 and m1A9, respectively) in tRNAs; HSD17B10/MRPP2 acting as a non-catalytic subunit (PubMed:23042678, PubMed:25925575, PubMed:28888424). The MRPP1-MRPP2 subcomplex also acts as a tRNA maturation platform: following 5'-end cleavage by the mitochondrial ribonuclease P complex, the MRPP1-MRPP2 subcomplex enhances the efficiency of 3'-processing catalyzed by ELAC2, retains the tRNA product after ELAC2 processing and presents the nascent tRNA to the mitochondrial CCA tRNA nucleotidyltransferase TRNT1 enzyme (PubMed:29040705). Associates with mitochondrial DNA complexes at the nucleoids to initiate RNA processing and ribosome assembly. {ECO:0000269|PubMed:18984158, ECO:0000269|PubMed:23042678, ECO:0000269|PubMed:24549042, ECO:0000269|PubMed:24703694, ECO:0000269|PubMed:25925575, ECO:0000269|PubMed:26950678, ECO:0000269|PubMed:28888424, ECO:0000269|PubMed:29040705}.

check buttonRetention analysis result of each fusion partner protein across 39 protein features of UniProt such as six molecule processing features, 13 region features, four site features, six amino acid modification features, two natural variation features, five experimental info features, and 3 secondary structure features. Here, because of limited space for viewing, we only show the protein feature retention information belong to the 13 regional features. All retention annotation result can be downloaded at

download page

* Minus value of BPloci means that the break pointn is located before the CDS.
- Retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
TgeneHSD17B10chr7:26240191chrX:53460833ENST000001682160612_419.0262.0Nucleotide bindingNAD
TgeneHSD17B10chr7:26240191chrX:53460833ENST000003753040612_419.0253.0Nucleotide bindingNAD
TgeneHSD17B10chr7:26240192chrX:53460833ENST000001682160612_419.0262.0Nucleotide bindingNAD
TgeneHSD17B10chr7:26240192chrX:53460833ENST000003753040612_419.0253.0Nucleotide bindingNAD

- Not-retained protein feature among the 13 regional features.
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenProtein featureProtein feature note
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-112202_3532.01115.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-111202_3532.0439.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-112202_3532.01115.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-111202_3532.0439.3333333333333Compositional biasNote=Gly-rich
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-112112_1912.01115.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-11221_1042.01115.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-111112_1912.0439.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-11121_1042.0439.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-112112_1912.01115.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-11221_1042.01115.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-111112_1912.0439.3333333333333DomainRRM 2
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-11121_1042.0439.3333333333333DomainRRM 1
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-1129_152.01115.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-1119_152.0439.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-1129_152.01115.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-1119_152.0439.3333333333333MotifNuclear localization signal
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-112193_3532.01115.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000354667-112308_3472.01115.3333333333333RegionNuclear targeting sequence
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-111193_3532.0439.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240191chrX:53460833ENST00000356674-111308_3472.0439.3333333333333RegionNuclear targeting sequence
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-112193_3532.01115.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000354667-112308_3472.01115.3333333333333RegionNuclear targeting sequence
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-111193_3532.0439.3333333333333RegionLow complexity (LC) region
HgeneHNRNPA2B1chr7:26240192chrX:53460833ENST00000356674-111308_3472.0439.3333333333333RegionNuclear targeting sequence


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Fusion Protein-Protein Interaction


check button Go to ChiPPI (Chimeric Protein-Protein interactions) to see the chimeric PPI interaction in

ChiPPI page.


check button Protein-protein interactors with each fusion partner protein in wild-type from validated records (BIOGRID-3.4.160)
GenePPI interactors


check button Protein-protein interactors based on sequence similarity (STRING)
GeneSTRING network
HNRNPA2B1
HSD17B10


check button - Retained interactions in fusion protein (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenStill interaction with


check button - Lost interactions due to fusion (protein functional feature from UniProt).
PartnerGeneHbpTbpENSTStrandBPexonTotalExonProtein feature loci*BPlociTotalLenInteraction lost with


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Related Drugs to HNRNPA2B1-HSD17B10


check button Drugs used for this fusion-positive patient.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDrugSourcePMID

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Related Diseases to HNRNPA2B1-HSD17B10


check button Diseases that have this fusion gene.
(Manual curation of PubMed, 04-30-2022 + MyCancerGenome)
HgeneTgeneDiseaseSourcePMID

check button Diseases associated with fusion partners.
(DisGeNet 4.0)
PartnerGeneDisease IDDisease name# pubmedsSource